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for symptoms that had been ongoing for several days consisting of peripheral vertigo&#44; mutism&#44; and a progressive decline in level of consciousness&#46; A CT &#40;computed tomography&#41; scan of the head was performed&#44; which showed a mass in the pineal gland compatible with pineocytoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">During his hospitalization&#44; he developed hyponatremia &#40;130&#160;mEq&#47;L&#41; with plasma hyposmolality &#40;268&#160;mOsm&#47;kg&#41;&#44; natriuresis &#40;135&#160;mEq&#47;L&#41;&#44; and a urine osmolality of 461&#160;mOsm&#47;kg&#46; In this context&#44; the patient was polyuric &#40;diuresis &#62;1&#160;mL&#47;kg&#47;h&#41; with clinical signs of volume depletion &#40;hypotension&#44; dry skin and mucosa&#44; and tachycardia&#41; and a negative fluid balance &#40;&#8722;3&#160;L in 24&#160;h&#41;&#46; Plasma levels of urea&#44; creatinine&#44; uric acid&#44; thyroid stimulating hormone &#40;TSH&#41;&#44; and free thyroxine &#40;T<span class="elsevierStyleInf">4</span>&#41; were normal&#46; Given these findings&#44; a diagnosis of CSWS was established and replacement fluid therapy was started&#44; with a slow&#44; progressive correction of the natremia&#44; in addition to the administration of mineralocorticoids&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of CSWS has classically been linked to two hypotheses&#58; one that points to the sympathetic nervous system as the cause of a reduction in proximal tubule sodium reabsorption and another that associates it with the action of natriuretic agents &#40;atrial natriuretic peptide and brain natriuretic peptide&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Four main criteria have been described for its diagnosis&#58; &#40;1&#41; clinical signs of hypovolemia&#59; 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Its frequency is less than 1&#37; and it can appear at any age&#44; though it is more recurrent in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The symptoms it produces can be varied&#44; from Parinaud syndrome to headaches&#44; deterioration in balance&#44; urinary incontinence&#44; or mood swings&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; in the diagnosis of CSWS&#44; unidentified intracranial pathology must be considered as a cause and its treatment will depend both on the underlying pathology and the time since onset&#44; both of which must be drawn on in order to provide the correct treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">This work has not received any type of funding&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflicts of interest&#46;</p></span></span>"
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Intracranial pineal tumor as a cause of a cerebral salt-wasting syndrome
Tumor intracraneal pineal como causa de un síndrome pierde sal cerebral
S. Martínez-Cuéllara, R. Gil-Montesdeocab, M.P. Arocha-Saavedrab, L. Santana-Cabreraa,b,
Corresponding author
lsancabx@gobiernodecanarias.org

Corresponding author.
a Servicio de Medicina Intensiva, Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria, Spain
b Universidad de Las Palmas de Gran Canaria, Spain
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for symptoms that had been ongoing for several days consisting of peripheral vertigo&#44; mutism&#44; and a progressive decline in level of consciousness&#46; A CT &#40;computed tomography&#41; scan of the head was performed&#44; which showed a mass in the pineal gland compatible with pineocytoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">During his hospitalization&#44; he developed hyponatremia &#40;130&#160;mEq&#47;L&#41; with plasma hyposmolality &#40;268&#160;mOsm&#47;kg&#41;&#44; natriuresis &#40;135&#160;mEq&#47;L&#41;&#44; and a urine osmolality of 461&#160;mOsm&#47;kg&#46; In this context&#44; the patient was polyuric &#40;diuresis &#62;1&#160;mL&#47;kg&#47;h&#41; with clinical signs of volume depletion &#40;hypotension&#44; dry skin and mucosa&#44; and tachycardia&#41; and a negative fluid balance &#40;&#8722;3&#160;L in 24&#160;h&#41;&#46; Plasma levels of urea&#44; creatinine&#44; uric acid&#44; thyroid stimulating hormone &#40;TSH&#41;&#44; and free thyroxine &#40;T<span class="elsevierStyleInf">4</span>&#41; were normal&#46; Given these findings&#44; a diagnosis of CSWS was established and replacement fluid therapy was started&#44; with a slow&#44; progressive correction of the natremia&#44; in addition to the administration of mineralocorticoids&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of CSWS has classically been linked to two hypotheses&#58; one that points to the sympathetic nervous system as the cause of a reduction in proximal tubule sodium reabsorption and another that associates it with the action of natriuretic agents &#40;atrial natriuretic peptide and brain natriuretic peptide&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Four main criteria have been described for its diagnosis&#58; &#40;1&#41; clinical signs of hypovolemia&#59; &#40;2&#41; analytical evidence of dehydration with elevation of hematocrit&#44; hemoglobin&#44; serum albumin&#44; or blood urea nitrogen&#59; &#40;3&#41; a negative fluid balance&#44; and &#40;4&#41; central venous pressure &#60;6&#160;cm of water&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Dehydration or hypovolemia are the main differentiating factor between a diagnosis of CSWS and SIADH&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">In regard to the etiology of CSWS&#44; this syndrome has been related to numerous pathologies that affect the CNS &#40;cerebrovascular accidents&#44; subarachnoid hemorrhage&#44; etc&#46;&#41;&#46; Its relation to CNS tumors has not been widely studied&#44; and after ruling out other causes that could explain the onset of this syndrome&#44; we propose that in our patient&#44; it is associated with a pineal gland tumor found on the CT scan of the head&#44; just like some cases reported in the literature&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Pineocytoma is a benign primary tumor of the pineal gland&#46; Its frequency is less than 1&#37; and it can appear at any age&#44; though it is more recurrent in childhood&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The symptoms it produces can be varied&#44; from Parinaud syndrome to headaches&#44; deterioration in balance&#44; urinary incontinence&#44; or mood swings&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; in the diagnosis of CSWS&#44; unidentified intracranial pathology must be considered as a cause and its treatment will depend both on the underlying pathology and the time since onset&#44; both of which must be drawn on in order to provide the correct treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">This work has not received any type of funding&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they do not have any conflicts of interest&#46;</p></span></span>"
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ISSN: 22548874
Original language: English
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