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Brief Original
Anti-NOR90 antibodies and their clinical significance: a multicenter experience in southern Spain
Anticuerpos anti-NOR90 y su significación clínica: experiencia multicéntrica en el sur de España
Javier Martínez de Victoria Carazoa,
Corresponding author
jmdvc94@gmail.com

Corresponding author.
, Daniel Fernández Reyesa, Francisco Javier de la Hera Fernándeza, Trinidad González CejudoNuria Navarrete Navarreteb,c, José Luís Callejas Rubioa
a Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario Clínico San Cecilio, Granada, Spain
b Laboratorio de Análisis Clínicos, Sección de Inmunología, Hospital Universitario Clínico San Cecilio, Granada, Spain
c Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Hospital Universitario Virgen de las Nieves, Granada, Spain
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Anti-NOR90 antibodies were initially described in patients with autoimmune diseases based on staining of a nucleolar region known as the nucleolar organizer region &#40;NOR&#41;&#46; This study aims to explore the clinical aspects of anti-NOR90 antibodies in patients with systemic autoimmune diseases&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Observational study of patients with positive anti-NOR90 antibodies using the EUROLINE Systemic Sclerosis profile &#40;IgG&#41; kit &#40;Euroimmun&#44; Germany&#41;&#46; Data on demographics&#44; comorbidities&#44; autoimmune diseases&#44; treatment&#44; and clinical manifestations were collected&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Fifteen Patients with positive anti-NOR90 antibodies were included&#46; Majority were female &#40;86&#46;7&#37;&#41;&#44; with median age of 54 years&#46; Most common clinical manifestations were Raynaud&#39;s phenomenon&#44; dryness&#44; and interstitial lung disease &#40;ILD&#41;&#46; Some patients had hematological or solid organ neoplasms&#46; EPID was prevalent&#44; with one case showing rapid progression requiring aggressive treatment&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Discussion and conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">This study highlights the association between anti-NOR90 antibodies and systemic autoimmune diseases&#44; particularly SS and ES&#46; EPID was a notable feature&#44; suggesting its consideration in IPAF diagnosis for anti-NOR90 positive patients&#46; Further multicenter studies are needed for better understanding and detection methods optimization&#46;</p></span>"
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Article information
ISSN: 22548874
Original language: English
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Revista Clínica Española (English Edition)