Impact of smoking cessation on metabolic parameters and renal function in patients with and without diabetes mellitus

Fu, C.-P.; Fu, P.-K.; Lu, M.-C.; Liao, Y.-Y.; Wang, J.-S.

doi:10.1016/j.rceng.2024.10.010

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Materials and methodsPatients who participated in a smoking cessation program received an assessment of the outcomes of interest. The outcomes were changes in metabolic parameters and renal function from baseline to 6-month follow-up after the smoking cessation program. ResultA total of 1,954 patients joined the smoking cessation program, and 1,381 patients were in the smoking cessation failure (SCF) group and 573 were in the smoking cessation success (SCS) group. The decrease in HbA1c after smoking cessation was only observed in patients with diabetes. Smoking cessation was also associated with a significant decrease in LDL cholesterol in patients with diabetes. In terms of renal function, smoking cessation was associated with an improvement in eGFR, and the trend was similar in patients with and without diabetes. ConclusionSuccessful smoking cessation was associated with improvement in renal function. Moreover, it was associated with improvements in HbA1c and LDL cholesterol in patients with diabetes, despite significant weight gain." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Backgroud and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Result" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "Antecedentes y objetivosDado que los pacientes con diabetes tienen un riesgo significativamente mayor de sufrir enfermedades cardiovasculares que aquellos sin diabetes, es importante obtener una comprensión clínica de los efectos diferenciales de dejar de fumar sobre varios factores de riesgo entre pacientes con y sin diabetes. Materiales y métodosLos pacientes que participaron en un programa para dejar de fumar recibieron una evaluación de los resultados de interés. Los resultados fueron cambios en los parámetros metabólicos y la función renal desde el inicio hasta el seguimiento de 6 meses después del programa para dejar de fumar. ResultadoUn total de 1.954 pacientes se unieron al programa para dejar de fumar, 1.381 pacientes estaban en el grupo de fracaso para dejar de fumar (SCF) y 573 estaban en el grupo de éxito para dejar de fumar (SCS). La disminución de la HbA1c tras dejar de fumar sólo se observó en pacientes con diabetes. Dejar de fumar también se asoció con una disminución significativa del colesterol LDL en pacientes con diabetes. En términos de función renal, dejar de fumar se asoció con una mejora en la TFGe, y la tendencia fue similar en pacientes con y sin diabetes. ConclusiónDejar de fumar exitosamente se asoció con una mejora en la función renal. Además, se asoció con mejoras en la HbA1c y el colesterol LDL en pacientes con diabetes, a pesar de un aumento de peso significativo." 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Revista Clínica Española (English Edition)

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Revista Clínica Española published its first issue in 1940 and is the body of expression of the Spanish Society of Internal Medicine (SEMI).
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Original article

DOI: 10.1016/j.rceng.2024.10.010

Pre-proof, online 4 November 2024

Impact of smoking cessation on metabolic parameters and renal function in patients with and without diabetes mellitus

Impacto del abandono del hábito de fumar sobre los parámetros metabólicos y la función renal en pacientes con y sin diabetes mellitus

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C.-P. Fua,b,c,d, P.-K. Fua,e, M.-C. Luc, Y.-Y. Liaoe, J.-S. Wanga,c,f,g,

Corresponding author

jswang@vghtc.gov.tw

Corresponding author at: Taichung Veterans General Hospital, No.1650, Sec. 4, Taiwan Boulevard, Taichung 407219, Taiwan.

a Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

b Graduate Institute of Biomedical Electronics and Bioinformatics, College of Electrical Engineering and Computer Science, National Taiwan University, Taipei, Taiwan

c Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

d Department of Medicine, Chung Shan Medical University, Taichung, Taiwan

e Smoking Cessation Treatment and Management Center, Taichung Veterans General Hospital, Taichung, Taiwan

f Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan

g Diabetes Center, Taichung Veterans General Hospital, Taichung, Taiwan

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Abstract

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Abstract

Backgroud and objectives

As patients with diabetes are at a significantly higher risk of cardiovascular diseases than those without diabetes, it is important to gain a clinical understanding of the differential effects of smoking cessation on several risk factors between patients with and without diabetes.

Materials and methods

Patients who participated in a smoking cessation program received an assessment of the outcomes of interest. The outcomes were changes in metabolic parameters and renal function from baseline to 6-month follow-up after the smoking cessation program.

Result

A total of 1,954 patients joined the smoking cessation program, and 1,381 patients were in the smoking cessation failure (SCF) group and 573 were in the smoking cessation success (SCS) group. The decrease in HbA1c after smoking cessation was only observed in patients with diabetes. Smoking cessation was also associated with a significant decrease in LDL cholesterol in patients with diabetes. In terms of renal function, smoking cessation was associated with an improvement in eGFR, and the trend was similar in patients with and without diabetes.

Conclusion

Successful smoking cessation was associated with improvement in renal function. Moreover, it was associated with improvements in HbA1c and LDL cholesterol in patients with diabetes, despite significant weight gain.

Keywords:

body weight

chronic kidney disease

diabetes mellitus

glycated hemoglobin

smoking cessation

Resumen

Antecedentes y objetivos

Dado que los pacientes con diabetes tienen un riesgo significativamente mayor de sufrir enfermedades cardiovasculares que aquellos sin diabetes, es importante obtener una comprensión clínica de los efectos diferenciales de dejar de fumar sobre varios factores de riesgo entre pacientes con y sin diabetes.

Materiales y métodos

Los pacientes que participaron en un programa para dejar de fumar recibieron una evaluación de los resultados de interés. Los resultados fueron cambios en los parámetros metabólicos y la función renal desde el inicio hasta el seguimiento de 6 meses después del programa para dejar de fumar.

Resultado

Un total de 1.954 pacientes se unieron al programa para dejar de fumar, 1.381 pacientes estaban en el grupo de fracaso para dejar de fumar (SCF) y 573 estaban en el grupo de éxito para dejar de fumar (SCS). La disminución de la HbA1c tras dejar de fumar sólo se observó en pacientes con diabetes. Dejar de fumar también se asoció con una disminución significativa del colesterol LDL en pacientes con diabetes. En términos de función renal, dejar de fumar se asoció con una mejora en la TFGe, y la tendencia fue similar en pacientes con y sin diabetes.

Conclusión

Dejar de fumar exitosamente se asoció con una mejora en la función renal. Además, se asoció con mejoras en la HbA1c y el colesterol LDL en pacientes con diabetes, a pesar de un aumento de peso significativo.

Palabras clave:

peso corporal

enfermedad renal crónica

diabetes mellitus

hemoglobina glucosilada

dejar de fumar

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