Original article
Impact of smoking cessation on metabolic parameters and renal function in patients with and without diabetes mellitus
Impacto del abandono del hábito de fumar sobre los parámetros metabólicos y la función renal en pacientes con y sin diabetes mellitus
C.-P. Fua,b,c,d, P.-K. Fua,e, M.-C. Luc, Y.-Y. Liaoe, J.-S. Wanga,c,f,g,
Corresponding author
jswang@vghtc.gov.tw
Corresponding author at: Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Boulevard, Taichung 407219, Taiwan.
Corresponding author at: Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Boulevard, Taichung 407219, Taiwan.
a Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
b Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan
c Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
d Department of Medicine, Chung Shan Medical University, Taichung, Taiwan
e Smoking Cessation Treatment and Management Center, Taichung Veterans General Hospital, Taichung, Taiwan
f Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan
g Diabetes Center, Taichung Veterans General Hospital, Taichung, Taiwan
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The outcomes were changes in metabolic parameters and renal function from baseline to 6-month follow-up after the smoking cessation program.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Result</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A total of 1,954 patients joined the smoking cessation program, and 1,381 patients were in the smoking cessation failure (SCF) group and 573 were in the smoking cessation success (SCS) group. The decrease in HbA1c after smoking cessation was only observed in patients with diabetes. Smoking cessation was also associated with a significant decrease in LDL cholesterol in patients with diabetes. In terms of renal function, smoking cessation was associated with an improvement in eGFR, and the trend was similar in patients with and without diabetes.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Successful smoking cessation was associated with improvement in renal function. Moreover, it was associated with improvements in HbA1c and LDL cholesterol in patients with diabetes, despite significant weight gain.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Backgroud and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Result" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Dado que los pacientes con diabetes tienen un riesgo significativamente mayor de sufrir enfermedades cardiovasculares que aquellos sin diabetes, es importante obtener una comprensión clínica de los efectos diferenciales de dejar de fumar sobre varios factores de riesgo entre pacientes con y sin diabetes.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y métodos</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Los pacientes que participaron en un programa para dejar de fumar recibieron una evaluación de los resultados de interés. Los resultados fueron cambios en los parámetros metabólicos y la función renal desde el inicio hasta el seguimiento de 6 meses después del programa para dejar de fumar.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultado</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Un total de 1.954 pacientes se unieron al programa para dejar de fumar, 1.381 pacientes estaban en el grupo de fracaso para dejar de fumar (SCF) y 573 estaban en el grupo de éxito para dejar de fumar (SCS). La disminución de la HbA1c tras dejar de fumar sólo se observó en pacientes con diabetes. Dejar de fumar también se asoció con una disminución significativa del colesterol LDL en pacientes con diabetes. En términos de función renal, dejar de fumar se asoció con una mejora en la TFGe, y la tendencia fue similar en pacientes con y sin diabetes.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusión</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Dejar de fumar exitosamente se asoció con una mejora en la función renal. 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