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Martín Guerra, M. Martín Asenjo, J.M. Prieto de Paula" "autores" => array:3 [ 0 => array:4 [ "nombre" => "J.M." "apellidos" => "Martín Guerra" "email" => array:1 [ 0 => "javi6vega@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "M. Martín" "apellidos" => "Asenjo" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Prieto de Paula" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Medicina Interna, Hospital Clínico Universitario de Valladolid, Valladolid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad de Fahr" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 829 "Ancho" => 900 "Tamanyo" => 53070 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">This case concerns a 62-year-old woman with a history of bipolar disorder diagnosed at the age of 39 years undergoing treatment with lithium. Her mother died with dementia, and the patient had a brother with a psychiatric disorder.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient consulted for disorganized behavior, striking hyperactivity and prejudicial ideation towards her husband. The hemogram and biochemistry results were normal, including intact thyrotropin and parathyroid hormone levels. The serology results for toxoplasma, rubella, syphilis, parvovirus B19, varicella-zoster virus and human immunodeficiency virus were negative. Cerebral computed tomography revealed the presence of calcification of the basal ganglia (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Fahr's disease, recently renamed primary familial brain calcification (PFBC), is a neurodegenerative disease in which 4 related genes have been reported (PDGFB, PDGFRB, SLC20A2 and XPR1) and is inherited in an autosomal dominant manner. There are 2 incidence peaks: the third decade of life (characterized by psychotic-like symptoms) and the fifth-sixth decade of life (characterized by progressive dementia and movement disorders). Cerebral computed tomography is the reference diagnostic test, although a number of authors have suggested diagnostic criteria. The treatment is symptomatic for neuropsychiatric manifestations; however, the use of bisphosphonates has recently been proposed.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Calcification of the basal ganglia is occasionally a nonspecific finding. In patients with neuropsychiatric symptoms, however, studying the neurodegenerative entities such as PFBC might be appropriate, to thereby offer genetic counseling to affected individuals.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-10-23" "fechaAceptado" => "2018-11-02" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Martín Guerra JM, Asenjo MM, Prieto de Paula JM. Enfermedad de Fahr. 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