Medicine in Image
Eruptive sebaceous hyperplasias secondary to ciclosporin in a renal transplant patient
Hiperplasias sebáceas eruptivas por ciclosporina en paciente trasplantado renal
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Gracia-Cazaña, M.P. Sánchez Salas, Y. Gilaberte" "autores" => array:3 [ 0 => array:4 [ "nombre" => "T." "apellidos" => "Gracia-Cazaña" "email" => array:1 [ 0 => "tamgracaz@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M.P." "apellidos" => "Sánchez Salas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Y." "apellidos" => "Gilaberte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, Hospital de Barbastro, Barbastro, Huesca, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hiperplasias sebáceas eruptivas por ciclosporina en paciente trasplantado renal" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 900 "Tamanyo" => 168066 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 68-year-old patient was admitted to the Department of Dermatology to assess asymptomatic lesions on the face and scalp that appeared 3 months earlier. The patient had started immunosuppressive therapy with cyclosporine at a dosage of 250<span class="elsevierStyleHsp" style=""></span>mg/day 6 months earlier after undergoing kidney transplantation due to end-stage renal failure secondary to IgA mesangial proliferative glomerulonephritis.</p><p id="par0010" class="elsevierStylePara elsevierViewall">During the physical examination, we observed numerous yellowish papules with central umbilication, which were located mainly on the forehead, scalp and chin. The lesions were clinically compatible with sebaceous hyperplasia secondary to the cyclosporine treatment. The cyclosporine dosage was decreased to 150<span class="elsevierStyleHsp" style=""></span>mg/day; however, neither the number nor the size of the lesions decreased (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Sebaceous hyperplasia is a benign proliferation of sebaceous glands that develops as the result of chronological aging, photoaging, exposure to ultraviolet radiation and genetic predisposition. Patients who have undergone a transplantation constitute another group with an increasing number of cases. Twenty-five percent of those who have undergone kidney transplantation present sebaceous hyperplasia during the first year. The reported cases are due to taking various immunosuppressants; however, it has been postulated that cyclosporine is the most implicated etiological agent. It has been shown that cyclosporine produces hypertrichosis, keratosis pilaris, acne and folliculitis, as well as nonmelanoma skin cancer. The effect of cyclosporine on the follicle-sebaceous unit, as well as immunosuppression, are mechanisms that can explain the etiopathogenesis of these adnexal tumors in patients who have undergone transplantation.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-08-14" "fechaAceptado" => "2018-09-17" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Gracia-Cazaña T, Sánchez Salas MP, Gilaberte Y. Hiperplasias sebáceas eruptivas por ciclosporina en paciente trasplantado renal. Rev Clin Esp. 2019;219:222–223.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 900 "Tamanyo" => 168066 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000021900000004/v1_201904260621/S2254887418301826/v1_201904260621/en/main.assets" "Apartado" => array:4 [ "identificador" => "71811" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Medicine in images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000021900000004/v1_201904260621/S2254887418301826/v1_201904260621/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418301826?idApp=WRCEE" ]
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