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the National Lung Screening Trial &#40;NLST&#41;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> showed how screening with low-dose computed tomography &#40;LDCT&#41; in high-risk individuals is effective in detecting early stages of the disease&#44; given that it achieved a reduction in mortality of approximately 20&#37;&#46; As a result&#44; the United States Preventive Services Task Force and numerous scientific societies recommended lung cancer screening with LDCT in the United States<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#59; however&#44; its implementation in Europe is still debated&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Factors have been identified that can act synergistically with cigarette smoke thereby increasing its effect&#46; Chronic obstructive pulmonary disease &#40;COPD&#41; increases the risk of developing lung cancer by 3- to 5-fold over &#8220;healthy&#8221; smokers&#44;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;11</span></a> with the degree of bronchial obstruction&#44; emphysema and chronic bronchitis as independent risk factors for the onset of lung cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;16</span></a> Risk prediction scales that integrate clinical &#40;age&#44; body mass index &#91;BMI&#93;&#44; packs-year index &#91;PYI&#93;&#44; family history of lung cancer or COPD&#41;&#44; radiological &#40;presence of emphysema in the computed tomography &#91;CT&#93;&#41; and functional variables &#40;reduction in the diffusing capacity of the lungs for carbon monoxide &#91;DLCO&#93;&#41; have shown their usefulness in selecting candidates for lung cancer screening using LDCT&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#8211;21</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> validated the COPD-LUCSS-DLCO scale as a useful tool for identifying patients with COPD at a high risk of dying of lung cancer&#44; who would benefit to a greater extent from a screening program&#46; To date&#44; however&#44; studies have not been conducted on the scale&#39;s clinical applicability in patients with COPD in outpatient follow-up&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of our study was to estimate the COPD-LUCSS-DLCO for patients with COPD treated in pulmonology consultations and to determine the incidence of lung cancer in each of the subgroups&#44; in order to develop future strategies for protocolized follow-up that help with the early detection of this cancer in such patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">An observational&#44; retrospective study was conducted on a cohort of patients diagnosed with COPD in pulmonology follow-up consultations between January 1&#44; 2011 and March 1&#44; 2017 at the University Hospital Nuestra Se&#241;ora de Candelaria &#40;HUNSC&#41;&#44; which has a reference population of 452&#44;000 inhabitants and 22 health areas&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The inclusion criteria were an age greater than 40 years&#44; active smoker or ex-smoker with a PYI &#8805;10 and a forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; to forced vital capacity &#40;FVC&#41; ratio &#60;70&#37; after administering salbutamol&#46; The exclusion criteria were the presence of chronic respiratory disease caused by something other than COPD&#44; a cancer diagnosis prior to inclusion and the presence of chronic airflow obstruction without exposure to tobacco smoke or a PYI &#60;10&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">After study approval by the HUNSC Ethics Committee&#44; we collected the following data from each patient&#39;s computerized medical history&#58; &#40;a&#41; COPD diagnosis date&#59; &#40;b&#41; date of respiratory function tests at the time of study inclusion&#59; &#40;c&#41; results of the respiratory function tests regarding FEV<span class="elsevierStyleInf">1</span> &#40;the patients were categorized according to the severity level recorded in the 2009 Global Initiative for Chronic Obstructive Lung Disease &#91;GOLD&#93; guidelines<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a>&#58; mild &#91;stage 1&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;80&#37;&#59; moderate &#91;stage 2&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;50&#37; and &#60;80&#37;&#59; severe &#91;stage 3&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;30&#37; and &#60;50&#37;&#59; and very severe &#91;stage 4&#93;&#41; FEV<span class="elsevierStyleInf">1</span> &#60;30&#37;&#41;&#44; FVC&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and DLCO using only the respiration test&#59; d&#41; BMI &#40;weight in kg&#47;&#91;height in m&#93;<span class="elsevierStyleSup">2</span>&#41;&#59; e&#41; PYI at the time of inclusion&#59; and f&#41; date of cancer diagnosis &#40;any location and lung cancer&#41; up to the end of the follow-up &#40;March 1&#44; 2017&#41;&#46; The other covariates recorded were age&#44; sex and age-adjusted Charlson comorbidity index&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Each of the patients had their COPD-LUCSS-DLCO<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> calculated at the time of study inclusion&#46; The scores for each component &#40;BMI &#60;25&#44; PYI &#62;60&#44; age &#62;60 years and DLCO &#60;60&#37;&#41; and the definition of &#8220;Low Risk&#8221; and &#8220;High Risk&#8221; are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">We performed an initial descriptive analysis using the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; or median and interquartile range &#40;P25&#8211;P75&#41; for the numerical variables and percentages &#40;&#37;&#41; for the qualitative variables&#44; with a point estimate and interval of 95&#37; &#40;95&#37; CI&#41; for the prevalence of high risk for lung cancer&#46; To determine the incidence rate of lung cancer&#44; we used the person-time to cancer diagnosis event index or the time to the completion of the follow-up period as the denominator&#46; The Kaplan&#8211;Meier survival analysis was employed to compare the incidence of lung cancer between the patients in the low and high-risk categories according to the COPD-LUCSS-DLCO criterion indicated in the Material and Methods section&#46; Statistical significance was determined by the log rank test&#46; We employed a Cox proportional hazards regression to assess the increase in risk adjusted for other variables&#46; All hypothesis tests were bilateral&#44; for a significance level of 5&#37;&#46; The analysis was performed using the statistical program SPSS&#47;PC &#40;version 24&#46;0 for Windows&#59; SPSS&#44; Inc&#46;&#44; Chicago&#44; IL&#41; and EPIDAT &#40;version 3&#46;0&#44; Department of Health&#44; Government of Galicia and the Pan American Health Organization&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The study included 159 patients with COPD&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> lists their characteristics&#44; which include a mean age of 66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#44; a 27&#37; rate of active smokers and a mostly male &#40;82&#37;&#41; proportion&#46; Taking into account the 2009 GOLD classification&#44; 9&#37; of the patients were categorized as GOLD 1&#44; 36&#37; as GOLD 2&#44; 44&#37; as GOLD 3 and 11&#37; as GOLD 4&#46; Sixty-two percent of the patients had a high-risk COPD-LUCSS-DLCO &#40;95&#37; CI 54&#8211;69&#41;&#46; The median follow-up time was 31 months &#40;range&#44; 15&#8211;37&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">During the study&#44; 12 of the 22 new cases of diagnosed cancer corresponded to lung cancer &#40;9 in high-risk patients and 3 in low-risk patients&#41;&#44; the latter of which had an estimated overall rate of 30 cases per 1000 patients with COPD-year &#40;95&#37; CI 16&#8211;53&#41;&#46; When classifying the patients as high-risk and low-risk&#44; we observed an incidence rate of 44 cases per 1000 patients with COPD-year &#40;95&#37; CI 18&#8211;76&#41; and 17 cases per 1000 patients with COPD-year &#40;95&#37; CI 4&#8211;50&#41;&#44; respectively&#44; showing a high-risk&#47;low-risk ratio of 2&#46;3 &#40;95&#37; CI 0&#46;58&#8211;13&#46;3&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;3155&#41;&#46; Seventy-five percent of the lung cancer cases were diagnosed in the first 31 months after inclusion&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Our series&#8217; survival curves showed a higher incidence of lung cancer among the patients categorized as high-risk &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;132&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In the Cox regression analysis&#44; we obtained a crude HR for the high-risk patients versus the low-risk patients of 3&#46;0 &#40;95&#37; CI 0&#46;65&#8211;13&#46;9&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;159&#41;&#46; After adjusting the HR&#44; using as covariate the Charlson comorbidity index calculated at the time of inclusion&#44; we obtained an adjusted HR of 4&#46;9 &#40;95&#37; CI 1&#46;02&#8211;23&#46;0&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;046&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">The following conclusions were extracted from our study&#58; &#40;1&#41; The COPD-LUCSS-DLCO can be a useful tool for detecting patients at a greater risk of lung cancer&#59; &#40;2&#41; the incidence of lung cancer in the high-risk patients was twice that of the low-risk patients&#44; although this increase was not statistically significant&#59; and &#40;3&#41; 62&#37; of the patients with COPD presented a high-risk score&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The association between lung cancer and COPD has been clearly established&#46; Various cohort studies&#44; including lung cancer detection trials&#44; have shown that patients with COPD have 2&#8211;4 times the risk of developing lung cancer than those who do not have COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;11</span></a> The degree of bronchial obstruction&#44; the presence of emphysema in the CT and chronic bronchitis are independent risk factors for the onset of lung cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;16</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> validated a scoring system for lung cancer screening to identify high-risk patients with COPD in 2 screening cohorts in Spain &#40;P-IELCAP&#41; and the United States &#40;PLuSS&#41;&#46; The scale included age&#44; BMI&#44; PYI and the visual presence of emphysema in the LDCT&#46; However&#44; to facilitate the scale&#39;s clinical implementation and avoid the application of an LDCT&#44; a new scoring system &#40;known as COPD-LUCSS-DLCO&#41; has been proposed&#44; which replaces the radiological emphysema with DLCO&#46; The high-risk patients showed a 2&#46;4-fold increase in lung cancer mortality compared with the low-risk group &#40;95&#37; CI 2&#46;0&#8211;2&#46;7&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">A notable result of our study was that 62&#37; of the patients were in the high-risk range&#46; If we compare our series with similar studies in Spanish populations&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> there were no significant differences in terms of mean age&#44; FEV<span class="elsevierStyleInf">1</span>&#44; BMI and PYI&#46; However&#44; more than half of our patients had an DLCO &#8804;60&#37; despite the fact that the percentage of patients with COPD with a PYI &#62;60 was lower &#40;20&#37; vs&#46; 42&#37;&#41;&#46; Although a lower prevalence of COPD has been reported in the Canary Islands compared with the national mean&#44; despite the high percentage of smokers&#44;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> we cannot rule out a greater susceptibility in our population with COPD to developing a greater degree of emphysema&#46; COPD is a complex and multifactorial disease in which the association between genetic polymorphisms and the phenotype is probably nonlinear and in which the final phenotype depends on the genetics&#44; the environment and the setting in which this genotype develops&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Consistent with the severity obtained in the score&#44; those high-risk patients with COPD demonstrated a higher incidence of lung cancer over the follow-up than the low-risk patients&#46; Although this finding was not statistically significant&#44; the magnitude of the signal achieved despite the low number of cancer diagnoses indicates the usefulness of the COPD-LUCSS-DLCO for detecting individuals in an outpatient population with a high probability of experiencing lung cancer&#44; which allows us to manage lung cancer screening more efficiently&#46; A study published by Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> conducted on 2 populations selected for follow-up &#40;a control population who were monitored according to the GOLD guidelines and another who underwent lung cancer screening with annual LDCT&#41; determined that the number of patients with COPD required for screening with the intent to save a life from lung cancer was only 34 patients&#44; a significantly low number considering that the number needed for screening with the intent to save a life in the NLST study<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> was 271&#46; In keeping with the above&#44; the COPD-LUCCS-DLCO could help define what population would require a closer follow-up&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">However&#44; once we have identified the presence of a &#8220;non-negligible&#8221; percentage of patients with COPD labeled as high risk&#44; the issue is how follow-up should be conducted&#46; Faced with the lack of favorable results in the lung cancer screening using chest radiography and given the ability of CT to detect smaller nodules than with conventional radiography&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26&#44;27</span></a> published data from the Early Lung Cancer Action Program group study<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> and subsequently from the NLST<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> showed that lung cancer screening using LDCT in individuals labeled as high risk helps diagnose most tumors in early phases of the disease&#44; thereby achieving a reduction in lung cancer-specific mortality of approximately 16&#8211;20&#37;&#46; However&#44; these results are currently the subject of debate in Europe&#44; especially regarding overdiagnosis&#44; radiation and associated risks&#44; as well as its cost-effectiveness and organizational complexity&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#44;29</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Despite the aforementioned discrepancies&#44; LDCT currently appears to be the imaging technique of choice for lung cancer screening&#46; However&#44; doubts arise as to periodicity of its implementation and its duration in the follow-up&#46; In our sample&#44; 9&#37; of the patients with COPD identified as high risk developed lung cancer in the first 31 months&#46; However&#44; we do not know the outcomes of high-risk patients who were not diagnosed during the follow-up period&#46; Based on the NLST&#44; the American Association for Thoracic Surgery<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> recommended performing LDCT annually in patients with a history of tobacco use and a PYI &#8805;30&#44; starting at 55 years of age and ending at 79 years of age&#46; It is likely that patients with COPD determined as high risk using the COPD-LUCSS-DLCO will benefit from this option&#44; while for those at low risk the implementation of the LDCT could be more spaced out&#44; enabling better management of the cases&#46; Nevertheless&#44; further studies are needed to verify this hypothesis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Our study had a several limitations&#46; Firstly&#44; the study population belonged to a single hospital&#44; and the sample size was limited&#46; Obviously&#44; a larger sample could have shown differences undetected in the current analysis&#46; Secondly&#44; it is possible than an information bias occurred due to obtaining the variables from the patients&#8217; medical history&#44; although the current standardization of diagnostic criteria minimizes this possibility&#46; Thirdly&#44; not having performed an LDCT at the start of the study could have led to a lack of early detection of lung carcinoma in patient enrollment&#44; with evidence of its clinical presence in the first 31 months of follow-up&#46; Nevertheless&#44; our study&#39;s objective was to use this score in an actual management situation in a pulmonology consultation&#44; where unfortunately&#44; not all patients undergo CT&#46; The strength of our study lies in that it is the first to evaluate the COPD-LUCSS-DLCO in patients with COPD in a typical situation of standard clinical practice&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In conclusion&#44; the COPD-LUCSS-DLCO is an independent predictor of the risk of lung cancer&#46; Its use in standard clinical practice could help detect patients at a greater risk of lung cancer&#44; although this first needs to be confirmed in studies with larger sample sizes&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The COPD-LUCSS-DLCO score had been validated as a predictive tool capable of identifying patients with chronic obstructive pulmonary disease &#40;COPD&#41; and a high mortality risk associated with lung cancer &#40;LC&#41;&#59; however&#44; studies have not been conducted yet on its use in standard clinical practice&#46; The aim of this study was to estimate the COPD-LUCSS-DLCO scores for patients with COPD treated in Pulmonology consultations and to determine the incidence of LC in each of the subgroups&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective observational study was conducted with a cohort of 159 patients with COPD in Pulmonology outpatient follow-up consultations&#46; We calculated the COPD-LUCSS-DLCO score &#40;0&#8211;8&#41; for each patient&#44; with low risk considered at 0&#8211;3 points and high risk at &#8805;3&#46;5 points&#46; We calculated the incidence rate of LC in each of the subgroups&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sixty-two percent of the patients had a high-risk score&#46; We estimated an overall LC rate of 30 per 1000 patients with COPD-year &#40;95&#37; CI&#58; 16&#8211;53&#41;&#44; 44 per 1000 patients with COPD-year &#40;95&#37; CI&#58; 18&#8211;76&#41; among those categorized as high risk and 17 per 1000 patients with COPD-year among those categorized as low risk &#40;95&#37; CI&#58; 4&#8211;50&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of the COPD-LUCSS-DLCO score in standard clinical practice could help detect patients with a greater risk of developing LC&#44; which could help to better manage cases in an LC screening program&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO ha sido validado como una herramienta predictiva capaz de identificar pacientes con enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; y alto riesgo de fallecer por c&#225;ncer de pulm&#243;n &#40;CP&#41;&#46; No obstante&#44; hasta la fecha no se han realizado estudios acerca de su uso en la pr&#225;ctica cl&#237;nica habitual&#46; El objetivo del estudio fue estimar las puntuaciones del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en pacientes con EPOC atendidos en consultas de Neumolog&#237;a&#44; as&#237; como determinar la incidencia de CP en cada uno de los subgrupos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional retrospectivo de una cohorte de 159 pacientes con EPOC en seguimiento en consultas ambulatorias de Neumolog&#237;a&#46; Se calcul&#243; la puntuaci&#243;n del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO &#40;puntuaci&#243;n de 0-8&#41; a cada uno de los sujetos&#44; considerando bajo riesgo &#40;BR&#41; entre 0-3 puntos y alto riesgo &#40;AR&#41; &#8805; 3&#44;5 puntos&#46; Se estim&#243; la incidencia del CP en cada uno de los subgrupos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 62&#37; presentaban un <span class="elsevierStyleItalic">score</span> de AR&#46; Se estim&#243; una tasa global de CP de 30 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58;16-53&#41;&#44; de 44 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58;&#160;18-76&#41; entre los catalogados de AR y de 17 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58; 4-50&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El uso del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en la pr&#225;ctica cl&#237;nica habitual podr&#237;a permitir detectar pacientes con un mayor riesgo de desarrollar CP&#44; lo cual ayudar&#237;a a una mejor gesti&#243;n de casos en un programa de <span class="elsevierStyleItalic">screening</span> de CP&#46;</p></span>"
        "secciones" => array:4 [
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            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Figueira Gon&#231;alves JM&#44; P&#233;rez Mendez LI&#44; Gurbani N&#44; Garc&#237;a-Talavera I&#44; P&#233;rez Pinilla JL&#46; Aplicabilidad del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en pacientes con enfermedad pulmonar obstructiva cr&#243;nica&#58; an&#225;lisis en condiciones de pr&#225;ctica cl&#237;nica habitual&#46; Rev Clin Esp&#46; 2018&#59;218&#58;336&#8211;341&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">This study was awarded the prize for best presentation at the XXXII Regional Congress of the Canary Islands Association of Pulmonology and Thoracic Surgery &#40;Neumocan&#41;&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Incidence curves for lung cancer according to the COPD-LUCSS-DLCO score&#46;</p>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; BMI&#44; body mass index&#59; DLCO&#44; diffusing capacity of the lungs for carbon monoxide&#59; PYI&#44; packs-year index&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Based on De Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">COPD-LUCSS-DLCO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Assigned score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Components</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#60;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PYI &#62;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age&#44; years &#62;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DLCO &#60;60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Categories</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Low risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#8211;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>High risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;5&#8211;8&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Components of the COPD-LUCSS-DLCO score&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; BMI&#44; body mass index&#59; COPD&#44; chronic obstructive pulmonary disease&#59; DLCO&#44; diffusing capacity of the lungs for carbon monoxide&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in one second&#59; FVC&#44; forced vital capacity&#59; GOLD&#44; Global Initiative for Chronic Obstructive Lung Disease&#59; IQR&#44; interquartile range&#59; PYI&#44; pack-year index&#59; SD&#44; standard deviation&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Global <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age&#44; years &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#62;60 years&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sex&#44; &#37; of males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BMI &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Degrees according to BMI&#44; &#37;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#60;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI 25&#8211;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#8805;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Active smokers&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PYI &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PYI &#62;60&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age-adjusted Charlson index &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FVC&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">DLCO&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">DLCO &#60;60&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">GOLD 2009 I&#47;II&#47;III&#47;IV</span> degrees&#44; <span class="elsevierStyleItalic">&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#47;36&#47;44&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with high-risk score&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Median follow-up time&#44; months &#40;IQR&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;15&#8211;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Number of lung cancer diagnoses in all patients&#47;in high-risk patients&#47;in low-risk patients</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#47;9&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Overall incidence of lung cancer</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Lung cancer incidence</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD-LUCSS-DLCO low risk score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD-LUCSS-DLCO high risk score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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Original article
Applicability of the COPD-LUCSS-DLCO score for patients with chronic obstructive pulmonary disease: Analysis in standard clinical practice conditions
Aplicabilidad del score COPD-LUCSS-DLCO en pacientes con enfermedad pulmonar obstructiva crónica: análisis en condiciones de práctica clínica habitual
J.M. Figueira Gonçalvesa,
Corresponding author
juanmarcofigueira@gmail.com

Corresponding author.
, L.I. Pérez Mendezb,c, N. Gurbania, I. García-Talaveraa, J.L. Pérez Pinillad
a Servicio de Neumología y Cirugía Torácica, Hospital Universitario Nuestra Señora de la Candelaria (HUNSC), Santa Cruz de Tenerife, Spain
b Departamento de Epidemiología Clínica y Bioestadística, Unidad de Investigación, Hospital Universitario Nuestra Señora de la Candelaria (HUNSC) y Gerencia de Atención Primaria AP, Santa Cruz de Tenerife, Spain
c CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
d Servicio de Medicina Física y Rehabilitación, Hospital Universitario Nuestra Señora de la Candelaria (HUNSC), Santa Cruz de Tenerife, Spain
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smokers&#44;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;11</span></a> with the degree of bronchial obstruction&#44; emphysema and chronic bronchitis as independent risk factors for the onset of lung cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;16</span></a> Risk prediction scales that integrate clinical &#40;age&#44; body mass index &#91;BMI&#93;&#44; packs-year index &#91;PYI&#93;&#44; family history of lung cancer or COPD&#41;&#44; radiological &#40;presence of emphysema in the computed tomography &#91;CT&#93;&#41; and functional variables &#40;reduction in the diffusing capacity of the lungs for carbon monoxide &#91;DLCO&#93;&#41; have shown their usefulness in selecting candidates for lung cancer screening using LDCT&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#8211;21</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> validated the COPD-LUCSS-DLCO scale as a useful tool for identifying patients with COPD at a high risk of dying of lung cancer&#44; 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2017 at the University Hospital Nuestra Se&#241;ora de Candelaria &#40;HUNSC&#41;&#44; which has a reference population of 452&#44;000 inhabitants and 22 health areas&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The inclusion criteria were an age greater than 40 years&#44; active smoker or ex-smoker with a PYI &#8805;10 and a forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; to forced vital capacity &#40;FVC&#41; ratio &#60;70&#37; after administering salbutamol&#46; The exclusion criteria were the presence of chronic respiratory disease caused by something other than COPD&#44; a cancer diagnosis prior to inclusion and the presence of chronic airflow obstruction without exposure to tobacco smoke or a PYI &#60;10&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">After study approval by the HUNSC Ethics Committee&#44; we collected the following data from each patient&#39;s computerized medical history&#58; &#40;a&#41; COPD diagnosis date&#59; &#40;b&#41; date of respiratory function tests at the time of study inclusion&#59; &#40;c&#41; results of the respiratory function tests regarding FEV<span class="elsevierStyleInf">1</span> &#40;the patients were categorized according to the severity level recorded in the 2009 Global Initiative for Chronic Obstructive Lung Disease &#91;GOLD&#93; guidelines<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a>&#58; mild &#91;stage 1&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;80&#37;&#59; moderate &#91;stage 2&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;50&#37; and &#60;80&#37;&#59; severe &#91;stage 3&#93; FEV<span class="elsevierStyleInf">1</span> &#8805;30&#37; and &#60;50&#37;&#59; and very severe &#91;stage 4&#93;&#41; FEV<span class="elsevierStyleInf">1</span> &#60;30&#37;&#41;&#44; FVC&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and DLCO using only the respiration test&#59; d&#41; BMI &#40;weight in kg&#47;&#91;height in m&#93;<span class="elsevierStyleSup">2</span>&#41;&#59; e&#41; PYI at the time of inclusion&#59; and f&#41; date of cancer diagnosis &#40;any location and lung cancer&#41; up to the end of the follow-up &#40;March 1&#44; 2017&#41;&#46; The other covariates recorded were age&#44; sex and age-adjusted Charlson comorbidity index&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Each of the patients had their COPD-LUCSS-DLCO<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> calculated at the time of study inclusion&#46; The scores for each component &#40;BMI &#60;25&#44; PYI &#62;60&#44; age &#62;60 years and DLCO &#60;60&#37;&#41; and the definition of &#8220;Low Risk&#8221; and &#8220;High Risk&#8221; are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">We performed an initial descriptive analysis using the mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard deviation &#40;SD&#41; or median and interquartile range &#40;P25&#8211;P75&#41; for the numerical variables and percentages &#40;&#37;&#41; for the qualitative variables&#44; with a point estimate and interval of 95&#37; &#40;95&#37; CI&#41; for the prevalence of high risk for lung cancer&#46; To determine the incidence rate of lung cancer&#44; we used the person-time to cancer diagnosis event index or the time to the completion of the follow-up period as the denominator&#46; The Kaplan&#8211;Meier survival analysis was employed to compare the incidence of lung cancer between the patients in the low and high-risk categories according to the COPD-LUCSS-DLCO criterion indicated in the Material and Methods section&#46; Statistical significance was determined by the log rank test&#46; We employed a Cox proportional hazards regression to assess the increase in risk adjusted for other variables&#46; All hypothesis tests were bilateral&#44; for a significance level of 5&#37;&#46; The analysis was performed using the statistical program SPSS&#47;PC &#40;version 24&#46;0 for Windows&#59; SPSS&#44; Inc&#46;&#44; Chicago&#44; IL&#41; and EPIDAT &#40;version 3&#46;0&#44; Department of Health&#44; Government of Galicia and the Pan American Health Organization&#41;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">The study included 159 patients with COPD&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> lists their characteristics&#44; which include a mean age of 66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#44; a 27&#37; rate of active smokers and a mostly male &#40;82&#37;&#41; proportion&#46; Taking into account the 2009 GOLD classification&#44; 9&#37; of the patients were categorized as GOLD 1&#44; 36&#37; as GOLD 2&#44; 44&#37; as GOLD 3 and 11&#37; as GOLD 4&#46; Sixty-two percent of the patients had a high-risk COPD-LUCSS-DLCO &#40;95&#37; CI 54&#8211;69&#41;&#46; The median follow-up time was 31 months &#40;range&#44; 15&#8211;37&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">During the study&#44; 12 of the 22 new cases of diagnosed cancer corresponded to lung cancer &#40;9 in high-risk patients and 3 in low-risk patients&#41;&#44; the latter of which had an estimated overall rate of 30 cases per 1000 patients with COPD-year &#40;95&#37; CI 16&#8211;53&#41;&#46; When classifying the patients as high-risk and low-risk&#44; we observed an incidence rate of 44 cases per 1000 patients with COPD-year &#40;95&#37; CI 18&#8211;76&#41; and 17 cases per 1000 patients with COPD-year &#40;95&#37; CI 4&#8211;50&#41;&#44; respectively&#44; showing a high-risk&#47;low-risk ratio of 2&#46;3 &#40;95&#37; CI 0&#46;58&#8211;13&#46;3&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;3155&#41;&#46; Seventy-five percent of the lung cancer cases were diagnosed in the first 31 months after inclusion&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Our series&#8217; survival curves showed a higher incidence of lung cancer among the patients categorized as high-risk &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;132&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In the Cox regression analysis&#44; we obtained a crude HR for the high-risk patients versus the low-risk patients of 3&#46;0 &#40;95&#37; CI 0&#46;65&#8211;13&#46;9&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;159&#41;&#46; After adjusting the HR&#44; using as covariate the Charlson comorbidity index calculated at the time of inclusion&#44; we obtained an adjusted HR of 4&#46;9 &#40;95&#37; CI 1&#46;02&#8211;23&#46;0&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;046&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">The following conclusions were extracted from our study&#58; &#40;1&#41; The COPD-LUCSS-DLCO can be a useful tool for detecting patients at a greater risk of lung cancer&#59; &#40;2&#41; the incidence of lung cancer in the high-risk patients was twice that of the low-risk patients&#44; although this increase was not statistically significant&#59; and &#40;3&#41; 62&#37; of the patients with COPD presented a high-risk score&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">The association between lung cancer and COPD has been clearly established&#46; Various cohort studies&#44; including lung cancer detection trials&#44; have shown that patients with COPD have 2&#8211;4 times the risk of developing lung cancer than those who do not have COPD&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;11</span></a> The degree of bronchial obstruction&#44; the presence of emphysema in the CT and chronic bronchitis are independent risk factors for the onset of lung cancer&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;16</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> validated a scoring system for lung cancer screening to identify high-risk patients with COPD in 2 screening cohorts in Spain &#40;P-IELCAP&#41; and the United States &#40;PLuSS&#41;&#46; The scale included age&#44; BMI&#44; PYI and the visual presence of emphysema in the LDCT&#46; However&#44; to facilitate the scale&#39;s clinical implementation and avoid the application of an LDCT&#44; a new scoring system &#40;known as COPD-LUCSS-DLCO&#41; has been proposed&#44; which replaces the radiological emphysema with DLCO&#46; The high-risk patients showed a 2&#46;4-fold increase in lung cancer mortality compared with the low-risk group &#40;95&#37; CI 2&#46;0&#8211;2&#46;7&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">A notable result of our study was that 62&#37; of the patients were in the high-risk range&#46; If we compare our series with similar studies in Spanish populations&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> there were no significant differences in terms of mean age&#44; FEV<span class="elsevierStyleInf">1</span>&#44; BMI and PYI&#46; However&#44; more than half of our patients had an DLCO &#8804;60&#37; despite the fact that the percentage of patients with COPD with a PYI &#62;60 was lower &#40;20&#37; vs&#46; 42&#37;&#41;&#46; Although a lower prevalence of COPD has been reported in the Canary Islands compared with the national mean&#44; despite the high percentage of smokers&#44;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> we cannot rule out a greater susceptibility in our population with COPD to developing a greater degree of emphysema&#46; COPD is a complex and multifactorial disease in which the association between genetic polymorphisms and the phenotype is probably nonlinear and in which the final phenotype depends on the genetics&#44; the environment and the setting in which this genotype develops&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Consistent with the severity obtained in the score&#44; those high-risk patients with COPD demonstrated a higher incidence of lung cancer over the follow-up than the low-risk patients&#46; Although this finding was not statistically significant&#44; the magnitude of the signal achieved despite the low number of cancer diagnoses indicates the usefulness of the COPD-LUCSS-DLCO for detecting individuals in an outpatient population with a high probability of experiencing lung cancer&#44; which allows us to manage lung cancer screening more efficiently&#46; A study published by Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> conducted on 2 populations selected for follow-up &#40;a control population who were monitored according to the GOLD guidelines and another who underwent lung cancer screening with annual LDCT&#41; determined that the number of patients with COPD required for screening with the intent to save a life from lung cancer was only 34 patients&#44; a significantly low number considering that the number needed for screening with the intent to save a life in the NLST study<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> was 271&#46; In keeping with the above&#44; the COPD-LUCCS-DLCO could help define what population would require a closer follow-up&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">However&#44; once we have identified the presence of a &#8220;non-negligible&#8221; percentage of patients with COPD labeled as high risk&#44; the issue is how follow-up should be conducted&#46; Faced with the lack of favorable results in the lung cancer screening using chest radiography and given the ability of CT to detect smaller nodules than with conventional radiography&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26&#44;27</span></a> published data from the Early Lung Cancer Action Program group study<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> and subsequently from the NLST<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> showed that lung cancer screening using LDCT in individuals labeled as high risk helps diagnose most tumors in early phases of the disease&#44; thereby achieving a reduction in lung cancer-specific mortality of approximately 16&#8211;20&#37;&#46; However&#44; these results are currently the subject of debate in Europe&#44; especially regarding overdiagnosis&#44; radiation and associated risks&#44; as well as its cost-effectiveness and organizational complexity&#46;<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">28&#44;29</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Despite the aforementioned discrepancies&#44; LDCT currently appears to be the imaging technique of choice for lung cancer screening&#46; However&#44; doubts arise as to periodicity of its implementation and its duration in the follow-up&#46; In our sample&#44; 9&#37; of the patients with COPD identified as high risk developed lung cancer in the first 31 months&#46; However&#44; we do not know the outcomes of high-risk patients who were not diagnosed during the follow-up period&#46; Based on the NLST&#44; the American Association for Thoracic Surgery<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> recommended performing LDCT annually in patients with a history of tobacco use and a PYI &#8805;30&#44; starting at 55 years of age and ending at 79 years of age&#46; It is likely that patients with COPD determined as high risk using the COPD-LUCSS-DLCO will benefit from this option&#44; while for those at low risk the implementation of the LDCT could be more spaced out&#44; enabling better management of the cases&#46; Nevertheless&#44; further studies are needed to verify this hypothesis&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Our study had a several limitations&#46; Firstly&#44; the study population belonged to a single hospital&#44; and the sample size was limited&#46; Obviously&#44; a larger sample could have shown differences undetected in the current analysis&#46; Secondly&#44; it is possible than an information bias occurred due to obtaining the variables from the patients&#8217; medical history&#44; although the current standardization of diagnostic criteria minimizes this possibility&#46; Thirdly&#44; not having performed an LDCT at the start of the study could have led to a lack of early detection of lung carcinoma in patient enrollment&#44; with evidence of its clinical presence in the first 31 months of follow-up&#46; Nevertheless&#44; our study&#39;s objective was to use this score in an actual management situation in a pulmonology consultation&#44; where unfortunately&#44; not all patients undergo CT&#46; The strength of our study lies in that it is the first to evaluate the COPD-LUCSS-DLCO in patients with COPD in a typical situation of standard clinical practice&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">In conclusion&#44; the COPD-LUCSS-DLCO is an independent predictor of the risk of lung cancer&#46; Its use in standard clinical practice could help detect patients at a greater risk of lung cancer&#44; although this first needs to be confirmed in studies with larger sample sizes&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The COPD-LUCSS-DLCO score had been validated as a predictive tool capable of identifying patients with chronic obstructive pulmonary disease &#40;COPD&#41; and a high mortality risk associated with lung cancer &#40;LC&#41;&#59; however&#44; studies have not been conducted yet on its use in standard clinical practice&#46; The aim of this study was to estimate the COPD-LUCSS-DLCO scores for patients with COPD treated in Pulmonology consultations and to determine the incidence of LC in each of the subgroups&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective observational study was conducted with a cohort of 159 patients with COPD in Pulmonology outpatient follow-up consultations&#46; We calculated the COPD-LUCSS-DLCO score &#40;0&#8211;8&#41; for each patient&#44; with low risk considered at 0&#8211;3 points and high risk at &#8805;3&#46;5 points&#46; We calculated the incidence rate of LC in each of the subgroups&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sixty-two percent of the patients had a high-risk score&#46; We estimated an overall LC rate of 30 per 1000 patients with COPD-year &#40;95&#37; CI&#58; 16&#8211;53&#41;&#44; 44 per 1000 patients with COPD-year &#40;95&#37; CI&#58; 18&#8211;76&#41; among those categorized as high risk and 17 per 1000 patients with COPD-year among those categorized as low risk &#40;95&#37; CI&#58; 4&#8211;50&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The use of the COPD-LUCSS-DLCO score in standard clinical practice could help detect patients with a greater risk of developing LC&#44; which could help to better manage cases in an LC screening program&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO ha sido validado como una herramienta predictiva capaz de identificar pacientes con enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; y alto riesgo de fallecer por c&#225;ncer de pulm&#243;n &#40;CP&#41;&#46; No obstante&#44; hasta la fecha no se han realizado estudios acerca de su uso en la pr&#225;ctica cl&#237;nica habitual&#46; El objetivo del estudio fue estimar las puntuaciones del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en pacientes con EPOC atendidos en consultas de Neumolog&#237;a&#44; as&#237; como determinar la incidencia de CP en cada uno de los subgrupos&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional retrospectivo de una cohorte de 159 pacientes con EPOC en seguimiento en consultas ambulatorias de Neumolog&#237;a&#46; Se calcul&#243; la puntuaci&#243;n del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO &#40;puntuaci&#243;n de 0-8&#41; a cada uno de los sujetos&#44; considerando bajo riesgo &#40;BR&#41; entre 0-3 puntos y alto riesgo &#40;AR&#41; &#8805; 3&#44;5 puntos&#46; Se estim&#243; la incidencia del CP en cada uno de los subgrupos&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">El 62&#37; presentaban un <span class="elsevierStyleItalic">score</span> de AR&#46; Se estim&#243; una tasa global de CP de 30 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58;16-53&#41;&#44; de 44 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58;&#160;18-76&#41; entre los catalogados de AR y de 17 por 1&#46;000 pacientes con EPOC-a&#241;o &#40;IC&#160;95&#37;&#58; 4-50&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El uso del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en la pr&#225;ctica cl&#237;nica habitual podr&#237;a permitir detectar pacientes con un mayor riesgo de desarrollar CP&#44; lo cual ayudar&#237;a a una mejor gesti&#243;n de casos en un programa de <span class="elsevierStyleItalic">screening</span> de CP&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Figueira Gon&#231;alves JM&#44; P&#233;rez Mendez LI&#44; Gurbani N&#44; Garc&#237;a-Talavera I&#44; P&#233;rez Pinilla JL&#46; Aplicabilidad del <span class="elsevierStyleItalic">score</span> COPD-LUCSS-DLCO en pacientes con enfermedad pulmonar obstructiva cr&#243;nica&#58; an&#225;lisis en condiciones de pr&#225;ctica cl&#237;nica habitual&#46; Rev Clin Esp&#46; 2018&#59;218&#58;336&#8211;341&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">This study was awarded the prize for best presentation at the XXXII Regional Congress of the Canary Islands Association of Pulmonology and Thoracic Surgery &#40;Neumocan&#41;&#46;</p>"
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        "etiqueta" => "Table 1"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; BMI&#44; body mass index&#59; DLCO&#44; diffusing capacity of the lungs for carbon monoxide&#59; PYI&#44; packs-year index&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Source&#58; Based on De Torres et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">COPD-LUCSS-DLCO&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Assigned score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Components</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#60;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PYI &#62;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age&#44; years &#62;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>DLCO &#60;60&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Total</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Categories</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Low risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#8211;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>High risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;5&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Components of the COPD-LUCSS-DLCO score&#46;</p>"
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      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>&#58; BMI&#44; body mass index&#59; COPD&#44; chronic obstructive pulmonary disease&#59; DLCO&#44; diffusing capacity of the lungs for carbon monoxide&#59; FEV<span class="elsevierStyleInf">1</span>&#44; forced expiratory volume in one second&#59; FVC&#44; forced vital capacity&#59; GOLD&#44; Global Initiative for Chronic Obstructive Lung Disease&#59; IQR&#44; interquartile range&#59; PYI&#44; pack-year index&#59; SD&#44; standard deviation&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Global <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age&#44; years &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#62;60 years&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Sex&#44; &#37; of males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">BMI &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Degrees according to BMI&#44; &#37;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#60;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI 25&#8211;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BMI &#8805;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Active smokers&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PYI &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PYI &#62;60&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age-adjusted Charlson index &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FEV</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">1</span></span><span class="elsevierStyleItalic">&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FVC&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">DLCO&#44; &#37; &#40;mean</span><span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">DLCO &#60;60&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">GOLD 2009 I&#47;II&#47;III&#47;IV</span> degrees&#44; <span class="elsevierStyleItalic">&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#47;36&#47;44&#47;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Patients with high-risk score&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Median follow-up time&#44; months &#40;IQR&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;15&#8211;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Number of lung cancer diagnoses in all patients&#47;in high-risk patients&#47;in low-risk patients</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#47;9&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Overall incidence of lung cancer</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Lung cancer incidence</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD-LUCSS-DLCO low risk score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD-LUCSS-DLCO high risk score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 per 1000 patients with COPD-year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the population with chronic obstructive pulmonary disease&#46;</p>"
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      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:30 [
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              "identificador" => "bib0155"
              "etiqueta" => "1"
              "referencia" => array:1 [
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                            1 => "G&#46;A&#46; Silvestri"
                          ]
                        ]
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                  "host" => array:1 [
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                      "doi" => "10.1164/rccm.200504-531OE"
                      "Revista" => array:6 [
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                            2 => "L&#46;B&#46; Woolner"
                            3 => "W&#46;F&#46; Taylor"
                            4 => "W&#46;E&#46; Miller"
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                          ]
                        ]
                      ]
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                  ]
                  "host" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3528436"
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            2 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early Lung Cancer Action Project&#58; overall design and findings from baseline screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            1 => "D&#46;I&#46; McCauley"
                            2 => "D&#46;F&#46; Yankelevitz"
                            3 => "D&#46;P&#46; Naidich"
                            4 => "G&#46; McGuinness"
                            5 => "O&#46;S&#46; Miettinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(99)06093-6"
                      "Revista" => array:6 [
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                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
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ISSN: 22548874
Original language: English
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