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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have read with interest the article by Boada Fern&#225;ndez del Campo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> on metformin-associated lactic acidosis &#40;MALA&#41;&#44; where the authors performed an excellent analysis on its association with acute renal dysfunction&#44; highlighting the creatinine levels detected in patients admitted with MALA&#46; However&#44; the authors did not analyze the previous renal dysfunction of the patients with metformin and hyperlactatemia&#44; which is clearly related to this sometimes fatal complication&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In a retrospective observational study from January 2016 to June 2018 in Hospital San Juan de Dios del Aljarafe&#44; a district hospital that treats 294&#44;000 inhabitants&#44; with a rate of metformin use of 430&#47;10&#44;000 inhabitants&#47;year&#44; we analyzed 9283 emergency episodes of patients treated with metformin &#40;10&#46;6 emergency episodes&#47;month&#47;10&#44;000 inhabitants&#41;&#46; We detected 222 cases with lactate levels &#8805;2&#46;7&#8239;mmol&#47;L&#46; In 56 cases&#44; hyperlactatemia was associated with acidosis and renal failure&#44; 17 of the which &#40;30&#37;&#41; were diagnosed with MALA &#40;5&#46;4 cases&#47;10&#44;000 patients with metformin&#47;year&#44; similar to the study by Boada Fern&#225;ndez del Campo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#41;&#46; Of these&#44; 10 were admitted to the ICU requiring dialysis&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> with an overall mortality of 53&#37;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> lists the baseline glomerular filtration rates &#40;GFR&#41; of the treated patients&#44; showing that 35&#37; of those who presented hyperlactatemia&#44; 53&#37; of those with associated renal dysfunction and acidosis&#44; and 76&#37; of those who developed MALA had previous renal dysfunction&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">We observed that the incidence rate of hyperlactatemia in both studies was higher than that reported in the datasheet &#40;&#60;1&#58;10&#44;000 exposed individuals&#41; and that reported in other studies&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Our study data also confirm that a high proportion of the patients with metformin-associated hyperlactatemia had a baseline GFR &#60;60&#8239;mL&#47;min&#47;1&#46;73&#8239;m<span class="elsevierStyleSup">2</span>&#46; Given the high associated mortality&#44; we believe that precautions need to be taken in handling metformin in patients with renal dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></span>"
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Journal Information
Vol. 220. Issue 1.
Pages 76-77 (January - February 2020)
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Vol. 220. Issue 1.
Pages 76-77 (January - February 2020)
Correspondence
Metformin-induced lactic acidosis: should we be more careful with renal dysfunction?
Acidosis láctica por metformina: ¿debemos ser más cautelosos con la disfunción renal?
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A.L. Blanco Taboadaa,
Corresponding author
blancoanalaura.92@gmail.com

Corresponding author.
, J. Castilla Yélamosa, S. Delgado Romeroa, J.L. García Garmendiab
a Servicio de Medicina Interna, Hospital San Juan de Dios de Aljarafe, Bormujos, Sevilla, Spain
b Servicio de Cuidados Críticos y Urgencias, Hospital San Juan de Dios de Aljarafe, Bormujos, Sevilla, Spain
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Table 1. Baseline glomerular filtration rate of patients who take metformin and experience hyperlactatemia in the emergency department.

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