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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old patient was admitted to the Department of Dermatology to assess asymptomatic lesions on the face and scalp that appeared 3 months earlier&#46; The patient had started immunosuppressive therapy with cyclosporine at a dosage of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;day 6 months earlier after undergoing kidney transplantation due to end-stage renal failure secondary to IgA mesangial proliferative glomerulonephritis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">During the physical examination&#44; we observed numerous yellowish papules with central umbilication&#44; which were located mainly on the forehead&#44; scalp and chin&#46; The lesions were clinically compatible with sebaceous hyperplasia secondary to the cyclosporine treatment&#46; The cyclosporine dosage was decreased to 150<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#59; however&#44; neither the number nor the size of the lesions decreased &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Sebaceous hyperplasia is a benign proliferation of sebaceous glands that develops as the result of chronological aging&#44; photoaging&#44; exposure to ultraviolet radiation and genetic predisposition&#46; Patients who have undergone a transplantation constitute another group with an increasing number of cases&#46; Twenty-five percent of those who have undergone kidney transplantation present sebaceous hyperplasia during the first year&#46; The reported cases are due to taking various immunosuppressants&#59; however&#44; it has been postulated that cyclosporine is the most implicated etiological agent&#46; It has been shown that cyclosporine produces hypertrichosis&#44; keratosis pilaris&#44; acne and folliculitis&#44; as well as nonmelanoma skin cancer&#46; The effect of cyclosporine on the follicle-sebaceous unit&#44; as well as immunosuppression&#44; are mechanisms that can explain the etiopathogenesis of these adnexal tumors in patients who have undergone transplantation&#46;</p></span>"
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May 2019 Eruptive sebaceous hyperplasias secondary to ciclosporin in a renal transplant...
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Vol. 219. Issue 4.
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Vol. 219. Issue 4.
Pages 222-223 (May 2019)
Medicine in Image
DOI: 10.1016/j.rceng.2018.11.006
Eruptive sebaceous hyperplasias secondary to ciclosporin in a renal transplant patient
Hiperplasias sebáceas eruptivas por ciclosporina en paciente trasplantado renal
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T. Gracia-Cazañaa,
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tamgracaz@gmail.com

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, M.P. Sánchez Salasa, Y. Gilaberteb
a Unidad de Dermatología, Hospital de Barbastro, Barbastro, Huesca, Spain
b Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, Spain
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