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Editorial
The dilemma of reducing treatment for patients with moderate-severe controlled asthma
El dilema de la reducción de tratamiento en pacientes con asma moderado-grave controlados
S. Marín Romero
Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Sevilla, Spain
L. Jara Palomaresa,b,
Corresponding author
luisoneumo@hotmail.com

Corresponding author at: Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
a Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b CIBERES, Instituto de Salud Carlos III, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Asthma is a significant public health problem that affects all ages&#44; and its prevalence is increasing in many countries&#44; with a predominant increase in children&#46; Asthma currently incurs significant healthcare expenditures due to its morbidity and mortality and from an economic standpoint&#46; However&#44; a reduction in mortality and hospitalizations has been observed in a number of countries&#46; The objective of asthma treatment is maintaining control for long periods&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> International guidelines recommend gradually decreasing the treatment once the asthma has been controlled for at least 3 months&#44; so as to find the minimum therapeutic needs required to maintain control &#40;step-down therapy&#41;&#46; However&#44; this suggestion has a low level of evidence&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> A meta-analysis in the Cochrane journal concluded that adults undergoing treatment with long-acting &#946;2-adrenergic agonists &#40;LABA&#41; and inhaled corticosteroids &#40;ICS&#41; for whom the treatment with the LABA was suspended had an increased likelihood of asthmatic exacerbations&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this issue of the journal&#44; we present an interesting study that analyzed the factors that determined the loss of control when conducting step-down therapy when treating moderate-severe asthma with a combination of ICS and LABA&#46; This retrospective multicenter study analyzed 374 patients and found that the therapy failed for 41&#46;7&#37; of the patients&#44; defining failure as the need to increase the treatment&#44; loss of asthma control measured by an asthma control test &#40;ACT&#41; score<span class="elsevierStyleHsp" style=""></span>&#60;20 and&#47;or the presence of exacerbation&#46; This study identified the following factors related to treatment failure&#58; age &#40;the greater the age&#44; the higher the risk&#41;&#44; severe asthma &#40;compared with moderate asthma&#41; and asthma controlled for less than 6 months&#46; Although the study had the limitation of being retrospective&#44; it helps identify the factors to consider when deciding to reduce the treatment&#44; although these findings need to be confirmed in prospective studies or clinical trials&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Recently&#44; P&#233;rez de Llano et al&#46; conducted a prospective&#44; multicenter study on adult patients with controlled asthma&#44; analyzing variables associated with the failure of step-down therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The authors analyzed 228 patients in the derivation cohort &#40;495 episodes of step-down therapy&#41; and identified the following factors associated with step-down therapy failure&#58; a forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#47; forced vital capacity &#40;FVC&#41; ratio<span class="elsevierStyleHsp" style=""></span>&#60;70&#37; &#40;&#43;2&#46;5 points&#41;&#44; an FEV<span class="elsevierStyleInf">1</span><span class="elsevierStyleHsp" style=""></span>&#60;80&#37; of the theoretical value &#40;&#43;2 points&#41;&#44; 1 or more severe exacerbations in the past year &#40;&#43;3 points&#41; and an ACT score &#60;25 &#40;&#43;2&#46;5 points&#41;&#46; According to this scale&#44; the patients with a score &#60;4&#46;5 points had a risk of step-down therapy failure of &#60;20&#37;&#44; and those with a score &#62;8 had a &#62;40&#37; risk of step-down therapy failure&#46; Nevertheless&#44; this scale needs to be validated in a different prospective cohort to have external validity&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In conclusion&#44; asthma is a complex disease to manage and requires follow-up&#44; especially to maintain good symptom control&#46; However&#44; for those patients with good disease control&#44; we face the challenge of deciding when to conduct step-down therapy and what tools to use&#46;</p></span>"
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    "NotaPie" => array:1 [
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mar&#237;n Romero S&#44; Jara Palomares L&#46; El dilema de la reducci&#243;n de tratamiento en pacientes con asma moderado-grave controlados&#46; Rev Clin Esp&#46; 2020&#59;220&#58;117&#8211;118&#46;</p>"
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Article information
ISSN: 22548874
Original language: English
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