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playing a significant role in their diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">5</span></a> On the other hand&#44; transbronchial mediastinal cryobiopsy guided by endobronchial ultrasonography &#40;EBUS-TBCB&#41; involves obtaining biopsy samples from within lymph nodes or mediastinal masses using a cryoprobe and real-time endobronchial ultrasonographic guidance&#46; It offers the advantage of providing larger samples and&#44; therefore&#44; improved diagnostic yield compared to EBUS-TBNA&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In recent years&#44; studies combining both techniques&#44; EBUS-TBNA and EBUS-TBCB&#44; have been published&#44; harnessing the advantages of both procedures&#44; enhancing performance&#44; and avoiding more invasive procedures such as mediastinoscopy and its associated complications&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">6&#44;7</span></a> There is still uncertainty about the technique in terms of its safety and yield&#59; 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suspected of malignant or benign mediastinal disease on imaging studies were included&#46; All patients provided informed consent&#46; The examinations were performed by the two usual bronchoscopists of the unit&#46; Patients with uncorrectable hemostasis abnormalities&#44; uncorrectable hypoxemia despite oxygen therapy or non-invasive mechanical ventilation&#44; and those who did not provide informed consent were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">During the procedure&#44; oxygen saturation&#44; heart rate&#44; and blood pressure were monitored&#46; Supplementary oxygen was administered via nasal cannula or Venturi mask&#46; Sedation was provided with midazolam&#44; fentanyl and propofol&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Both EBUS-TBNA and EBUS-TBCB were performed in a single procedure and at the same adenoopathy&#46; The needles used were EBUS-TBNA Cook ECHO-HD-22-G in 70&#37; of cases and the remaining used the Medi-Globe TopGain needle&#44; along with a flexible 1&#46;1<span class="elsevierStyleHsp" style=""></span>mm cryoprobe &#40;ERBECRYO 20402-401&#44; T&#252;bingen&#44; Germany&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The sampling technique followed the method developed by Ariza-Pallar&#233;s&#44;8 and rapid on-site evaluation &#40;ROSE&#41; was not available&#46; In cases where the final result was negative&#44; patients were followed up&#46; The collected variables included age&#44; sex&#44; type and dose of sedatives&#44; ultrasound characteristics of biopsied lymph nodes&#44; diagnostic yield&#44; and complications&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Of the 50 patients&#44; 74&#37; were male with a mean age of 62&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;75 years&#46; 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compared to 32 cases &#40;64&#37;&#41; through EBUS-TBNA&#44; resulting in a difference of 26&#37; &#40;95&#37; confidence interval&#58; 14&#8211;40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Concordance between both tests was found in 36&#37; of cases&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">In the 9 cases where the sample was insufficient by EBUS-TBNA&#44; a definitive diagnosis was achieved through EBUS-TBCB &#40;4 adenocarcinomas&#44; 3 reactive histiocytosis&#44; 1 small cell carcinoma&#44; and 1 negative case for neoplasia&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In 6 patients&#44; the sample obtained by EBUS-TBNA was considered negative for malignancy&#44; but EBUS-TBCB provided a diagnosis in 4 cases of reactive histiocytosis&#44; 1 neuroendocrine carcinoma&#44; and 1 case of silicosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In the 9 samples taken by EBUS-TBNA that were deemed inadequate for diagnosis by the pathologist&#44; a definitive result was obtained through EBUS-TBCB &#40;5 reactive histiocytosis&#44; 2 squamous carcinomas&#44; 1 infection&#44; and 1 small cell carcinoma&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">It is worth ponting out that 5 patients with negative results through EBUS-TBCB had positive results in samples obtained through EBUS-TBNA&#44; all of which were neoplasias&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; EBUS-TBCB was more sensitive for diagnosing both malignant and inflammatory pathologies&#46; It is also noteworthy that only 6 patients experienced complications&#44; all of which were minor&#46; Three cases involved mild bleeding&#44; two experienced oxygen desaturation that promptly improved with increased oxygen supplementation&#44; and one had vocal cord hematoma&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In 2013&#44; a study evaluating the feasibility&#44; effect&#44; and safety of a new cryoprobe for intrathoracic lymph node puncture guided by EBUS in pigs was published&#46; This was the first study to combine both techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">6</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Years later&#44; Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">10</span></a> performed the first human case&#44; diagnosing primary mediastinal seminoma through transbronchial mediastinal biopsy using a cryoprobe&#46; They created an incision with an electrocautery to create an opening in the mucosa before inserting the cryoprobe&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Subsequently&#44; the same group presented the largest series published to date&#44; including 197 patients who underwent both EBUS-TBNA and EBUS-TBCB&#44; with an overall diagnostic yield of 79&#46;9&#37; and 91&#46;8&#37;&#44; respectively &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Diagnostic yields were similar for metastatic adenopathy and benign lesions &#40;94&#46;1&#37; vs&#46; 95&#46;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;58&#41;&#44; while mediastinal cryobiopsy was more sensitive than EBUS-TBNA for rare tumors &#40;91&#46;7&#37; vs&#46; 25&#46;0&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and benign disorders &#40;80&#46;9&#37; vs&#46; 53&#46;2&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; Regarding complications&#44; they reported 2 cases of pneumothorax and 1 case of pneumomediastinum&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">11</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This study inspired another group<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">12</span></a> to develop a less invasive and simpler method that does not require electrocautery incision&#44; recently described as the Ariza-Pallares method&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">8</span></a> In their initial series of 50 patients&#44; they achieved diagnostic yields of 82&#37; for EBUS-TBNA and 96&#37; for EBUS-TBCB&#46; Diagnostic yields were similar for sarcoidosis&#44; while cryobiopsy was more sensitive than TBNA for lymphomas and metastatic adenopathies&#46; No complications occurred during the procedure or during patient follow-up&#46; They concluded that EBUS-TBCB&#44; following their method&#44; is a minimally invasive&#44; rapid&#44; and safe technique that can be performed in a bronchoscopy suite under moderate sedation&#44; with superior diagnostic yield compared to EBUS-TBNA&#44; especially in cases of lymphoproliferative disorders and lymph node metastases or when more biopsy material is needed for molecular testing&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In our series&#44; we achieved diagnostic yields of 64&#37; and 90&#37;&#44; respectively&#46; We were concerned about the low yield of EBUS-TBNA&#44; which we attributed to the small number of samples obtained per puncture &#40;an average of 2&#41;&#44; with 70&#37; of these performed using cytology needles and without ROSE&#46; However&#44; in terms of diagnostic yield&#44; viability&#44; and safety of the EBUS-TBCB technique&#44; our results are comparable to those currently published&#46; As explained in the material and methods section&#44; we used the technique described by Ariza-Pallares<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">12</span></a> in our study&#44; which enhances the safety and simplicity of the procedure by eliminating the need for incision and electrocautery&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Moreover&#44; sample quality is essential for achieving a good diagnostic yield&#46; Maturu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">13</span></a> observed an increase in diagnostic yield of 59&#46;3&#37; with EBUS-TBCB in patients with inadequate samples by EBUS-TBNA&#46; Therefore&#44; we believe that the larger size and better preservation of tissue architecture in samples obtained through EBUS-TBCB are the significant advantages of cryobiopsies&#46; In our series&#44; the average size of cryobiopsies was 0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28<span class="elsevierStyleHsp" style=""></span>cm&#44; compared to 0&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;16<span class="elsevierStyleHsp" style=""></span>cm for puncture-obtained samples&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Cases diagnosed as neoplasms &#40;including lymphoproliferative syndromes&#41; were very similar between EBUS-TBNA and EBUS-TBCB&#44; with 19 and 21 cases&#44; respectively&#46; The difference in diagnostic yield was much more favorable for EBUS-TBCB in benign &#40;infectious&#47;inflammatory&#41; pathologies&#58; 7 cases compared to 24 mediastinal cryobiopsies&#46; Most of these cases were related to adenopathy with sinus histiocytosis and reactive lymphadenitis&#44; including a case of tuberculosis and one of Actinomyces infection&#46; These cases were monitored over time to confirm the benign nature of the findings&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">Our study&#44; conducted in 50 patients with mediastinal adenopathies&#44; demonstrates that the use of EBUS-TBCB significantly improves diagnostic yield compared to EBUS-TBNA&#44; with a low number of procedure-related complications&#44; all of which were minor&#46; Furthermore&#44; our findings are consistent with those reported in the current literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">12&#44;13</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In conclusion&#44; EBUS-TBCB is a viable&#44; cost-effective&#44; and safe technique for diagnosing mediastinal lesions&#44; both malignant and&#44; especially&#44; benign ones that require high-quality histological samples&#46; It could potentially obviate the need for repeat procedures &#40;rebiopsies&#41; or other more invasive and costly surgical interventions&#46; However&#44; the technique is of very recent description&#44; and the literature remains limited&#44; necessitating further studies to establish its role in the diagnosis of mediastinal lesions accessible via bronchoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">14</span></a></p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Endobronchial ultrasonography-guided transbronchial fine-needle aspiration &#40;EBUS-TBNA&#41; has the drawback of providing small sample sizes for accurate diagnosis&#46; Transbronchial mediastinal cryobiopsy &#40;EBUS-TBCB&#41;&#44; which allows for larger samples&#44; could improve diagnostic yield&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We prospectively studied 50 patients with mediastinal lymphadenopathy who underwent EBUS-TBNA and EBUS-TBCB in a single procedure&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB improved the diagnostic performance compared with EBUS-TBNA from a definite diagnosis of 32 &#40;64&#37;&#41; patients to 45 &#40;90&#37;&#41; patients &#91;difference 26&#37; &#40;95&#37; confidence interval&#58; 14-40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; EBUS-TBCB was more sensitive to both malignant and inflammatory diseases&#46; EBUS-TBCB produced 6 mild complications resolved during the same procedure&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB is a cost-effective and safe technique superior to EBUS-TBNA&#46; Future studies could confirm our findings&#46;</p></span>"
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            "identificador" => "abst0005"
            "titulo" => "Introduction"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La aspiraci&#243;n transbronquial con aguja fina guiada por ultrasonograf&#237;a endobronquial &#40;EBUS-TBNA&#41; tiene el inconveniente de ofrecer tama&#241;os de muestra peque&#241;os para un diagn&#243;stico preciso&#46; La criobiopsia mediast&#237;nica transbronquial &#40;EBUS-TBCB&#41;&#44; que permite obtener muestras de mayor tama&#241;o&#44; podr&#237;a mejorar el rendimiento diagn&#243;stico&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudiamos prospectivamente a 50 pacientes con adenopat&#237;as mediast&#237;nicas a los que se les realiz&#243; EBUS-TBNA y EBUS-TBCB en un solo procedimiento&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB mejor&#243; el rendimiento diagn&#243;stico en comparaci&#243;n con EBUS-TBNA desde un diagn&#243;stico definitivo de 32 &#40;64 &#37;&#41; pacientes a 45 &#40;90&#37;&#41; pacientes &#91;diferencia 26&#37; &#40;95&#37; intervalo de confianza&#58; 14&#8211;40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; EBUS-TBCB fue m&#225;s sensible tanto para diagn&#243;stico de enfermedades malignas como inflamatorias&#46; EBUS-TBCB produjo 6 complicaciones leves resueltas durante el mismo procedimiento&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB es una t&#233;cnica rentable y segura superior a EBUS-TBNA&#46; Futuros estudios pueden confirmar nuestros hallazgos&#46;</p></span>"
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            "titulo" => "Introducci&#243;n"
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Subcarinal&#58; 35 casesLeft hilum&#58; 7 casesRight hilum&#58; 4 casesRight paratracheal&#58; 3 casesMediastinal mass&#58; 1 case&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sonographic appearance&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Homogeneous&#58; 29 casesHeterogeneous&#58; 21 cases&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Shape&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Polilobulated&#58; 23 casesOval&#58; 21 casesRounded&#58; 6 cases&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBNA&#44; Transbronchial fine-needle aspiration guided by ultrasonography&#59; EBUS-TBCB&#44; Transbronchial cryobiopsy guided by ultrasonography&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sample size &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">Neoplasms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">19 cases &#40;1 lymphoma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">21 cases &#40;1 lymphoma&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Inadequate samples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insufficient for study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative for malignancy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reactive histiocytosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sarcoidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Silicosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3336942.png"
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            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Results obtained via EBUS-TBNA and EBUS-TBCB&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:12 [
            0 => array:3 [
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                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.21037/med-21-2"
                      "Revista" => array:5 [
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                    ]
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            1 => array:3 [
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            ]
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                  "contribucion" => array:1 [
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00408-013-9502-4"
                      "Revista" => array:7 [
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/JTO.0b013e3181753b5e"
                      "Revista" => array:6 [
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                  ]
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              ]
            ]
            5 => array:3 [
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                  "contribucion" => array:1 [
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                            0 => "M&#46;A&#46; Ariza-Prota"
                            1 => "J&#46; P&#233;rez-Pallar&#233;s"
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                  ]
                  "host" => array:1 [
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                      "doi" => "10.1016/j.arbres.2022.05.006"
                      "Revista" => array:7 [
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                ]
              ]
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            6 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Criobiopsia mediast&#237;nica guiada por ecobroncoscopia&#46; Un nuevo enfoque&#44; a prop&#243;sito de tres casos"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Salcedo"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000505936"
                      "Revista" => array:7 [
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                        "volumen" => "99"
                        "numero" => "5"
                        "paginaInicial" => "426"
                        "paginaFinal" => "430"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions&#58; a randomised trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Zhang"
                            1 => "J&#46;R&#46; Guo"
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                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2021"
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            ]
            9 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions&#58; safety&#44; feasibility and diagnostic yield - experience in 50 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Ariza-Prota"
                            1 => "J&#46; P&#233;rez-Pallar&#233;s"
                            2 => "A&#46; Fern&#225;ndez-Fern&#225;ndez"
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                            4 => "J&#46;A&#46; Casc&#243;n"
                            5 => "H&#46; Torres-Rivas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/23120541.00448-2023"
                      "Revista" => array:7 [
                        "tituloSerie" => "ERJ Open Res&#46;"
                        "fecha" => "2023"
                        "volumen" => "9"
                        "numero" => "2"
                        "paginaInicial" => "00448"
                        "paginaFinal" => "02022"
                        "link" => array:1 [
                          0 => array:2 [
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound-guided mediastinal lymph nodal cryobiopsy in patients with nondiagnostic&#47;inadequate rapid on-site evaluation&#58; a new step in the diagnostic algorithm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "V&#46;N&#46; Maturu"
                            1 => "V&#46;P&#46; Prasad"
                            2 => "C&#46;R&#46; Vaddepally"
                            3 => "R&#46;R&#46; Dommata"
                            4 => "S&#46; Sethi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "J Bronchology Interv Pulmonol&#46;"
                        "fecha" => "2023"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential application of cryobiopsy for histo-molecular characterization of mediastinal lymph nodes in patients with thoracic malignancies&#58; a case presentation series and implications for future developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Genova"
                            1 => "E&#46; Tagliabue"
                            2 => "M&#46; Mora"
                            3 => "T&#46; Alo&#232;"
                            4 => "M&#46; Dono"
                            5 => "S&#46; Salvi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMC Pulm Med"
                        "fecha" => "2022"
                        "volumen" => "22"
                        "paginaInicial" => "5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: series of 50 cases
Criobiopsia transbronquial mediastínica guiada por ultrasonografía endobronquial: casuística de 50 casos
E. Salcedo Lobera
Corresponding author
esalcedolobera@gmail.com

Corresponding author.
, F.M. Páez Codeso, E. Casado Miranda
Unidad de Gestión Clínica Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Regional Universitario de Málaga, Málaga, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Transbronchial fine-needle aspiration guided by endobronchial ultrasonography &#40;EBUS-TBNA&#41; is considered one of the preferred techniques for studying mediastinal lesions&#44; both benign and malignant&#44; showing good yield and safety&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In fact&#44; there are consensus guidelines recommending EBUS as the initial technique for investigating mediastinal pathology&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Transbronchial cryobiopsy is a recent endoscopic technique that has gained prominence in the study of diffuse interstitial lung diseases&#44; playing a significant role in their diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">5</span></a> On the other hand&#44; transbronchial mediastinal cryobiopsy guided by endobronchial ultrasonography &#40;EBUS-TBCB&#41; involves obtaining biopsy samples from within lymph nodes or mediastinal masses using a cryoprobe and real-time endobronchial ultrasonographic guidance&#46; It offers the advantage of providing larger samples and&#44; therefore&#44; improved diagnostic yield compared to EBUS-TBNA&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In recent years&#44; studies combining both techniques&#44; EBUS-TBNA and EBUS-TBCB&#44; have been published&#44; harnessing the advantages of both procedures&#44; enhancing performance&#44; and avoiding more invasive procedures such as mediastinoscopy and its associated complications&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">6&#44;7</span></a> There is still uncertainty about the technique in terms of its safety and yield&#59; however&#44; small case series of 4 and 3 patients&#44; respectively&#44; undergoing both EBUS-TBNA and EBUS-TBCB in a single procedure have recently been published in Spain&#44; describing a very promising technique and preliminary results&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of our study has been to describe our experience&#44; analyzing the procedure&#44; the diagnostic yield in different pathologies studied&#44; and the safety of the technique&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">Descriptive study of the first 50 consecutive patients from April 2022 to April 2023 referred to our bronchopleural techniques unit at a tertiary hospital for the performance of an EBUS&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Adult patients with pathological adenopathy &#40;&#62;1<span class="elsevierStyleHsp" style=""></span>cm&#41; suspected of malignant or benign mediastinal disease on imaging studies were included&#46; All patients provided informed consent&#46; The examinations were performed by the two usual bronchoscopists of the unit&#46; Patients with uncorrectable hemostasis abnormalities&#44; uncorrectable hypoxemia despite oxygen therapy or non-invasive mechanical ventilation&#44; and those who did not provide informed consent were excluded&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">During the procedure&#44; oxygen saturation&#44; heart rate&#44; and blood pressure were monitored&#46; Supplementary oxygen was administered via nasal cannula or Venturi mask&#46; Sedation was provided with midazolam&#44; fentanyl and propofol&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Both EBUS-TBNA and EBUS-TBCB were performed in a single procedure and at the same adenoopathy&#46; The needles used were EBUS-TBNA Cook ECHO-HD-22-G in 70&#37; of cases and the remaining used the Medi-Globe TopGain needle&#44; along with a flexible 1&#46;1<span class="elsevierStyleHsp" style=""></span>mm cryoprobe &#40;ERBECRYO 20402-401&#44; T&#252;bingen&#44; Germany&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The sampling technique followed the method developed by Ariza-Pallar&#233;s&#44;8 and rapid on-site evaluation &#40;ROSE&#41; was not available&#46; In cases where the final result was negative&#44; patients were followed up&#46; The collected variables included age&#44; sex&#44; type and dose of sedatives&#44; ultrasound characteristics of biopsied lymph nodes&#44; diagnostic yield&#44; and complications&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">Of the 50 patients&#44; 74&#37; were male with a mean age of 62&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;75 years&#46; Conscious sedation by bronchoscopists was used in 54&#37; of cases&#44; with midazolam &#40;average dose of 5&#46;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;63<span class="elsevierStyleHsp" style=""></span>mg&#41; and fentanyl &#40;average dose of 0&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;091<span class="elsevierStyleHsp" style=""></span>mg&#41;&#46; The remaining 46&#37; received propofol anesthesia&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The ultrasound characteristics of the adenopathies are presented in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; On average&#44; 2 TBNA needle punctures and 4 cryobiopsies were performed&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A definitive diagnosis through EBUS-TBCB was obtained in 45 cases &#40;90&#37;&#41; compared to 32 cases &#40;64&#37;&#41; through EBUS-TBNA&#44; resulting in a difference of 26&#37; &#40;95&#37; confidence interval&#58; 14&#8211;40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Concordance between both tests was found in 36&#37; of cases&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">In the 9 cases where the sample was insufficient by EBUS-TBNA&#44; a definitive diagnosis was achieved through EBUS-TBCB &#40;4 adenocarcinomas&#44; 3 reactive histiocytosis&#44; 1 small cell carcinoma&#44; and 1 negative case for neoplasia&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In 6 patients&#44; the sample obtained by EBUS-TBNA was considered negative for malignancy&#44; but EBUS-TBCB provided a diagnosis in 4 cases of reactive histiocytosis&#44; 1 neuroendocrine carcinoma&#44; and 1 case of silicosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In the 9 samples taken by EBUS-TBNA that were deemed inadequate for diagnosis by the pathologist&#44; a definitive result was obtained through EBUS-TBCB &#40;5 reactive histiocytosis&#44; 2 squamous carcinomas&#44; 1 infection&#44; and 1 small cell carcinoma&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">It is worth ponting out that 5 patients with negative results through EBUS-TBCB had positive results in samples obtained through EBUS-TBNA&#44; all of which were neoplasias&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; EBUS-TBCB was more sensitive for diagnosing both malignant and inflammatory pathologies&#46; It is also noteworthy that only 6 patients experienced complications&#44; all of which were minor&#46; Three cases involved mild bleeding&#44; two experienced oxygen desaturation that promptly improved with increased oxygen supplementation&#44; and one had vocal cord hematoma&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In 2013&#44; a study evaluating the feasibility&#44; effect&#44; and safety of a new cryoprobe for intrathoracic lymph node puncture guided by EBUS in pigs was published&#46; This was the first study to combine both techniques&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">6</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Years later&#44; Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">10</span></a> performed the first human case&#44; diagnosing primary mediastinal seminoma through transbronchial mediastinal biopsy using a cryoprobe&#46; They created an incision with an electrocautery to create an opening in the mucosa before inserting the cryoprobe&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Subsequently&#44; the same group presented the largest series published to date&#44; including 197 patients who underwent both EBUS-TBNA and EBUS-TBCB&#44; with an overall diagnostic yield of 79&#46;9&#37; and 91&#46;8&#37;&#44; respectively &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; Diagnostic yields were similar for metastatic adenopathy and benign lesions &#40;94&#46;1&#37; vs&#46; 95&#46;6&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;58&#41;&#44; while mediastinal cryobiopsy was more sensitive than EBUS-TBNA for rare tumors &#40;91&#46;7&#37; vs&#46; 25&#46;0&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and benign disorders &#40;80&#46;9&#37; vs&#46; 53&#46;2&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41;&#46; Regarding complications&#44; they reported 2 cases of pneumothorax and 1 case of pneumomediastinum&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">11</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">This study inspired another group<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">12</span></a> to develop a less invasive and simpler method that does not require electrocautery incision&#44; recently described as the Ariza-Pallares method&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">8</span></a> In their initial series of 50 patients&#44; they achieved diagnostic yields of 82&#37; for EBUS-TBNA and 96&#37; for EBUS-TBCB&#46; Diagnostic yields were similar for sarcoidosis&#44; while cryobiopsy was more sensitive than TBNA for lymphomas and metastatic adenopathies&#46; No complications occurred during the procedure or during patient follow-up&#46; They concluded that EBUS-TBCB&#44; following their method&#44; is a minimally invasive&#44; rapid&#44; and safe technique that can be performed in a bronchoscopy suite under moderate sedation&#44; with superior diagnostic yield compared to EBUS-TBNA&#44; especially in cases of lymphoproliferative disorders and lymph node metastases or when more biopsy material is needed for molecular testing&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In our series&#44; we achieved diagnostic yields of 64&#37; and 90&#37;&#44; respectively&#46; We were concerned about the low yield of EBUS-TBNA&#44; which we attributed to the small number of samples obtained per puncture &#40;an average of 2&#41;&#44; with 70&#37; of these performed using cytology needles and without ROSE&#46; However&#44; in terms of diagnostic yield&#44; viability&#44; and safety of the EBUS-TBCB technique&#44; our results are comparable to those currently published&#46; As explained in the material and methods section&#44; we used the technique described by Ariza-Pallares<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">12</span></a> in our study&#44; which enhances the safety and simplicity of the procedure by eliminating the need for incision and electrocautery&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Moreover&#44; sample quality is essential for achieving a good diagnostic yield&#46; Maturu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">13</span></a> observed an increase in diagnostic yield of 59&#46;3&#37; with EBUS-TBCB in patients with inadequate samples by EBUS-TBNA&#46; Therefore&#44; we believe that the larger size and better preservation of tissue architecture in samples obtained through EBUS-TBCB are the significant advantages of cryobiopsies&#46; In our series&#44; the average size of cryobiopsies was 0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28<span class="elsevierStyleHsp" style=""></span>cm&#44; compared to 0&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;16<span class="elsevierStyleHsp" style=""></span>cm for puncture-obtained samples&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Cases diagnosed as neoplasms &#40;including lymphoproliferative syndromes&#41; were very similar between EBUS-TBNA and EBUS-TBCB&#44; with 19 and 21 cases&#44; respectively&#46; The difference in diagnostic yield was much more favorable for EBUS-TBCB in benign &#40;infectious&#47;inflammatory&#41; pathologies&#58; 7 cases compared to 24 mediastinal cryobiopsies&#46; Most of these cases were related to adenopathy with sinus histiocytosis and reactive lymphadenitis&#44; including a case of tuberculosis and one of Actinomyces infection&#46; These cases were monitored over time to confirm the benign nature of the findings&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conclusion</span><p id="par0125" class="elsevierStylePara elsevierViewall">Our study&#44; conducted in 50 patients with mediastinal adenopathies&#44; demonstrates that the use of EBUS-TBCB significantly improves diagnostic yield compared to EBUS-TBNA&#44; with a low number of procedure-related complications&#44; all of which were minor&#46; Furthermore&#44; our findings are consistent with those reported in the current literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">12&#44;13</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">In conclusion&#44; EBUS-TBCB is a viable&#44; cost-effective&#44; and safe technique for diagnosing mediastinal lesions&#44; both malignant and&#44; especially&#44; benign ones that require high-quality histological samples&#46; It could potentially obviate the need for repeat procedures &#40;rebiopsies&#41; or other more invasive and costly surgical interventions&#46; However&#44; the technique is of very recent description&#44; and the literature remains limited&#44; necessitating further studies to establish its role in the diagnosis of mediastinal lesions accessible via bronchoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">14</span></a></p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Endobronchial ultrasonography-guided transbronchial fine-needle aspiration &#40;EBUS-TBNA&#41; has the drawback of providing small sample sizes for accurate diagnosis&#46; Transbronchial mediastinal cryobiopsy &#40;EBUS-TBCB&#41;&#44; which allows for larger samples&#44; could improve diagnostic yield&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We prospectively studied 50 patients with mediastinal lymphadenopathy who underwent EBUS-TBNA and EBUS-TBCB in a single procedure&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB improved the diagnostic performance compared with EBUS-TBNA from a definite diagnosis of 32 &#40;64&#37;&#41; patients to 45 &#40;90&#37;&#41; patients &#91;difference 26&#37; &#40;95&#37; confidence interval&#58; 14-40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; EBUS-TBCB was more sensitive to both malignant and inflammatory diseases&#46; EBUS-TBCB produced 6 mild complications resolved during the same procedure&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB is a cost-effective and safe technique superior to EBUS-TBNA&#46; Future studies could confirm our findings&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La aspiraci&#243;n transbronquial con aguja fina guiada por ultrasonograf&#237;a endobronquial &#40;EBUS-TBNA&#41; tiene el inconveniente de ofrecer tama&#241;os de muestra peque&#241;os para un diagn&#243;stico preciso&#46; La criobiopsia mediast&#237;nica transbronquial &#40;EBUS-TBCB&#41;&#44; que permite obtener muestras de mayor tama&#241;o&#44; podr&#237;a mejorar el rendimiento diagn&#243;stico&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Estudiamos prospectivamente a 50 pacientes con adenopat&#237;as mediast&#237;nicas a los que se les realiz&#243; EBUS-TBNA y EBUS-TBCB en un solo procedimiento&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB mejor&#243; el rendimiento diagn&#243;stico en comparaci&#243;n con EBUS-TBNA desde un diagn&#243;stico definitivo de 32 &#40;64 &#37;&#41; pacientes a 45 &#40;90&#37;&#41; pacientes &#91;diferencia 26&#37; &#40;95&#37; intervalo de confianza&#58; 14&#8211;40&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; EBUS-TBCB fue m&#225;s sensible tanto para diagn&#243;stico de enfermedades malignas como inflamatorias&#46; EBUS-TBCB produjo 6 complicaciones leves resueltas durante el mismo procedimiento&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">EBUS-TBCB es una t&#233;cnica rentable y segura superior a EBUS-TBNA&#46; Futuros estudios pueden confirmar nuestros hallazgos&#46;</p></span>"
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t">Location&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Subcarinal&#58; 35 casesLeft hilum&#58; 7 casesRight hilum&#58; 4 casesRight paratracheal&#58; 3 casesMediastinal mass&#58; 1 case&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Homogeneous&#58; 29 casesHeterogeneous&#58; 21 cases&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Polilobulated&#58; 23 casesOval&#58; 21 casesRounded&#58; 6 cases&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>&#8722;0&#46;16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Neoplasms&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 cases &#40;1 lymphoma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 cases &#40;1 lymphoma&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Inadequate samples&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Insufficient for study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Negative for malignancy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reactive histiocytosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sarcoidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Silicosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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              "imagenFichero" => array:1 [
                0 => "xTab3336942.png"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Results obtained via EBUS-TBNA and EBUS-TBCB&#46;</p>"
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      ]
    ]
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
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            0 => array:3 [
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                0 => array:2 [
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.21037/med-21-2"
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                          0 => array:2 [
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              "identificador" => "bib0010"
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                  "host" => array:1 [
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                  "contribucion" => array:1 [
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                            0 => "F&#46; Hernandez-Gonzalez"
                            1 => "C&#46;M&#46; Lucena"
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                    0 => array:2 [
                      "doi" => "10.1007/s00408-013-9502-4"
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                        "tituloSerie" => "Lung&#46;"
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                            0 => "A&#46; Ernst"
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                    0 => array:2 [
                      "doi" => "10.1097/JTO.0b013e3181753b5e"
                      "Revista" => array:6 [
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                            4 => "J&#46;A&#46; Casc&#243;n"
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                      "titulo" => "Criobiopsia mediast&#237;nica guiada por ecobroncoscopia&#46; Un nuevo enfoque&#44; a prop&#243;sito de tres casos"
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                        0 => array:2 [
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Zhang"
                            1 => "W&#46;L&#46; Fu"
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                    0 => array:2 [
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                      "titulo" => "Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions&#58; a randomised trial"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Zhang"
                            1 => "J&#46;R&#46; Guo"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2021"
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            9 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
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                      "titulo" => "Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions&#58; safety&#44; feasibility and diagnostic yield - experience in 50 cases"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "J&#46; P&#233;rez-Pallar&#233;s"
                            2 => "A&#46; Fern&#225;ndez-Fern&#225;ndez"
                            3 => "L&#46; Garc&#237;a-Alfonso"
                            4 => "J&#46;A&#46; Casc&#243;n"
                            5 => "H&#46; Torres-Rivas"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/23120541.00448-2023"
                      "Revista" => array:7 [
                        "tituloSerie" => "ERJ Open Res&#46;"
                        "fecha" => "2023"
                        "volumen" => "9"
                        "numero" => "2"
                        "paginaInicial" => "00448"
                        "paginaFinal" => "02022"
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            10 => array:3 [
              "identificador" => "bib0055"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Endobronchial ultrasound-guided mediastinal lymph nodal cryobiopsy in patients with nondiagnostic&#47;inadequate rapid on-site evaluation&#58; a new step in the diagnostic algorithm"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:5 [
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                            2 => "C&#46;R&#46; Vaddepally"
                            3 => "R&#46;R&#46; Dommata"
                            4 => "S&#46; Sethi"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "J Bronchology Interv Pulmonol&#46;"
                        "fecha" => "2023"
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                    ]
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                ]
              ]
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            11 => array:3 [
              "identificador" => "bib0060"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Potential application of cryobiopsy for histo-molecular characterization of mediastinal lymph nodes in patients with thoracic malignancies&#58; a case presentation series and implications for future developments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Genova"
                            1 => "E&#46; Tagliabue"
                            2 => "M&#46; Mora"
                            3 => "T&#46; Alo&#232;"
                            4 => "M&#46; Dono"
                            5 => "S&#46; Salvi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "BMC Pulm Med"
                        "fecha" => "2022"
                        "volumen" => "22"
                        "paginaInicial" => "5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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Article information
ISSN: 22548874
Original language: English
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