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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The potential health risks of wheat are not always a well-founded reason for concern in western society&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The media repercussion and prevalence of food allergies are increasing&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; the strictly allergic condition related to wheat and cereals has merited less attention&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Wheat allergy can manifest in several ways&#46; In childhood&#44; wheat allergy can form part of food allergies&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> while in adulthood&#44; it can be an occupational disease&#44; as happens with baker&#39;s asthma&#44; which is related to flour inhalation&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and the less well-known but no less important wheat-dependent exercise-induced allergy&#46; In this issue of <span class="elsevierStyleItalic">Revista Clinica Espa&#241;ola</span>&#44; Agull&#243;-Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> present their experience along with an excellent review of the topic&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Wheat-dependent exercise-induced allergy is encompassed in the group of exercise-induced food allergies&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Although the condition was described 40 years ago&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> not much is known about it due to its large clinical variability&#46; These patients frequently present allergies to other foods&#44; but the condition is not consistent&#46; Patients can eat the food daily without presenting symptoms or presenting mild local symptoms &#40;oral pruritus&#41; without necessitating exercise&#46; In the end&#44; symptom onset is abrupt after the intake of the food and the performance of exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The condition has been reported with numerous food items&#44; with frequently associated allergic disease&#44; such as allergy to some food &#40;although often not to that food&#41; or the presence&#44; without exercise&#44; of mild symptoms &#40;oral pruritus&#41; that do not prevent the intake of the food&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">One of the best known of these foods&#44; which has gained importance and has given its own name to the syndrome&#44; is wheat&#47;gliadin&#44; which is probably due to several of its characteristics&#44; such as its regular &#40;often daily&#41; consumption&#44; the absence of previously known allergic disease in many cases and the sudden onset of symptoms&#46; The most commonly involved wheat allergen &#40;but not the only one&#41; in these symptoms is a gliadin fraction &#40;&#969;-5 gliadin&#41;&#44; unlike those involved in the pathogenesis of celiac disease &#40;&#945; and &#946; gliadins&#44; especially&#41; but&#44; like them&#44; is difficult to digest&#46; This adds another source of confusion in naming the condition&#44; which is frequently called &#8220;gliadin allergy&#8221; or &#8220;&#969;-5 gliadin allergy&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">This syndrome requires a change in the previously established concepts regarding allergic reactions&#46; It is easy to imagine an allergy as an abnormal bodily reaction to exposure to that substance to which it is allergic&#46; We therefore tend to think that if an individual consumes a food without problem&#44; they cannot be allergic to that food&#46; Food-dependent exercise-induced anaphylaxis challenges this concept and requires a paradigm shift&#46; In this case&#44; the ingestion of the allergen&#47;food by itself does not trigger any type of symptom&#44; despite its regular consumption&#46; In this case&#44; the symptoms only appear when one or several factors &#40;commonly known as cofactors&#41; coincide with the ingestion of the food&#59; in other words&#44; the food is necessary but not sufficient for symptom onset&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The most common and best-known factor is exercise&#44; and therefore this peculiar syndrome has been given various names&#44; many of which refer to exercise&#44; although this starts to get left out&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> To complicate the diagnosis&#44; the food &#40;in this case&#44; one as common as wheat &#91;e&#46;g&#46;&#44; bread&#44; pasta&#93;&#41; can be ingested several hours before performing physical exertions&#44; with no direct relationship with symptom onset&#46; It is therefore difficult to determine the cause&#44; with patient incredulity not being uncommon &#40;&#8220;Are you really telling me that this is because of the bread I eat every day&#63;&#8221;&#41;&#46; The frequently severe clinical manifestations &#40;anaphylaxis&#47;anaphylactic shock&#41; usually have an abrupt onset&#59; however&#44; the exercise intensity and duration necessary to trigger the symptoms can vary significantly and might depend on the concomitant presence of other cofactors &#40;stress&#44; premenstrual phase in women&#44; previously taking anti-inflammatory agents or alcohol&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Gastrointestinal tract disorders that increase the absorption and availability of the allergen have been implicated in the pathogenesis of exercise-induced wheat-dependent allergy&#46; There is also increased reactivity of mast cells and basophils&#44; which react with smaller quantities of the allergen&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> It has recently been shown that the symptoms can be reproduced without the need for exercise or cofactors&#44; although with much larger quantities of the allergen than are regularly consumed&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The diagnosis of wheat-dependent exercise-induced allergy is difficult&#46; On one hand&#44; the gold standard consists of the placebo-controlled&#44; double-blind tolerance test&#44; which is rarely employed as a routine diagnostic test&#46; On the other&#44; the need to include physical exercise &#40;at the necessary intensity and duration&#41; can&#44; along with the amount of food and other triggers&#44; affect symptom onset and intensity&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In this specific condition&#44; the confirmation diagnosis is even more complicated by having to include the performance of exercise and having to consider the variability of the syndrome&#44; both in the quantity of food necessary&#44; the exercise intensity and duration and the need for including other factors associated with the triggering of the condition&#46; A negative test therefore cannot completely rule out the diagnosis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the frequently severe reactions advise against or contraindicate implementing these tests&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Recognizing this condition is important because it helps prevent the onset of new episodes with a diet that is currently fairly accessible &#40;gluten-free diet&#41; or&#44; in selected cases&#44; by avoiding only the combination of the 2 factors &#40;restricted diet only before exercising&#41;&#46; Understanding this condition can help reduce the delay in diagnosing a potentially severe disease that is highly susceptible to occurring in an open environment&#46; Recognizing the symptoms and administering adrenaline early &#40;which all diagnosed patients should carry with them&#41; can be vital&#46;</p></span>"
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Editorial
Wheat and exercise: An explosive combination
Trigo y ejercicio: Una combinación explosiva
C.H. Larramendi
Sección de Alergia. Hospital Marina Baixa. La Vila Joiosa, Alicante, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The potential health risks of wheat are not always a well-founded reason for concern in western society&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The media repercussion and prevalence of food allergies are increasing&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; the strictly allergic condition related to wheat and cereals has merited less attention&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Wheat allergy can manifest in several ways&#46; In childhood&#44; wheat allergy can form part of food allergies&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> while in adulthood&#44; it can be an occupational disease&#44; as happens with baker&#39;s asthma&#44; which is related to flour inhalation&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and the less well-known but no less important wheat-dependent exercise-induced allergy&#46; In this issue of <span class="elsevierStyleItalic">Revista Clinica Espa&#241;ola</span>&#44; Agull&#243;-Garc&#237;a et al&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> present their experience along with an excellent review of the topic&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Wheat-dependent exercise-induced allergy is encompassed in the group of exercise-induced food allergies&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Although the condition was described 40 years ago&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> not much is known about it due to its large clinical variability&#46; These patients frequently present allergies to other foods&#44; but the condition is not consistent&#46; Patients can eat the food daily without presenting symptoms or presenting mild local symptoms &#40;oral pruritus&#41; without necessitating exercise&#46; In the end&#44; symptom onset is abrupt after the intake of the food and the performance of exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The condition has been reported with numerous food items&#44; with frequently associated allergic disease&#44; such as allergy to some food &#40;although often not to that food&#41; or the presence&#44; without exercise&#44; of mild symptoms &#40;oral pruritus&#41; that do not prevent the intake of the food&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">One of the best known of these foods&#44; which has gained importance and has given its own name to the syndrome&#44; is wheat&#47;gliadin&#44; which is probably due to several of its characteristics&#44; such as its regular &#40;often daily&#41; consumption&#44; the absence of previously known allergic disease in many cases and the sudden onset of symptoms&#46; The most commonly involved wheat allergen &#40;but not the only one&#41; in these symptoms is a gliadin fraction &#40;&#969;-5 gliadin&#41;&#44; unlike those involved in the pathogenesis of celiac disease &#40;&#945; and &#946; gliadins&#44; especially&#41; but&#44; like them&#44; is difficult to digest&#46; This adds another source of confusion in naming the condition&#44; which is frequently called &#8220;gliadin allergy&#8221; or &#8220;&#969;-5 gliadin allergy&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">This syndrome requires a change in the previously established concepts regarding allergic reactions&#46; It is easy to imagine an allergy as an abnormal bodily reaction to exposure to that substance to which it is allergic&#46; We therefore tend to think that if an individual consumes a food without problem&#44; they cannot be allergic to that food&#46; Food-dependent exercise-induced anaphylaxis challenges this concept and requires a paradigm shift&#46; In this case&#44; the ingestion of the allergen&#47;food by itself does not trigger any type of symptom&#44; despite its regular consumption&#46; In this case&#44; the symptoms only appear when one or several factors &#40;commonly known as cofactors&#41; coincide with the ingestion of the food&#59; in other words&#44; the food is necessary but not sufficient for symptom onset&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The most common and best-known factor is exercise&#44; and therefore this peculiar syndrome has been given various names&#44; many of which refer to exercise&#44; although this starts to get left out&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> To complicate the diagnosis&#44; the food &#40;in this case&#44; one as common as wheat &#91;e&#46;g&#46;&#44; bread&#44; pasta&#93;&#41; can be ingested several hours before performing physical exertions&#44; with no direct relationship with symptom onset&#46; It is therefore difficult to determine the cause&#44; with patient incredulity not being uncommon &#40;&#8220;Are you really telling me that this is because of the bread I eat every day&#63;&#8221;&#41;&#46; The frequently severe clinical manifestations &#40;anaphylaxis&#47;anaphylactic shock&#41; usually have an abrupt onset&#59; however&#44; the exercise intensity and duration necessary to trigger the symptoms can vary significantly and might depend on the concomitant presence of other cofactors &#40;stress&#44; premenstrual phase in women&#44; previously taking anti-inflammatory agents or alcohol&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Gastrointestinal tract disorders that increase the absorption and availability of the allergen have been implicated in the pathogenesis of exercise-induced wheat-dependent allergy&#46; There is also increased reactivity of mast cells and basophils&#44; which react with smaller quantities of the allergen&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> It has recently been shown that the symptoms can be reproduced without the need for exercise or cofactors&#44; although with much larger quantities of the allergen than are regularly consumed&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The diagnosis of wheat-dependent exercise-induced allergy is difficult&#46; On one hand&#44; the gold standard consists of the placebo-controlled&#44; double-blind tolerance test&#44; which is rarely employed as a routine diagnostic test&#46; On the other&#44; the need to include physical exercise &#40;at the necessary intensity and duration&#41; can&#44; along with the amount of food and other triggers&#44; affect symptom onset and intensity&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In this specific condition&#44; the confirmation diagnosis is even more complicated by having to include the performance of exercise and having to consider the variability of the syndrome&#44; both in the quantity of food necessary&#44; the exercise intensity and duration and the need for including other factors associated with the triggering of the condition&#46; A negative test therefore cannot completely rule out the diagnosis&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and the frequently severe reactions advise against or contraindicate implementing these tests&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Recognizing this condition is important because it helps prevent the onset of new episodes with a diet that is currently fairly accessible &#40;gluten-free diet&#41; or&#44; in selected cases&#44; by avoiding only the combination of the 2 factors &#40;restricted diet only before exercising&#41;&#46; Understanding this condition can help reduce the delay in diagnosing a potentially severe disease that is highly susceptible to occurring in an open environment&#46; Recognizing the symptoms and administering adrenaline early &#40;which all diagnosed patients should carry with them&#41; can be vital&#46;</p></span>"
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