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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The coronavirus-2019 disease &#40;COVID-19&#41;&#44; caused by SARS-CoV-2&#44; is associated with elevated morbidity and mortality<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Since the onset of the pandemic&#44; cardiovascular disease has been identified as a risk factor for COVID-19&#44; with cardiovascular complications being common over the course of the disease<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Spain is one of the countries with the highest number of patients with SARS-CoV-2 in the world&#46; The first case of COVID-19 infection was confirmed on 31 January 2020&#44; with 2&#44;670&#44;102 confirmed cases as of 27 January 2021<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Heart failure &#40;HF&#41; in Spain represents 3&#37; of hospital admissions and is the number one cause of hospitalisation in patients over the age of 65<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; The aging population and healthcare advancements are the main factors associated with this growing increase in admissions due to HF<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">To date&#44; few studies have been published regarding mortality in patients with HF and COVID-19 infection&#46; &#193;lvarez-Garc&#237;a et al&#46; found that patients with a history of HF show a significant increase in mortality and need for invasive mechanical ventilation associated with COVID-19 infection&#44; regardless of their ventricular ejection fraction<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Rey et al&#46; concluded that patients infected with COVID-19 are at higher risk of developing HF during hospital admission&#44; with high mortality rates<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the significant impact of both diseases independent of one another and their potential feedback when combined&#44; the main aim of this study is to describe the clinical characteristics of patients with a history of HF and&#47;or new-onset HF who are admitted for COVID-19&#44; and to identify risk factors at admission for in-hospital mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0025" class="elsevierStylePara elsevierViewall">An observational&#44; retrospective&#44; multicentre national study was conducted with patients hospitalised due to COVID-19 from 01 March to 01 October 2020&#46; The data was obtained from the SEMI-COVID-19 Registry from the Spanish Society for Internal Medicine &#40;SEMI&#41;&#46; A total of 150 Spanish hospitals participated in the registry<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; The SEMI-COVID-19 Registry includes consecutive patients over the age of 18 with COVID-19 disease microbiologically confirmed via reverse transcription polymerase chain reaction testing &#40;RT-PCR&#41; obtained via nasal swab&#44; saliva sample&#44; or bronchoalveolar lavage<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">For this study&#44; we selected those patients with a history of HF and&#47;or that had suffered from HF as a complication during hospital admission due to COVID-19&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical&#44; epidemiological&#44; radiological&#44; and therapeutic variables were analysed as well as mortality during admission or early readmission&#44; defined as a new episode of hospital admission within 30 days post-discharge&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The researchers collected the data from the SEMI-COVID-19 Registry database<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diagnosis of HF was determined according to the clinical congestion criteria &#40;dyspnoea&#44; oedema&#44; and increased jugular venous pressure&#41; in the medical history&#46; The comorbidity burden of patients was established with the Age-Adjusted Charlson Comorbidity Index<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The Barthel Index was used to establish functional condition prior to hospital admission<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> &#40;independent or slight dependency&#58; 100-91&#59; moderate dependency&#58; 90-61&#59; severe dependency&#58; &#8804;60&#41;&#46; Patients were considered to have arterial hypertension&#44; diabetes mellitus&#44; or dyslipidaemia if they had a prior diagnosis in their medical history or were receiving medical treatment for these diseases&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Diabetes mellitus was classified according to 2 subgroups&#58; with target organ damage &#40;brain&#44; heart&#44; kidney&#44; or retinal involvement&#41; or without target organ damage&#46; Chronic lung disease was defined as a prior diagnosis of chronic obstructive pulmonary disease and&#47;or asthma&#46; Arteriosclerotic cardiovascular disease was defined as a prior history of ischaemic heart disease &#40;acute myocardial infarction&#44; acute coronary syndrome&#44; angina&#44; or coronary revascularization&#41;&#46; Neoplastic disease included all non-metastatic solid tumours &#40;excluding non-melanoma skin tumours&#41;&#46; Moderate-severe kidney disease was defined as glomerular filtration&#160;&#60;&#160;45&#160;mL&#47;min&#47;1&#46;73&#160;m<span class="elsevierStyleSup">2</span> according to the CKD-EPI equation<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#46; Moderate-severe liver disease was defined as class B or C according to the Child-Pugh score<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#46; Obesity was considered a body mass index&#160;&#8805;&#160;30&#160;kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Comorbidities were recorded from the medical histories from each hospital&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The laboratory data &#40;hemogram&#44; biochemical profile&#44; blood gas&#44; coagulation tests&#41; and imaging tests were collected at admission&#46; Treatments used were classified as&#58; &#40;1&#41; antimicrobial therapy &#40;hydroxychloroquine&#44; lopinavir&#47;ritonavir or remdesivir&#41;&#59; &#40;2&#41; immunomodulatory therapy &#40;systemic glucocorticoids&#44; immunoglobulins&#44; baricitinib or tocilizumab&#41;&#59; &#40;3&#41; anticoagulant therapy &#40;low molecular weight heparin&#41;&#59; &#40;4&#41; ventilator support &#40;high flow nasal cannula&#44; invasive and non-invasive mechanical ventilation&#41;&#44; and &#40;5&#41; pronation therapy&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In-hospital complications included&#58; admission to the intensive care unit &#40;ICU&#41; and presence of acute respiratory distress syndrome &#40;ARDS&#41;&#44; acute coronary syndrome&#44; acute HF&#44; arrhythmia&#44; shock&#44; sepsis&#44; acute kidney failure&#44; venous thromboembolism&#44; or acute arterial ischaemia&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Patients were classified according to the categorical variable of mortality as deceased or not deceased&#46; The categorical and continuous variables were expressed as absolute values and percentages and as medians &#40;ranges&#41;&#44; respectively&#46; The differences between groups were analysed using Student&#8217;s <span class="elsevierStyleItalic">t</span>-test or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for continuous variables or Pearson&#39;s chi-squared test for categorical variables&#46; A <span class="elsevierStyleItalic">p</span>-value &#60;&#46;05 was considered statistically significant&#59; subsequently&#44; a multivariate analysis was performed expressed as an adjusted odds ratio &#40;AOR&#41;&#44; with a 95&#37; confidence interval &#40;95&#37; CI&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A logistic regression analysis was used to identify independent factors at admission for in-hospital mortality&#44; including variables with statistical significance in the bivariate analysis and with a percentage of missing data of less than 20&#37;&#46; The statistical analysis was conducted with SPSS software version 26&#46;0 &#40;IBM SPSS Statistics&#169;&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical aspects</span><p id="par0080" class="elsevierStylePara elsevierViewall">All the patients gave their informed consent&#46; This study was conducted according to the Declaration of Helsinki and was approved by the M&#225;laga Ethics Committee &#40;Code&#58; SEMI-COVID-19 27-03-20&#41;&#46; The STROBE initiative for the publication of observational studies was followed &#40;available at <a href="http://www.strobe-statement.org">www&#46;strobe-statement&#46;org</a>&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">Of the 16&#44;461 patients included in the SEMI-COVID-19 Registry&#44; 1740 had documented history of HF and&#47;or had suffered from HF as a complication during hospital admission due to COVID-19<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; A total of 22 patients were excluded due to a lack of basic data for correct demographics&#44; meaning the final analysis was conducted with 1718 patients &#40;10&#46;4&#37;&#41;&#46; Of these&#44; 819 &#40;47&#46;6&#37;&#41; died during admission &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The clinical characteristics and laboratory data for the patients classified as deceased and not deceased are included in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The patients who died were significantly older&#44; were male&#44; and had higher comorbidity and dependency&#46; In addition&#44; there was a higher proportion of diabetics with target organ damage&#44; arterial hypertension&#44; and moderate-severe kidney failure among the deceased&#46; Other conditions that were also more frequent in the deceased patients were high heart rate&#44; presence of tachypnoea&#44; low oxygen saturation&#44; and the present of bilateral pulmonary consolidation at admission&#46; Likewise&#44; high mortality was associated with higher blood levels of c-reactive protein &#40;CRP&#41;&#44; D-dimer&#44; lactate dehydrogenase &#40;LDH&#41;&#44; urea&#44; creatinine and lactate&#44; and a lower number of lymphocytes at admission&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">A total of 1167 patients &#40;67&#46;9&#37;&#41; had a history of chronic HF prior to admission&#44; and 526 of those died &#40;45&#37;&#41;&#46; Mortality was higher for patients who experienced acute HF complications during admission than for those with a history of chronic HF prior to admission &#40;53&#37; vs&#46; 45&#37;&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;05&#41;&#46; The data for treatment and in-hospital complications can be seen in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Following the logistic regression analysis&#44; the risk factors at admission associated with higher in-hospital mortality were&#58; age &#40;&#62;80 years&#41;&#44; severe dependency class&#44; tachycardia &#40;&#62;100 beats per minute&#41;&#44; and elevated levels of CRP&#44; LDH&#44; and serum creatinine &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Heart failure represents one of the main reasons for hospitalisation in our environment<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a>&#46; In recent years&#44; the mortality rate for HF in Spain has been trending downwards thanks to the incorporation of different treatments that have shown significant benefits<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; the high level of adherence to guidelines by health professionals<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#44; and the change of components of disease decompensation such as ischaemic heart disease&#44; which has also been decreasing in recent years<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In a recent study&#44; Bromage et al&#46; showed a clear increase in the mortality of patients admitted for HF and COVID-19&#44; though it is unknown whether this is due to true mortality or due to a selection of critical patients who were admitted during the pandemic<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Our study has shown that the presence of HF&#44; both in patients with a prior history and those who developed it as a complication during admission&#44; is associated with high hospital mortality rates close to 50&#37;&#46; In addition&#44; it makes clear that patients who experienced decompensation due to acute HF while admitted died at a higher rate than patients with a history of HF prior to admission&#44; with the former affecting mortality more than the latter&#46; This reflects the impact of COVID-19 on developing acute HF&#46; These percentages represent a significant increase compared to the mortality described in previous studies of patients hospitalised with HF&#44; which range from 9&#46;5&#37; to 11&#37;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The most frequent causes of death in patients with a history of HF have been described as decompensated HF&#44; sudden death&#44; and non-cardiovascular causes<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; At the present moment&#44; as our study suggests&#44; SARS-CoV-2 is the primary cause of death in hospitalised HF patients&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Older age&#44; elevated comorbidity burden&#44; and degree of dependency are characteristic elements of patients with HF hospitalised due to COVID-19 in our country&#46; This clinical profile&#44; with figures close to 80&#37; for arterial hypertension&#44; 40&#37; for atrial fibrillation&#44; 20&#37; for diabetes mellitus&#44; 17&#37; for moderate-severe chronic kidney disease&#44; 25&#37; for obesity&#44; and 38&#37; for severe functional dependency&#44; represents a continuation of previous studies performed in our setting which have reported similar figures for these HF-related pathologies<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The patients with HF hospitalised due to COVID-19 from our study presented a large number of complications&#46; The most frequent complication was ARDS&#44; which exposes the inflammatory process that occurs in this patient profile induced by SARS-CoV-2&#46; The severe inflammatory response triggered in COVID-19 has been described in previous studies&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Old age and chronic conditions are just some of the various clinical conditioning factors that could favour its development and predispose patients to the onset of complications and adverse events<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; In this sense&#44; in our study we identified factors at admission that have been associated as risk factors for mortality in patients with HF hospitalised due to COVID-19&#46; Old age has been determined to be one of the main factors associated with higher mortality due to COVID-19<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#44; and we confirmed this in our population with HF&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">On the other hand&#44; the importance of assessing clinical condition at the time of admission is worth mentioning&#46; Patients who present in critical condition will have a significantly worse prognosis than those presenting with these characteristics&#44; with the former requiring stricter monitoring and follow-up&#46; Other studies have also stressed this issue and its severity in COVID-19 illness<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In addition&#44; the presence of certain altered biological markers in patients with HF can be aggravated by COVID-19 infection&#46; In this way&#44; kidney failure and high CRP and LDH levels were significantly associated with an increase in mortality&#46; However&#44; other markers of poor prognosis in COVID-19&#44; such as lymphopenia or elevated D-dimer levels<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#44; were not related to higher mortality in our population of patients with HF&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In any case&#44; though the variables of heart rate and elevated LDH and CRP have been statistically associated with mortality&#44; we must bear in mind that the association of these factors has been less important from the clinical perspective than other variables such as dependency or age&#46; All of these factors&#44; which are easily identifiable when patients are being admitted to hospital&#44; define a patient profile that requires special care due to the high risk of complications and death that they entail&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">This study presents important data regarding the clinical profile of a large number of patients with HF hospitalised due to COVID-19 and identifies at admission diverse clinical and analytical factors that are associated with mortality&#46; Though it is the first study with these characteristics in our country and one of few around the world&#44; it does have some limitations&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">First&#44; as an observational and retrospective study focusing on hospitalised patients&#44; we analysed patients with more critical clinical situations&#44; which could limit the results of the patient profile and not allow it to be extrapolated to the rest of the population of patients with HF&#46; In addition&#44; despite conducting a multivariate regression analysis&#44; the possibility of unmeasured confounding variables cannot be ruled out&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">On the other hand&#44; the data were collected by a large number of researchers from hospitals with different levels of care&#44; which entails a great degree of heterogeneity in its processing&#46; It is also worth noting that&#44; despite the large number of variables included in this registry&#44; we are lacking important data about the characterisation of HF such as aetiology&#44; the New York Heart Association functional class&#44; the left ventricular ejection fraction&#44; the level of natriuretic peptides&#44; and the proportion of patients receiving other treatments such as beta blockers&#44; neprilysin receptor antagonists&#44; aldosterone antagonists&#44; or diuretics&#46; Lastly&#44; nor does the provided information include data on the degree of compliance or the duration of the treatments prior to admission&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">In terms of the strength of our study&#44; the large number of patients with HF included in our series is worthy of mention&#44; as it represented different centres from around the entire country&#44; offering a wide-reaching vision of this patient group&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall">This study shows that patients with HF hospitalised due to COVID-19 in Spain have a high rate of mortality&#46; Older age&#44; severe dependency class&#44; greater severity at initial presentation&#44; kidney function decline&#44; and elevated inflammatory blood parameters have been identified as predictors of mortality&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Given the impact of HF on COVID-19 and the involvement of various factors&#44; it is necessary to develop prognostic scales that are easy to implement for these patients&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">This research did not receive any specific funding from agencies from the public sector&#44; commercial sector&#44; or not-for-profit organisations&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">There are few studies on patients with heart failure &#40;HF&#41; hospitalized for COVID-19&#46; Our aim is to describe the clinical characteristics of patients with HF hospitalized for COVID-19 and identify risk factors for in-hospital mortality upon admission&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective&#44; multicenter study in patients with HF hospitalized for COVID-19 in 150 Spanish hospitals &#40;SEMI-COVID-19 Registry&#41;&#46; A multivariate logistic regression analysis was performed to identify admission factors associated with in-hospital mortality&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">A total of 1718 patients were analyzed &#40;56&#46;5&#37; men&#59; median age 81&#46;4 years&#41;&#46; The overall case fatality rate was 47&#46;6&#37; &#40;n&#160;&#61;&#160;819&#41;&#46; The independent risk factors at admission for in-hospital mortality were&#58; age &#40;adjusted odds ratio &#91;AOR&#93;&#58; 1&#46;03&#59; 95&#37; confidence interval &#91;95&#37;CI&#93;&#58; 1&#46;02&#8211;1&#46;05&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#59; severe dependence &#40;AOR&#58; 1&#46;62&#59; 95&#37;CI&#58; 1&#46;19&#8211;2&#46;20&#59; <span class="elsevierStyleItalic">p</span>&#160;&#61;&#160;0&#46;002&#41;&#59; tachycardia &#40;AOR&#58; 1&#46;01&#59; 95&#37;CI&#58; 1&#46;00&#8211;1&#46;01&#59; <span class="elsevierStyleItalic">p</span>&#160;&#61;&#160;0&#46;004&#41;&#59; and high C-reactive protein &#40;AOR&#58; 1&#46;004&#59; 95&#37;CI&#58;1&#46;002&#8722;1&#46;004&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#44; LDH &#40;AOR&#58; 1&#46;001&#59; 95&#37;CI&#58; 1&#46;001&#8722;1&#46;002&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#44; and serum creatinine levels &#40;AOR&#58; 1&#46;35&#59; 95&#37;CI&#58; 1&#46;18&#8722;1&#46;54&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Patients with HF hospitalized for COVID-19 have a high in-hospital mortality rate&#46; Some simple clinical and laboratory tests can help to identify patients with a worse prognosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios sobre pacientes con insuficiencia card&#237;aca &#40;IC&#41; ingresados por COVID-19&#46; Nuestro objetivo es describir las caracter&#237;sticas cl&#237;nicas de los pacientes con IC ingresados por COVID-19 e identificar los factores de riesgo al ingreso de mortalidad intrahospitalaria&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo y multic&#233;ntrico de pacientes con IC ingresados por COVID-19 en 150 hospitales espa&#241;oles &#40;Registro SEMI-COVID-19&#41;&#46; Se realiz&#243; un an&#225;lisis de regresi&#243;n log&#237;stica para identificar los factores de riesgo al ingreso asociados a la mortalidad&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Se analizaron 1&#46;718 pacientes &#40;56&#44;5&#37; varones&#59; edad mediana 81&#44;4 a&#241;os&#41;&#46; La tasa de mortalidad global fue del 47&#44;6&#37; &#40;n&#160;&#61;&#160;819&#41;&#46; Los factores de riesgo independientes al ingreso para mortalidad fueron&#58; la edad &#40;odds ratio ajustado &#91;ORA&#93;&#58; 1&#44;03&#59; intervalo de confianza 95&#37; &#91;IC95&#37;&#93;&#58; 1&#44;02&#8211;1&#44;05&#59; p&#160;&#60;&#160;0&#44;001&#41;&#44; la dependencia severa &#40;ORA&#58; 1&#44;62&#59; IC95&#37;&#58; 1&#44;19&#8211;2&#44;20&#59; p&#160;&#61;&#160;0&#44;002&#41;&#44; la taquicardia &#40;ORA&#58; 1&#44;01&#59; IC95&#37;&#58; 1&#44;00&#8211;1&#44;01&#59; p&#160;&#61;&#160;0&#44;004&#41;&#44; la prote&#237;na C reactiva &#40;ORA&#58; 1&#44;004&#59; IC95&#37;&#58;1&#44;002&#8211;1&#44;004&#59; p&#160;&#60;&#160;0&#44;001&#41;&#44; la LDH &#40;ORA&#58; 1&#44;001&#59; IC95&#37;&#58; 1&#44;001&#8211;1&#44;002&#59; p&#160;&#60;&#160;0&#44;001&#41; y la creatinina s&#233;rica &#40;ORA&#58; 1&#44;35&#59; IC95&#37;&#58; 1&#44;18&#8211;1&#44;54&#59; p&#160;&#60;&#160;0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con IC hospitalizados por COVID-19 tienen una alta mortalidad intrahospitalaria&#46; Existen factores cl&#237;nico-anal&#237;ticos simples que pueden ayudar a identificar a los pacientes con peor pron&#243;stico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:3 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salinas-Botr&#225;n A&#44; Sanz-C&#225;novas J&#44; P&#233;rez-Somarriba J&#44; P&#233;rez-Belmonte LM&#44; Cobos-Palacios L&#44; Rubio-Rivas M&#44; et al&#46; Caracter&#237;sticas cl&#237;nicas y factores de riesgo de mortalidad al ingreso en pacientes con insuficiencia card&#237;aca hospitalizados por COVID-19 en Espa&#241;a&#46; Rev Clin Esp&#46; 2022&#59;222&#58;255&#8211;265&#46;</p>"
      ]
      1 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Doctors M&#233;ndez-Bail&#243;n and G&#243;mez-Huelgas share the final authorship&#46;</p>"
        "identificador" => "fn0005"
      ]
      2 => array:3 [
        "etiqueta" => "2"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">The complete list of members of the SEMI-COVID-19 group is listed in the Appendix <a class="elsevierStyleCrossRef" href="#sec0060">A</a>&#46;</p>"
        "identificador" => "fn0010"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Coordinator of the SEMI-COVID-19 Registry&#58;</span> Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Members of the SEMI-COVID-19 Registry Scientific Committee&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez-Huelgas&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Members of the SEMI-COVID-19 Group&#58;</span></p> <p id="par0215" class="elsevierStylePara elsevierViewall">H&#46; U&#46; 12 de Octubre&#46; Madrid&#58; Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Lucia Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Barbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#46; Madrid&#58; Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Crhistian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Antunez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o Miguez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall">Hospital Universitari de Bellvitge&#46; L&#39;Hospitalet de Llobregat&#46; Barcelona&#58; Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio Rivas&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Paz-Cantoblanco-Carlos III&#46; Madrid&#58; Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Albacete&#46; Albacete&#58; Jos&#233; Luis Beato P&#233;rez&#44; Mar&#237;a Lourdes S&#225;ez M&#233;ndez&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall">Complejo Asistencial de Segovia&#46; Segovia&#58; Eva Mar&#237;a Ferreira Pasos&#44; Daniel Monge Monge&#44; Alba Varela Garc&#237;a&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Puerta de Hierro&#46; Majadahonda&#46; Madrid&#58; Mar&#237;a &#193;lvarez Bello&#44; Ane Andr&#233;s Eisenhofer&#44; Ana Arias Milla&#44; Isolina Ba&#241;os P&#233;rez&#44; Javier Bilbao Garay&#44; Silvia Blanco Alonso&#44; Jorge Calder&#243;n Parra&#44; Alejandro Callejas D&#237;az&#44; Jos&#233; Mar&#237;a Camino Salvador&#44; M&#170; Cruz Carre&#241;o Hern&#225;ndez&#44; Valent&#237;n Cuervas-Mons Mart&#237;nez&#44; Sara de la Fuente Moral&#44; Miguel del Pino Jim&#233;nez&#44; Alberto D&#237;az de Santiago&#44; Itziar Diego Yag&#252;e&#44; Ignacio Donate Velasco&#44; Ana Mar&#237;a Duca&#44; Pedro Dur&#225;n del Campo&#44; Gabriela Escudero L&#243;pez&#44; Esther Exp&#243;sito Palomo&#44; Ana Fern&#225;ndez Cruz&#44; Esther Fiz Benito&#44; Andrea Fraile L&#243;pez&#44; Amy Gal&#225;n G&#243;mez&#44; Sonia Garc&#237;a Prieto&#44; Claudia Garc&#237;a Rodr&#237;guez-Maim&#243;n&#44; Miguel &#193;ngel Garc&#237;a Viejo&#44; Javier G&#243;mez Irusta&#44; Edith Vanessa Guti&#233;rrez Abreu&#44; Isabel Guti&#233;rrez Mart&#237;n&#44; &#193;ngela Guti&#233;rrez Rojas&#44; Andrea Guti&#233;rrez Villanueva&#44; Jes&#250;s Herr&#225;iz Jim&#233;nez&#44; Pedro Laguna del Estal&#44; M&#170; Carmen M&#225;inez S&#225;iz&#44; Cristina Mart&#237;n Mart&#237;n&#44; Mar&#237;a Mart&#237;nez Urbistondo&#44; Fernando Mart&#237;nez Vera&#44; Susana Mellor Pita&#44; Patricia Mills S&#225;nchez&#44; Esther Montero Hern&#225;ndez&#44; Alberto Mora Vargas&#44; Cristina Moreno L&#243;pez&#44; Alfonso &#193;ngel-Moreno Maroto&#44; V&#237;ctor Moreno-Torres Concha&#44; Ignacio Morr&#225;s De La Torre&#44; Elena M&#250;&#241;ez Rubio&#44; Ana Mu&#241;oz G&#243;mez&#44; Rosa Mu&#241;oz de Benito&#44; Alejandro Mu&#241;oz Serrano&#44; Jos&#233; Mar&#237;a Palau Fay&#243;s&#44; Ilduara Pintos Pascual&#44; Antonio Ramos Mart&#237;nez&#44; Isabel Redondo C&#225;novas del Castillo&#44; Alberto Rold&#225;n Montaud&#44; Luc&#237;a Romero Imaz&#44; Yolanda Romero Pizarro&#44; M&#243;nica S&#225;nchez Santiuste&#44; David S&#225;nchez Ortiz&#44; Enrique S&#225;nchez Chica&#44; Patricia Serrano de la Fuente&#44; Pablo Tutor de Ureta&#44; &#193;ngela Valencia Alijo&#44; Mercedes Valent&#237;n-Pastrana Aguilar&#44; Juan Antonio Vargas N&#250;&#241;ez&#44; Jos&#233; Manuel V&#225;zquez Comendador&#44; Gema V&#225;zquez Contreras&#44; Carmen Vizoso G&#225;lvez&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall">H&#46; Miguel Servet&#46; Zaragoza&#58; Gonzalo Acebes Repiso&#44; Uxua As&#237;n Samper&#44; Mar&#237;a Aranzazu Caudevilla Mart&#237;nez&#44; Jos&#233; Miguel Garc&#237;a Bru&#241;&#233;n&#44; Rosa Garc&#237;a Fenoll&#44; Jes&#250;s Javier Gonz&#225;lez Igual&#44; Laura Letona Gim&#233;nez&#44; M&#243;nica Llorente Barrio&#44; Luis S&#225;ez Comet&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Princesa&#46; Madrid&#58; Mar&#237;a Aguilera Garc&#237;a&#44; Ester Alonso Monge&#44; Jes&#250;s &#193;lvarez Rodr&#237;guez&#44; Claudia &#193;lvarez Varela&#44; Miquel Berniz G&#242;dia&#44; Marta Briega Molina&#44; Marta Bustamante Vega&#44; Jos&#233; Curbelo&#44; Alicia de las Heras Moreno&#44; Ignacio Descalzo Godoy&#44; Alexia Constanza Espi&#241;o &#193;lvarez&#44; Ignacio Fern&#225;ndez Mart&#237;n-Caro&#44; Alejandra Franquet L&#243;pez-Mosteiro&#44; Gonzalo G&#225;lvez M&#225;rquez&#44; Mar&#237;a J&#46; Garc&#237;a Blanco&#44; Yaiza Garc&#237;a del &#193;lamo Hern&#225;ndez&#44; Clara Garc&#237;a-Rayo Encina&#44; Noem&#237; Gilabert Gonz&#225;lez&#44; Carolina Guillamo Rodr&#237;guez&#44; Nicol&#225;s Labrador San Mart&#237;n&#44; Manuel Molina B&#225;ez&#44; Carmen Mu&#241;oz Delgado&#44; Pedro Parra Caballero&#44; Javier P&#233;rez Serrano&#44; Laura Rabes Rodr&#237;guez&#44; Pablo Rodr&#237;guez Cort&#233;s&#44; Carlos Rodr&#237;guez Franco&#44; Emilia Roy-Vallejo&#44; M&#243;nica Rueda Vega&#44; Aresio Sancha Lloret&#44; Beatriz S&#225;nchez Moreno&#44; Marta Sanz Alba&#44; Jorge Serrano Ballester&#44; Alba Somovilla&#44; Carmen Suarez Fern&#225;ndez&#44; Macarena Vargas Tirado&#44; Almudena Villa Mart&#237;&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall">H&#46; U&#46; de A Coru&#241;a&#46; A Coru&#241;a&#58; Alicia Alonso &#193;lvarez&#44; Olaya Alonso Juarros&#44; Ariadna Ar&#233;valo L&#243;pez&#44; Carmen Casariego Casti&#241;eira&#44; Ana Cerezales Calvi&#241;o&#44; Marta Contreras S&#225;nchez&#44; Ram&#243;n Fern&#225;ndez Varela&#44; Santiago J&#46; Freire Castro&#44; Ana Pad&#237;n Trigo&#44; Rafael Prieto Jarel&#44; F&#225;tima Raad Varea&#44; Laura Ramos Alonso&#44; Francisco Javier Sanmart&#237;n Pensado&#44; David Vieito Porto&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nico San Carlos&#46; Madrid&#58; In&#233;s Armenteros Yeguas&#44; Javier Aza&#241;a G&#243;mez&#44; Julia Barrado Cuchillo&#44; Irene Burruezo L&#243;pez&#44; Noem&#237; Cabello Clotet&#44; Alberto E&#46; Calvo El&#237;as&#44; Elpidio Calvo Manuel&#44; Carmen Mar&#237;a Cano de Luque&#44; Cynthia Chocron Benbunan&#44; Laura Dans Vil&#225;n&#44; Ester Emilia Dubon Peralta&#44; Vicente Estrada P&#233;rez&#44; Santiago Fernandez-Castelao&#44; Marcos Oliver Fragiel Saavedra&#44; Jos&#233; Luis Garc&#237;a Klepzig&#44; Mar&#237;a del Rosario Iguar&#225;n Berm&#250;dez&#44; Esther Ja&#233;n Ferrer&#44; Rub&#233;n &#193;ngel Mart&#237;n S&#225;nchez&#44; Manuel M&#233;ndez Bail&#243;n&#44; Mar&#237;a Jos&#233; N&#250;&#241;ez Orantos&#44; Carolina Olmos Mata&#44; Eva Orviz Garc&#237;a&#44; David Oteo Mata&#44; Cristina Outon Gonz&#225;lez&#44; Juncal P&#233;rez-Somarriba&#44; Pablo P&#233;rez Mateos&#44; Mar&#237;a Esther Ramos Mu&#241;oz&#44; Xabier Rivas Regaira&#44; I&#241;igo Sagastagoitia Fornie&#44; Alejandro Salinas Botr&#225;n&#44; Miguel Su&#225;rez Robles&#44; Maddalena Elena Urbano&#44; Miguel Villar Mart&#237;nez&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall">H&#46; Infanta Sof&#237;a&#46; S&#46; S&#46; de los Reyes&#46; Madrid&#58; Rafael del Castillo Cantero&#44; Rebeca Fuerte Mart&#237;nez&#44; Arturo Mu&#241;oz Blanco&#44; Jos&#233; Francisco Pascual Pareja&#44; Isabel Perales Fraile&#44; Isabel R&#225;bago Lorite&#44; Llanos Soler Rangel&#44; In&#233;s Su&#225;rez Garc&#237;a&#44; Jos&#233; Luis Valle L&#243;pez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Dr&#46; Peset&#46; Valencia&#58; Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabet Mateo Sanchis&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nico de Santiago&#46; Santiago de Compostela&#58; Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel P&#225;ez Guill&#225;n&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall">H&#46; Nuestra Se&#241;ora del Prado&#46; Talavera de la Reina&#46; Toledo&#58; Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Ram&#243;n y Cajal&#46; Madrid&#58; Luis Fernando Abrego Vaca&#44; Ana Andr&#233;u Arnanz&#44; Octavio Arce Garc&#237;a&#44; Marta Bajo Gonz&#225;lez&#44; Pablo Borque Sanz&#44; Alberto Cozar Llisto&#44; Sonia de Pedro Baena&#44; Beatriz Del Hoyo Cuenda&#44; Mar&#237;a Alejandra Gamboa Osorio&#44; Isabel Garc&#237;a S&#225;nchez&#44; Andr&#233;s Gonz&#225;lez Garc&#237;a&#44; Oscar Alberto L&#243;pez Cisneros&#44; Miguel Mart&#237;nez Lacalzada&#44; Borja Merino Ortiz&#44; Jimena Rey-Garc&#237;a&#44; Elisa Riera Gonz&#225;lez&#44; Cristina S&#225;nchez D&#237;az&#44; Grisell Starita Fajardo&#44; Cecilia Su&#225;rez Caranto&#241;a&#44; Adri&#225;n Viteri Noel&#44; Svetlana Zhilina Zhilina&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall">H&#46; Royo Villanova&#46; Zaragoza&#58; Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Gerico Aseguinolaza&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Infanta Cristina&#46; Parla&#46; Madrid&#58; Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Coralia Bueno Mui&#241;o&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Francesco Deodati&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A Melero Bermejo&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall">H&#46; de Cabue&#241;es&#46; Gij&#243;n&#46; Asturias&#58; Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall">H&#46; de Urduliz Alfredo Espinosa&#46; Urd&#250;liz&#46; Vizcaya&#58; Mar&#237;a Aparicio L&#243;pez&#44; Asier Aranguren Arostegui&#44; Paula Arriola Mart&#237;nez&#44; Gorka Arroita Gonz&#225;lez&#44; M&#170; Soledad Azcona Losada&#44; Miriam Garc&#237;a G&#243;mez&#44; Eduardo Garc&#237;a L&#243;pez&#44; Amalur Iza Jim&#233;nez&#44; Alazne Lartategi Iraurgi&#44; Esther Mart&#237;nez Becerro&#44; Itziar Ori&#241;uela Gonz&#225;lez&#44; Isabel Mar&#237;a Portales Fern&#225;ndez&#44; Pablo Ram&#237;rez S&#225;nchez&#44; Beatriz Ruiz Est&#233;vez&#44; Cristian Vidal N&#250;&#241;ez&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall">H&#46; Regional Universitario de M&#225;laga&#46; M&#225;laga&#58; M&#170; Mar Ayala Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Mar&#237;a Dolores L&#243;pez Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Martin Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Araceli Pineda Cantero&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall">H&#46; Santa Marina&#46; Bilbao&#58; Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Elbire Labirua-Iturburu Ruiz&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall">H&#46; Mois&#232;s Broggi&#46; Sant Joan Desp&#237;&#46; Barcelona&#58; Judit Aranda Lobo&#44; Jos&#233; Loureiro Amigo&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicolas Rhyman&#44; Nuria V&#225;zquez Piqueras&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall">H&#46; HLA Moncloa&#46; Madrid&#58; Guillermo Estrada&#44; Teresa Garc&#237;a Delange&#44; Isabel Jim&#233;nez Mart&#237;nez&#44; Carmen Mart&#237;nez Cilleros&#44; Nuria Parra Arribas&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall">H&#46; del Henares&#46; Coslada&#46; Madrid&#58; Jes&#250;s Ballano Rodr&#237;guez-Sol&#237;s&#44; Luis Cabeza Osorio&#44; Mar&#237;a del Pilar Fidalgo Montero&#44; M&#170; Isabel Fuentes Soriano&#44; Erika Esperanza Lozano Rinc&#243;n&#44; Ana Mart&#237;n Hermida&#44; Jes&#250;s Mart&#237;nez Carrilero&#44; Jos&#233; &#193;ngel Pesta&#241;a Santiago&#44; Manuel S&#225;nchez Robledo&#44; Patricia Sanz Rojas&#44; Nahum Jacobo Torres Yebes&#44; Vanessa Vento&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Torrevieja&#46; Torrevieja&#46; Alicante&#58; Julio C&#233;sar Bl&#225;zquez Encinar&#44; Joaqu&#237;n Fern&#225;ndez-Cuervo&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Fe&#46; Valencia&#58; Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">H&#46; San Pedro&#46; Logro&#241;o&#58; Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Luis Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Ntra&#46; Sra&#46; Candelaria&#46; Santa Cruz de Tenerife&#58; Lucy Abella&#44; Andrea Afonso D&#237;az&#44; Selena Gala Aguilera Garc&#237;a&#44; Marta Bethencourt Feria&#44; Eduardo Mauricio Calder&#243;n Ledezma&#44; Sara Casta&#241;o P&#237;rez&#44; Guillermo Castro Gainett&#44; Jos&#233; Manuel del Arco Delgado&#44; Joaqu&#237;n Delgado Casamayor&#44; Diego Garc&#237;a Silvera&#44; Alba G&#243;mez Hidalgo&#44; Marcelino Hayek Peraza&#44; Carolina Hern&#225;ndez Carballo&#44; Rub&#233;n Hern&#225;ndez Luis&#44; Francisco Javier Herrera Herrera&#44; Mar&#237;a del Mar L&#243;pez G&#225;mez&#44; Julia Marfil Daza&#44; Mar&#237;a Jos&#233; Monedero Prieto&#44; Mar&#237;a Blanca Monereo Mu&#241;oz&#44; Mar&#237;a de la Luz Padilla Salazar&#44; Daniel Rodr&#237;guez D&#237;az&#44; Alicia Tejera&#44; Laura Torres Hern&#225;ndez&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall">H&#46; U&#46; San Juan de Alicante&#46; San Juan de Alicante&#58; David Balaz&#44; David Bonet Tur&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0365" class="elsevierStylePara elsevierViewall">H&#46; U&#46; San Agust&#237;n&#46; Avil&#233;s&#58; Andrea &#193;lvarez Garc&#237;a&#44; V&#237;ctor Arenas Garc&#237;a&#44; Alba Barrag&#225;n Mateos&#44; Demelsa Blanco Su&#225;rez&#44; Mar&#237;a Ca&#241;o Rubia&#44; Jaime Casal &#193;lvarez&#44; David Castrod&#225; Copa&#44; Jos&#233; Ferreiro Celeiro&#44; Natalia Garc&#237;a Arenas&#44; Raquel Garc&#237;a Noriega&#44; Joaqu&#237;n Llorente Garc&#237;a&#44; Irene Maderuelo Riesco&#44; Paula Mart&#237;nez Garc&#237;a&#44; Mar&#237;a Jos&#233; Men&#233;ndez Calder&#243;n&#44; Diego Eduardo Olivo Aguilar&#44; Marta Nataya Sol&#237;s Marqu&#237;nez&#44; Luis Trapiella Mart&#237;nez&#44; Andr&#233;s Astur Trece&#241;o Garc&#237;a&#44; Juan Vald&#233;s B&#233;cares&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall">H&#46; de Matar&#243;&#46; Matar&#243;&#58; Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0375" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Son Ll&#224;tzer&#46; Palma de Mallorca&#58; Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall">H&#46; Virgen de la Salud&#46; Toledo&#58; Ana Mar&#237;a Alguacil Mu&#241;oz&#44; Marta Blanco Fern&#225;ndez&#44; Ver&#243;nica Cano&#44; Ricardo Crespo Moreno&#44; Fernando Cuadra Garc&#237;a-Tenorio&#44; Blanca D&#237;az-Tendero N&#225;jera&#44; Raquel Est&#233;vez Gonz&#225;lez&#44; Mar&#237;a Paz Garc&#237;a Butenegro&#44; Alberto Gato D&#237;ez&#44; Ver&#243;nica G&#243;mez Caverzaschi&#44; Piedad Mar&#237;a G&#243;mez Pedraza&#44; Julio Gonz&#225;lez Moraleja&#44; Ra&#250;l Hidalgo Carvajal&#44; Patricia Jim&#233;nez Aranda&#44; Raquel Labra Gonz&#225;lez&#44; &#193;xel Legua Caparachini&#44; Pilar L&#243;pez Casta&#241;eyra&#44; Agust&#237;n Lozano Anc&#237;n&#44; Jos&#233; Domingo Mart&#237;n Garc&#237;a&#44; Cristina Morata Romero&#44; Mar&#237;a Jes&#250;s Moya Saiz&#44; Helena Moza Mor&#237;&#241;igo&#44; Gemma Mu&#241;iz Nicol&#225;s&#44; Enriqueta Mu&#241;oz Plat&#243;n&#44; Filomena Oliveri&#44; Elena Ortiz Ortiz&#44; Ra&#250;l Perea Rafael&#44; Pilar Redondo Gal&#225;n&#44; Mar&#237;a Antonia Sep&#250;lveda Berrocal&#44; Vicente Serrano Romero de &#193;vila&#44; Pilar Toledano Sierra&#44; Yamilex Urbano Aranda&#44; Jes&#250;s V&#225;zquez Clemente&#44; Carmen Yera Bergua&#46;</p> <p id="par0385" class="elsevierStylePara elsevierViewall">H&#46; Juan Ram&#243;n Jim&#233;nez&#46; Huelva&#58; Francisco Javier Bejarano Luque&#44; Francisco Javier Carrasco-S&#225;nchez&#44; Mercedes de Sousa Baena&#44; Jaime D&#237;az Leal&#44; Aurora Espinar Rubio&#44; Mar&#237;a Franco Huertas&#44; Juan Antonio Garc&#237;a Bravo&#44; Andr&#233;s Gonz&#225;lez Mac&#237;as&#44; Encarnaci&#243;n Guti&#233;rrez Jim&#233;nez&#44; Alicia Hidalgo Jim&#233;nez&#44; Constantino Lozano Quintero&#44; Carmen Mancilla Reguera&#44; Francisco Javier Mart&#237;nez Marcos&#44; Francisco Mu&#241;oz Beamud&#44; Mar&#237;a P&#233;rez Aguilera&#44; Alicia P&#233;rez Jim&#233;nez&#44; Virginia Rodr&#237;guez Casta&#241;o&#44; &#193;lvaro S&#225;nchez de Alc&#225;zar del R&#237;o&#44; Leire Toscano Ruiz&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Reina Sof&#237;a&#46; C&#243;rdoba&#58; Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Mart&#237;n Piedra&#44; Javier Pascual Vinagre&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres Pe&#241;a&#46;</p> <p id="par0395" class="elsevierStylePara elsevierViewall">H&#46; Infanta Margarita&#46; Cabra&#58; Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0400" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Virgen de las Nieves&#46; Granada&#58; Pablo Conde Baena&#44; Joaqu&#237;n Escobar Sevilla&#44; Laura Gallo Padilla&#44; Patricia G&#243;mez Ronquillo&#44; Pablo Gonz&#225;lez Bustos&#44; Mar&#237;a Nav&#237;o Bot&#237;as&#44; Jessica Ram&#237;rez Taboada&#44; Mar Rivero Rodr&#237;guez&#46;</p> <p id="par0405" class="elsevierStylePara elsevierViewall">H&#46; Costa del Sol&#46; Marbella&#58; Victoria August&#237;n Bandera&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#46;</p> <p id="par0410" class="elsevierStylePara elsevierViewall">H&#46; San Juan de la Cruz&#46; &#218;beda&#58; Marcos Guzm&#225;n Garc&#237;a&#44; Francisco Javier Vicente Hern&#225;ndez&#46;</p> <p id="par0415" class="elsevierStylePara elsevierViewall">Complejo Asistencial Universitario de Le&#243;n&#46; Le&#243;n&#58; Rosario Mar&#237;a Garc&#237;a Die&#44; Manuel Martin Regidor&#44; &#193;ngel Luis Mart&#237;nez Gonz&#225;lez&#44; Alberto Muela Molinero&#44; Raquel Rodr&#237;guez D&#237;ez&#44; Beatriz Vicente Montes&#46;</p> <p id="par0420" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nic Barcelona&#46; Barcelona&#58; J&#250;lia Calvo Jim&#233;nez&#44; Aina Capdevila Reniu&#44; Irene Carbonell De Boulle&#44; Emmanuel Coloma Baz&#225;n&#44; Joaquim Fern&#225;ndez Sol&#224;&#44; Cristina Gabara Xanc&#243;&#44; Joan Ribot Grabalosa&#44; Olga Rodr&#237;guez N&#250;&#241;ez&#46;</p> <p id="par0425" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Ferrol&#46; Ferrol&#58; Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trig&#225;s Ferr&#237;n&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0430" class="elsevierStylePara elsevierViewall">H&#46; Marina Baixa&#46; Villajoyosa&#58; Javier Ena&#44; Santiago P&#233;rez-Mart&#237;n&#46;</p> <p id="par0435" class="elsevierStylePara elsevierViewall">H&#46; del Tajo&#46; Aranjuez&#58; Ruth Gonz&#225;lez Ferrer&#44; Raquel Monsalvo Arroyo&#46;</p> <p id="par0440" class="elsevierStylePara elsevierViewall">H&#46; Insular de Gran Canaria&#46; Las Palmas de Gran Canaria&#58; Marina Aroza Espinar&#44; Jorge Orihuela Mart&#237;n&#44; Carlos Jorge Ripper&#44; Selena Santana Jim&#233;nez&#46;</p> <p id="par0445" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Marqu&#233;s de Valdecilla&#46; Santander&#58; Marta Fern&#225;ndez-Ayala Novo&#44; Jos&#233; Javier Napal Lecumberri&#44; Nuria Puente Ruiz&#44; Jos&#233; Riancho&#44; Isabel Sampedro Garc&#237;a&#46;</p> <p id="par0450" class="elsevierStylePara elsevierViewall">H&#46; Torrec&#225;rdenas&#46; Almer&#237;a&#58; Luis Felipe D&#237;ez Garc&#237;a&#44; Iris El Attar Acedo&#44; B&#225;rbara Hern&#225;ndez Sierra&#44; Carmen Mar S&#225;nchez Cano&#46;</p> <p id="par0455" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Severo Ochoa&#46; Legan&#233;s&#58; Yolanda Casillas Viera&#44; Luc&#237;a Cayuela Rodr&#237;guez&#44; Carmen de Juan &#193;lvarez&#44; Gema Flox Ben&#237;tez&#44; Laura Garc&#237;a Escudero&#44; Juan Martin Torres&#44; Patricia Moreira Escriche&#44; Susana Plaza Canteli&#44; M&#46; Carmen Romero P&#233;rez&#46;</p> <p id="par0460" class="elsevierStylePara elsevierViewall">H&#46; Valle del Nal&#243;n&#46; Ria&#241;o&#46; Langreo&#58; Sara Fuente Cos&#237;o&#44; C&#233;sar Manuel Gallo &#193;lvaro&#44; Julia Lobo Garc&#237;a&#44; Ant&#237;a P&#233;rez Pi&#241;eiro&#46;</p> <p id="par0465" class="elsevierStylePara elsevierViewall">H&#46; U&#46; del Vinalop&#243;&#46; Elche&#58; Francisco Amor&#243;s Mart&#237;nez&#44; Erika Ascu&#241;a V&#225;squez&#44; Jos&#233; Carlos Escribano Stabl&#233;&#44; Adriana Hern&#225;ndez Belmonte&#44; Ana Maestre Peir&#243;&#44; Raquel Mart&#237;nez Go&#241;i&#44; M&#46; Carmen Pacheco Castellanos&#44; Bernardino Sold&#225;n Belda&#44; David Vicente Navarro&#46;</p> <p id="par0470" class="elsevierStylePara elsevierViewall">H&#46; Alto Guadalquivir&#46; And&#250;jar&#58; Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0475" class="elsevierStylePara elsevierViewall">H&#46; Francesc de Borja&#46; Gand&#237;a&#58; Alba Camarena Molina&#44; Simona Cioaia&#44; Anna Ferrer Santolaria&#44; Jos&#233; Mar&#237;a Frutos P&#233;rez&#44; Eva Gil Tom&#225;s&#44; Leyre Jorquer Vidal&#44; Marina Llopis Sanch&#237;s&#44; Mari &#193;ngeles Mart&#237;nez Pascual&#44; &#193;lvaro Navarro Batet&#44; Mari Amparo Perea Ribis&#44; Ricardo Peris S&#225;nchez&#44; Jos&#233; Manuel Querol Ribelles&#44; Silvia Rodr&#237;guez Mercadal&#44; Ana Ventura Esteve&#46;</p> <p id="par0480" class="elsevierStylePara elsevierViewall">H&#46; G&#46; U&#46; de Castell&#243;n&#46; Castell&#243;n de la Plana&#58; Jorge Andr&#233;s Soler&#44; Mari&#225;n Bennasar Remolar&#44; Alejandro Cardenal &#193;lvarez&#44; Daniela D&#237;az Carlotti&#44; Mar&#237;a Jos&#233; Esteve Gimeno&#44; Sergio Fabra Juana&#44; Paula Garc&#237;a L&#243;pez&#44; Mar&#237;a Teresa Guinot Soler&#44; Daniela Palomo de la Sota&#44; Guillem Pascual Castellanos&#44; Ignacio P&#233;rez Catal&#225;n&#44; Celia Roig Mart&#237;&#44; Paula Rubert Monz&#243;&#44; Javier Ruiz Padilla&#44; Nuria Tornador Gaya&#44; Jorge Us&#243; Blasco&#46;</p> <p id="par0485" class="elsevierStylePara elsevierViewall">H&#46; Santa B&#225;rbara&#46; Soria&#58; Marta Le&#243;n T&#233;llez&#46;</p> <p id="par0490" class="elsevierStylePara elsevierViewall">C&#46; A&#46; U&#46; de Salamanca&#46; Salamanca&#58; Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ramon Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0495" class="elsevierStylePara elsevierViewall">H&#46; U&#46; de Canarias&#46; Santa Cruz de Tenerife&#58; Julio Cesar Alvisa Negr&#237;n&#44; Jos&#233; Fernando Armas Gonz&#225;lez&#44; Lourdes Gonz&#225;lez Navarrete&#44; Iballa Jim&#233;nez&#44; Mar&#237;a Candelaria Mart&#237;n Gonz&#225;lez&#44; Miguel Nicolas Navarrete Lorite&#44; Paula Ortega Toledo&#44; On&#225;n P&#233;rez Hern&#225;ndez&#44; Alina P&#233;rez Ram&#237;rez&#46;</p> <p id="par0500" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Badajoz&#46; Badajoz&#58; Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0505" class="elsevierStylePara elsevierViewall">H&#46; U&#46; del Sureste&#46; Arganda del Rey&#58; Jon Cabrejas Ugartondo&#44; Ana Bel&#233;n Mancebo Plaza&#44; Arturo Noguerado Asensio&#44; Bethania P&#233;rez Alves&#44; Natalia Vicente L&#243;pez&#46;</p> <p id="par0510" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Quironsalud Madrid&#46; Pozuelo de Alarc&#243;n&#46; Madrid&#58; Pablo Guisado Vasco&#44; Ana Roda Santacruz&#44; Ana Valverde Mu&#241;oz&#46;</p> <p id="par0515" class="elsevierStylePara elsevierViewall">H&#46; de Poniente&#46; Almer&#237;a&#58; Juan Antonio Montes Romero&#44; Encarna S&#225;nchez Mart&#237;n&#44; Jos&#233; Luis Serrano Carrillo de Albornoz&#44; Manuel Jes&#250;s Soriano P&#233;rez&#46;</p> <p id="par0520" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Lucus Augusti&#46; Lugo&#58; Raquel G&#243;mez M&#233;ndez&#44; Ana Rodr&#237;guez &#193;lvarez&#46;</p> <p id="par0525" class="elsevierStylePara elsevierViewall">H&#46; San Pedro de Alc&#225;ntara&#46; C&#225;ceres&#58; &#193;ngela Agea Garc&#237;a&#44; Javier Gal&#225;n Gonz&#225;lez&#44; Luis G&#225;mez Salazar&#44; Eva Garc&#237;a Sard&#243;n&#44; Antonio Gonz&#225;lez Nieto&#44; Itziar Montero D&#237;as&#44; Selene N&#250;&#241;ez Gaspar&#44; &#193;lvaro Santaella G&#243;mez&#46;</p> <p id="par0530" class="elsevierStylePara elsevierViewall">H&#46; de Pozoblanco&#46; Pozoblanco&#58; Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0535" class="elsevierStylePara elsevierViewall">H&#46; Virgen de los Lirios&#46; Alcoy&#46; Alicante&#58; M&#170; Jos&#233; Esteban Giner&#46;</p> <p id="par0540" class="elsevierStylePara elsevierViewall">H&#46; Doctor Jos&#233; Molina Orosa&#46; Arrecife&#46; Lanzarote&#58; Virginia Herrero Garc&#237;a&#44; Berta Rom&#225;n Bernal&#46;</p> <p id="par0545" class="elsevierStylePara elsevierViewall">H&#46; Nuestra Se&#241;ora de Sonsoles&#46; &#193;vila&#58; Alaaeldeen Abdelhady Kishta&#46;</p> <p id="par0550" class="elsevierStylePara elsevierViewall">H&#46; G&#46; U&#46; de Elda&#46; Elda&#58; Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0555" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Puerta del Mar&#46; C&#225;diz&#58; Jos&#233; Antonio Gir&#243;n Gonz&#225;lez&#44; Susana Fabiola Pascual P&#233;rez&#44; Cristina Rodr&#237;guez Fern&#225;ndez-Viagas&#44; Mar&#237;a Jos&#233; Soto C&#225;rdenas&#46;</p> <p id="par0560" class="elsevierStylePara elsevierViewall">H&#46; Parc Tauli&#46; Sabadell&#58; Francisco Epelde&#44; Isabel Torrente&#46;</p> <p id="par0565" class="elsevierStylePara elsevierViewall">H&#46; de Montilla&#46; Montilla&#58; Ana Cristina Delgado Zamorano&#44; Beatriz G&#243;mez Mar&#237;n&#44; Adri&#225;n Monta&#241;o Mart&#237;nez&#44; Jos&#233; Luis Zambrana Garc&#237;a&#46;</p> <p id="par0570" class="elsevierStylePara elsevierViewall">H&#46; Infanta Elena&#46; Huelva&#58; Mar&#237;a Gloria Rojano Rivero&#46;</p> <p id="par0575" class="elsevierStylePara elsevierViewall">H&#46; de la Axarqu&#237;a&#46; V&#233;lez- M&#225;laga&#58; Antonio L&#243;pez Ruiz&#46;</p> <p id="par0580" class="elsevierStylePara elsevierViewall">H&#46; Virgen del Mar&#46; Madrid&#58; Thamar Capel Astrua&#44; Paola Tatiana Garc&#237;a Giraldo&#44; Mar&#237;a Jes&#250;s Gonz&#225;lez Ju&#225;rez&#44; Victoria M&#225;rquez Fern&#225;ndez&#44; Ada Viviana Romero Echevarry&#46;</p> <p id="par0585" class="elsevierStylePara elsevierViewall">Hospital do Salnes&#46; Vilagarc&#237;a de Arousa&#58; Vanesa Alende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Mar&#237;a Rodr&#237;guez Ferreira&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0590" class="elsevierStylePara elsevierViewall">H&#46; La Fuenfr&#237;a&#46; Cercedilla&#46; Madrid&#58; Daniel Arregui Gallego&#44; Jorge Blanco Briones&#44; Gonzalo M Muzquiz Rueda&#44; Isabel Rodr&#237;guez Fraile&#44; Javier Rodr&#237;guez Hern&#225;ndez&#44; Mar&#237;a &#193;ngeles Ruiz Rodr&#237;guez&#44; Mikaela Zubillaga G&#243;mez&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Members of the SEMI-COVID-19 Registry"
            "identificador" => "sec0060"
          ]
        ]
      ]
    ]
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1514
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            "identificador" => "at0005"
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            "rol" => "short"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow diagram of the study&#46;</p>"
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        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The categorical and continuous variables were expressed as absolute values and percentages and as medians &#40;ranges&#41;&#44; respectively&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">BPM&#58; beats per minute&#59; COPD&#58; chronic obstructive pulmonary disease&#59; COVID-19&#58; disease caused by coronavirus-2019&#59; CRP&#58; C-reactive protein&#59; DM&#58; diabetes mellitus&#59; HF&#58; heart failure&#59; HR&#58; heart rate&#59; LDH&#58; lactate dehydrogenase&#59; RR&#58; respiratory rate &#40;breaths per minute&#41;&#59; SatO<span class="elsevierStyleInf">2</span>&#58; baseline oxygen saturation&#59; SBP&#58; systolic blood pressure&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total &#40;n&#160;&#61;&#160;1&#44;718&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Deceased &#40;n&#160;&#61;&#160;819&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Not deceased &#40;n&#160;&#61;&#160;899&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#46;4 &#40;22&#8211;102&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;6 &#40;26&#8211;102&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;4 &#40;26&#46;5&#8211;101&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Male sex</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">971 &#40;56&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">489 &#40;59&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">482 &#40;53&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Charlson Index &#62;&#160;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;11&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;6&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Barthel Index &#8804;&#160;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">648 &#40;37&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">380 &#40;46&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">268 &#40;29&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tobacco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;4&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;6&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DM without organ damage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">313 &#40;18&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">147 &#40;17&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">166 &#40;18&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DM with organ damage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">261 &#40;15&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;18&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arterial hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1350 &#40;78&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">670 &#40;81&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">680 &#40;75&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyslipidaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">453 &#40;55&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">476 &#40;53&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">269 &#40;15&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;17&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;14&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coronary artery disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">312 &#40;18&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157 &#40;19&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;17&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atrial fibrillation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">709 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">357 &#40;43&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">352 &#40;39&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;065&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1167 &#40;67&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">526 &#40;64&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">641 &#40;71&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Solid neoplasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">158 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;10&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;8&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderate-severe chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">296 &#40;17&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">169 &#40;20&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;14&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Liver disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;2&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;2&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;2&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;648&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">435 &#40;25&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">190 &#40;23&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">245 &#40;27&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Physical examination</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HR &#40;bpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#40;34&#8211;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;34&#8211;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;34&#8211;170&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tachypnoea &#40;&#62;&#160;20 RR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">785 &#40;45&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">459 &#40;51&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">326 &#40;36&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SatO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;53&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;54&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">128 &#40;50&#8211;225&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bilateral pulmonary consolidation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">515 &#40;29&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">297 &#40;36&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">218 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP &#40;mg&#47; L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;5 &#40;0&#8211;950&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;0&#46;4&#8211;950&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">55&#46;1 &#40;0&#8211;597&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D-dimer &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">946 &#40;21&#8211;489&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1205 &#40;21&#8211;489&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">801 &#40;1618&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LDH &#40;U&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">390 &#40;92&#8211;5209&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">316 &#40;18&#8211;1735&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Leukocytes &#40;x10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6860 &#40;324&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">7500 &#40;1618&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">6400 &#40;324&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lymphocytes &#40;x10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">850 &#40;0&#8211;75&#44;500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">768 &#40;0&#8211;57&#44;830&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">910 &#40;49&#8211;75&#44;500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Urea &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;5 &#40;10&#8211;369&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;10&#8211;364&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;18 &#40;0&#46;2&#8211;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;35 &#40;0&#46;33&#8211;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;02 &#40;0&#46;27&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactate &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;8 &#40;0&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;9 &#40;0&#46;1&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7 &#40;0&#46;1&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Deceased &#40;n&#160;&#61;&#160;819&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Not deceased &#40;n&#160;&#61;&#160;899&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Antimicrobial treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lopinavir-ritonavir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">776 &#40;45&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">348 &#40;42&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">428 &#40;47&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Remdesivir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;1&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hydroxychloroquine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1327 &#40;77&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">577 &#40;70&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">750 &#40;83&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Immunomodulators</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tocilizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;7&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;8&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Immunoglobulins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;0&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;689&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baricitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;0&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Glucocorticoids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">764 &#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">389 &#40;47&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;41&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Anticoagulant therapy</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LMWH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1358 &#40;79&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;46&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">731&#40;53&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ventilation support</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>High-flow nasal cannula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;10&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;14&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;7&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NIMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139 &#40;8&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92 &#40;11&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;5&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141 &#40;8&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;10&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;6&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pronation therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Original article
Clinical characteristics and risk factors for mortality upon admission in patients with heart failure hospitalized due to COVID-19 in Spain
Características clínicas y factores de riesgo de mortalidad al ingreso en pacientes con insuficiencia cardíaca hospitalizados por COVID-19 en España
A. Salinas-Botrána,
Corresponding author
asalinasbotran@yahoo.es

Corresponding authors.
, J. Sanz-Cánovasb, J. Pérez-Somarribaa, L.M. Pérez-Belmonteb,
Corresponding author
luismiguelpb1984@gmail.com

Corresponding authors.
, L. Cobos-Palaciosb, M. Rubio-Rivasc, S. de-Cossío-Tejidod, J.M. Ramos-Rincóne, M. Méndez-Bailóna,1, R. Gómez-Huelgasb,1, on behalf of the SEMI-COVID-19 group 2
a Servicio de Medicina Interna, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain
b Servicio de Medicina Interna, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga (UMA), Málaga, Spain
c Servicio de Medicina Interna, Hospital Universitario Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
d Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain
e Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Alicante, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The coronavirus-2019 disease &#40;COVID-19&#41;&#44; caused by SARS-CoV-2&#44; is associated with elevated morbidity and mortality<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Since the onset of the pandemic&#44; cardiovascular disease has been identified as a risk factor for COVID-19&#44; with cardiovascular complications being common over the course of the disease<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Spain is one of the countries with the highest number of patients with SARS-CoV-2 in the world&#46; The first case of COVID-19 infection was confirmed on 31 January 2020&#44; with 2&#44;670&#44;102 confirmed cases as of 27 January 2021<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Heart failure &#40;HF&#41; in Spain represents 3&#37; of hospital admissions and is the number one cause of hospitalisation in patients over the age of 65<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; The aging population and healthcare advancements are the main factors associated with this growing increase in admissions due to HF<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">To date&#44; few studies have been published regarding mortality in patients with HF and COVID-19 infection&#46; &#193;lvarez-Garc&#237;a et al&#46; found that patients with a history of HF show a significant increase in mortality and need for invasive mechanical ventilation associated with COVID-19 infection&#44; regardless of their ventricular ejection fraction<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46; Rey et al&#46; concluded that patients infected with COVID-19 are at higher risk of developing HF during hospital admission&#44; with high mortality rates<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the significant impact of both diseases independent of one another and their potential feedback when combined&#44; the main aim of this study is to describe the clinical characteristics of patients with a history of HF and&#47;or new-onset HF who are admitted for COVID-19&#44; and to identify risk factors at admission for in-hospital mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Study design</span><p id="par0025" class="elsevierStylePara elsevierViewall">An observational&#44; retrospective&#44; multicentre national study was conducted with patients hospitalised due to COVID-19 from 01 March to 01 October 2020&#46; The data was obtained from the SEMI-COVID-19 Registry from the Spanish Society for Internal Medicine &#40;SEMI&#41;&#46; A total of 150 Spanish hospitals participated in the registry<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; The SEMI-COVID-19 Registry includes consecutive patients over the age of 18 with COVID-19 disease microbiologically confirmed via reverse transcription polymerase chain reaction testing &#40;RT-PCR&#41; obtained via nasal swab&#44; saliva sample&#44; or bronchoalveolar lavage<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">For this study&#44; we selected those patients with a history of HF and&#47;or that had suffered from HF as a complication during hospital admission due to COVID-19&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Variables</span><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical&#44; epidemiological&#44; radiological&#44; and therapeutic variables were analysed as well as mortality during admission or early readmission&#44; defined as a new episode of hospital admission within 30 days post-discharge&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The researchers collected the data from the SEMI-COVID-19 Registry database<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diagnosis of HF was determined according to the clinical congestion criteria &#40;dyspnoea&#44; oedema&#44; and increased jugular venous pressure&#41; in the medical history&#46; The comorbidity burden of patients was established with the Age-Adjusted Charlson Comorbidity Index<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The Barthel Index was used to establish functional condition prior to hospital admission<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> &#40;independent or slight dependency&#58; 100-91&#59; moderate dependency&#58; 90-61&#59; severe dependency&#58; &#8804;60&#41;&#46; Patients were considered to have arterial hypertension&#44; diabetes mellitus&#44; or dyslipidaemia if they had a prior diagnosis in their medical history or were receiving medical treatment for these diseases&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Diabetes mellitus was classified according to 2 subgroups&#58; with target organ damage &#40;brain&#44; heart&#44; kidney&#44; or retinal involvement&#41; or without target organ damage&#46; Chronic lung disease was defined as a prior diagnosis of chronic obstructive pulmonary disease and&#47;or asthma&#46; Arteriosclerotic cardiovascular disease was defined as a prior history of ischaemic heart disease &#40;acute myocardial infarction&#44; acute coronary syndrome&#44; angina&#44; or coronary revascularization&#41;&#46; Neoplastic disease included all non-metastatic solid tumours &#40;excluding non-melanoma skin tumours&#41;&#46; Moderate-severe kidney disease was defined as glomerular filtration&#160;&#60;&#160;45&#160;mL&#47;min&#47;1&#46;73&#160;m<span class="elsevierStyleSup">2</span> according to the CKD-EPI equation<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a>&#46; Moderate-severe liver disease was defined as class B or C according to the Child-Pugh score<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#46; Obesity was considered a body mass index&#160;&#8805;&#160;30&#160;kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Comorbidities were recorded from the medical histories from each hospital&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The laboratory data &#40;hemogram&#44; biochemical profile&#44; blood gas&#44; coagulation tests&#41; and imaging tests were collected at admission&#46; Treatments used were classified as&#58; &#40;1&#41; antimicrobial therapy &#40;hydroxychloroquine&#44; lopinavir&#47;ritonavir or remdesivir&#41;&#59; &#40;2&#41; immunomodulatory therapy &#40;systemic glucocorticoids&#44; immunoglobulins&#44; baricitinib or tocilizumab&#41;&#59; &#40;3&#41; anticoagulant therapy &#40;low molecular weight heparin&#41;&#59; &#40;4&#41; ventilator support &#40;high flow nasal cannula&#44; invasive and non-invasive mechanical ventilation&#41;&#44; and &#40;5&#41; pronation therapy&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In-hospital complications included&#58; admission to the intensive care unit &#40;ICU&#41; and presence of acute respiratory distress syndrome &#40;ARDS&#41;&#44; acute coronary syndrome&#44; acute HF&#44; arrhythmia&#44; shock&#44; sepsis&#44; acute kidney failure&#44; venous thromboembolism&#44; or acute arterial ischaemia&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Patients were classified according to the categorical variable of mortality as deceased or not deceased&#46; The categorical and continuous variables were expressed as absolute values and percentages and as medians &#40;ranges&#41;&#44; respectively&#46; The differences between groups were analysed using Student&#8217;s <span class="elsevierStyleItalic">t</span>-test or the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test for continuous variables or Pearson&#39;s chi-squared test for categorical variables&#46; A <span class="elsevierStyleItalic">p</span>-value &#60;&#46;05 was considered statistically significant&#59; subsequently&#44; a multivariate analysis was performed expressed as an adjusted odds ratio &#40;AOR&#41;&#44; with a 95&#37; confidence interval &#40;95&#37; CI&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">A logistic regression analysis was used to identify independent factors at admission for in-hospital mortality&#44; including variables with statistical significance in the bivariate analysis and with a percentage of missing data of less than 20&#37;&#46; The statistical analysis was conducted with SPSS software version 26&#46;0 &#40;IBM SPSS Statistics&#169;&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethical aspects</span><p id="par0080" class="elsevierStylePara elsevierViewall">All the patients gave their informed consent&#46; This study was conducted according to the Declaration of Helsinki and was approved by the M&#225;laga Ethics Committee &#40;Code&#58; SEMI-COVID-19 27-03-20&#41;&#46; The STROBE initiative for the publication of observational studies was followed &#40;available at <a href="http://www.strobe-statement.org">www&#46;strobe-statement&#46;org</a>&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">Of the 16&#44;461 patients included in the SEMI-COVID-19 Registry&#44; 1740 had documented history of HF and&#47;or had suffered from HF as a complication during hospital admission due to COVID-19<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a>&#46; A total of 22 patients were excluded due to a lack of basic data for correct demographics&#44; meaning the final analysis was conducted with 1718 patients &#40;10&#46;4&#37;&#41;&#46; Of these&#44; 819 &#40;47&#46;6&#37;&#41; died during admission &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">The clinical characteristics and laboratory data for the patients classified as deceased and not deceased are included in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The patients who died were significantly older&#44; were male&#44; and had higher comorbidity and dependency&#46; In addition&#44; there was a higher proportion of diabetics with target organ damage&#44; arterial hypertension&#44; and moderate-severe kidney failure among the deceased&#46; Other conditions that were also more frequent in the deceased patients were high heart rate&#44; presence of tachypnoea&#44; low oxygen saturation&#44; and the present of bilateral pulmonary consolidation at admission&#46; Likewise&#44; high mortality was associated with higher blood levels of c-reactive protein &#40;CRP&#41;&#44; D-dimer&#44; lactate dehydrogenase &#40;LDH&#41;&#44; urea&#44; creatinine and lactate&#44; and a lower number of lymphocytes at admission&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">A total of 1167 patients &#40;67&#46;9&#37;&#41; had a history of chronic HF prior to admission&#44; and 526 of those died &#40;45&#37;&#41;&#46; Mortality was higher for patients who experienced acute HF complications during admission than for those with a history of chronic HF prior to admission &#40;53&#37; vs&#46; 45&#37;&#44; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;05&#41;&#46; The data for treatment and in-hospital complications can be seen in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Following the logistic regression analysis&#44; the risk factors at admission associated with higher in-hospital mortality were&#58; age &#40;&#62;80 years&#41;&#44; severe dependency class&#44; tachycardia &#40;&#62;100 beats per minute&#41;&#44; and elevated levels of CRP&#44; LDH&#44; and serum creatinine &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">Heart failure represents one of the main reasons for hospitalisation in our environment<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a>&#46; In recent years&#44; the mortality rate for HF in Spain has been trending downwards thanks to the incorporation of different treatments that have shown significant benefits<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; the high level of adherence to guidelines by health professionals<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#44; and the change of components of disease decompensation such as ischaemic heart disease&#44; which has also been decreasing in recent years<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In a recent study&#44; Bromage et al&#46; showed a clear increase in the mortality of patients admitted for HF and COVID-19&#44; though it is unknown whether this is due to true mortality or due to a selection of critical patients who were admitted during the pandemic<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Our study has shown that the presence of HF&#44; both in patients with a prior history and those who developed it as a complication during admission&#44; is associated with high hospital mortality rates close to 50&#37;&#46; In addition&#44; it makes clear that patients who experienced decompensation due to acute HF while admitted died at a higher rate than patients with a history of HF prior to admission&#44; with the former affecting mortality more than the latter&#46; This reflects the impact of COVID-19 on developing acute HF&#46; These percentages represent a significant increase compared to the mortality described in previous studies of patients hospitalised with HF&#44; which range from 9&#46;5&#37; to 11&#37;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The most frequent causes of death in patients with a history of HF have been described as decompensated HF&#44; sudden death&#44; and non-cardiovascular causes<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; At the present moment&#44; as our study suggests&#44; SARS-CoV-2 is the primary cause of death in hospitalised HF patients&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Older age&#44; elevated comorbidity burden&#44; and degree of dependency are characteristic elements of patients with HF hospitalised due to COVID-19 in our country&#46; This clinical profile&#44; with figures close to 80&#37; for arterial hypertension&#44; 40&#37; for atrial fibrillation&#44; 20&#37; for diabetes mellitus&#44; 17&#37; for moderate-severe chronic kidney disease&#44; 25&#37; for obesity&#44; and 38&#37; for severe functional dependency&#44; represents a continuation of previous studies performed in our setting which have reported similar figures for these HF-related pathologies<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a>&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The patients with HF hospitalised due to COVID-19 from our study presented a large number of complications&#46; The most frequent complication was ARDS&#44; which exposes the inflammatory process that occurs in this patient profile induced by SARS-CoV-2&#46; The severe inflammatory response triggered in COVID-19 has been described in previous studies&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Old age and chronic conditions are just some of the various clinical conditioning factors that could favour its development and predispose patients to the onset of complications and adverse events<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a>&#46; In this sense&#44; in our study we identified factors at admission that have been associated as risk factors for mortality in patients with HF hospitalised due to COVID-19&#46; Old age has been determined to be one of the main factors associated with higher mortality due to COVID-19<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a>&#44; and we confirmed this in our population with HF&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">On the other hand&#44; the importance of assessing clinical condition at the time of admission is worth mentioning&#46; Patients who present in critical condition will have a significantly worse prognosis than those presenting with these characteristics&#44; with the former requiring stricter monitoring and follow-up&#46; Other studies have also stressed this issue and its severity in COVID-19 illness<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">In addition&#44; the presence of certain altered biological markers in patients with HF can be aggravated by COVID-19 infection&#46; In this way&#44; kidney failure and high CRP and LDH levels were significantly associated with an increase in mortality&#46; However&#44; other markers of poor prognosis in COVID-19&#44; such as lymphopenia or elevated D-dimer levels<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a>&#44; were not related to higher mortality in our population of patients with HF&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In any case&#44; though the variables of heart rate and elevated LDH and CRP have been statistically associated with mortality&#44; we must bear in mind that the association of these factors has been less important from the clinical perspective than other variables such as dependency or age&#46; All of these factors&#44; which are easily identifiable when patients are being admitted to hospital&#44; define a patient profile that requires special care due to the high risk of complications and death that they entail&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">This study presents important data regarding the clinical profile of a large number of patients with HF hospitalised due to COVID-19 and identifies at admission diverse clinical and analytical factors that are associated with mortality&#46; Though it is the first study with these characteristics in our country and one of few around the world&#44; it does have some limitations&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">First&#44; as an observational and retrospective study focusing on hospitalised patients&#44; we analysed patients with more critical clinical situations&#44; which could limit the results of the patient profile and not allow it to be extrapolated to the rest of the population of patients with HF&#46; In addition&#44; despite conducting a multivariate regression analysis&#44; the possibility of unmeasured confounding variables cannot be ruled out&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">On the other hand&#44; the data were collected by a large number of researchers from hospitals with different levels of care&#44; which entails a great degree of heterogeneity in its processing&#46; It is also worth noting that&#44; despite the large number of variables included in this registry&#44; we are lacking important data about the characterisation of HF such as aetiology&#44; the New York Heart Association functional class&#44; the left ventricular ejection fraction&#44; the level of natriuretic peptides&#44; and the proportion of patients receiving other treatments such as beta blockers&#44; neprilysin receptor antagonists&#44; aldosterone antagonists&#44; or diuretics&#46; Lastly&#44; nor does the provided information include data on the degree of compliance or the duration of the treatments prior to admission&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">In terms of the strength of our study&#44; the large number of patients with HF included in our series is worthy of mention&#44; as it represented different centres from around the entire country&#44; offering a wide-reaching vision of this patient group&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conclusions</span><p id="par0175" class="elsevierStylePara elsevierViewall">This study shows that patients with HF hospitalised due to COVID-19 in Spain have a high rate of mortality&#46; Older age&#44; severe dependency class&#44; greater severity at initial presentation&#44; kidney function decline&#44; and elevated inflammatory blood parameters have been identified as predictors of mortality&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Given the impact of HF on COVID-19 and the involvement of various factors&#44; it is necessary to develop prognostic scales that are easy to implement for these patients&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">This research did not receive any specific funding from agencies from the public sector&#44; commercial sector&#44; or not-for-profit organisations&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">There are few studies on patients with heart failure &#40;HF&#41; hospitalized for COVID-19&#46; Our aim is to describe the clinical characteristics of patients with HF hospitalized for COVID-19 and identify risk factors for in-hospital mortality upon admission&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective&#44; multicenter study in patients with HF hospitalized for COVID-19 in 150 Spanish hospitals &#40;SEMI-COVID-19 Registry&#41;&#46; A multivariate logistic regression analysis was performed to identify admission factors associated with in-hospital mortality&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">A total of 1718 patients were analyzed &#40;56&#46;5&#37; men&#59; median age 81&#46;4 years&#41;&#46; The overall case fatality rate was 47&#46;6&#37; &#40;n&#160;&#61;&#160;819&#41;&#46; The independent risk factors at admission for in-hospital mortality were&#58; age &#40;adjusted odds ratio &#91;AOR&#93;&#58; 1&#46;03&#59; 95&#37; confidence interval &#91;95&#37;CI&#93;&#58; 1&#46;02&#8211;1&#46;05&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#59; severe dependence &#40;AOR&#58; 1&#46;62&#59; 95&#37;CI&#58; 1&#46;19&#8211;2&#46;20&#59; <span class="elsevierStyleItalic">p</span>&#160;&#61;&#160;0&#46;002&#41;&#59; tachycardia &#40;AOR&#58; 1&#46;01&#59; 95&#37;CI&#58; 1&#46;00&#8211;1&#46;01&#59; <span class="elsevierStyleItalic">p</span>&#160;&#61;&#160;0&#46;004&#41;&#59; and high C-reactive protein &#40;AOR&#58; 1&#46;004&#59; 95&#37;CI&#58;1&#46;002&#8722;1&#46;004&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#44; LDH &#40;AOR&#58; 1&#46;001&#59; 95&#37;CI&#58; 1&#46;001&#8722;1&#46;002&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#44; and serum creatinine levels &#40;AOR&#58; 1&#46;35&#59; 95&#37;CI&#58; 1&#46;18&#8722;1&#46;54&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;&#160;0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Patients with HF hospitalized for COVID-19 have a high in-hospital mortality rate&#46; Some simple clinical and laboratory tests can help to identify patients with a worse prognosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Existen pocos estudios sobre pacientes con insuficiencia card&#237;aca &#40;IC&#41; ingresados por COVID-19&#46; Nuestro objetivo es describir las caracter&#237;sticas cl&#237;nicas de los pacientes con IC ingresados por COVID-19 e identificar los factores de riesgo al ingreso de mortalidad intrahospitalaria&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo y multic&#233;ntrico de pacientes con IC ingresados por COVID-19 en 150 hospitales espa&#241;oles &#40;Registro SEMI-COVID-19&#41;&#46; Se realiz&#243; un an&#225;lisis de regresi&#243;n log&#237;stica para identificar los factores de riesgo al ingreso asociados a la mortalidad&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Se analizaron 1&#46;718 pacientes &#40;56&#44;5&#37; varones&#59; edad mediana 81&#44;4 a&#241;os&#41;&#46; La tasa de mortalidad global fue del 47&#44;6&#37; &#40;n&#160;&#61;&#160;819&#41;&#46; Los factores de riesgo independientes al ingreso para mortalidad fueron&#58; la edad &#40;odds ratio ajustado &#91;ORA&#93;&#58; 1&#44;03&#59; intervalo de confianza 95&#37; &#91;IC95&#37;&#93;&#58; 1&#44;02&#8211;1&#44;05&#59; p&#160;&#60;&#160;0&#44;001&#41;&#44; la dependencia severa &#40;ORA&#58; 1&#44;62&#59; IC95&#37;&#58; 1&#44;19&#8211;2&#44;20&#59; p&#160;&#61;&#160;0&#44;002&#41;&#44; la taquicardia &#40;ORA&#58; 1&#44;01&#59; IC95&#37;&#58; 1&#44;00&#8211;1&#44;01&#59; p&#160;&#61;&#160;0&#44;004&#41;&#44; la prote&#237;na C reactiva &#40;ORA&#58; 1&#44;004&#59; IC95&#37;&#58;1&#44;002&#8211;1&#44;004&#59; p&#160;&#60;&#160;0&#44;001&#41;&#44; la LDH &#40;ORA&#58; 1&#44;001&#59; IC95&#37;&#58; 1&#44;001&#8211;1&#44;002&#59; p&#160;&#60;&#160;0&#44;001&#41; y la creatinina s&#233;rica &#40;ORA&#58; 1&#44;35&#59; IC95&#37;&#58; 1&#44;18&#8211;1&#44;54&#59; p&#160;&#60;&#160;0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con IC hospitalizados por COVID-19 tienen una alta mortalidad intrahospitalaria&#46; Existen factores cl&#237;nico-anal&#237;ticos simples que pueden ayudar a identificar a los pacientes con peor pron&#243;stico&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:3 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Salinas-Botr&#225;n A&#44; Sanz-C&#225;novas J&#44; P&#233;rez-Somarriba J&#44; P&#233;rez-Belmonte LM&#44; Cobos-Palacios L&#44; Rubio-Rivas M&#44; et al&#46; Caracter&#237;sticas cl&#237;nicas y factores de riesgo de mortalidad al ingreso en pacientes con insuficiencia card&#237;aca hospitalizados por COVID-19 en Espa&#241;a&#46; Rev Clin Esp&#46; 2022&#59;222&#58;255&#8211;265&#46;</p>"
      ]
      1 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Doctors M&#233;ndez-Bail&#243;n and G&#243;mez-Huelgas share the final authorship&#46;</p>"
        "identificador" => "fn0005"
      ]
      2 => array:3 [
        "etiqueta" => "2"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">The complete list of members of the SEMI-COVID-19 group is listed in the Appendix <a class="elsevierStyleCrossRef" href="#sec0060">A</a>&#46;</p>"
        "identificador" => "fn0010"
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Coordinator of the SEMI-COVID-19 Registry&#58;</span> Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Members of the SEMI-COVID-19 Registry Scientific Committee&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez-Huelgas&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Members of the SEMI-COVID-19 Group&#58;</span></p> <p id="par0215" class="elsevierStylePara elsevierViewall">H&#46; U&#46; 12 de Octubre&#46; Madrid&#58; Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Lucia Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Barbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0220" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#46; Madrid&#58; Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Crhistian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Antunez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o Miguez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0225" class="elsevierStylePara elsevierViewall">Hospital Universitari de Bellvitge&#46; L&#39;Hospitalet de Llobregat&#46; Barcelona&#58; Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio Rivas&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Paz-Cantoblanco-Carlos III&#46; Madrid&#58; Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0235" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Albacete&#46; Albacete&#58; Jos&#233; Luis Beato P&#233;rez&#44; Mar&#237;a Lourdes S&#225;ez M&#233;ndez&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall">Complejo Asistencial de Segovia&#46; Segovia&#58; Eva Mar&#237;a Ferreira Pasos&#44; Daniel Monge Monge&#44; Alba Varela Garc&#237;a&#46;</p> <p id="par0245" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Puerta de Hierro&#46; Majadahonda&#46; Madrid&#58; Mar&#237;a &#193;lvarez Bello&#44; Ane Andr&#233;s Eisenhofer&#44; Ana Arias Milla&#44; Isolina Ba&#241;os P&#233;rez&#44; Javier Bilbao Garay&#44; Silvia Blanco Alonso&#44; Jorge Calder&#243;n Parra&#44; Alejandro Callejas D&#237;az&#44; Jos&#233; Mar&#237;a Camino Salvador&#44; M&#170; Cruz Carre&#241;o Hern&#225;ndez&#44; Valent&#237;n Cuervas-Mons Mart&#237;nez&#44; Sara de la Fuente Moral&#44; Miguel del Pino Jim&#233;nez&#44; Alberto D&#237;az de Santiago&#44; Itziar Diego Yag&#252;e&#44; Ignacio Donate Velasco&#44; Ana Mar&#237;a Duca&#44; Pedro Dur&#225;n del Campo&#44; Gabriela Escudero L&#243;pez&#44; Esther Exp&#243;sito Palomo&#44; Ana Fern&#225;ndez Cruz&#44; Esther Fiz Benito&#44; Andrea Fraile L&#243;pez&#44; Amy Gal&#225;n G&#243;mez&#44; Sonia Garc&#237;a Prieto&#44; Claudia Garc&#237;a Rodr&#237;guez-Maim&#243;n&#44; Miguel &#193;ngel Garc&#237;a Viejo&#44; Javier G&#243;mez Irusta&#44; Edith Vanessa Guti&#233;rrez Abreu&#44; Isabel Guti&#233;rrez Mart&#237;n&#44; &#193;ngela Guti&#233;rrez Rojas&#44; Andrea Guti&#233;rrez Villanueva&#44; Jes&#250;s Herr&#225;iz Jim&#233;nez&#44; Pedro Laguna del Estal&#44; M&#170; Carmen M&#225;inez S&#225;iz&#44; Cristina Mart&#237;n Mart&#237;n&#44; Mar&#237;a Mart&#237;nez Urbistondo&#44; Fernando Mart&#237;nez Vera&#44; Susana Mellor Pita&#44; Patricia Mills S&#225;nchez&#44; Esther Montero Hern&#225;ndez&#44; Alberto Mora Vargas&#44; Cristina Moreno L&#243;pez&#44; Alfonso &#193;ngel-Moreno Maroto&#44; V&#237;ctor Moreno-Torres Concha&#44; Ignacio Morr&#225;s De La Torre&#44; Elena M&#250;&#241;ez Rubio&#44; Ana Mu&#241;oz G&#243;mez&#44; Rosa Mu&#241;oz de Benito&#44; Alejandro Mu&#241;oz Serrano&#44; Jos&#233; Mar&#237;a Palau Fay&#243;s&#44; Ilduara Pintos Pascual&#44; Antonio Ramos Mart&#237;nez&#44; Isabel Redondo C&#225;novas del Castillo&#44; Alberto Rold&#225;n Montaud&#44; Luc&#237;a Romero Imaz&#44; Yolanda Romero Pizarro&#44; M&#243;nica S&#225;nchez Santiuste&#44; David S&#225;nchez Ortiz&#44; Enrique S&#225;nchez Chica&#44; Patricia Serrano de la Fuente&#44; Pablo Tutor de Ureta&#44; &#193;ngela Valencia Alijo&#44; Mercedes Valent&#237;n-Pastrana Aguilar&#44; Juan Antonio Vargas N&#250;&#241;ez&#44; Jos&#233; Manuel V&#225;zquez Comendador&#44; Gema V&#225;zquez Contreras&#44; Carmen Vizoso G&#225;lvez&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall">H&#46; Miguel Servet&#46; Zaragoza&#58; Gonzalo Acebes Repiso&#44; Uxua As&#237;n Samper&#44; Mar&#237;a Aranzazu Caudevilla Mart&#237;nez&#44; Jos&#233; Miguel Garc&#237;a Bru&#241;&#233;n&#44; Rosa Garc&#237;a Fenoll&#44; Jes&#250;s Javier Gonz&#225;lez Igual&#44; Laura Letona Gim&#233;nez&#44; M&#243;nica Llorente Barrio&#44; Luis S&#225;ez Comet&#46;</p> <p id="par0255" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Princesa&#46; Madrid&#58; Mar&#237;a Aguilera Garc&#237;a&#44; Ester Alonso Monge&#44; Jes&#250;s &#193;lvarez Rodr&#237;guez&#44; Claudia &#193;lvarez Varela&#44; Miquel Berniz G&#242;dia&#44; Marta Briega Molina&#44; Marta Bustamante Vega&#44; Jos&#233; Curbelo&#44; Alicia de las Heras Moreno&#44; Ignacio Descalzo Godoy&#44; Alexia Constanza Espi&#241;o &#193;lvarez&#44; Ignacio Fern&#225;ndez Mart&#237;n-Caro&#44; Alejandra Franquet L&#243;pez-Mosteiro&#44; Gonzalo G&#225;lvez M&#225;rquez&#44; Mar&#237;a J&#46; Garc&#237;a Blanco&#44; Yaiza Garc&#237;a del &#193;lamo Hern&#225;ndez&#44; Clara Garc&#237;a-Rayo Encina&#44; Noem&#237; Gilabert Gonz&#225;lez&#44; Carolina Guillamo Rodr&#237;guez&#44; Nicol&#225;s Labrador San Mart&#237;n&#44; Manuel Molina B&#225;ez&#44; Carmen Mu&#241;oz Delgado&#44; Pedro Parra Caballero&#44; Javier P&#233;rez Serrano&#44; Laura Rabes Rodr&#237;guez&#44; Pablo Rodr&#237;guez Cort&#233;s&#44; Carlos Rodr&#237;guez Franco&#44; Emilia Roy-Vallejo&#44; M&#243;nica Rueda Vega&#44; Aresio Sancha Lloret&#44; Beatriz S&#225;nchez Moreno&#44; Marta Sanz Alba&#44; Jorge Serrano Ballester&#44; Alba Somovilla&#44; Carmen Suarez Fern&#225;ndez&#44; Macarena Vargas Tirado&#44; Almudena Villa Mart&#237;&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall">H&#46; U&#46; de A Coru&#241;a&#46; A Coru&#241;a&#58; Alicia Alonso &#193;lvarez&#44; Olaya Alonso Juarros&#44; Ariadna Ar&#233;valo L&#243;pez&#44; Carmen Casariego Casti&#241;eira&#44; Ana Cerezales Calvi&#241;o&#44; Marta Contreras S&#225;nchez&#44; Ram&#243;n Fern&#225;ndez Varela&#44; Santiago J&#46; Freire Castro&#44; Ana Pad&#237;n Trigo&#44; Rafael Prieto Jarel&#44; F&#225;tima Raad Varea&#44; Laura Ramos Alonso&#44; Francisco Javier Sanmart&#237;n Pensado&#44; David Vieito Porto&#46;</p> <p id="par0265" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nico San Carlos&#46; Madrid&#58; In&#233;s Armenteros Yeguas&#44; Javier Aza&#241;a G&#243;mez&#44; Julia Barrado Cuchillo&#44; Irene Burruezo L&#243;pez&#44; Noem&#237; Cabello Clotet&#44; Alberto E&#46; Calvo El&#237;as&#44; Elpidio Calvo Manuel&#44; Carmen Mar&#237;a Cano de Luque&#44; Cynthia Chocron Benbunan&#44; Laura Dans Vil&#225;n&#44; Ester Emilia Dubon Peralta&#44; Vicente Estrada P&#233;rez&#44; Santiago Fernandez-Castelao&#44; Marcos Oliver Fragiel Saavedra&#44; Jos&#233; Luis Garc&#237;a Klepzig&#44; Mar&#237;a del Rosario Iguar&#225;n Berm&#250;dez&#44; Esther Ja&#233;n Ferrer&#44; Rub&#233;n &#193;ngel Mart&#237;n S&#225;nchez&#44; Manuel M&#233;ndez Bail&#243;n&#44; Mar&#237;a Jos&#233; N&#250;&#241;ez Orantos&#44; Carolina Olmos Mata&#44; Eva Orviz Garc&#237;a&#44; David Oteo Mata&#44; Cristina Outon Gonz&#225;lez&#44; Juncal P&#233;rez-Somarriba&#44; Pablo P&#233;rez Mateos&#44; Mar&#237;a Esther Ramos Mu&#241;oz&#44; Xabier Rivas Regaira&#44; I&#241;igo Sagastagoitia Fornie&#44; Alejandro Salinas Botr&#225;n&#44; Miguel Su&#225;rez Robles&#44; Maddalena Elena Urbano&#44; Miguel Villar Mart&#237;nez&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall">H&#46; Infanta Sof&#237;a&#46; S&#46; S&#46; de los Reyes&#46; Madrid&#58; Rafael del Castillo Cantero&#44; Rebeca Fuerte Mart&#237;nez&#44; Arturo Mu&#241;oz Blanco&#44; Jos&#233; Francisco Pascual Pareja&#44; Isabel Perales Fraile&#44; Isabel R&#225;bago Lorite&#44; Llanos Soler Rangel&#44; In&#233;s Su&#225;rez Garc&#237;a&#44; Jos&#233; Luis Valle L&#243;pez&#46;</p> <p id="par0275" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Dr&#46; Peset&#46; Valencia&#58; Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabet Mateo Sanchis&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nico de Santiago&#46; Santiago de Compostela&#58; Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel P&#225;ez Guill&#225;n&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0285" class="elsevierStylePara elsevierViewall">H&#46; Nuestra Se&#241;ora del Prado&#46; Talavera de la Reina&#46; Toledo&#58; Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Ram&#243;n y Cajal&#46; Madrid&#58; Luis Fernando Abrego Vaca&#44; Ana Andr&#233;u Arnanz&#44; Octavio Arce Garc&#237;a&#44; Marta Bajo Gonz&#225;lez&#44; Pablo Borque Sanz&#44; Alberto Cozar Llisto&#44; Sonia de Pedro Baena&#44; Beatriz Del Hoyo Cuenda&#44; Mar&#237;a Alejandra Gamboa Osorio&#44; Isabel Garc&#237;a S&#225;nchez&#44; Andr&#233;s Gonz&#225;lez Garc&#237;a&#44; Oscar Alberto L&#243;pez Cisneros&#44; Miguel Mart&#237;nez Lacalzada&#44; Borja Merino Ortiz&#44; Jimena Rey-Garc&#237;a&#44; Elisa Riera Gonz&#225;lez&#44; Cristina S&#225;nchez D&#237;az&#44; Grisell Starita Fajardo&#44; Cecilia Su&#225;rez Caranto&#241;a&#44; Adri&#225;n Viteri Noel&#44; Svetlana Zhilina Zhilina&#46;</p> <p id="par0295" class="elsevierStylePara elsevierViewall">H&#46; Royo Villanova&#46; Zaragoza&#58; Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Gerico Aseguinolaza&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Infanta Cristina&#46; Parla&#46; Madrid&#58; Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Coralia Bueno Mui&#241;o&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Francesco Deodati&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A Melero Bermejo&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0305" class="elsevierStylePara elsevierViewall">H&#46; de Cabue&#241;es&#46; Gij&#243;n&#46; Asturias&#58; Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall">H&#46; de Urduliz Alfredo Espinosa&#46; Urd&#250;liz&#46; Vizcaya&#58; Mar&#237;a Aparicio L&#243;pez&#44; Asier Aranguren Arostegui&#44; Paula Arriola Mart&#237;nez&#44; Gorka Arroita Gonz&#225;lez&#44; M&#170; Soledad Azcona Losada&#44; Miriam Garc&#237;a G&#243;mez&#44; Eduardo Garc&#237;a L&#243;pez&#44; Amalur Iza Jim&#233;nez&#44; Alazne Lartategi Iraurgi&#44; Esther Mart&#237;nez Becerro&#44; Itziar Ori&#241;uela Gonz&#225;lez&#44; Isabel Mar&#237;a Portales Fern&#225;ndez&#44; Pablo Ram&#237;rez S&#225;nchez&#44; Beatriz Ruiz Est&#233;vez&#44; Cristian Vidal N&#250;&#241;ez&#46;</p> <p id="par0315" class="elsevierStylePara elsevierViewall">H&#46; Regional Universitario de M&#225;laga&#46; M&#225;laga&#58; M&#170; Mar Ayala Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Mar&#237;a Dolores L&#243;pez Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Martin Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Araceli Pineda Cantero&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall">H&#46; Santa Marina&#46; Bilbao&#58; Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Elbire Labirua-Iturburu Ruiz&#46;</p> <p id="par0325" class="elsevierStylePara elsevierViewall">H&#46; Mois&#232;s Broggi&#46; Sant Joan Desp&#237;&#46; Barcelona&#58; Judit Aranda Lobo&#44; Jos&#233; Loureiro Amigo&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicolas Rhyman&#44; Nuria V&#225;zquez Piqueras&#46;</p> <p id="par0330" class="elsevierStylePara elsevierViewall">H&#46; HLA Moncloa&#46; Madrid&#58; Guillermo Estrada&#44; Teresa Garc&#237;a Delange&#44; Isabel Jim&#233;nez Mart&#237;nez&#44; Carmen Mart&#237;nez Cilleros&#44; Nuria Parra Arribas&#46;</p> <p id="par0335" class="elsevierStylePara elsevierViewall">H&#46; del Henares&#46; Coslada&#46; Madrid&#58; Jes&#250;s Ballano Rodr&#237;guez-Sol&#237;s&#44; Luis Cabeza Osorio&#44; Mar&#237;a del Pilar Fidalgo Montero&#44; M&#170; Isabel Fuentes Soriano&#44; Erika Esperanza Lozano Rinc&#243;n&#44; Ana Mart&#237;n Hermida&#44; Jes&#250;s Mart&#237;nez Carrilero&#44; Jos&#233; &#193;ngel Pesta&#241;a Santiago&#44; Manuel S&#225;nchez Robledo&#44; Patricia Sanz Rojas&#44; Nahum Jacobo Torres Yebes&#44; Vanessa Vento&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Torrevieja&#46; Torrevieja&#46; Alicante&#58; Julio C&#233;sar Bl&#225;zquez Encinar&#44; Joaqu&#237;n Fern&#225;ndez-Cuervo&#46;</p> <p id="par0345" class="elsevierStylePara elsevierViewall">H&#46; U&#46; La Fe&#46; Valencia&#58; Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall">H&#46; San Pedro&#46; Logro&#241;o&#58; Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Luis Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0355" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Ntra&#46; Sra&#46; Candelaria&#46; Santa Cruz de Tenerife&#58; Lucy Abella&#44; Andrea Afonso D&#237;az&#44; Selena Gala Aguilera Garc&#237;a&#44; Marta Bethencourt Feria&#44; Eduardo Mauricio Calder&#243;n Ledezma&#44; Sara Casta&#241;o P&#237;rez&#44; Guillermo Castro Gainett&#44; Jos&#233; Manuel del Arco Delgado&#44; Joaqu&#237;n Delgado Casamayor&#44; Diego Garc&#237;a Silvera&#44; Alba G&#243;mez Hidalgo&#44; Marcelino Hayek Peraza&#44; Carolina Hern&#225;ndez Carballo&#44; Rub&#233;n Hern&#225;ndez Luis&#44; Francisco Javier Herrera Herrera&#44; Mar&#237;a del Mar L&#243;pez G&#225;mez&#44; Julia Marfil Daza&#44; Mar&#237;a Jos&#233; Monedero Prieto&#44; Mar&#237;a Blanca Monereo Mu&#241;oz&#44; Mar&#237;a de la Luz Padilla Salazar&#44; Daniel Rodr&#237;guez D&#237;az&#44; Alicia Tejera&#44; Laura Torres Hern&#225;ndez&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall">H&#46; U&#46; San Juan de Alicante&#46; San Juan de Alicante&#58; David Balaz&#44; David Bonet Tur&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0365" class="elsevierStylePara elsevierViewall">H&#46; U&#46; San Agust&#237;n&#46; Avil&#233;s&#58; Andrea &#193;lvarez Garc&#237;a&#44; V&#237;ctor Arenas Garc&#237;a&#44; Alba Barrag&#225;n Mateos&#44; Demelsa Blanco Su&#225;rez&#44; Mar&#237;a Ca&#241;o Rubia&#44; Jaime Casal &#193;lvarez&#44; David Castrod&#225; Copa&#44; Jos&#233; Ferreiro Celeiro&#44; Natalia Garc&#237;a Arenas&#44; Raquel Garc&#237;a Noriega&#44; Joaqu&#237;n Llorente Garc&#237;a&#44; Irene Maderuelo Riesco&#44; Paula Mart&#237;nez Garc&#237;a&#44; Mar&#237;a Jos&#233; Men&#233;ndez Calder&#243;n&#44; Diego Eduardo Olivo Aguilar&#44; Marta Nataya Sol&#237;s Marqu&#237;nez&#44; Luis Trapiella Mart&#237;nez&#44; Andr&#233;s Astur Trece&#241;o Garc&#237;a&#44; Juan Vald&#233;s B&#233;cares&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall">H&#46; de Matar&#243;&#46; Matar&#243;&#58; Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0375" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Son Ll&#224;tzer&#46; Palma de Mallorca&#58; Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall">H&#46; Virgen de la Salud&#46; Toledo&#58; Ana Mar&#237;a Alguacil Mu&#241;oz&#44; Marta Blanco Fern&#225;ndez&#44; Ver&#243;nica Cano&#44; Ricardo Crespo Moreno&#44; Fernando Cuadra Garc&#237;a-Tenorio&#44; Blanca D&#237;az-Tendero N&#225;jera&#44; Raquel Est&#233;vez Gonz&#225;lez&#44; Mar&#237;a Paz Garc&#237;a Butenegro&#44; Alberto Gato D&#237;ez&#44; Ver&#243;nica G&#243;mez Caverzaschi&#44; Piedad Mar&#237;a G&#243;mez Pedraza&#44; Julio Gonz&#225;lez Moraleja&#44; Ra&#250;l Hidalgo Carvajal&#44; Patricia Jim&#233;nez Aranda&#44; Raquel Labra Gonz&#225;lez&#44; &#193;xel Legua Caparachini&#44; Pilar L&#243;pez Casta&#241;eyra&#44; Agust&#237;n Lozano Anc&#237;n&#44; Jos&#233; Domingo Mart&#237;n Garc&#237;a&#44; Cristina Morata Romero&#44; Mar&#237;a Jes&#250;s Moya Saiz&#44; Helena Moza Mor&#237;&#241;igo&#44; Gemma Mu&#241;iz Nicol&#225;s&#44; Enriqueta Mu&#241;oz Plat&#243;n&#44; Filomena Oliveri&#44; Elena Ortiz Ortiz&#44; Ra&#250;l Perea Rafael&#44; Pilar Redondo Gal&#225;n&#44; Mar&#237;a Antonia Sep&#250;lveda Berrocal&#44; Vicente Serrano Romero de &#193;vila&#44; Pilar Toledano Sierra&#44; Yamilex Urbano Aranda&#44; Jes&#250;s V&#225;zquez Clemente&#44; Carmen Yera Bergua&#46;</p> <p id="par0385" class="elsevierStylePara elsevierViewall">H&#46; Juan Ram&#243;n Jim&#233;nez&#46; Huelva&#58; Francisco Javier Bejarano Luque&#44; Francisco Javier Carrasco-S&#225;nchez&#44; Mercedes de Sousa Baena&#44; Jaime D&#237;az Leal&#44; Aurora Espinar Rubio&#44; Mar&#237;a Franco Huertas&#44; Juan Antonio Garc&#237;a Bravo&#44; Andr&#233;s Gonz&#225;lez Mac&#237;as&#44; Encarnaci&#243;n Guti&#233;rrez Jim&#233;nez&#44; Alicia Hidalgo Jim&#233;nez&#44; Constantino Lozano Quintero&#44; Carmen Mancilla Reguera&#44; Francisco Javier Mart&#237;nez Marcos&#44; Francisco Mu&#241;oz Beamud&#44; Mar&#237;a P&#233;rez Aguilera&#44; Alicia P&#233;rez Jim&#233;nez&#44; Virginia Rodr&#237;guez Casta&#241;o&#44; &#193;lvaro S&#225;nchez de Alc&#225;zar del R&#237;o&#44; Leire Toscano Ruiz&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Reina Sof&#237;a&#46; C&#243;rdoba&#58; Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Mart&#237;n Piedra&#44; Javier Pascual Vinagre&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres Pe&#241;a&#46;</p> <p id="par0395" class="elsevierStylePara elsevierViewall">H&#46; Infanta Margarita&#46; Cabra&#58; Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0400" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Virgen de las Nieves&#46; Granada&#58; Pablo Conde Baena&#44; Joaqu&#237;n Escobar Sevilla&#44; Laura Gallo Padilla&#44; Patricia G&#243;mez Ronquillo&#44; Pablo Gonz&#225;lez Bustos&#44; Mar&#237;a Nav&#237;o Bot&#237;as&#44; Jessica Ram&#237;rez Taboada&#44; Mar Rivero Rodr&#237;guez&#46;</p> <p id="par0405" class="elsevierStylePara elsevierViewall">H&#46; Costa del Sol&#46; Marbella&#58; Victoria August&#237;n Bandera&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#46;</p> <p id="par0410" class="elsevierStylePara elsevierViewall">H&#46; San Juan de la Cruz&#46; &#218;beda&#58; Marcos Guzm&#225;n Garc&#237;a&#44; Francisco Javier Vicente Hern&#225;ndez&#46;</p> <p id="par0415" class="elsevierStylePara elsevierViewall">Complejo Asistencial Universitario de Le&#243;n&#46; Le&#243;n&#58; Rosario Mar&#237;a Garc&#237;a Die&#44; Manuel Martin Regidor&#44; &#193;ngel Luis Mart&#237;nez Gonz&#225;lez&#44; Alberto Muela Molinero&#44; Raquel Rodr&#237;guez D&#237;ez&#44; Beatriz Vicente Montes&#46;</p> <p id="par0420" class="elsevierStylePara elsevierViewall">H&#46; Cl&#237;nic Barcelona&#46; Barcelona&#58; J&#250;lia Calvo Jim&#233;nez&#44; Aina Capdevila Reniu&#44; Irene Carbonell De Boulle&#44; Emmanuel Coloma Baz&#225;n&#44; Joaquim Fern&#225;ndez Sol&#224;&#44; Cristina Gabara Xanc&#243;&#44; Joan Ribot Grabalosa&#44; Olga Rodr&#237;guez N&#250;&#241;ez&#46;</p> <p id="par0425" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Ferrol&#46; Ferrol&#58; Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trig&#225;s Ferr&#237;n&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0430" class="elsevierStylePara elsevierViewall">H&#46; Marina Baixa&#46; Villajoyosa&#58; Javier Ena&#44; Santiago P&#233;rez-Mart&#237;n&#46;</p> <p id="par0435" class="elsevierStylePara elsevierViewall">H&#46; del Tajo&#46; Aranjuez&#58; Ruth Gonz&#225;lez Ferrer&#44; Raquel Monsalvo Arroyo&#46;</p> <p id="par0440" class="elsevierStylePara elsevierViewall">H&#46; Insular de Gran Canaria&#46; Las Palmas de Gran Canaria&#58; Marina Aroza Espinar&#44; Jorge Orihuela Mart&#237;n&#44; Carlos Jorge Ripper&#44; Selena Santana Jim&#233;nez&#46;</p> <p id="par0445" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Marqu&#233;s de Valdecilla&#46; Santander&#58; Marta Fern&#225;ndez-Ayala Novo&#44; Jos&#233; Javier Napal Lecumberri&#44; Nuria Puente Ruiz&#44; Jos&#233; Riancho&#44; Isabel Sampedro Garc&#237;a&#46;</p> <p id="par0450" class="elsevierStylePara elsevierViewall">H&#46; Torrec&#225;rdenas&#46; Almer&#237;a&#58; Luis Felipe D&#237;ez Garc&#237;a&#44; Iris El Attar Acedo&#44; B&#225;rbara Hern&#225;ndez Sierra&#44; Carmen Mar S&#225;nchez Cano&#46;</p> <p id="par0455" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Severo Ochoa&#46; Legan&#233;s&#58; Yolanda Casillas Viera&#44; Luc&#237;a Cayuela Rodr&#237;guez&#44; Carmen de Juan &#193;lvarez&#44; Gema Flox Ben&#237;tez&#44; Laura Garc&#237;a Escudero&#44; Juan Martin Torres&#44; Patricia Moreira Escriche&#44; Susana Plaza Canteli&#44; M&#46; Carmen Romero P&#233;rez&#46;</p> <p id="par0460" class="elsevierStylePara elsevierViewall">H&#46; Valle del Nal&#243;n&#46; Ria&#241;o&#46; Langreo&#58; Sara Fuente Cos&#237;o&#44; C&#233;sar Manuel Gallo &#193;lvaro&#44; Julia Lobo Garc&#237;a&#44; Ant&#237;a P&#233;rez Pi&#241;eiro&#46;</p> <p id="par0465" class="elsevierStylePara elsevierViewall">H&#46; U&#46; del Vinalop&#243;&#46; Elche&#58; Francisco Amor&#243;s Mart&#237;nez&#44; Erika Ascu&#241;a V&#225;squez&#44; Jos&#233; Carlos Escribano Stabl&#233;&#44; Adriana Hern&#225;ndez Belmonte&#44; Ana Maestre Peir&#243;&#44; Raquel Mart&#237;nez Go&#241;i&#44; M&#46; Carmen Pacheco Castellanos&#44; Bernardino Sold&#225;n Belda&#44; David Vicente Navarro&#46;</p> <p id="par0470" class="elsevierStylePara elsevierViewall">H&#46; Alto Guadalquivir&#46; And&#250;jar&#58; Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0475" class="elsevierStylePara elsevierViewall">H&#46; Francesc de Borja&#46; Gand&#237;a&#58; Alba Camarena Molina&#44; Simona Cioaia&#44; Anna Ferrer Santolaria&#44; Jos&#233; Mar&#237;a Frutos P&#233;rez&#44; Eva Gil Tom&#225;s&#44; Leyre Jorquer Vidal&#44; Marina Llopis Sanch&#237;s&#44; Mari &#193;ngeles Mart&#237;nez Pascual&#44; &#193;lvaro Navarro Batet&#44; Mari Amparo Perea Ribis&#44; Ricardo Peris S&#225;nchez&#44; Jos&#233; Manuel Querol Ribelles&#44; Silvia Rodr&#237;guez Mercadal&#44; Ana Ventura Esteve&#46;</p> <p id="par0480" class="elsevierStylePara elsevierViewall">H&#46; G&#46; U&#46; de Castell&#243;n&#46; Castell&#243;n de la Plana&#58; Jorge Andr&#233;s Soler&#44; Mari&#225;n Bennasar Remolar&#44; Alejandro Cardenal &#193;lvarez&#44; Daniela D&#237;az Carlotti&#44; Mar&#237;a Jos&#233; Esteve Gimeno&#44; Sergio Fabra Juana&#44; Paula Garc&#237;a L&#243;pez&#44; Mar&#237;a Teresa Guinot Soler&#44; Daniela Palomo de la Sota&#44; Guillem Pascual Castellanos&#44; Ignacio P&#233;rez Catal&#225;n&#44; Celia Roig Mart&#237;&#44; Paula Rubert Monz&#243;&#44; Javier Ruiz Padilla&#44; Nuria Tornador Gaya&#44; Jorge Us&#243; Blasco&#46;</p> <p id="par0485" class="elsevierStylePara elsevierViewall">H&#46; Santa B&#225;rbara&#46; Soria&#58; Marta Le&#243;n T&#233;llez&#46;</p> <p id="par0490" class="elsevierStylePara elsevierViewall">C&#46; A&#46; U&#46; de Salamanca&#46; Salamanca&#58; Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ramon Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0495" class="elsevierStylePara elsevierViewall">H&#46; U&#46; de Canarias&#46; Santa Cruz de Tenerife&#58; Julio Cesar Alvisa Negr&#237;n&#44; Jos&#233; Fernando Armas Gonz&#225;lez&#44; Lourdes Gonz&#225;lez Navarrete&#44; Iballa Jim&#233;nez&#44; Mar&#237;a Candelaria Mart&#237;n Gonz&#225;lez&#44; Miguel Nicolas Navarrete Lorite&#44; Paula Ortega Toledo&#44; On&#225;n P&#233;rez Hern&#225;ndez&#44; Alina P&#233;rez Ram&#237;rez&#46;</p> <p id="par0500" class="elsevierStylePara elsevierViewall">C&#46; H&#46; U&#46; de Badajoz&#46; Badajoz&#58; Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0505" class="elsevierStylePara elsevierViewall">H&#46; U&#46; del Sureste&#46; Arganda del Rey&#58; Jon Cabrejas Ugartondo&#44; Ana Bel&#233;n Mancebo Plaza&#44; Arturo Noguerado Asensio&#44; Bethania P&#233;rez Alves&#44; Natalia Vicente L&#243;pez&#46;</p> <p id="par0510" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Quironsalud Madrid&#46; Pozuelo de Alarc&#243;n&#46; Madrid&#58; Pablo Guisado Vasco&#44; Ana Roda Santacruz&#44; Ana Valverde Mu&#241;oz&#46;</p> <p id="par0515" class="elsevierStylePara elsevierViewall">H&#46; de Poniente&#46; Almer&#237;a&#58; Juan Antonio Montes Romero&#44; Encarna S&#225;nchez Mart&#237;n&#44; Jos&#233; Luis Serrano Carrillo de Albornoz&#44; Manuel Jes&#250;s Soriano P&#233;rez&#46;</p> <p id="par0520" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Lucus Augusti&#46; Lugo&#58; Raquel G&#243;mez M&#233;ndez&#44; Ana Rodr&#237;guez &#193;lvarez&#46;</p> <p id="par0525" class="elsevierStylePara elsevierViewall">H&#46; San Pedro de Alc&#225;ntara&#46; C&#225;ceres&#58; &#193;ngela Agea Garc&#237;a&#44; Javier Gal&#225;n Gonz&#225;lez&#44; Luis G&#225;mez Salazar&#44; Eva Garc&#237;a Sard&#243;n&#44; Antonio Gonz&#225;lez Nieto&#44; Itziar Montero D&#237;as&#44; Selene N&#250;&#241;ez Gaspar&#44; &#193;lvaro Santaella G&#243;mez&#46;</p> <p id="par0530" class="elsevierStylePara elsevierViewall">H&#46; de Pozoblanco&#46; Pozoblanco&#58; Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0535" class="elsevierStylePara elsevierViewall">H&#46; Virgen de los Lirios&#46; Alcoy&#46; Alicante&#58; M&#170; Jos&#233; Esteban Giner&#46;</p> <p id="par0540" class="elsevierStylePara elsevierViewall">H&#46; Doctor Jos&#233; Molina Orosa&#46; Arrecife&#46; Lanzarote&#58; Virginia Herrero Garc&#237;a&#44; Berta Rom&#225;n Bernal&#46;</p> <p id="par0545" class="elsevierStylePara elsevierViewall">H&#46; Nuestra Se&#241;ora de Sonsoles&#46; &#193;vila&#58; Alaaeldeen Abdelhady Kishta&#46;</p> <p id="par0550" class="elsevierStylePara elsevierViewall">H&#46; G&#46; U&#46; de Elda&#46; Elda&#58; Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0555" class="elsevierStylePara elsevierViewall">H&#46; U&#46; Puerta del Mar&#46; C&#225;diz&#58; Jos&#233; Antonio Gir&#243;n Gonz&#225;lez&#44; Susana Fabiola Pascual P&#233;rez&#44; Cristina Rodr&#237;guez Fern&#225;ndez-Viagas&#44; Mar&#237;a Jos&#233; Soto C&#225;rdenas&#46;</p> <p id="par0560" class="elsevierStylePara elsevierViewall">H&#46; Parc Tauli&#46; Sabadell&#58; Francisco Epelde&#44; Isabel Torrente&#46;</p> <p id="par0565" class="elsevierStylePara elsevierViewall">H&#46; de Montilla&#46; Montilla&#58; Ana Cristina Delgado Zamorano&#44; Beatriz G&#243;mez Mar&#237;n&#44; Adri&#225;n Monta&#241;o Mart&#237;nez&#44; Jos&#233; Luis Zambrana Garc&#237;a&#46;</p> <p id="par0570" class="elsevierStylePara elsevierViewall">H&#46; Infanta Elena&#46; Huelva&#58; Mar&#237;a Gloria Rojano Rivero&#46;</p> <p id="par0575" class="elsevierStylePara elsevierViewall">H&#46; de la Axarqu&#237;a&#46; V&#233;lez- M&#225;laga&#58; Antonio L&#243;pez Ruiz&#46;</p> <p id="par0580" class="elsevierStylePara elsevierViewall">H&#46; Virgen del Mar&#46; Madrid&#58; Thamar Capel Astrua&#44; Paola Tatiana Garc&#237;a Giraldo&#44; Mar&#237;a Jes&#250;s Gonz&#225;lez Ju&#225;rez&#44; Victoria M&#225;rquez Fern&#225;ndez&#44; Ada Viviana Romero Echevarry&#46;</p> <p id="par0585" class="elsevierStylePara elsevierViewall">Hospital do Salnes&#46; Vilagarc&#237;a de Arousa&#58; Vanesa Alende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Mar&#237;a Rodr&#237;guez Ferreira&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0590" class="elsevierStylePara elsevierViewall">H&#46; La Fuenfr&#237;a&#46; Cercedilla&#46; Madrid&#58; Daniel Arregui Gallego&#44; Jorge Blanco Briones&#44; Gonzalo M Muzquiz Rueda&#44; Isabel Rodr&#237;guez Fraile&#44; Javier Rodr&#237;guez Hern&#225;ndez&#44; Mar&#237;a &#193;ngeles Ruiz Rodr&#237;guez&#44; Mikaela Zubillaga G&#243;mez&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Members of the SEMI-COVID-19 Registry"
            "identificador" => "sec0060"
          ]
        ]
      ]
    ]
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        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1514
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            "identificador" => "at0005"
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            "rol" => "short"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow diagram of the study&#46;</p>"
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        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The categorical and continuous variables were expressed as absolute values and percentages and as medians &#40;ranges&#41;&#44; respectively&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">BPM&#58; beats per minute&#59; COPD&#58; chronic obstructive pulmonary disease&#59; COVID-19&#58; disease caused by coronavirus-2019&#59; CRP&#58; C-reactive protein&#59; DM&#58; diabetes mellitus&#59; HF&#58; heart failure&#59; HR&#58; heart rate&#59; LDH&#58; lactate dehydrogenase&#59; RR&#58; respiratory rate &#40;breaths per minute&#41;&#59; SatO<span class="elsevierStyleInf">2</span>&#58; baseline oxygen saturation&#59; SBP&#58; systolic blood pressure&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total &#40;n&#160;&#61;&#160;1&#44;718&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Deceased &#40;n&#160;&#61;&#160;819&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Not deceased &#40;n&#160;&#61;&#160;899&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#46;4 &#40;22&#8211;102&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#46;6 &#40;26&#8211;102&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79&#46;4 &#40;26&#46;5&#8211;101&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Male sex</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">971 &#40;56&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">489 &#40;59&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">482 &#40;53&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidities</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Charlson Index &#62;&#160;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;11&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;6&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Barthel Index &#8804;&#160;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">648 &#40;37&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">380 &#40;46&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">268 &#40;29&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tobacco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36 &#40;4&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;6&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DM without organ damage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">313 &#40;18&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">147 &#40;17&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">166 &#40;18&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;758&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DM with organ damage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">261 &#40;15&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">149 &#40;18&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">112 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arterial hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1350 &#40;78&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">670 &#40;81&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">680 &#40;75&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyslipidaemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">929 &#40;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">453 &#40;55&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">476 &#40;53&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">269 &#40;15&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">142 &#40;17&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;14&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coronary artery disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">312 &#40;18&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157 &#40;19&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">155 &#40;17&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atrial fibrillation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">709 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">357 &#40;43&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">352 &#40;39&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;065&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic HF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1167 &#40;67&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">526 &#40;64&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">641 &#40;71&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Solid neoplasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">158 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;10&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;8&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;205&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Moderate-severe chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">296 &#40;17&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">169 &#40;20&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127 &#40;14&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Liver disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;2&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;2&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;2&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;648&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">435 &#40;25&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">190 &#40;23&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">245 &#40;27&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Physical examination</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HR &#40;bpm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#40;34&#8211;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;34&#8211;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;34&#8211;170&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tachypnoea &#40;&#62;&#160;20 RR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">785 &#40;45&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">459 &#40;51&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">326 &#40;36&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SatO<span class="elsevierStyleInf">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93 &#40;53&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">94 &#40;54&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP &#40;mmHg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">128 &#40;50&#8211;225&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bilateral pulmonary consolidation&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">515 &#40;29&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">297 &#40;36&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">218 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CRP &#40;mg&#47; L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;5 &#40;0&#8211;950&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;0&#46;4&#8211;950&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">55&#46;1 &#40;0&#8211;597&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D-dimer &#40;ng&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">946 &#40;21&#8211;489&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1205 &#40;21&#8211;489&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">801 &#40;1618&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LDH &#40;U&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">390 &#40;92&#8211;5209&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">316 &#40;18&#8211;1735&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Leukocytes &#40;x10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6860 &#40;324&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">7500 &#40;1618&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">6400 &#40;324&#8211;90&#44;000&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lymphocytes &#40;x10<span class="elsevierStyleSup">6</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">850 &#40;0&#8211;75&#44;500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">768 &#40;0&#8211;57&#44;830&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">910 &#40;49&#8211;75&#44;500&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Urea &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&#46;5 &#40;10&#8211;369&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;10&#8211;364&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;18 &#40;0&#46;2&#8211;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;35 &#40;0&#46;33&#8211;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;02 &#40;0&#46;27&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactate &#40;mmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;8 &#40;0&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;9 &#40;0&#46;1&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7 &#40;0&#46;1&#8211;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Deceased &#40;n&#160;&#61;&#160;819&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Not deceased &#40;n&#160;&#61;&#160;899&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p-</span>value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Antimicrobial treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lopinavir-ritonavir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">776 &#40;45&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">348 &#40;42&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">428 &#40;47&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;039&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Remdesivir&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;1&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hydroxychloroquine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1327 &#40;77&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">577 &#40;70&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">750 &#40;83&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Immunomodulators</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tocilizumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">132 &#40;7&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;8&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;7&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;575&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Immunoglobulins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;0&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;689&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baricitinib&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;0&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;0&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Glucocorticoids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">764 &#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">389 &#40;47&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">375 &#40;41&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Anticoagulant therapy</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LMWH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1358 &#40;79&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;46&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">731&#40;53&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ventilation support</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>High-flow nasal cannula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;10&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">117 &#40;14&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;7&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NIMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">139 &#40;8&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92 &#40;11&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;5&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141 &#40;8&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;10&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;6&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pronation therapy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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Article information
ISSN: 22548874
Original language: English
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Revista Clínica Española (English Edition)