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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">As of April 16&#44; 2021&#44; the number of COVID-19 cases caused by SARS-CoV-2 &#40;severe acute respiratory syndrome coronavirus 2&#41; in Spain was 3&#44;407&#44;283&#46; Of them&#44; 340&#44;130 &#40;9&#46;98&#37;&#41; required hospital admission and 31&#44;054 &#40;0&#46;91&#37;&#41; were admitted to intensive care units &#40;ICU&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The clinical spectrum of SARS-CoV-2 infection varies from mild symptoms of fever and cough followed by expectoration and fatigue to severe symptoms in critical patients&#44; including sepsis&#44; coagulopathy&#44; respiratory failure&#44; and onset of severe acute respiratory distress syndrome<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cumulative mortality in Spain as of April 16&#44; 2021 was 76&#44;981 &#40;2&#46;25&#37;&#41; patients&#44; but among patients admitted to the ICU&#44; mortality was 31&#37;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Various studies concur that the risk factors associated with mortality include advanced age&#44; presence of kidney failure&#44; low oxygen saturation levels&#44; and high C-reactive protein values<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Early identification of patients who are going to need critical care may be important for providing more appropriate treatment and optimizing available resources&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The purpose of this study is to use an extensive national registry of patients with COVID-19 in order to develop a risk scale for ICU admission applicable to patients who have just been admitted to the hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Data source</span><p id="par0030" class="elsevierStylePara elsevierViewall">The data source was the SEMI-COVID-19 registry&#44; an ongoing retrospective cohort that includes the majority of patients who were discharged or died following hospitalization for confirmed COVID-19 in 150 Spanish hospitals from March 1&#44; 2020 until September 1&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; The sample comprised 16&#44;298 patients&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Outcomes</span><p id="par0035" class="elsevierStylePara elsevierViewall">The outcome evaluated was admission to the ICU&#44; measured from the time of admission to the hospital&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Predictor variables</span><p id="par0040" class="elsevierStylePara elsevierViewall">To develop the prediction rule&#44; we used variables that were routinely available at the time of hospital admission and which have been associated with ICU admission in other studies&#46; These variables included&#58; &#40;1&#41; demographics&#44; age&#44; and sex&#59; &#40;2&#41; comorbidities and Charlson Comorbidity Index&#59; &#40;3&#41; signs or symptoms&#44; including dyspnea&#44; confusion&#44; hemoptysis&#59; &#40;4&#41; laboratory data&#44; oxygen saturation in ambient air&#44; LDH levels&#44; the neutrophil-lymphocyte ratio&#44; and C-reactive protein levels&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Derivation model</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the derivation model&#44; we randomly selected two-thirds &#40;n &#61; 10&#44;865&#41; of the sample&#46; To create the derivation model&#44; we conducted a multiple logistic regression analysis with ICU admission as the primary outcome and the previously described clinical parameters as predictor variables&#46; Using the &#946; coefficients&#44; we created a scoring system that divided patients into different risk categories&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Validation model</span><p id="par0050" class="elsevierStylePara elsevierViewall">The validation model was created using the remaining one-third &#40;n &#61; 5433&#41; of the sample&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">We followed the recommendations of the TRIPOD guidelines in developing the multivariate analysis model<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Continuous variables are expressed as means and standard deviations&#46; Categorical variables are expressed as frequencies and percentages&#46; The chi-square test was used to compare categorical variables and Student&#39;s <span class="elsevierStyleItalic">t</span>-test was used to compare continuous variables between groups&#46; Values of <span class="elsevierStyleItalic">p</span> &#60; &#46;05 were considered statistically significant&#46; A multiple logistic regression analysis was conducted in the derivation sample to estimate probability of ICU admission&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To build the derivation model&#44; variables with a <span class="elsevierStyleItalic">p</span> value lower than &#46;10 on the univariate model were selected&#46; The odds ratio &#40;OR&#41; and 95&#37; confidence intervals &#40;95&#37; CI&#41; were estimated based on the regression coefficients&#46; Various regression models were built and the one that was simplest and most explicative based on the Hosmer-Lemeshow goodness of fit test was selected for application to the validation cohort&#46; Nagelkerke&#8217;s R<span class="elsevierStyleSup">2</span> was used to estimate the proportion of variation explained by the model&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The model&#8217;s final performance was evaluated by means of the receiver operating characteristic &#40;ROC&#41; curve and calculation of the area under the ROC curve&#46; Finally&#44; based on the &#946; coefficients&#44; we created a scoring system for establishing different risk levels for ICU admission&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The statistical analysis was conducted using the free R software&#44; version 4&#46;0&#46;2 &#40;Free Software Foundation&#44; Inc&#46; Boston&#44; MA&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Ethical considerations</span><p id="par0075" class="elsevierStylePara elsevierViewall">Personal data were processed pursuant to Law 14&#47;2007&#44; of July 3&#44; on Biomedical Research&#59; Regulation &#40;EU&#41; 2016&#47;679 of the European Parliament and of the Council of 27 April 2016&#44; General Data Protection Regulation&#59; and Organic Law 3&#47;2018&#44; of December 5&#44; on Personal Data Protection and Guarantee of Digital Rights&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The SEMI-COVID-19 Registry was approved by the Research Ethics Committee of the Province of M&#225;laga&#46; The Department of Medicines for Human Use of the Spanish Agency of Medicines and Health Products &#40;AEMPS&#44; for its initials in Spanish&#41;&#44; in accordance with the applicable precepts&#44; has designated the study to be a &#8220;non-post-authorization observational study&#46;&#8221;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Characteristics of patients admitted to the ICU</span><p id="par0085" class="elsevierStylePara elsevierViewall">A total of 1420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Patients who were admitted to the ICU were younger &#40;mean age 63&#46;3 &#177; 12&#46;3 years&#41; than those who were admitted to conventional hospitalization wards &#40;67&#46;7 &#177; 16&#46;4 years&#41; &#40;<span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#46; Male sex was associated with greater risk of ICU admission &#40;69&#46;5&#37; vs&#46; 56&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span> &#60; &#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">There were comorbidities that were associated with greater risk of ICU admission&#44; including obesity&#44; among others&#44; whereas others were associated with a lower frequency of ICU admission&#44; such as chronic kidney disease&#44; COPD&#44; or chronic heart failure&#46; Smoking was a risk factor for ICU admission&#46; A greater proportion of patients who were admitted to the ICU presented with dyspnea at the time of admission &#40;75&#46;4&#37; vs&#46; 56&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; as well as a lower rate of altered consciousness &#40;8&#46;4&#37; vs&#46; 12&#46;2&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; a greater frequency of presence of diffuse infiltrates on a chest x-ray on admission than patients who were admitted to the ICU &#40;43&#37; vs&#46; 29&#46;3&#37; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; and lower oxygen saturation levels &#40;SpO<span class="elsevierStyleInf">2</span>&#41; than patients admitted to conventional hospitalization wards &#40;89&#37; vs&#46; 93&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Regarding laboratory variables&#44; patients hospitalized in the ICU had a greater neutrophil-lymphocyte ratio &#40;9&#46;7&#37; vs&#46; 7&#46;0&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; and higher <span class="elsevierStyleSmallCaps">d</span>-dimer &#40;2&#44;969&#46;8 vs&#46; 1&#44;906&#46;6 ng&#47;mL&#44; <span class="elsevierStyleItalic">p</span> &#61; &#46;004&#41;&#44; glucose &#40;138&#46;6 vs&#46; 127&#46;5 mg&#47;dL&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; alanine aminotransferase &#40;ALT&#41; &#40;49&#46;7 vs&#46; 40&#46;5 U&#47;L&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; lactate dehydrogenase &#40;501&#46;5 vs&#46; 359&#46;5 U&#47;L&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; and C-reactive protein &#40;130&#46;7 vs&#46; 84&#46;5 mg&#47;dL&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; values than patients hospitalized in conventional hospitalization wards&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 568 &#40;40&#37;&#41; of patients admitted to the ICU died whereas those among those admitted to conventional hospitalization wards&#44; there were 2851 &#40;19&#46;2&#37;&#41; deaths&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Predictive model</span><p id="par0105" class="elsevierStylePara elsevierViewall">To create the predictive model&#44; we randomly divided the sample into two parts&#58; two-thirds were the derivation cohort and the remaining one-third was the validation cohort&#46; The characteristics of patients in both cohorts are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">In the derivation cohort&#44; variables that had a greater association with ICU admission on the univariate analysis were age younger than 75 years&#44; a lower Charlson Comorbidity Index&#44; presence of dyspnea or tachypnea&#44; a neutrophil-lymphocyte ratio greater than five&#44; lactate dehydrogenase values greater than 250 U&#47;L&#44; urea values greater than 40 mg&#47;dL&#44; and presence of diffuse infiltrates on the chest x-ray&#46; The presence of cancer &#40;solid tumor&#44; metastases&#44; hematologic tumor&#41; and altered levels of consciousness were factors that reduced the risk of ICU admission &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">According to the multivariate analysis&#44; the variables of age&#44; presence of dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-lymphocyte ratio&#44; lactate dehydrogenase values&#44; and chest x-ray data on admission remained in the model &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">p</span> value for goodness of fit for the multivariate model&#44; calculated using the Hosmer-Lemeshow statistic&#44; was 0&#46;154&#44; indicating a good fit&#46; Nagelkerke&#39;s R<span class="elsevierStyleSup">2</span> value showing the model&#39;s explanatory value was 0&#46;196&#46; The evaluation of the predictive model&#8217;s performance showed an area under the receiver operator characteristic curve &#40;AUROC&#41; of 0&#46;780 &#40;95&#37; CI 0&#46;763&#8722;0&#46;797&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; For a probability of ICU admission of 0&#46;102 &#40;cut-off point&#41;&#44; the model showed a sensitivity of 67&#46;8&#37; and a specificity of 74&#46;6&#37; in the derivation sample&#46; In the validation cohort&#44; the AUROC was 0&#46;734 and the model showed a sensitivity of 62&#46;1&#37; and a specificity of 72&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Building the scoring system</span><p id="par0125" class="elsevierStylePara elsevierViewall">We built a scoring system based on the &#946; coefficients estimated in the logistic regression model &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; The total individual score &#40;range from 0 to 100 points&#41; was obtained by adding the points of each patient characteristic&#46; This scoring system allows for estimating probability of ICU admission &#40;positive predictive value&#41; with the data obtained at the time of admission&#46; For scores greater than 75 points&#44; the probability of ICU admission is greater than 30&#37; and for scores lower than 50 points&#44; the probability of ICU admission is less than 15&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0130" class="elsevierStylePara elsevierViewall">We developed and validated a clinical prediction model to identify patients with SARS-CoV-2 infection who will require ICU admission&#46; The predictive model&#8217;s performance showed an AUC of 0&#46;780 for a probability of ICU admission of 0&#46;102&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Risk of ICU admission increased progressively according to the number of independent variables&#44; which included age younger than 75 years&#44; presence of dyspnea&#44; Charlson Comorbidity Index score of less than 3&#44; a neutrophil-lymphocyte ratio greater than 5&#44; lactate dehydrogenase values greater than 250 U&#47;L&#44; and presence of diffuse infiltrates on the chest x-ray&#46; Using these variables&#44; which are easily available at the time of the patient&#8217;s hospital admission&#44; we built a scoring system that allows for determining the probability of ICU admission&#46; This study allows for anticipating the necessary intensive care resources for patients hospitalized due to COVID-19&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The percentage of patients admitted to the ICU in the derivation cohort was 8&#46;9&#37; and in the validation cohort it was 7&#46;7&#37;&#46; These values are similar to what has been reported in other studies conducted in Spain<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; The proportion of hospitalized patients admitted to the ICU in other countries was 16&#46;8&#37; in Italy&#44; 17&#37; in the United Kingdom&#44; 11&#37; in France&#44; 32&#37; in the USA&#44; and 8&#46;2&#37; in China<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a>&#46; A higher percentage of patients admitted to the ICU applied to our model would entail an increase in the positive predictive value of the scoring system&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The demographic characteristics of the study population also show differences according to country&#44; with a mean age of around 70 years for studies conducted in Europe and a mean age around 50 years for studies conducted in China&#46; All studies showed the determining factors for ICU admission to be older age and male sex&#44; greater comorbidity&#44; and presence of dyspnea&#46; Among the laboratory data&#44; signs of poor prognosis that have been found in all studies include a greater neutrophil-lymphocyte ratio and a greater increase in lactate dehydrogenase levels<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a>&#46; Likewise&#44; a diffuse&#44; bilateral pattern with ground glass opacity on the chest x-ray has also been associated with greater risk of severe disease<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The performance of our predictive model for ICU admission is in line with data found by other authors&#44; who report AUROC values of 0&#46;74 to 0&#46;88 in studies with derivation and validation models<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Nevertheless&#44; we must be cautious when extrapolating the performance of models when applying them to other countries&#44; given that they can have differences that&#44; in some instances&#44; are notable<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46; These differences can be due to the demographic characteristics of the subjects studied&#44; the incidence of cases at one particular moment in the pandemic&#44; or the structure of the healthcare system&#44; among others&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Among the strengths of this study are the large sample size&#44; which allowed for considering a large number of variables in the predictive model&#44; as well as a robust analysis of the derivation and validation models&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">It is advisable to interpret this study as an aid for determining intensive care unit bed requirements for patients with severe COVID-19&#46; Although the risk score refers to clinical deterioration related to COVID-19&#44; the benefit of ICU admission may be conditioned by other aspects&#46; The patient&#8217;s comorbidity&#44; presence of advanced cognitive decline&#44; or inability to perform basic activities of daily living can constitute limitations for ICU admission in subjects with severe COVID-19<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">On the other hand&#44; the probability of ICU admission may be influenced by the percentage of beds occupied during different periods of the pandemic&#46; It is possible that during periods when there is good access to supportive treatment&#44; it is decided to provide this treatment to patients with moderate risk of mortality&#46; On the contrary&#44; in periods or areas with more limited resources&#44; the decision could be made to limit intensive supportive treatment in patients with moderate risk in order to optimize available resources&#46; Likewise&#44; the admission of patients with severe COVID-19 in respiratory intensive care units was not taken into consideration&#59; the availability of these facilities could alter the scale validation results&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Finally&#44; the development and validation of the predictive model was carried out in Spain&#46; This could limit the generalization of the scoring system to other areas of the world with different healthcare systems&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; we developed a clinical prediction rule for ICU admission for patients with COVID-19&#46; The predictor variables are easy to obtain at the time of admission&#46; Our prediction rule has been validated in a large cohort of patients and has been demonstrated to be reproducible&#46; The incorporation of the rule into the electronic medical record would facilitate its implementation and help clinicians appropriately adapt the patient admissions department&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">J&#46;V&#46; Segura-Heras received a competitive grant from the <span class="elsevierStyleGrantSponsor" id="gs0005">Ministry of Economy and Competitiveness of Spain</span>&#44; Grant No&#46; <span class="elsevierStyleGrantNumber" refid="gs0005">MTM2017-83850-P</span>&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The Spanish Society of Internal Medicine &#40;SEMI&#41; is the sponsor of this study&#46; The research has not received specific grants from agencies in the public&#44; commercial&#44; or non-profit sectors&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This work aims to identify and validate a risk scale for admission to intensive care units &#40;ICU&#41; in hospitalized patients with coronavirus disease 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 &#40;N &#61; 16&#44;298&#41;&#46; We analyzed the available demographic&#44; clinical&#44; radiological&#44; and laboratory variables recorded at hospital admission&#46; We evaluated the performance of the risk score by estimating the area under the receiver operating characteristic curve &#40;AUROC&#41;&#46; Using the &#946; coefficients of the regression model&#44; we developed a score &#40;0&#8211;100 points&#41; associated with ICU admission&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The mean age of the patients was 67 years&#59; 57&#37; were men&#46; A total of 1420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU&#46; The variables independently associated with ICU admission were age&#44; dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-to-lymphocyte ratio&#44; lactate dehydrogenase levels&#44; and presence of diffuse infiltrates on a chest X-ray&#46; The model showed an AUROC of 0&#46;780 &#40;CI&#58; 0&#46;763&#8722;0&#46;797&#41; in the derivation cohort and an AUROC of 0&#46;734 &#40;CI&#58; 0&#46;708&#8722;0&#46;761&#41; in the validation cohort&#46; A score of greater than 75 points was associated with a more than 30&#37; probability of ICU admission while a score of less than 50 points reduced the likelihood of ICU admission to 15&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A simple prediction score was a useful tool for forecasting the probability of ICU admission with a high degree of precision&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Fundamento</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Identificar y validar una escala de riesgo de ingreso en las unidades de cuidados intensivos &#40;UCI&#41; en pacientes hospitalizados con enfermedad por coronavirus 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Realizamos una regla de derivaci&#243;n y otra de validaci&#243;n para ingreso en UCI utilizando los datos de un registro nacional de cohortes de pacientes con infecci&#243;n confirmada por SARS-CoV-2 ingresados entre marzo y agosto del a&#241;o 2020 &#40;N &#61; 16&#46;298&#41;&#46; Analizamos variables demogr&#225;ficas&#44; cl&#237;nicas&#44; radiol&#243;gicas y de laboratorio disponibles en el ingreso hospitalario&#46; Evaluamos el rendimiento de la escala de riesgo mediante estimaci&#243;n del &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41;&#46; Utilizamos los coeficientes &#946; del modelo de regresi&#243;n para elaborar una puntuaci&#243;n &#40;0 a 100 puntos&#41; asociada con ingreso en UCI&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue 67 a&#241;os&#59; 57&#37; varones&#46; Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes ingresaron en la UCI&#46; Las variables independientes asociadas con el ingreso en UCI fueron&#58; edad&#44; disnea&#44; &#237;ndice de comorbilidad de Charlson&#44; cociente neutr&#243;filos-linfocitos&#44; lactato deshidrogenasa e infiltrados difusos en la radiografia de t&#243;rax&#46; El modelo mostr&#243; un AROC de 0&#44;780 &#40;IC&#58; 0&#44;763&#8722;0&#44;797&#41; en la cohorte de derivaci&#243;n y un AROC de 0&#44;734 &#40;IC&#58; 0&#44;708&#8722;0&#44;761&#41; en la cohorte de validaci&#243;n&#46; Una puntuaci&#243;n &#62; 75 se asoci&#243; con una probabilidad de ingreso en UCI superior a un 30&#37;&#44; mientras que una puntuaci&#243;n &#60; 50 redujo la probabilidad de ingreso en UCI al 15&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Una puntuaci&#243;n de predicci&#243;n simple proporcion&#243; una herramienta &#250;til para predecir la probabilidad de ingreso en la UCI con un alto grado de precisi&#243;n&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Fundamento"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ena J&#44; Segura-Heras JV&#44; Fonseca-Aizpuru EM&#44; L&#243;pez-Reboiro ML&#44; Gracia-Guti&#233;rrez A&#44; Mart&#237;n-Oterino JA&#44; et al&#46; Derivaci&#243;n y validaci&#243;n de una puntuaci&#243;n de riesgo de ingreso en la Unidad de Cuidados Intensivos para pacientes con COVID-19&#46; Rev Clin Esp&#46; 2022&#59;222&#58;1&#8211;12&#46;</p>"
      ]
      1 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">The full list of members of the SEMI-COVID-19 working group is provided in Appendix A&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:5 [
            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall">SEMI-COVID-19 Registry Coordinator&#58; Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SEMI-COVID-19 Members of the Scientific Committee&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez Huelgas&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "List of SEMI-COVID-19 network members"
            "identificador" => "sec0085"
            "apendiceSeccion" => array:1 [
              0 => array:3 [
                "apendice" => "<p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; de Bellvitge&#46; L<span class="elsevierStyleUnderline">&#39;</span>Hospitalet de Llobregat&#44; Barcelona&#58;</span> Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio-Rivas&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; 12 de Octubre&#44; Madrid&#58;</span> Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Laura Ibarra Veganzones&#44; Luc&#237;a Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Jaime Lora-Tamayo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Rodrigo Miranda Godoy&#44; B&#225;rbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#44; Madrid&#58;</span> Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Christian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro D&#46; Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Ant&#250;nez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o M&#237;guez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Costa del Sol&#44; Marbella&#44; M&#225;laga&#58;</span> Victoria August&#237;n Bandera&#44; Javier Garc&#237;a Alegr&#237;a&#44; Nicol&#225;s Jim&#233;nez-Garc&#237;a&#44; Jairo Luque del Pino&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#44; Francisco Navarro Romero&#44; Victoria N&#250;&#241;ez Rodr&#237;guez&#44; Juli&#225;n Olalla Sierra&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Cabue&#241;es&#44; Gij&#243;n&#44; Asturias&#58;</span> Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Mar&#237;a Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Diego L&#243;pez Mart&#237;nez&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Luc&#237;a P&#233;rez Casado&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Paz&#44; Madrid&#58;</span> Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Royo Villanova&#44; Zaragoza&#58;</span> Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral Beamonte&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Geric&#243; Aseguinolaza&#44; Cristina Gallego Lezaun&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Reg&#46; U&#46; de M&#225;laga&#44; M&#225;laga&#58;</span> Mar&#237;a Mar Ayala-Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Jos&#233; Antonio Hurtado Oliver&#44; Sergio Jansen-Chaparro&#44; Mar&#237;a Dolores L&#243;pez-Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo-Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Mart&#237;n Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Iv&#225;n P&#233;rez de Pedro&#44; Araceli Pineda-Cantero&#44; Carlos Romero G&#243;mez&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Cl&#237;nico de Santiago de Compostela&#44; A Coru&#241;a&#58;</span> Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel Paez Guillan&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Dr&#46; Peset&#44; Valencia&#58;</span> Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabeth Mateo Sanch&#237;s&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Mois&#232;s Broggi&#44; Sant Joan Desp&#237;&#44; Barcelona&#58;</span> Judit Aranda Lobo&#44; Luc&#237;a Feria Casanovas&#44; Jos&#233; Loureiro Amigo&#44; Miguel Mart&#237;n Fern&#225;ndez&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicol&#225;s Rhyman&#44; Nuria V&#225;zquez Piqueras&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Badajoz&#44; Badajoz&#58;</span> Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; R&#237;o Hortega&#44; Valladolid&#58;</span> Irene Arroyo Jim&#233;nez&#44; Marina Cazorla Gonz&#225;lez&#44; Marta Cobos-Siles&#44; Luis Corral-Gudino&#44; Pablo Cubero-Morais&#44; Mar&#237;a Gonz&#225;lez Fern&#225;ndez&#44; Jos&#233; Pablo Miramontes Gonz&#225;lez&#44; Marina Prieto Dehesa&#44; Pablo Sanz Espinosa&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Reina Sof&#237;a&#44; C&#243;rdoba&#58;</span> Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Francisco Fuentes-Jim&#233;nez&#44; Mar&#237;a del Carmen Guerrero Mart&#237;nez&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Limia P&#233;rez&#44; Jos&#233; L&#243;pez-Miranda&#44; Laura Mart&#237;n Piedra&#44; Marta Mill&#225;n Orge&#44; Javier Pascual Vinagre&#44; Pablo P&#233;rez-Mart&#237;nez&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; &#193;ngela Rodrigo Mart&#237;nez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres-Pe&#241;a&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; S&#46; Juan de Alicante&#44; Alicante&#58;</span> Marisa Asensio Tom&#225;s&#44; David Balaz&#44; David Bonet Tur&#44; Ruth Ca&#241;izares Navarro&#44; Paloma Chazarra P&#233;rez&#44; Jes&#250;s Corbacho Redondo&#44; Eliana Damonte White&#44; Mar&#237;a Escamilla Esp&#237;nola&#44; Leticia Espinosa Del Barrio&#44; Pedro Jes&#250;s Esteve Ati&#233;nzar&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Francisco Garrido Navarro&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Ver&#243;nica Mart&#237;nez Sempere&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Rafael Pi&#241;ol Pleguezuelos&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Azucena Sempere Mira&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo&#58;</span> Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#44; Cristina Salazar Mosteiro&#44; Andrea Silva Asiain&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Pozoblanco&#44; C&#243;rdoba&#58;</span> Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Infanta Cristina&#44; Parla&#44; Madrid&#58;</span> Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Blanca Beamonte Vela&#44; Coralia Bueno Mui&#241;o&#44; Charo Bur&#243;n Fern&#225;ndez&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Pilar Cubo Romano&#44; Francesco Deodati&#44; Alejandro Estrada Santiago&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Francisco Javier Garc&#237;a S&#225;nchez&#44; Pilar Garc&#237;a de la Torre&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A&#46; Melero Bermejo&#44; Cruz Pastor Valverde&#44; Jos&#233; Luis P&#233;rez Quero&#44; Fernando Roque Rojas&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Francisco Javier Teigell Mu&#241;oz&#44; Juan Vicente de la Sota&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; G&#46; U&#46; de Elda&#44; Alicante&#58;</span> Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Santiago L&#243;pez Gil&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Nuria Ram&#237;rez Perea&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Santa Marina&#44; Bilbao&#58;</span> Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Labirua-Iturburu Ruiz&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; San Pedro&#44; Logro&#241;o&#44; La Rioja&#58;</span> Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Lu&#237;s Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Son Ll&#224;tzer&#44; Palma de Mallorca&#58;</span> Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; Ourense&#44; Ourense&#58;</span> Raquel Fern&#225;ndez Gonz&#225;lez&#44; Amara Gonz&#225;lez Noya&#44; Carlos Hern&#225;ndez Cer&#243;n&#44; Isabel Izuzquiza Avanzini&#44; Ana Latorre Diez&#44; Pablo L&#243;pez Mato&#44; Ana Mar&#237;a Lorenzo Vizcaya&#44; Daniel Pe&#241;a Ben&#237;tez&#44; Milagros Mar&#237;a Pe&#241;a Zemsch&#44; Luc&#237;a P&#233;rez Exp&#243;sito&#44; Marta Pose Bar&#44; Lara Rey Gonz&#225;lez&#44; Laura Rodrigo Lara&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Fe&#44; Valencia&#58;</span> Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Matar&#243;&#44; Barcelona&#58;</span> Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Javier Fern&#225;ndez Fern&#225;ndez&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Sagunto&#44; Valencia&#58;</span> Enrique Rodilla Sala&#44; Jos&#233; Mar&#237;a Pascual Izuel&#44; Zineb Karroud Zamrani&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Alto Guadalquivir&#44; And&#250;jar&#44; Ja&#233;n&#58;</span> Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Infanta Margarita&#44; Cabra&#44; C&#243;rdoba&#58;</span> Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Ferrol&#44; A Coru&#241;a&#58;</span> Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trigas Ferrin&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Marina Baixa&#44; Villajoyosa&#44; Alicante&#58;</span> Javier Ena&#44; Santiago P&#233;rez Mart&#237;n&#46;</p> <p id="par0365" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Virgen del Roc&#237;o&#44; Sevilla&#58;</span> Reyes Aparicio Santos&#44; M&#225;ximo Bernabeu-Wittel&#44; Santiago Rodr&#237;guez Su&#225;rez&#44; Mar&#237;a Nieto&#44; Luis Gim&#233;nez Miranda&#44; Rosa Mar&#237;a G&#225;mez Mancera&#44; F&#225;tima Espinosa Torre&#44; Carlos Hern&#225;ndez Quiles&#44; Concepci&#243;n Conde Guzm&#225;n&#44; Juan Delgado de la Cuesta&#44; Jara Elo&#237;sa Ternero Vega&#44; Mar&#237;a del Carmen L&#243;pez R&#237;os&#44; Pablo D&#237;az Jim&#233;nez&#44; Bosco Bar&#243;n Franco&#44; Carlos Jim&#233;nez de Juan&#44; Sonia Guti&#233;rrez Rivero&#44; Julia Lanseros Tenllado&#44; Ver&#243;nica Alfaro Lara&#44; Aurora Gonz&#225;lez Estrada&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; P&#250;blico de Monforte de Lemos&#44; Lugo&#58;</span> Jos&#233; L&#243;pez Castro&#44; Manuel Lorenzo L&#243;pez Reboiro&#44; Cristina Sardi&#241;a Gonz&#225;lez&#46;</p> <p id="par0375" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; General Defensa&#44; Zaragoza&#58;</span> Anyuli Gracia Guti&#233;rrez&#44; Leticia Esther Royo Trallero&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; A&#46; U&#46; de Salamanca&#44; Salamanca&#58;</span> Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ram&#243;n Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0385" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Palam&#243;s&#44; Girona&#58;</span> Ana Alberich Conesa&#44; Mari Cruz Almendros Rivas&#44; Miquel Hortos Alsina&#44; Jos&#233; Marchena Romero&#44; Anabel Mart&#237;n-Urda Diez-Canseco&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; do Salnes&#44; Vilagarc&#237;a de Arousa&#44; Pontevedra&#58;</span> Vanesa Allende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Rodr&#237;guez Ferreira&#44; Diana Sande Llovo&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0395" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; HM Montepr&#237;ncipe&#44; Boadilla del Monte&#44; Madrid&#58;</span> Jos&#233; F&#46; Varona Arche&#46;</p>"
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Age&#44; years&#44; mean &#177; SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;298&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">67&#46;7 &#177; 16&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">63&#46;3 &#177; 12&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male sex&#8212;No&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8367 &#40;56&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">987 &#40;69&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dependence</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Independent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#44;092 &#40;82&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1377 &#40;97&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Partially dependent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Totally dependent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbidity&#8212;No&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9980 &#40;70&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">876 &#40;64&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ex-smoker&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3567 &#40;25&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Active Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">717 &#40;5&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">85 &#40;6&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hypertension</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;264&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7631 &#40;51&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">705 &#40;49&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#46;226&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Type 2 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2128 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">228 &#40;16&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Type 1 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">817 &#40;5&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">65 &#40;4&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#46;159&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chronic kidney disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">936 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">47 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Obesity &#40;BMI &#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">14&#44;973&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">885 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">404 &#40;30&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dementia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;288&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1594 &#40;10&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3 &#40;0&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cancer</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">660 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">HIV infection</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Signs and symptoms&#8212;No&#46; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Temperature&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cough&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Dry&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">933 &#40;65&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">With sputum production&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anosmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;897&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1126 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;4&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asthenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6377 &#40;43&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;490&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anorexia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;025&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2931 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">262 &#40;18&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1765 &#40;12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;548&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arthromyalgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4486 &#40;30&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">473 &#40;33&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ageusia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1266 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;6&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Altered level of consciousness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1794 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">119 &#40;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyspnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8299 &#40;56&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1069 &#40;75&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vomiting&#47;nausea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2100 &#40;14&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarrhea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3566 &#40;24&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">321 &#40;22&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Radiology&#8212;No&#46; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7789 &#40;53&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">630 &#40;44&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unilateral infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2567 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4300 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604 &#40;43&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Physical examination&#44; mean &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SpO<span class="elsevierStyleInf">2</span>&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;3 &#177; 5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#46;0 &#177; 8&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Systolic blood pressure&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#44;666&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">128&#46;8 &#177; 21&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">127&#46;8 &#177; 21&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diastolic blood pressure&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">73&#46;9 &#177; 13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">72&#46;8 &#177; 13&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate&#44; beats&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#44;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">88&#46;3 &#177; 17&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">92&#46;8 &#177; 17&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tachypnea &#40;&#60;30 breaths&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#44;942&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4258 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">793 &#40;56&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laboratory tests&#44; mean &#177; SD</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neutrophil-lymphocyte ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">7&#46;0 &#177; 11&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">9&#46;7 &#177; 9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Platelets&#8212;x10<span class="elsevierStyleSup">9</span>&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">207&#44;227 &#177; 93&#44;637&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">203&#44;388 &#177; 90&#44;454&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#46;140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D-dimer&#8212;ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12&#44;852&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&#44;906 &#177; 10&#44;702&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;969 &#177; 11&#44;865&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Glucose&#8212;mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;714&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">127&#46;5 &#177; 58&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">138&#46;6 &#177; 55&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Creatinine&#8212;mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">16&#44;151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;1 &#177; 0&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&#46;1 &#177; 0&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;881&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ALT&#8212;U&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">15&#44;238&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">40&#46;5 &#177; 62&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">49&#46;7 &#177; 51&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactate dehydrogenase&#8212;U&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">14&#44;112&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">359&#46;5 &#177; 197&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">501&#46;5 &#177; 365&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>C-reactive protein&#8212;mg&#47;dL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;652&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">84&#46;5 &#177; 86&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">130&#46;7 &#177; 108&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Lactate dehydrogenase&#44; U&#47;L</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;250&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;2&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;655&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>250&#8722;500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">442 &#40;8&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">209 &#40;7&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">318 &#40;19&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133 &#40;17&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Altered level of consciousness</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">902 &#40;9&#46;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">389 &#40;8&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;062&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#40;6&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;5&#46;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chest x-ray</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">435 &#40;7&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;6&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;197&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unilateral infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114 &#40;6&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;6&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432 &#40;13&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172 &#40;10&#46;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasm</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">961 &#40;9&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">411 &#40;7&#46;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;665&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;5&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;6&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tachypnea &#40;&#62; 30 breaths&#47;min&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409 &#40;5&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;5&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">567 &#40;16&#46;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226 &#40;13&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Urea elevation &#62; 40 mg&#47;dL</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">406 &#40;8&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;8&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">447 &#40;10&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183 &#40;8&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Type 1 diabetes mellitus</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">947 &#40;9&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">407 &#40;7&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;848&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#46;597&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;397&#44; 0&#46;863&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Type 1 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;770&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;553&#44; 1&#46;045&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;107&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Type 2 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;146&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#46;956&#44; 1&#46;367&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;135&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Altered level of consciousness</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;648&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;0&#46;511&#44; 0&#46;812&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tachypnea&#44;&#60; 30 breaths&#47;min</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;327&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;2&#46;910&#44; 3&#46;808&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dyspnea</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;659&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;2&#46;286&#44; 3&#46;104&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neutrophil-lymphocyte ratio</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8722;10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;974&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#46;686&#46; 2&#46;311&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;027&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;2&#46;565&#46; 3&#46;571&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactate dehydrogenase&#44; U&#47;L</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;250&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>250&#8722;500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;475&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#46;963&#44; 3&#46;157&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;237 &#40;1&#46;874&#44; 2&#46;680&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Charlson Comorbidity Index&#44; points</span></td><td class="td" title="\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;102 &#40;0&#46;577&#44; 2&#46;057&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;468 &#40;0&#46;869&#44; 2&#46;498&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;153&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;864 &#40;1&#46;203&#44; 2&#46;967&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;013 &#40;1&#46;338&#44; 3&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;084 &#40;1&#46;408&#44; 3&#46;195&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neutrophil-lymphocyte ratio</span></td><td class="td" title="\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;747 &#40;1&#46;455&#44; 2&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactate dehydrogenase&#44; U&#47;L</span></td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;250&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>250&#8722;500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;941 &#40;1&#46;518&#44; 2&#46;510&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Chest x-ray</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;071&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;565&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;412&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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Original article
Derivation and validation of a risk score for admission to the Intensive Care Unit in patients with COVID-19
Derivación y validación de una puntuación de riesgo de ingreso en la Unidad de Cuidados Intensivos para pacientes con COVID-19
J. Enaa,
Corresponding author
ena_jav@gva.es

Corresponding author.
, J.V. Segura-Herasb, E.M. Fonseca-Aizpuruc, M.L. López-Reboirod, A. Gracia-Gutiérreze, J.A. Martín-Oterinof, A. Martin-Urda Diez-Cansecog, C. Pérez-Garcíah, J.M. Ramos-Rincóni, R. Gómez-Huelgasj, on behalf of the SEMI-COVID-19 working group 1
a Servicio de Medicina Interna, Hospital Marina Baixa, Alicante, Spain
b Instituto Universitario de Investigación «Centro de Investigación Operativa» (CIO), Universidad Miguel Hernández, Alicante, Spain
c Servicio de Medicina Interna, Hospital de Cabueñes, Gijón, Asturias, Spain
d Servicio de Medicina Interna, Hospital Público de Monforte de Lemos, Lugo, Spain
e Servicio de Medicina Interna, Hospital General Defensa, Zaragoza, Spain
f Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain
g Servicio de Medicina Interna, Hospital de Palamós, Girona, Spain
h Servicio de Medicina Interna, Hospital do Salnes, Vilagarcía de Arousa, Pontevedra, Spain
i Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Alicante, Spain
j Departamento de Medicina Interna, Hospital Regional de Málaga, Instituto de Investigación Biomédica (IBIMA), Universidad de Málaga, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">As of April 16&#44; 2021&#44; the number of COVID-19 cases caused by SARS-CoV-2 &#40;severe acute respiratory syndrome coronavirus 2&#41; in Spain was 3&#44;407&#44;283&#46; Of them&#44; 340&#44;130 &#40;9&#46;98&#37;&#41; required hospital admission and 31&#44;054 &#40;0&#46;91&#37;&#41; were admitted to intensive care units &#40;ICU&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The clinical spectrum of SARS-CoV-2 infection varies from mild symptoms of fever and cough followed by expectoration and fatigue to severe symptoms in critical patients&#44; including sepsis&#44; coagulopathy&#44; respiratory failure&#44; and onset of severe acute respiratory distress syndrome<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Cumulative mortality in Spain as of April 16&#44; 2021 was 76&#44;981 &#40;2&#46;25&#37;&#41; patients&#44; but among patients admitted to the ICU&#44; mortality was 31&#37;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Various studies concur that the risk factors associated with mortality include advanced age&#44; presence of kidney failure&#44; low oxygen saturation levels&#44; and high C-reactive protein values<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Early identification of patients who are going to need critical care may be important for providing more appropriate treatment and optimizing available resources&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The purpose of this study is to use an extensive national registry of patients with COVID-19 in order to develop a risk scale for ICU admission applicable to patients who have just been admitted to the hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Data source</span><p id="par0030" class="elsevierStylePara elsevierViewall">The data source was the SEMI-COVID-19 registry&#44; an ongoing retrospective cohort that includes the majority of patients who were discharged or died following hospitalization for confirmed COVID-19 in 150 Spanish hospitals from March 1&#44; 2020 until September 1&#44; 2020<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; The sample comprised 16&#44;298 patients&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Outcomes</span><p id="par0035" class="elsevierStylePara elsevierViewall">The outcome evaluated was admission to the ICU&#44; measured from the time of admission to the hospital&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Predictor variables</span><p id="par0040" class="elsevierStylePara elsevierViewall">To develop the prediction rule&#44; we used variables that were routinely available at the time of hospital admission and which have been associated with ICU admission in other studies&#46; These variables included&#58; &#40;1&#41; demographics&#44; age&#44; and sex&#59; &#40;2&#41; comorbidities and Charlson Comorbidity Index&#59; &#40;3&#41; signs or symptoms&#44; including dyspnea&#44; confusion&#44; hemoptysis&#59; &#40;4&#41; laboratory data&#44; oxygen saturation in ambient air&#44; LDH levels&#44; the neutrophil-lymphocyte ratio&#44; and C-reactive protein levels&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Derivation model</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the derivation model&#44; we randomly selected two-thirds &#40;n &#61; 10&#44;865&#41; of the sample&#46; To create the derivation model&#44; we conducted a multiple logistic regression analysis with ICU admission as the primary outcome and the previously described clinical parameters as predictor variables&#46; Using the &#946; coefficients&#44; we created a scoring system that divided patients into different risk categories&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Validation model</span><p id="par0050" class="elsevierStylePara elsevierViewall">The validation model was created using the remaining one-third &#40;n &#61; 5433&#41; of the sample&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">We followed the recommendations of the TRIPOD guidelines in developing the multivariate analysis model<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Continuous variables are expressed as means and standard deviations&#46; Categorical variables are expressed as frequencies and percentages&#46; The chi-square test was used to compare categorical variables and Student&#39;s <span class="elsevierStyleItalic">t</span>-test was used to compare continuous variables between groups&#46; Values of <span class="elsevierStyleItalic">p</span> &#60; &#46;05 were considered statistically significant&#46; A multiple logistic regression analysis was conducted in the derivation sample to estimate probability of ICU admission&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To build the derivation model&#44; variables with a <span class="elsevierStyleItalic">p</span> value lower than &#46;10 on the univariate model were selected&#46; The odds ratio &#40;OR&#41; and 95&#37; confidence intervals &#40;95&#37; CI&#41; were estimated based on the regression coefficients&#46; Various regression models were built and the one that was simplest and most explicative based on the Hosmer-Lemeshow goodness of fit test was selected for application to the validation cohort&#46; Nagelkerke&#8217;s R<span class="elsevierStyleSup">2</span> was used to estimate the proportion of variation explained by the model&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The model&#8217;s final performance was evaluated by means of the receiver operating characteristic &#40;ROC&#41; curve and calculation of the area under the ROC curve&#46; Finally&#44; based on the &#946; coefficients&#44; we created a scoring system for establishing different risk levels for ICU admission&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The statistical analysis was conducted using the free R software&#44; version 4&#46;0&#46;2 &#40;Free Software Foundation&#44; Inc&#46; Boston&#44; MA&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Ethical considerations</span><p id="par0075" class="elsevierStylePara elsevierViewall">Personal data were processed pursuant to Law 14&#47;2007&#44; of July 3&#44; on Biomedical Research&#59; Regulation &#40;EU&#41; 2016&#47;679 of the European Parliament and of the Council of 27 April 2016&#44; General Data Protection Regulation&#59; and Organic Law 3&#47;2018&#44; of December 5&#44; on Personal Data Protection and Guarantee of Digital Rights&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The SEMI-COVID-19 Registry was approved by the Research Ethics Committee of the Province of M&#225;laga&#46; The Department of Medicines for Human Use of the Spanish Agency of Medicines and Health Products &#40;AEMPS&#44; for its initials in Spanish&#41;&#44; in accordance with the applicable precepts&#44; has designated the study to be a &#8220;non-post-authorization observational study&#46;&#8221;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Characteristics of patients admitted to the ICU</span><p id="par0085" class="elsevierStylePara elsevierViewall">A total of 1420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Patients who were admitted to the ICU were younger &#40;mean age 63&#46;3 &#177; 12&#46;3 years&#41; than those who were admitted to conventional hospitalization wards &#40;67&#46;7 &#177; 16&#46;4 years&#41; &#40;<span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#46; Male sex was associated with greater risk of ICU admission &#40;69&#46;5&#37; vs&#46; 56&#46;3&#37;&#59; <span class="elsevierStyleItalic">P</span> &#60; &#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">There were comorbidities that were associated with greater risk of ICU admission&#44; including obesity&#44; among others&#44; whereas others were associated with a lower frequency of ICU admission&#44; such as chronic kidney disease&#44; COPD&#44; or chronic heart failure&#46; Smoking was a risk factor for ICU admission&#46; A greater proportion of patients who were admitted to the ICU presented with dyspnea at the time of admission &#40;75&#46;4&#37; vs&#46; 56&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; as well as a lower rate of altered consciousness &#40;8&#46;4&#37; vs&#46; 12&#46;2&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; a greater frequency of presence of diffuse infiltrates on a chest x-ray on admission than patients who were admitted to the ICU &#40;43&#37; vs&#46; 29&#46;3&#37; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; and lower oxygen saturation levels &#40;SpO<span class="elsevierStyleInf">2</span>&#41; than patients admitted to conventional hospitalization wards &#40;89&#37; vs&#46; 93&#46;3&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Regarding laboratory variables&#44; patients hospitalized in the ICU had a greater neutrophil-lymphocyte ratio &#40;9&#46;7&#37; vs&#46; 7&#46;0&#37;&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; and higher <span class="elsevierStyleSmallCaps">d</span>-dimer &#40;2&#44;969&#46;8 vs&#46; 1&#44;906&#46;6 ng&#47;mL&#44; <span class="elsevierStyleItalic">p</span> &#61; &#46;004&#41;&#44; glucose &#40;138&#46;6 vs&#46; 127&#46;5 mg&#47;dL&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; alanine aminotransferase &#40;ALT&#41; &#40;49&#46;7 vs&#46; 40&#46;5 U&#47;L&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; lactate dehydrogenase &#40;501&#46;5 vs&#46; 359&#46;5 U&#47;L&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41;&#44; and C-reactive protein &#40;130&#46;7 vs&#46; 84&#46;5 mg&#47;dL&#44; <span class="elsevierStyleItalic">p</span> &#60; &#46;001&#41; values than patients hospitalized in conventional hospitalization wards&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">A total of 568 &#40;40&#37;&#41; of patients admitted to the ICU died whereas those among those admitted to conventional hospitalization wards&#44; there were 2851 &#40;19&#46;2&#37;&#41; deaths&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Predictive model</span><p id="par0105" class="elsevierStylePara elsevierViewall">To create the predictive model&#44; we randomly divided the sample into two parts&#58; two-thirds were the derivation cohort and the remaining one-third was the validation cohort&#46; The characteristics of patients in both cohorts are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">In the derivation cohort&#44; variables that had a greater association with ICU admission on the univariate analysis were age younger than 75 years&#44; a lower Charlson Comorbidity Index&#44; presence of dyspnea or tachypnea&#44; a neutrophil-lymphocyte ratio greater than five&#44; lactate dehydrogenase values greater than 250 U&#47;L&#44; urea values greater than 40 mg&#47;dL&#44; and presence of diffuse infiltrates on the chest x-ray&#46; The presence of cancer &#40;solid tumor&#44; metastases&#44; hematologic tumor&#41; and altered levels of consciousness were factors that reduced the risk of ICU admission &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">According to the multivariate analysis&#44; the variables of age&#44; presence of dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-lymphocyte ratio&#44; lactate dehydrogenase values&#44; and chest x-ray data on admission remained in the model &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">p</span> value for goodness of fit for the multivariate model&#44; calculated using the Hosmer-Lemeshow statistic&#44; was 0&#46;154&#44; indicating a good fit&#46; Nagelkerke&#39;s R<span class="elsevierStyleSup">2</span> value showing the model&#39;s explanatory value was 0&#46;196&#46; The evaluation of the predictive model&#8217;s performance showed an area under the receiver operator characteristic curve &#40;AUROC&#41; of 0&#46;780 &#40;95&#37; CI 0&#46;763&#8722;0&#46;797&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; For a probability of ICU admission of 0&#46;102 &#40;cut-off point&#41;&#44; the model showed a sensitivity of 67&#46;8&#37; and a specificity of 74&#46;6&#37; in the derivation sample&#46; In the validation cohort&#44; the AUROC was 0&#46;734 and the model showed a sensitivity of 62&#46;1&#37; and a specificity of 72&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Building the scoring system</span><p id="par0125" class="elsevierStylePara elsevierViewall">We built a scoring system based on the &#946; coefficients estimated in the logistic regression model &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; The total individual score &#40;range from 0 to 100 points&#41; was obtained by adding the points of each patient characteristic&#46; This scoring system allows for estimating probability of ICU admission &#40;positive predictive value&#41; with the data obtained at the time of admission&#46; For scores greater than 75 points&#44; the probability of ICU admission is greater than 30&#37; and for scores lower than 50 points&#44; the probability of ICU admission is less than 15&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0130" class="elsevierStylePara elsevierViewall">We developed and validated a clinical prediction model to identify patients with SARS-CoV-2 infection who will require ICU admission&#46; The predictive model&#8217;s performance showed an AUC of 0&#46;780 for a probability of ICU admission of 0&#46;102&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Risk of ICU admission increased progressively according to the number of independent variables&#44; which included age younger than 75 years&#44; presence of dyspnea&#44; Charlson Comorbidity Index score of less than 3&#44; a neutrophil-lymphocyte ratio greater than 5&#44; lactate dehydrogenase values greater than 250 U&#47;L&#44; and presence of diffuse infiltrates on the chest x-ray&#46; Using these variables&#44; which are easily available at the time of the patient&#8217;s hospital admission&#44; we built a scoring system that allows for determining the probability of ICU admission&#46; This study allows for anticipating the necessary intensive care resources for patients hospitalized due to COVID-19&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The percentage of patients admitted to the ICU in the derivation cohort was 8&#46;9&#37; and in the validation cohort it was 7&#46;7&#37;&#46; These values are similar to what has been reported in other studies conducted in Spain<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46; The proportion of hospitalized patients admitted to the ICU in other countries was 16&#46;8&#37; in Italy&#44; 17&#37; in the United Kingdom&#44; 11&#37; in France&#44; 32&#37; in the USA&#44; and 8&#46;2&#37; in China<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a>&#46; A higher percentage of patients admitted to the ICU applied to our model would entail an increase in the positive predictive value of the scoring system&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The demographic characteristics of the study population also show differences according to country&#44; with a mean age of around 70 years for studies conducted in Europe and a mean age around 50 years for studies conducted in China&#46; All studies showed the determining factors for ICU admission to be older age and male sex&#44; greater comorbidity&#44; and presence of dyspnea&#46; Among the laboratory data&#44; signs of poor prognosis that have been found in all studies include a greater neutrophil-lymphocyte ratio and a greater increase in lactate dehydrogenase levels<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a>&#46; Likewise&#44; a diffuse&#44; bilateral pattern with ground glass opacity on the chest x-ray has also been associated with greater risk of severe disease<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The performance of our predictive model for ICU admission is in line with data found by other authors&#44; who report AUROC values of 0&#46;74 to 0&#46;88 in studies with derivation and validation models<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Nevertheless&#44; we must be cautious when extrapolating the performance of models when applying them to other countries&#44; given that they can have differences that&#44; in some instances&#44; are notable<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#46; These differences can be due to the demographic characteristics of the subjects studied&#44; the incidence of cases at one particular moment in the pandemic&#44; or the structure of the healthcare system&#44; among others&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Among the strengths of this study are the large sample size&#44; which allowed for considering a large number of variables in the predictive model&#44; as well as a robust analysis of the derivation and validation models&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">It is advisable to interpret this study as an aid for determining intensive care unit bed requirements for patients with severe COVID-19&#46; Although the risk score refers to clinical deterioration related to COVID-19&#44; the benefit of ICU admission may be conditioned by other aspects&#46; The patient&#8217;s comorbidity&#44; presence of advanced cognitive decline&#44; or inability to perform basic activities of daily living can constitute limitations for ICU admission in subjects with severe COVID-19<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">On the other hand&#44; the probability of ICU admission may be influenced by the percentage of beds occupied during different periods of the pandemic&#46; It is possible that during periods when there is good access to supportive treatment&#44; it is decided to provide this treatment to patients with moderate risk of mortality&#46; On the contrary&#44; in periods or areas with more limited resources&#44; the decision could be made to limit intensive supportive treatment in patients with moderate risk in order to optimize available resources&#46; Likewise&#44; the admission of patients with severe COVID-19 in respiratory intensive care units was not taken into consideration&#59; the availability of these facilities could alter the scale validation results&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Finally&#44; the development and validation of the predictive model was carried out in Spain&#46; This could limit the generalization of the scoring system to other areas of the world with different healthcare systems&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; we developed a clinical prediction rule for ICU admission for patients with COVID-19&#46; The predictor variables are easy to obtain at the time of admission&#46; Our prediction rule has been validated in a large cohort of patients and has been demonstrated to be reproducible&#46; The incorporation of the rule into the electronic medical record would facilitate its implementation and help clinicians appropriately adapt the patient admissions department&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">J&#46;V&#46; Segura-Heras received a competitive grant from the <span class="elsevierStyleGrantSponsor" id="gs0005">Ministry of Economy and Competitiveness of Spain</span>&#44; Grant No&#46; <span class="elsevierStyleGrantNumber" refid="gs0005">MTM2017-83850-P</span>&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">The Spanish Society of Internal Medicine &#40;SEMI&#41; is the sponsor of this study&#46; The research has not received specific grants from agencies in the public&#44; commercial&#44; or non-profit sectors&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflicts of interest</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">This work aims to identify and validate a risk scale for admission to intensive care units &#40;ICU&#41; in hospitalized patients with coronavirus disease 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 &#40;N &#61; 16&#44;298&#41;&#46; We analyzed the available demographic&#44; clinical&#44; radiological&#44; and laboratory variables recorded at hospital admission&#46; We evaluated the performance of the risk score by estimating the area under the receiver operating characteristic curve &#40;AUROC&#41;&#46; Using the &#946; coefficients of the regression model&#44; we developed a score &#40;0&#8211;100 points&#41; associated with ICU admission&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The mean age of the patients was 67 years&#59; 57&#37; were men&#46; A total of 1420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU&#46; The variables independently associated with ICU admission were age&#44; dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-to-lymphocyte ratio&#44; lactate dehydrogenase levels&#44; and presence of diffuse infiltrates on a chest X-ray&#46; The model showed an AUROC of 0&#46;780 &#40;CI&#58; 0&#46;763&#8722;0&#46;797&#41; in the derivation cohort and an AUROC of 0&#46;734 &#40;CI&#58; 0&#46;708&#8722;0&#46;761&#41; in the validation cohort&#46; A score of greater than 75 points was associated with a more than 30&#37; probability of ICU admission while a score of less than 50 points reduced the likelihood of ICU admission to 15&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A simple prediction score was a useful tool for forecasting the probability of ICU admission with a high degree of precision&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Fundamento</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Identificar y validar una escala de riesgo de ingreso en las unidades de cuidados intensivos &#40;UCI&#41; en pacientes hospitalizados con enfermedad por coronavirus 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Realizamos una regla de derivaci&#243;n y otra de validaci&#243;n para ingreso en UCI utilizando los datos de un registro nacional de cohortes de pacientes con infecci&#243;n confirmada por SARS-CoV-2 ingresados entre marzo y agosto del a&#241;o 2020 &#40;N &#61; 16&#46;298&#41;&#46; Analizamos variables demogr&#225;ficas&#44; cl&#237;nicas&#44; radiol&#243;gicas y de laboratorio disponibles en el ingreso hospitalario&#46; Evaluamos el rendimiento de la escala de riesgo mediante estimaci&#243;n del &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41;&#46; Utilizamos los coeficientes &#946; del modelo de regresi&#243;n para elaborar una puntuaci&#243;n &#40;0 a 100 puntos&#41; asociada con ingreso en UCI&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue 67 a&#241;os&#59; 57&#37; varones&#46; Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes ingresaron en la UCI&#46; Las variables independientes asociadas con el ingreso en UCI fueron&#58; edad&#44; disnea&#44; &#237;ndice de comorbilidad de Charlson&#44; cociente neutr&#243;filos-linfocitos&#44; lactato deshidrogenasa e infiltrados difusos en la radiografia de t&#243;rax&#46; El modelo mostr&#243; un AROC de 0&#44;780 &#40;IC&#58; 0&#44;763&#8722;0&#44;797&#41; en la cohorte de derivaci&#243;n y un AROC de 0&#44;734 &#40;IC&#58; 0&#44;708&#8722;0&#44;761&#41; en la cohorte de validaci&#243;n&#46; Una puntuaci&#243;n &#62; 75 se asoci&#243; con una probabilidad de ingreso en UCI superior a un 30&#37;&#44; mientras que una puntuaci&#243;n &#60; 50 redujo la probabilidad de ingreso en UCI al 15&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Una puntuaci&#243;n de predicci&#243;n simple proporcion&#243; una herramienta &#250;til para predecir la probabilidad de ingreso en la UCI con un alto grado de precisi&#243;n&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ena J&#44; Segura-Heras JV&#44; Fonseca-Aizpuru EM&#44; L&#243;pez-Reboiro ML&#44; Gracia-Guti&#233;rrez A&#44; Mart&#237;n-Oterino JA&#44; et al&#46; Derivaci&#243;n y validaci&#243;n de una puntuaci&#243;n de riesgo de ingreso en la Unidad de Cuidados Intensivos para pacientes con COVID-19&#46; Rev Clin Esp&#46; 2022&#59;222&#58;1&#8211;12&#46;</p>"
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            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall">SEMI-COVID-19 Registry Coordinator&#58; Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SEMI-COVID-19 Members of the Scientific Committee&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez Huelgas&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "List of SEMI-COVID-19 network members"
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                "apendice" => "<p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; de Bellvitge&#46; L<span class="elsevierStyleUnderline">&#39;</span>Hospitalet de Llobregat&#44; Barcelona&#58;</span> Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio-Rivas&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; 12 de Octubre&#44; Madrid&#58;</span> Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Laura Ibarra Veganzones&#44; Luc&#237;a Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Jaime Lora-Tamayo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Rodrigo Miranda Godoy&#44; B&#225;rbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#44; Madrid&#58;</span> Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Christian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro D&#46; Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Ant&#250;nez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o M&#237;guez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Costa del Sol&#44; Marbella&#44; M&#225;laga&#58;</span> Victoria August&#237;n Bandera&#44; Javier Garc&#237;a Alegr&#237;a&#44; Nicol&#225;s Jim&#233;nez-Garc&#237;a&#44; Jairo Luque del Pino&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#44; Francisco Navarro Romero&#44; Victoria N&#250;&#241;ez Rodr&#237;guez&#44; Juli&#225;n Olalla Sierra&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Cabue&#241;es&#44; Gij&#243;n&#44; Asturias&#58;</span> Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Mar&#237;a Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Diego L&#243;pez Mart&#237;nez&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Luc&#237;a P&#233;rez Casado&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Paz&#44; Madrid&#58;</span> Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Royo Villanova&#44; Zaragoza&#58;</span> Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral Beamonte&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Geric&#243; Aseguinolaza&#44; Cristina Gallego Lezaun&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Reg&#46; U&#46; de M&#225;laga&#44; M&#225;laga&#58;</span> Mar&#237;a Mar Ayala-Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Jos&#233; Antonio Hurtado Oliver&#44; Sergio Jansen-Chaparro&#44; Mar&#237;a Dolores L&#243;pez-Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo-Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Mart&#237;n Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Iv&#225;n P&#233;rez de Pedro&#44; Araceli Pineda-Cantero&#44; Carlos Romero G&#243;mez&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Cl&#237;nico de Santiago de Compostela&#44; A Coru&#241;a&#58;</span> Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel Paez Guillan&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Dr&#46; Peset&#44; Valencia&#58;</span> Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabeth Mateo Sanch&#237;s&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Mois&#232;s Broggi&#44; Sant Joan Desp&#237;&#44; Barcelona&#58;</span> Judit Aranda Lobo&#44; Luc&#237;a Feria Casanovas&#44; Jos&#233; Loureiro Amigo&#44; Miguel Mart&#237;n Fern&#225;ndez&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicol&#225;s Rhyman&#44; Nuria V&#225;zquez Piqueras&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Badajoz&#44; Badajoz&#58;</span> Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; R&#237;o Hortega&#44; Valladolid&#58;</span> Irene Arroyo Jim&#233;nez&#44; Marina Cazorla Gonz&#225;lez&#44; Marta Cobos-Siles&#44; Luis Corral-Gudino&#44; Pablo Cubero-Morais&#44; Mar&#237;a Gonz&#225;lez Fern&#225;ndez&#44; Jos&#233; Pablo Miramontes Gonz&#225;lez&#44; Marina Prieto Dehesa&#44; Pablo Sanz Espinosa&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Reina Sof&#237;a&#44; C&#243;rdoba&#58;</span> Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Francisco Fuentes-Jim&#233;nez&#44; Mar&#237;a del Carmen Guerrero Mart&#237;nez&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Limia P&#233;rez&#44; Jos&#233; L&#243;pez-Miranda&#44; Laura Mart&#237;n Piedra&#44; Marta Mill&#225;n Orge&#44; Javier Pascual Vinagre&#44; Pablo P&#233;rez-Mart&#237;nez&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; &#193;ngela Rodrigo Mart&#237;nez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres-Pe&#241;a&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; S&#46; Juan de Alicante&#44; Alicante&#58;</span> Marisa Asensio Tom&#225;s&#44; David Balaz&#44; David Bonet Tur&#44; Ruth Ca&#241;izares Navarro&#44; Paloma Chazarra P&#233;rez&#44; Jes&#250;s Corbacho Redondo&#44; Eliana Damonte White&#44; Mar&#237;a Escamilla Esp&#237;nola&#44; Leticia Espinosa Del Barrio&#44; Pedro Jes&#250;s Esteve Ati&#233;nzar&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Francisco Garrido Navarro&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Ver&#243;nica Mart&#237;nez Sempere&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Rafael Pi&#241;ol Pleguezuelos&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Azucena Sempere Mira&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo&#58;</span> Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#44; Cristina Salazar Mosteiro&#44; Andrea Silva Asiain&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Pozoblanco&#44; C&#243;rdoba&#58;</span> Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Infanta Cristina&#44; Parla&#44; Madrid&#58;</span> Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Blanca Beamonte Vela&#44; Coralia Bueno Mui&#241;o&#44; Charo Bur&#243;n Fern&#225;ndez&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Pilar Cubo Romano&#44; Francesco Deodati&#44; Alejandro Estrada Santiago&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Francisco Javier Garc&#237;a S&#225;nchez&#44; Pilar Garc&#237;a de la Torre&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A&#46; Melero Bermejo&#44; Cruz Pastor Valverde&#44; Jos&#233; Luis P&#233;rez Quero&#44; Fernando Roque Rojas&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Francisco Javier Teigell Mu&#241;oz&#44; Juan Vicente de la Sota&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; G&#46; U&#46; de Elda&#44; Alicante&#58;</span> Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Santiago L&#243;pez Gil&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Nuria Ram&#237;rez Perea&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Santa Marina&#44; Bilbao&#58;</span> Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Labirua-Iturburu Ruiz&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; San Pedro&#44; Logro&#241;o&#44; La Rioja&#58;</span> Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Lu&#237;s Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Son Ll&#224;tzer&#44; Palma de Mallorca&#58;</span> Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; Ourense&#44; Ourense&#58;</span> Raquel Fern&#225;ndez Gonz&#225;lez&#44; Amara Gonz&#225;lez Noya&#44; Carlos Hern&#225;ndez Cer&#243;n&#44; Isabel Izuzquiza Avanzini&#44; Ana Latorre Diez&#44; Pablo L&#243;pez Mato&#44; Ana Mar&#237;a Lorenzo Vizcaya&#44; Daniel Pe&#241;a Ben&#237;tez&#44; Milagros Mar&#237;a Pe&#241;a Zemsch&#44; Luc&#237;a P&#233;rez Exp&#243;sito&#44; Marta Pose Bar&#44; Lara Rey Gonz&#225;lez&#44; Laura Rodrigo Lara&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Fe&#44; Valencia&#58;</span> Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Matar&#243;&#44; Barcelona&#58;</span> Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Javier Fern&#225;ndez Fern&#225;ndez&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Sagunto&#44; Valencia&#58;</span> Enrique Rodilla Sala&#44; Jos&#233; Mar&#237;a Pascual Izuel&#44; Zineb Karroud Zamrani&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Alto Guadalquivir&#44; And&#250;jar&#44; Ja&#233;n&#58;</span> Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Infanta Margarita&#44; Cabra&#44; C&#243;rdoba&#58;</span> Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Ferrol&#44; A Coru&#241;a&#58;</span> Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trigas Ferrin&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Marina Baixa&#44; Villajoyosa&#44; Alicante&#58;</span> Javier Ena&#44; Santiago P&#233;rez Mart&#237;n&#46;</p> <p id="par0365" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Virgen del Roc&#237;o&#44; Sevilla&#58;</span> Reyes Aparicio Santos&#44; M&#225;ximo Bernabeu-Wittel&#44; Santiago Rodr&#237;guez Su&#225;rez&#44; Mar&#237;a Nieto&#44; Luis Gim&#233;nez Miranda&#44; Rosa Mar&#237;a G&#225;mez Mancera&#44; F&#225;tima Espinosa Torre&#44; Carlos Hern&#225;ndez Quiles&#44; Concepci&#243;n Conde Guzm&#225;n&#44; Juan Delgado de la Cuesta&#44; Jara Elo&#237;sa Ternero Vega&#44; Mar&#237;a del Carmen L&#243;pez R&#237;os&#44; Pablo D&#237;az Jim&#233;nez&#44; Bosco Bar&#243;n Franco&#44; Carlos Jim&#233;nez de Juan&#44; Sonia Guti&#233;rrez Rivero&#44; Julia Lanseros Tenllado&#44; Ver&#243;nica Alfaro Lara&#44; Aurora Gonz&#225;lez Estrada&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; P&#250;blico de Monforte de Lemos&#44; Lugo&#58;</span> Jos&#233; L&#243;pez Castro&#44; Manuel Lorenzo L&#243;pez Reboiro&#44; Cristina Sardi&#241;a Gonz&#225;lez&#46;</p> <p id="par0375" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; General Defensa&#44; Zaragoza&#58;</span> Anyuli Gracia Guti&#233;rrez&#44; Leticia Esther Royo Trallero&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; A&#46; U&#46; de Salamanca&#44; Salamanca&#58;</span> Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ram&#243;n Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0385" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Palam&#243;s&#44; Girona&#58;</span> Ana Alberich Conesa&#44; Mari Cruz Almendros Rivas&#44; Miquel Hortos Alsina&#44; Jos&#233; Marchena Romero&#44; Anabel Mart&#237;n-Urda Diez-Canseco&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; do Salnes&#44; Vilagarc&#237;a de Arousa&#44; Pontevedra&#58;</span> Vanesa Allende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Rodr&#237;guez Ferreira&#44; Diana Sande Llovo&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0395" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; HM Montepr&#237;ncipe&#44; Boadilla del Monte&#44; Madrid&#58;</span> Jos&#233; F&#46; Varona Arche&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Comorbidity&#8212;No&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Obesity &#40;BMI &#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;37 &#176;C&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2418 &#40;16&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#62;38 &#176;C&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1038 &#40;73&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cough&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Dry&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">With sputum production&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anosmia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asthenia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;490&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anorexia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2931 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">262 &#40;18&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#46;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Headache&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1765 &#40;12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">161 &#40;11&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#46;548&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arthromyalgia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4486 &#40;30&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">473 &#40;33&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ageusia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1266 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">86 &#40;6&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Altered level of consciousness&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1794 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">119 &#40;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyspnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#44;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8299 &#40;56&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1069 &#40;75&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vomiting&#47;nausea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2100 &#40;14&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarrhea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3566 &#40;24&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">321 &#40;22&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Radiology&#8212;No&#46; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7789 &#40;53&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">630 &#40;44&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unilateral infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2567 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">171 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">4300 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">604 &#40;43&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Physical examination&#44; mean &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SpO<span class="elsevierStyleInf">2</span>&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#46;3 &#177; 5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#46;0 &#177; 8&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Systolic blood pressure&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;666&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#46;8 &#177; 21&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#46;8 &#177; 21&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diastolic blood pressure&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;9 &#177; 13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#46;8 &#177; 13&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate&#44; beats&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#46;3 &#177; 17&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;8 &#177; 17&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tachypnea &#40;&#60;30 breaths&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;942&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4258 &#40;29&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">793 &#40;56&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laboratory tests&#44; mean &#177; SD</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Neutrophil-lymphocyte ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;0 &#177; 11&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;7 &#177; 9&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Platelets&#8212;x10<span class="elsevierStyleSup">9</span>&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#46;461&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">24 &#40;5&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">119 &#40;9&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">36 &#40;4&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">202 &#40;8&#46;29&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Neutrophil-lymphocyte ratio</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">326 &#40;5&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">144 &#40;5&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;335&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&#8722;10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">350 &#40;10&#46;92&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">152 &#40;9&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">308 &#40;15&#46;83&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">131 &#40;13&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Lactate dehydrogenase&#44; U&#47;L</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;250&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">85 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;2&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;655&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">442 &#40;8&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">209 &#40;7&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">318 &#40;19&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">133 &#40;17&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Altered level of consciousness</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">902 &#40;9&#46;54&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">389 &#40;8&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;062&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">84 &#40;6&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;5&#46;83&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chest x-ray</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">435 &#40;7&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;6&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;197&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unilateral infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">114 &#40;6&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;6&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">432 &#40;13&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">172 &#40;10&#46;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasm</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">961 &#40;9&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">411 &#40;7&#46;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;665&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;5&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;6&#46;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tachypnea &#40;&#62; 30 breaths&#47;min&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409 &#40;5&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;5&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">567 &#40;16&#46;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">226 &#40;13&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Urea elevation &#62; 40 mg&#47;dL</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">406 &#40;8&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;8&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">447 &#40;10&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183 &#40;8&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Type 1 diabetes mellitus</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">947 &#40;9&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">407 &#40;7&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;848&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;7&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;7&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Type 2 diabetes mellitus</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">831 &#40;8&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">360 &#40;7&#46;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159 &#40;10&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;8&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Odds ratio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; confidence interval&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Charlson Comorbidity Index</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;828&#44; 2&#46;029&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#46;155&#44; 2&#46;506&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#46;364&#44; 2&#46;822&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#46;659&#44; 3&#46;328&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasm</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;597&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;397&#44; 0&#46;863&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Type 1 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Type 2 diabetes mellitus</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;135&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Altered level of consciousness</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;648&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#46;511&#44; 0&#46;812&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tachypnea&#44;&#60; 30 breaths&#47;min</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;327&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;2&#46;910&#44; 3&#46;808&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  """
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Odds ratio &#40;95&#37; confidence interval&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Points assigned&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 75&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60;65&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;461&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;311 &#40;3&#46;410&#44; 5&#46;492&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>65&#8722;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;982 &#40;4&#46;720&#44; 7&#46;633&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dyspnea</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;805&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;237 &#40;1&#46;874&#44; 2&#46;680&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Charlson Comorbidity Index&#44; points</span></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;098&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;102 &#40;0&#46;577&#44; 2&#46;057&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;762&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;384&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;468 &#40;0&#46;869&#44; 2&#46;498&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;153&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;623&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;864 &#40;1&#46;203&#44; 2&#46;967&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;699&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;013 &#40;1&#46;338&#44; 3&#46;128&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;921 &#40;2&#46;392&#44; 3&#46;568&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Absence of infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Unilateral infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diffuse infiltrates&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;412&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;509 &#40;1&#46;279&#44; 1&#46;781&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  "referenciaCompleta" => "Secretar&#237;a de Estado de Sanidad&#47;Centro de Coordinaci&#243;n de Alertas y Emergencias Sanitarias&#46; Actualizaci&#243;n n&#186; 350&#46; Enfermedad por el coronavirus &#40;COVID-19&#41; &#91;Accessed 14 April 2021&#93;&#46; Available from&#58; <a target="_blank" href="https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Actualizacion_355_COVID-19.pdf">https&#58;&#47;&#47;www&#46;mscbs&#46;gob&#46;es&#47;profesionales&#47;saludPublica&#47;ccayes&#47;alertasActual&#47;nCov&#47;documentos&#47;Actualizacion&#95;355&#95;COVID-19&#46;pdf</a>&#46;"
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                    0 => array:2 [
                      "titulo" => "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan&#44; China&#58; a retrospective cohort study"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Zhou"
                            1 => "T&#46; Yu"
                            2 => "R&#46; Du"
                            3 => "G&#46; Fan"
                            4 => "Y&#46; Liu"
                            5 => "Z&#46; Liu"
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                      "doi" => "10.1016/S0140-6736(20)30566-3"
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                        "tituloSerie" => "Lancet&#46;"
                        "fecha" => "2020"
                        "volumen" => "395"
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Article information
ISSN: 22548874
Original language: English
DOI:10.1016/j.rceng.2021.06.001
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