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Vol. 214. Issue 9.
Pages 491-498 (December 2014)
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Vol. 214. Issue 9.
Pages 491-498 (December 2014)
Original article
Atherogenic dyslipidemia: prevalence and management in lipid clinics
Dislipemia aterogénica: prevalencia y control en las unidades de lípidos
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135
J. Pedro-Boteta,
Corresponding author
86620@parcdesalutmar.cat

Corresponding author.
, J.A. Flores-Le Rouxa, J.M. Mostazab, X. Pintóc, J.J. de la Cruzd, J.R. Banegasd, en nombre del grupo de investigadores EDICONDIS-ULISEA
a Unidad de Lípidos y Riesgo Vascular, Servicio de Endocrinología y Nutrición, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
b Servicio de Medicina Interna, Hospital Carlos III, Madrid, Spain
c Unidad de Lípidos, Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Universitat de Barcelona, CIBERobn-ISCIII, Barcelona, Spain
d Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid/IdiPAZ CIBERESP, Madrid, Spain
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Tables (3)
Table 1. Demographic, anthropometric and clinical characteristics of the patients according to the presence of atherogenic dyslipidemia.
Table 2. Hazard ratio and confidence intervals for the factors associated with the presence of atherogenic dyslipidemia in the logistic regression analysis.
Table 3. relationship between age, sex, and anthropometric and clinical characteristics and the achievement of therapeutic objectives in hdl-cholesterol and triglyceride levels.
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Abstract
Background and objective

Atherogenic dyslipidemia, which is characterized by increased triglyceride levels and reduced HDL cholesterol levels, is underestimated and undertreated in clinical practice. We assessed its prevalence and the achievement of therapeutic objectives for HDL cholesterol and triglyceride levels in patients treated at lipid and vascular risk units in Spain.

Patients and method

This was an observational, longitudinal, retrospective, multicenter study performed in 14 autonomous Spanish communities that consecutively included 1828 patients aged ≥18 years who were referred for dyslipidemia and vascular risk to 43 lipid clinics accredited by the Spanish Society of Arteriosclerosis. We collected information from the medical records corresponding to 2 visits conducted during 2010 and 2011–2012, respectively.

Results

Of the 1649 patients who had a lipid profile in the first visit (90.2%), 295 (17.9%) had atherogenic dyslipidemia. The factors associated with atherogenic dyslipidemia were excess weight/obesity, not taking hypolipidemic drugs (statins and/or fibrates), diabetes, myocardial infarction and previous heart failure. Of the 273 (92.5%) patients with atherogenic dyslipidemia that had a lipid profile in the last visit, 44 (16.1%) achieved the therapeutic objectives for HDL cholesterol and triglyceride levels. The predictors of therapeutic success were normal weight and normoglycemia.

Conclusion

One of every 6 patients treated in lipid and vascular risk units had atherogenic dyslipidemia. The degree to which the therapeutic goals for HDL cholesterol and triglyceride levels were achieved in these patients was very low.

Keywords:
Atherogenic dyslipidemia
HDL cholesterol
Epidemiology
Cardiovascular risk prevention
Lipid clinics
Triglycerides
Resumen
Antecedentes y objetivo

La dislipemia aterogénica, caracterizada por un aumento de triglicéridos y descenso del colesterol HDL, está infravalorada e infratratada en la práctica clínica. Hemos evaluado su prevalencia y la consecución de los objetivos terapéuticos de colesterol HDL y triglicéridos en los pacientes atendidos en unidades de lípidos y riesgo vascular en España.

Pacientes y método

Estudio observacional, longitudinal, retrospectivo, multicéntrico, realizado en 14 Comunidades Autónomas, que incluyó de forma consecutiva a 1.828 pacientes ≥18 años de edad remitidos por dislipemia y riesgo vascular a 43 unidades de lípidos acreditadas por la Sociedad Española de Arteriosclerosis. Se recogió información de la historia clínica correspondiente a dos visitas realizadas durante los años 2010 y 2011–12, respectivamente.

Resultados

De los 1.649 pacientes que disponían de un perfil lipídico en la visita inicial (90,2%), 295 (17,9%) tenían una dislipemia aterogénica. Los factores asociados a la dislipemia aterogénica fueron el sobrepeso/obesidad, no recibir fármacos hipolipemiantes (estatinas y/o fibratos), diabetes, infarto de miocardio e insuficiencia cardiaca previos. De los 273 (92,5%) pacientes con dislipemia aterogénica que disponían del perfil lipídico en la última visita, 44 (16,1%) alcanzaron el objetivo terapéutico de colesterol HDL y triglicéridos. Los factores predictivos del éxito terapéutico fueron el normopeso y la normoglucemia.

Conclusión

Uno de cada seis pacientes atendidos en las unidades de lípidos y riesgo vascular presenta una dislipemia aterogénica. El grado de consecución del objetivo terapéutico en colesterol HDL y triglicéridos en estos pacientes es muy bajo.

Palabras clave:
Dislipemia aterogénica
Colesterol HDL
Epidemiología
Prevención cardiovascular
Unidades de lípidos
Triglicéridos

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