Yellow nails syndrome

Robles Marhuenda, Á.; Molina Collada, J.; Arnalich Fernández, F.

doi:10.1016/j.rceng.2019.07.020

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The images show some of the physical stigma of this disease, such as facial congestion, labial and nail bed cyanosis, watch-glass nails and distal hyperpigmentation, palmar erythema, and varicose veins in the legs. Images provided by Dr. Francisco C. Villafuerte." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Garrido, J. Botella de Maglia, O. Castillo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Garrido" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Botella de Maglia" ] 2 => array:2 [ "nombre" => "O." 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Robles Marhuenda, J. Molina Collada, F. Arnalich Fernández" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Á." "apellidos" => "Robles Marhuenda" "email" => array:1 [ 0 => "aroblesmarhuenda@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Molina Collada" ] 2 => array:2 [ "nombre" => "F." 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The patient, a Caucasian ex-smoker, presented no occupational exposure. The physical examination only revealed slight crackles in both lower lung fields and thickened nails that were yellow in colour, excessively curved, and of abnormally slow growth (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The patient reported episodes of oedema in the upper limbs, particularly in the evening, and previous respiratory decline. The chest x-ray showed bronchiectasis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) bilaterally affecting the lower lobes and blunting of the left costophrenic angle. Nail fungal cultures showed no microbial growth. Yellow nail syndrome is a rare disease of unknown cause that is characterised by a triad of thickened yellow nails, lymphoedema, and respiratory manifestations.<a class="elsevierStyleCrossRefs" href="#bib0005">1,2</a> The available data suggest that the presence of acquired lymphatic impairment is the predominant underlying mechanism that causes these clinical manifestations.<a class="elsevierStyleCrossRefs" href="#bib0015">3,4</a><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-07-15" "fechaAceptado" => "2019-07-25" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Robles Marhuenda Á, Molina Collada J, Arnalich Fernández F. Síndrome de uñas amarillas. Rev Clin Esp. 2021;221:491–492." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1112 "Ancho" => 1674 "Tamanyo" => 98379 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1421 "Ancho" => 1424 "Tamanyo" => 76532 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The yellow nail syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.D. Samman" 1 => "W.F. White" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.1964.tb14499.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1964" "volumen" => "76" "paginaInicial" => "153" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14140738" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Yellow nails, lymphoedema, and pleural effusions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.A. Emerson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.21.3.247" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1966" "volumen" => "21" "paginaInicial" => "247" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5914998" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Yellow nail syndrome: does protein leakage play a role?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. D’Alessandro" 1 => "G. Muzi" 2 => "A. Monaco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.01.17101490" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "149" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11307745" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nailing the diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Rajagopala" 1 => "N. Singh" 2 => "D. Gupta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2009.07.014" "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "2009" "volumen" => "122" "paginaInicial" => "1085" "paginaFinal" => "1087" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19958883" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000022100000008/v2_202110011208/S2254887421001089/v2_202110011208/en/main.assets" "Apartado" => array:4 [ "identificador" => "71811" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Medicine in images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000022100000008/v2_202110011208/S2254887421001089/v2_202110011208/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887421001089?idApp=WRCEE"]

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Vol. 221. Issue 8.

Pages 491-492 (October 2021)

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