Correspondence
Response to the article A population-based survey of the prevalence and risk factors of chronic obstructive pulmonary disease in Shanxi province (China)
Respuesta al artículo Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)
J.M. Hernández-Pérez
, C.V. López-Charry
Corresponding author
Servicio de Neumología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain
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Hernández-Pérez, C.V. López-Charry" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J.M." "apellidos" => "Hernández-Pérez" "email" => array:1 [ 0 => "jmherper@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "C.V." "apellidos" => "López-Charry" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neumología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta al artículo <span class="elsevierStyleItalic">Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)</span>" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have read with great interest your article on the prevalence and risk factors of Chronic Obstructive Pulmonary Disease (COPD) in the province of Shanxi (China)<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>. We found that authors explored significant aetiological agents of COPD, such as smoking, use of biomass, exposure to pollution, or personal history of pneumonia or bronchial infections in childhood. However, there was no mention of the role of genetic factors such as alpha-1 antitrypsin deficiency.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Alpha-1 antitrypsin deficiency is responsible for up to 2% of all COPD cases<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>. Although this genetic predisposition is infrequent in China<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>, we believe that the reason could lie in the small number of studies addressing this topic in that country.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since alpha-1 antitrypsin deficiency has a specific augmentation therapy to reduce morbidity and mortality, European guidelines and World Health Organization recommend screening patients with COPD at least once in life<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>. The diagnosis of alpha-1 antitrypsin deficiency is confirmed by demonstrating low serum levels with a severe deficient genotype.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Alfa-1 antitrypsin genotyping can be carried out by drop extraction or buccal smear. Both genotype methods, proved by themselves to be a test fast, objective, specific, cheap, and therefore efficient<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>.</p><p id="par0025" class="elsevierStylePara elsevierViewall">For these reasons, we advise and encourage ruling-out alpha-1 antitrypsin deficiency as a potential causative agent in patients with COPD.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Hernández-Pérez JM, López-Charry CV. Respuesta al artículo <span class="elsevierStyleItalic">Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)</span>. Rev Clin Esp. 2022;222:253.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Wang" 1 => "J. Xu" 2 => "Y. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rce.2021.04.010" "Revista" => array:5 [ "tituloSerie" => "Rev Clin Esp" "fecha" => "2022" "volumen" => "222" "paginaInicial" => "218" "paginaFinal" => "228" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.168.7.818" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "168" "numero" => "7" "paginaInicial" => "818" "paginaFinal" => "900" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14522813" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Blanco" 1 => "P. Bueno" 2 => "I. Diego" 3 => "S. Pérez-Holanda" 4 => "F. Casas-Maldonado" 5 => "C. Esquinas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/COPD.S125389" "Revista" => array:6 [ "tituloSerie" => "Int J Chron Obstruct Pulmon Dis" "fecha" => "2017" "volumen" => "12" "paginaInicial" => "561" "paginaFinal" => "569" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28243076" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Miravitlles" 1 => "A. Dirksen" 2 => "I. Ferrarotti" 3 => "V. Koblizek" 4 => "P. Lange" 5 => "R. Mahadeva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/13993003.00711-2017" "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2017" "volumen" => "50" "numero" => "November" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29025888" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of a diagnostic procedure based on multiplex technology on dried blood spots and buccal swabs for subjects with suspected alpha1 antitrypsin deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Lopez-Campos" 1 => "F. Casas-Maldonado" 2 => "M. Torres-Duran" 3 => "A. Medina-Gonzálvez" 4 => "M.L. Rodriguez-Fidalgo" 5 => "I. 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