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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">This case concerns a 62-year-old woman with a history of bipolar disorder diagnosed at the age of 39 years undergoing treatment with lithium&#46; Her mother died with dementia&#44; and the patient had a brother with a psychiatric disorder&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient consulted for disorganized behavior&#44; striking hyperactivity and prejudicial ideation towards her husband&#46; The hemogram and biochemistry results were normal&#44; including intact thyrotropin and parathyroid hormone levels&#46; The serology results for toxoplasma&#44; rubella&#44; syphilis&#44; parvovirus B19&#44; varicella-zoster virus and human immunodeficiency virus were negative&#46; Cerebral computed tomography revealed the presence of calcification of the basal ganglia &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Fahr&#39;s disease&#44; recently renamed primary familial brain calcification &#40;PFBC&#41;&#44; is a neurodegenerative disease in which 4 related genes have been reported &#40;PDGFB&#44; PDGFRB&#44; SLC20A2 and XPR1&#41; and is inherited in an autosomal dominant manner&#46; There are 2 incidence peaks&#58; the third decade of life &#40;characterized by psychotic-like symptoms&#41; and the fifth-sixth decade of life &#40;characterized by progressive dementia and movement disorders&#41;&#46; Cerebral computed tomography is the reference diagnostic test&#44; although a number of authors have suggested diagnostic criteria&#46; The treatment is symptomatic for neuropsychiatric manifestations&#59; however&#44; the use of bisphosphonates has recently been proposed&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Calcification of the basal ganglia is occasionally a nonspecific finding&#46; In patients with neuropsychiatric symptoms&#44; however&#44; studying the neurodegenerative entities such as PFBC might be appropriate&#44; to thereby offer genetic counseling to affected individuals&#46;</p></span>"
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Vol. 220. Issue 2.
Pages 143 (March 2020)
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Vol. 220. Issue 2.
Pages 143 (March 2020)
Medicine in Images
Fahr's disease
Enfermedad de Fahr
Visits
11
J.M. Martín Guerra
Corresponding author
javi6vega@hotmail.com

Corresponding author.
, M. Martín Asenjo, J.M. Prieto de Paula
Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
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