array:25 [
  "pii" => "S2254887418300535"
  "issn" => "22548874"
  "doi" => "10.1016/j.rceng.2018.03.002"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1495"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "edi"
  "cita" => "Rev Clin Esp. 2018;218:190-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1
    "PDF" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0014256518300882"
      "issn" => "00142565"
      "doi" => "10.1016/j.rce.2018.03.007"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1495"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "edi"
      "cita" => "Rev Clin Esp. 2018;218:190-1"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 19
        "formatos" => array:2 [
          "HTML" => 14
          "PDF" => 5
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
        "titulo" => "Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "190"
            "paginaFinal" => "191"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Genetic studies and alcoholic liver disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Zapater"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Zapater"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2254887418300535"
          "doi" => "10.1016/j.rceng.2018.03.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300535?idApp=WRCEE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300882?idApp=WRCEE"
      "url" => "/00142565/0000021800000004/v2_201805060410/S0014256518300882/v2_201805060410/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2254887418300444"
    "issn" => "22548874"
    "doi" => "10.1016/j.rceng.2018.02.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1472"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Clin Esp. 2018;218:192-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 12
      "formatos" => array:2 [
        "HTML" => 4
        "PDF" => 8
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "Positioning document on incorporating point-of-care ultrasound in Internal Medicine departments"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "192"
          "paginaFinal" => "198"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Documento de posicionamiento sobre la incorporaci&#243;n de la ecograf&#237;a cl&#237;nica en los servicios de Medicina Interna"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Torres Macho, F&#46;J&#46; Garc&#237;a S&#225;nchez, P&#46; Garmilla Ezquerra, L&#46; Beltr&#225;n Romero, J&#46; Canora Lebrato, J&#46;M&#46; Casas Rojo, P&#46; Arribas Arribas, S&#46; L&#243;pez Palmero, S&#46; Pintos Mart&#237;nez, J&#46;M&#46; Cepeda Rodrigo, D&#46; Luordo, M&#46; Beltr&#225;n L&#243;pez, M&#46; M&#233;ndez Bail&#243;n, E&#46; Rodilla Sala, L&#46; Manzano Espinosa, A&#46; Zapatero Gaviria, G&#46; Garc&#237;a de Casasola"
          "autores" => array:18 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Torres Macho"
            ]
            1 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Garc&#237;a S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Garmilla Ezquerra"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Beltr&#225;n Romero"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Canora Lebrato"
            ]
            5 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Casas Rojo"
            ]
            6 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Arribas Arribas"
            ]
            7 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "L&#243;pez Palmero"
            ]
            8 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Pintos Mart&#237;nez"
            ]
            9 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Cepeda Rodrigo"
            ]
            10 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Luordo"
            ]
            11 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Beltr&#225;n L&#243;pez"
            ]
            12 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "M&#233;ndez Bail&#243;n"
            ]
            13 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Rodilla Sala"
            ]
            14 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Manzano Espinosa"
            ]
            15 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Zapatero Gaviria"
            ]
            16 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Garc&#237;a de Casasola"
            ]
            17 => array:1 [
              "colaborador" => "on behalf of the Sociedad Espa&#241;ola de Medicina Interna y de su Grupo de Trabajo de Ecograf&#237;a Cl&#237;nica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0014256518300481"
        "doi" => "10.1016/j.rce.2018.02.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300481?idApp=WRCEE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300444?idApp=WRCEE"
    "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300444/v2_201805060420/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2254887418300365"
    "issn" => "22548874"
    "doi" => "10.1016/j.rceng.2018.02.003"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1475"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "cita" => "Rev Clin Esp. 2018;218:187-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3
      "PDF" => 3
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "A geriatric assessment followed by geriatric intervention is essential for elderly hospitalized patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "187"
          "paginaFinal" => "189"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Es b&#225;sico realizar una valoraci&#243;n e intervenci&#243;n geri&#225;tricas en el paciente anciano hospitalizado"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Formiga, D&#46; Chivite"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Formiga"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Chivite"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0014256518300560"
        "doi" => "10.1016/j.rce.2018.02.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300560?idApp=WRCEE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300365?idApp=WRCEE"
    "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300365/v2_201805060420/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S225488741830050X"
      "issn" => "22548874"
      "doi" => "10.1016/j.rceng.2018.02.009"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1476"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Rev Clin Esp. 2018;218:170-6"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 2
        "PDF" => 2
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Analysis of the relationship between interleukin polymorphisms within miRNA-binding regions and alcoholic liver disease"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "170"
            "paginaFinal" => "176"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "An&#225;lisis de la relaci&#243;n entre polimorfismos en regiones diana de micro-ARN y la enfermedad hep&#225;tica alcoh&#243;lica"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Novo-Veleiro, C&#46; Cieza-Borrella, I&#46; Pastor, R&#46; Gonz&#225;lez-Sarmiento, F&#46;J&#46; Laso, M&#46; Marcos"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Novo-Veleiro"
              ]
              1 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Cieza-Borrella"
              ]
              2 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Pastor"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Gonz&#225;lez-Sarmiento"
              ]
              4 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Laso"
              ]
              5 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Marcos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S0014256518300572"
          "doi" => "10.1016/j.rce.2018.02.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300572?idApp=WRCEE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S225488741830050X?idApp=WRCEE"
      "url" => "/22548874/0000021800000004/v2_201805060420/S225488741830050X/v2_201805060420/en/main.assets"
    ]
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "Genetic studies and alcoholic liver disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "190"
        "paginaFinal" => "191"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "P&#46; Zapater"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Zapater"
            "email" => array:1 [
              0 => "zapater&#95;ped&#64;gva&#46;es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "CIBERehd&#44; Instituto de Salud Carlos III&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Farmacolog&#237;a Cl&#237;nica&#46; Hospital General Universitario de Alicante&#44; Instituto de Investigaci&#243;n Sanitaria y Biom&#233;dica de Alicante &#40;ISABIAL-Fundaci&#243;n FISABIO&#41;&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Instituto de Bioingenier&#237;a&#46; Universidad Miguel Hern&#225;ndez&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Alcoholic liver disease &#40;ALD&#41; is a complex disease that can present in various histological stages&#58; steatosis&#44; steatohepatitis&#44; fibrosis and cirrhosis&#46; The onset of hepatic steatosis is early and predictable in individuals with moderate-high alcohol consumption&#46; However&#44; only 10&#8211;35&#37; of patients with steatosis develop steatohepatitis&#44; and of these 10&#8211;20&#37; end up with cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The mechanisms that could explain such a variable progression are unknown&#44; although concordance studies on monozygotic twins suggest that a genetic component explains up to 50&#37; of the variability in the progression of ALD&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Numerous studies have attempted to identify the genetic polymorphisms potentially associated with the development of ALD&#46; Basically&#44; 2 types of case-control studies have been used&#58; &#40;a&#41; candidate gene association studies that compared the frequency of the onset of polymorphisms of one or several genes chosen based on previous knowledge of their participation in the disease and &#40;b&#41; whole genome association studies that compared the genetic variation of all or a large part of the human genome &#40;thousands of polymorphisms are studied at a time&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The candidate gene association studies in ALD have evaluated genes involved in alcohol metabolism &#40;alcohol dehydrogenase&#44; aldehyde dehydrogenase&#44; cytochrome P450 2E1&#41;&#44; oxidative stress &#40;glutamate-cysteine ligase&#44; superoxide dismutase&#41;&#44; lipid metabolism &#40;MBOAT7&#41; and the immune response &#40;IL10&#44; IL1B&#44; CTLA4&#41;&#46; Overall&#44; the results of these studies have been disappointing because&#44; although significant associations were found between particular polymorphisms and the development of cirrhosis&#44; many of these results have not been replicated&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The main reasons for not finding significant associations are a lack of statistical power&#44; inadequate selection of the candidate gene and the presence of confounding factors in the observational studies&#46; There is also a publication bias that has favored the dissemination of studies with significant associations but not those studies with negative results&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Several whole genome association studies on ALD have found significant relationships between polymorphisms of genes PNPLA3 and TM6SF2 and the risk of developing cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> There are studies underway that seek to validate the clinical utility of these polymorphisms for predicting the prognosis and response to treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Alcohol and its metabolites increase intestinal patency and serum concentrations of bacterial lipopolysaccharide&#46; This effect causes the inflammatory condition that is observed in patients with ALD&#46; Accordingly&#44; several candidate gene association studies have focused on studying the genes involved in the inflammatory response&#44; although most of the findings were not able to be confirmed in subsequent whole genome association studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">MicroRNA &#40;miRNA&#41; are small noncoding RNA molecules of 19&#8211;23 nucleotides that can modulate messenger RNA concentrations by modifying their transcription and regulating post-transcriptional processes&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Two of these miRNAs &#40;miR-155 and miR-21&#41; have been correlated in ALD to an increased production of TNF-alpha by Kupffer cells in response to the presence of lipopolysaccharide&#46; Similarly&#44; in patients with steatohepatitis&#44; a relationship was found between miR-122 concentrations and alanine aminotransferase readings&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> These effects of miRNA in ALD are thought to be the result of their capacity to modify the expression of cytokine genes&#44; cytokine receptors and nuclear factors involved in the immune response&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> It has therefore been assumed that these miRNA could serve as markers to identify candidate genes for association studies on ALD&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue of Revista Cl&#237;nica Espa&#241;ola&#44; Novo-Veleiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> presents the results of a new association study between a number of cytokine gene polymorphisms &#40;IL-12B&#44; IL-16&#44; NFKB1 and IL-1 receptor type 1&#41; involved in the immune response to the lipopolysaccharide and the development of hepatic lesions in ALD&#46; The study by Novo-Veleiro et al&#46; is the first to analyze polymorphisms chosen for their relationship with miRNA that have shown their association with inflammation or hepatic damage in ALD&#46; The other strengths of the study by Novo-Veleiro et al&#46; include the high number of analyzed patients and the incorporation of 2 controls for each case&#44; consisting of healthy volunteers and individuals who abuse alcohol but have not developed liver disease&#46; The availability of these 2 control groups helps differentiate between the polymorphisms associated with excessive alcohol intake and those related to a poorer progression of the liver disease&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Lastly&#44; the study has not shown the association between the polymorphisms of genes that encode inflammatory cytokines and the development of liver injury&#46; Although the proportion of T allele carriers of one of the studied polymorphisms &#40;rs3917328&#41; is lower in the patients with alcoholism than in the healthy volunteers&#44; the multivariate analysis adjusted for confounding factors ruled out this association&#46; It should not surprise us that a study with these characteristics would conclude with negative results&#46; As previously indicated&#44; the reasons could be varied&#46; However&#44; the publication of these results by Revista Cl&#237;nica Espa&#241;ola is important&#44; both for the new methodology in selecting the polymorphisms and by the publication of results with considerable statistical validity&#46; These findings will be useful in implementing future studies that analyze the relationship between genes that encode the inflammatory response and the development of liver injury in ALD&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Zapater P&#46; Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica&#46; Rev Clin Esp&#46; 2018&#59;218&#58;190&#8211;191&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic factors that affect risk of alcohol and nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Q&#46;M&#46; Anstee"
                            1 => "D&#46; Seth"
                            2 => "C&#46;P&#46; Day"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2016.01.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2016"
                        "volumen" => "150"
                        "paginaInicial" => "1728"
                        "paginaFinal" => "1744"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26873399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heritability of hepatic fibrosis and steatosis based on a prospective twin study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Loomba"
                            1 => "N&#46; Schork"
                            2 => "C&#46;-H&#46; Chen"
                            3 => "R&#46; Bettencourt"
                            4 => "A&#46; Bhatt"
                            5 => "B&#46; Ang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2015.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2015"
                        "volumen" => "149"
                        "paginaInicial" => "1784"
                        "paginaFinal" => "1793"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26299412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The genetics of alcohol dependence and alcohol-related liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Stickel"
                            1 => "C&#46; Moreno"
                            2 => "J&#46; Hampe"
                            3 => "M&#46;Y&#46; Morgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2016.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2017"
                        "volumen" => "66"
                        "paginaInicial" => "195"
                        "paginaFinal" => "211"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27575312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Buch"
                            1 => "F&#46; Stickel"
                            2 => "E&#46; Tr&#233;po"
                            3 => "M&#46; Way"
                            4 => "A&#46; Herrmann"
                            5 => "H&#46;D&#46; Nischalke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.3417"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2015"
                        "volumen" => "47"
                        "paginaInicial" => "1443"
                        "paginaFinal" => "1448"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26482880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations between the tumor necrosis factor-&#945; gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;-Y&#46; Zhao"
                            1 => "M&#46; Xiao"
                            2 => "C&#46;-L&#46; Zhang"
                            3 => "K&#46;-Q&#46; Xie"
                            4 => "T&#46; Zeng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinre.2015.10.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Res Hepatol Gastroenterol"
                        "fecha" => "2016"
                        "volumen" => "40"
                        "paginaInicial" => "428"
                        "paginaFinal" => "439"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26656007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of microRNAs in alcohol-induced multi-organ injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;K&#46; Natarajan"
                            1 => "J&#46;M&#46; Pachunka"
                            2 => "J&#46;L&#46; Mott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/biom5043309"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biomolecules"
                        "fecha" => "2015"
                        "volumen" => "5"
                        "paginaInicial" => "3309"
                        "paginaFinal" => "3338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26610589"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The functional role of microRNAs in alcoholic liver injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; McDaniel"
                            1 => "L&#46; Herrera"
                            2 => "T&#46; Zhou"
                            3 => "H&#46; Francis"
                            4 => "Y&#46; Han"
                            5 => "P&#46; Levine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jcmm.12223"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cell Mol Med"
                        "fecha" => "2014"
                        "volumen" => "18"
                        "paginaInicial" => "197"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24400890"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de la relaci&#243;n entre polimorfismos en regiones diana de micro-ARN y la enfermedad hep&#225;tica alcoh&#243;lica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Novo-Veleiro"
                            1 => "C&#46; Cieza-Borrella"
                            2 => "I&#46; Pastor"
                            3 => "R&#46; Gonz&#225;lez-Sarmiento"
                            4 => "F&#46;J&#46; Laso"
                            5 => "M&#46; Marcos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2018.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2018"
                        "volumen" => "218"
                        "paginaInicial" => "170"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29566963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300535/v2_201805060420/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "72714"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorials"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/22548874/0000021800000004/v2_201805060420/S2254887418300535/v2_201805060420/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300535?idApp=WRCEE"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Editorial
Genetic studies and alcoholic liver disease
Los estudios genéticos y la enfermedad hepática alcohólica
P. Zapatera,b,c
a CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
b Unidad de Farmacología Clínica. Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Alicante, Spain
c Instituto de Bioingeniería. Universidad Miguel Hernández, Elche, Alicante, Spain
Read
13
Times
was read the article
6
Total PDF
7
Total HTML
Share statistics
 array:25 [
  "pii" => "S2254887418300535"
  "issn" => "22548874"
  "doi" => "10.1016/j.rceng.2018.03.002"
  "estado" => "S300"
  "fechaPublicacion" => "2018-05-01"
  "aid" => "1495"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
  "copyrightAnyo" => "2018"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "edi"
  "cita" => "Rev Clin Esp. 2018;218:190-1"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1
    "PDF" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0014256518300882"
      "issn" => "00142565"
      "doi" => "10.1016/j.rce.2018.03.007"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1495"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "edi"
      "cita" => "Rev Clin Esp. 2018;218:190-1"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 19
        "formatos" => array:2 [
          "HTML" => 14
          "PDF" => 5
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
        "titulo" => "Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "190"
            "paginaFinal" => "191"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Genetic studies and alcoholic liver disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Zapater"
            "autores" => array:1 [
              0 => array:2 [
                "nombre" => "Pedro"
                "apellidos" => "Zapater"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2254887418300535"
          "doi" => "10.1016/j.rceng.2018.03.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300535?idApp=WRCEE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300882?idApp=WRCEE"
      "url" => "/00142565/0000021800000004/v2_201805060410/S0014256518300882/v2_201805060410/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2254887418300444"
    "issn" => "22548874"
    "doi" => "10.1016/j.rceng.2018.02.004"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1472"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Clin Esp. 2018;218:192-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 12
      "formatos" => array:2 [
        "HTML" => 4
        "PDF" => 8
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>"
      "titulo" => "Positioning document on incorporating point-of-care ultrasound in Internal Medicine departments"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "192"
          "paginaFinal" => "198"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Documento de posicionamiento sobre la incorporaci&#243;n de la ecograf&#237;a cl&#237;nica en los servicios de Medicina Interna"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Torres Macho, F&#46;J&#46; Garc&#237;a S&#225;nchez, P&#46; Garmilla Ezquerra, L&#46; Beltr&#225;n Romero, J&#46; Canora Lebrato, J&#46;M&#46; Casas Rojo, P&#46; Arribas Arribas, S&#46; L&#243;pez Palmero, S&#46; Pintos Mart&#237;nez, J&#46;M&#46; Cepeda Rodrigo, D&#46; Luordo, M&#46; Beltr&#225;n L&#243;pez, M&#46; M&#233;ndez Bail&#243;n, E&#46; Rodilla Sala, L&#46; Manzano Espinosa, A&#46; Zapatero Gaviria, G&#46; Garc&#237;a de Casasola"
          "autores" => array:18 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Torres Macho"
            ]
            1 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Garc&#237;a S&#225;nchez"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Garmilla Ezquerra"
            ]
            3 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Beltr&#225;n Romero"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Canora Lebrato"
            ]
            5 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Casas Rojo"
            ]
            6 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Arribas Arribas"
            ]
            7 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "L&#243;pez Palmero"
            ]
            8 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Pintos Mart&#237;nez"
            ]
            9 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Cepeda Rodrigo"
            ]
            10 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Luordo"
            ]
            11 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Beltr&#225;n L&#243;pez"
            ]
            12 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "M&#233;ndez Bail&#243;n"
            ]
            13 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Rodilla Sala"
            ]
            14 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Manzano Espinosa"
            ]
            15 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Zapatero Gaviria"
            ]
            16 => array:2 [
              "nombre" => "G&#46;"
              "apellidos" => "Garc&#237;a de Casasola"
            ]
            17 => array:1 [
              "colaborador" => "on behalf of the Sociedad Espa&#241;ola de Medicina Interna y de su Grupo de Trabajo de Ecograf&#237;a Cl&#237;nica"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0014256518300481"
        "doi" => "10.1016/j.rce.2018.02.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300481?idApp=WRCEE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300444?idApp=WRCEE"
    "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300444/v2_201805060420/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2254887418300365"
    "issn" => "22548874"
    "doi" => "10.1016/j.rceng.2018.02.003"
    "estado" => "S300"
    "fechaPublicacion" => "2018-05-01"
    "aid" => "1475"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "edi"
    "cita" => "Rev Clin Esp. 2018;218:187-9"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3
      "PDF" => 3
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
      "titulo" => "A geriatric assessment followed by geriatric intervention is essential for elderly hospitalized patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "187"
          "paginaFinal" => "189"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Es b&#225;sico realizar una valoraci&#243;n e intervenci&#243;n geri&#225;tricas en el paciente anciano hospitalizado"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "F&#46; Formiga, D&#46; Chivite"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Formiga"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Chivite"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0014256518300560"
        "doi" => "10.1016/j.rce.2018.02.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300560?idApp=WRCEE"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300365?idApp=WRCEE"
    "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300365/v2_201805060420/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S225488741830050X"
      "issn" => "22548874"
      "doi" => "10.1016/j.rceng.2018.02.009"
      "estado" => "S300"
      "fechaPublicacion" => "2018-05-01"
      "aid" => "1476"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Rev Clin Esp. 2018;218:170-6"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 2
        "PDF" => 2
      ]
      "en" => array:12 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Analysis of the relationship between interleukin polymorphisms within miRNA-binding regions and alcoholic liver disease"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "170"
            "paginaFinal" => "176"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "An&#225;lisis de la relaci&#243;n entre polimorfismos en regiones diana de micro-ARN y la enfermedad hep&#225;tica alcoh&#243;lica"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Novo-Veleiro, C&#46; Cieza-Borrella, I&#46; Pastor, R&#46; Gonz&#225;lez-Sarmiento, F&#46;J&#46; Laso, M&#46; Marcos"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Novo-Veleiro"
              ]
              1 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Cieza-Borrella"
              ]
              2 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Pastor"
              ]
              3 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Gonz&#225;lez-Sarmiento"
              ]
              4 => array:2 [
                "nombre" => "F&#46;J&#46;"
                "apellidos" => "Laso"
              ]
              5 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Marcos"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S0014256518300572"
          "doi" => "10.1016/j.rce.2018.02.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256518300572?idApp=WRCEE"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S225488741830050X?idApp=WRCEE"
      "url" => "/22548874/0000021800000004/v2_201805060420/S225488741830050X/v2_201805060420/en/main.assets"
    ]
  ]
  "en" => array:12 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>"
    "titulo" => "Genetic studies and alcoholic liver disease"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "190"
        "paginaFinal" => "191"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "P&#46; Zapater"
        "autores" => array:1 [
          0 => array:4 [
            "nombre" => "P&#46;"
            "apellidos" => "Zapater"
            "email" => array:1 [
              0 => "zapater&#95;ped&#64;gva&#46;es"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "CIBERehd&#44; Instituto de Salud Carlos III&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Farmacolog&#237;a Cl&#237;nica&#46; Hospital General Universitario de Alicante&#44; Instituto de Investigaci&#243;n Sanitaria y Biom&#233;dica de Alicante &#40;ISABIAL-Fundaci&#243;n FISABIO&#41;&#44; Alicante&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Instituto de Bioingenier&#237;a&#46; Universidad Miguel Hern&#225;ndez&#44; Elche&#44; Alicante&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Alcoholic liver disease &#40;ALD&#41; is a complex disease that can present in various histological stages&#58; steatosis&#44; steatohepatitis&#44; fibrosis and cirrhosis&#46; The onset of hepatic steatosis is early and predictable in individuals with moderate-high alcohol consumption&#46; However&#44; only 10&#8211;35&#37; of patients with steatosis develop steatohepatitis&#44; and of these 10&#8211;20&#37; end up with cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The mechanisms that could explain such a variable progression are unknown&#44; although concordance studies on monozygotic twins suggest that a genetic component explains up to 50&#37; of the variability in the progression of ALD&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Numerous studies have attempted to identify the genetic polymorphisms potentially associated with the development of ALD&#46; Basically&#44; 2 types of case-control studies have been used&#58; &#40;a&#41; candidate gene association studies that compared the frequency of the onset of polymorphisms of one or several genes chosen based on previous knowledge of their participation in the disease and &#40;b&#41; whole genome association studies that compared the genetic variation of all or a large part of the human genome &#40;thousands of polymorphisms are studied at a time&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The candidate gene association studies in ALD have evaluated genes involved in alcohol metabolism &#40;alcohol dehydrogenase&#44; aldehyde dehydrogenase&#44; cytochrome P450 2E1&#41;&#44; oxidative stress &#40;glutamate-cysteine ligase&#44; superoxide dismutase&#41;&#44; lipid metabolism &#40;MBOAT7&#41; and the immune response &#40;IL10&#44; IL1B&#44; CTLA4&#41;&#46; Overall&#44; the results of these studies have been disappointing because&#44; although significant associations were found between particular polymorphisms and the development of cirrhosis&#44; many of these results have not been replicated&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The main reasons for not finding significant associations are a lack of statistical power&#44; inadequate selection of the candidate gene and the presence of confounding factors in the observational studies&#46; There is also a publication bias that has favored the dissemination of studies with significant associations but not those studies with negative results&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Several whole genome association studies on ALD have found significant relationships between polymorphisms of genes PNPLA3 and TM6SF2 and the risk of developing cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> There are studies underway that seek to validate the clinical utility of these polymorphisms for predicting the prognosis and response to treatment&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Alcohol and its metabolites increase intestinal patency and serum concentrations of bacterial lipopolysaccharide&#46; This effect causes the inflammatory condition that is observed in patients with ALD&#46; Accordingly&#44; several candidate gene association studies have focused on studying the genes involved in the inflammatory response&#44; although most of the findings were not able to be confirmed in subsequent whole genome association studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">MicroRNA &#40;miRNA&#41; are small noncoding RNA molecules of 19&#8211;23 nucleotides that can modulate messenger RNA concentrations by modifying their transcription and regulating post-transcriptional processes&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Two of these miRNAs &#40;miR-155 and miR-21&#41; have been correlated in ALD to an increased production of TNF-alpha by Kupffer cells in response to the presence of lipopolysaccharide&#46; Similarly&#44; in patients with steatohepatitis&#44; a relationship was found between miR-122 concentrations and alanine aminotransferase readings&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> These effects of miRNA in ALD are thought to be the result of their capacity to modify the expression of cytokine genes&#44; cytokine receptors and nuclear factors involved in the immune response&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> It has therefore been assumed that these miRNA could serve as markers to identify candidate genes for association studies on ALD&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In this issue of Revista Cl&#237;nica Espa&#241;ola&#44; Novo-Veleiro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> presents the results of a new association study between a number of cytokine gene polymorphisms &#40;IL-12B&#44; IL-16&#44; NFKB1 and IL-1 receptor type 1&#41; involved in the immune response to the lipopolysaccharide and the development of hepatic lesions in ALD&#46; The study by Novo-Veleiro et al&#46; is the first to analyze polymorphisms chosen for their relationship with miRNA that have shown their association with inflammation or hepatic damage in ALD&#46; The other strengths of the study by Novo-Veleiro et al&#46; include the high number of analyzed patients and the incorporation of 2 controls for each case&#44; consisting of healthy volunteers and individuals who abuse alcohol but have not developed liver disease&#46; The availability of these 2 control groups helps differentiate between the polymorphisms associated with excessive alcohol intake and those related to a poorer progression of the liver disease&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Lastly&#44; the study has not shown the association between the polymorphisms of genes that encode inflammatory cytokines and the development of liver injury&#46; Although the proportion of T allele carriers of one of the studied polymorphisms &#40;rs3917328&#41; is lower in the patients with alcoholism than in the healthy volunteers&#44; the multivariate analysis adjusted for confounding factors ruled out this association&#46; It should not surprise us that a study with these characteristics would conclude with negative results&#46; As previously indicated&#44; the reasons could be varied&#46; However&#44; the publication of these results by Revista Cl&#237;nica Espa&#241;ola is important&#44; both for the new methodology in selecting the polymorphisms and by the publication of results with considerable statistical validity&#46; These findings will be useful in implementing future studies that analyze the relationship between genes that encode the inflammatory response and the development of liver injury in ALD&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Zapater P&#46; Los estudios gen&#233;ticos y la enfermedad hep&#225;tica alcoh&#243;lica&#46; Rev Clin Esp&#46; 2018&#59;218&#58;190&#8211;191&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic factors that affect risk of alcohol and nonalcoholic fatty liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Q&#46;M&#46; Anstee"
                            1 => "D&#46; Seth"
                            2 => "C&#46;P&#46; Day"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2016.01.037"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2016"
                        "volumen" => "150"
                        "paginaInicial" => "1728"
                        "paginaFinal" => "1744"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26873399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heritability of hepatic fibrosis and steatosis based on a prospective twin study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Loomba"
                            1 => "N&#46; Schork"
                            2 => "C&#46;-H&#46; Chen"
                            3 => "R&#46; Bettencourt"
                            4 => "A&#46; Bhatt"
                            5 => "B&#46; Ang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2015.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2015"
                        "volumen" => "149"
                        "paginaInicial" => "1784"
                        "paginaFinal" => "1793"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26299412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The genetics of alcohol dependence and alcohol-related liver disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Stickel"
                            1 => "C&#46; Moreno"
                            2 => "J&#46; Hampe"
                            3 => "M&#46;Y&#46; Morgan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2016.08.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2017"
                        "volumen" => "66"
                        "paginaInicial" => "195"
                        "paginaFinal" => "211"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27575312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Buch"
                            1 => "F&#46; Stickel"
                            2 => "E&#46; Tr&#233;po"
                            3 => "M&#46; Way"
                            4 => "A&#46; Herrmann"
                            5 => "H&#46;D&#46; Nischalke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.3417"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2015"
                        "volumen" => "47"
                        "paginaInicial" => "1443"
                        "paginaFinal" => "1448"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26482880"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations between the tumor necrosis factor-&#945; gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;-Y&#46; Zhao"
                            1 => "M&#46; Xiao"
                            2 => "C&#46;-L&#46; Zhang"
                            3 => "K&#46;-Q&#46; Xie"
                            4 => "T&#46; Zeng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clinre.2015.10.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Res Hepatol Gastroenterol"
                        "fecha" => "2016"
                        "volumen" => "40"
                        "paginaInicial" => "428"
                        "paginaFinal" => "439"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26656007"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of microRNAs in alcohol-induced multi-organ injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;K&#46; Natarajan"
                            1 => "J&#46;M&#46; Pachunka"
                            2 => "J&#46;L&#46; Mott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3390/biom5043309"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biomolecules"
                        "fecha" => "2015"
                        "volumen" => "5"
                        "paginaInicial" => "3309"
                        "paginaFinal" => "3338"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26610589"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The functional role of microRNAs in alcoholic liver injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; McDaniel"
                            1 => "L&#46; Herrera"
                            2 => "T&#46; Zhou"
                            3 => "H&#46; Francis"
                            4 => "Y&#46; Han"
                            5 => "P&#46; Levine"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jcmm.12223"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cell Mol Med"
                        "fecha" => "2014"
                        "volumen" => "18"
                        "paginaInicial" => "197"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24400890"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An&#225;lisis de la relaci&#243;n entre polimorfismos en regiones diana de micro-ARN y la enfermedad hep&#225;tica alcoh&#243;lica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Novo-Veleiro"
                            1 => "C&#46; Cieza-Borrella"
                            2 => "I&#46; Pastor"
                            3 => "R&#46; Gonz&#225;lez-Sarmiento"
                            4 => "F&#46;J&#46; Laso"
                            5 => "M&#46; Marcos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rce.2018.02.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2018"
                        "volumen" => "218"
                        "paginaInicial" => "170"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29566963"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/22548874/0000021800000004/v2_201805060420/S2254887418300535/v2_201805060420/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "72714"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Editorials"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/22548874/0000021800000004/v2_201805060420/S2254887418300535/v2_201805060420/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300535?idApp=WRCEE"
]
Article information
ISSN: 22548874
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2023 March 7 4 11
2020 September 0 1 1
2018 May 0 1 1

Follow this link to access the full text of the article

Idiomas
Revista Clínica Española (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?