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The diagnosis of this last entity is the most complex and usually requires additional studies such as stress testing and computed angiotomography&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">For most patients with an initial clinical suspicion of ACS&#44; this entity is eventually ruled out&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> at the cost of extended observation times and various additional examinations&#46; It is therefore essential to have strategies that enable clinicians to quickly differentiate patients with chest pain but no ACS from those who do have ACS&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Numerous strategies have been proposed to identify patients without ACS&#44; strategies based on the medical history and additional examinations&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> combinations of biomarkers and risk scales<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> and even the implementation of imaging tests&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> In the study by Montero-P&#233;rez et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> published in this issue of <span class="elsevierStyleSmallCaps">Revista Cl&#237;nica Espa&#241;ola</span>&#44; the authors proposed a clinical scale for the patient group with suspected ACS&#44; in which the ECG and biomarkers are not conclusive&#46; The aim of the scale is to discern which of these patients have unstable angina or pain of noncoronary origin&#46; To this end&#44; the study prospectively included 286 patients treated for chest pain in an emergency department of a tertiary hospital&#44; with normal ECG results and no cTn increase&#46; The final diagnosis was ACS in 103 patients &#40;36&#37;&#41; and was conducted by consensus of at least 2 physicians&#44; based on clinical data and additional tests&#44; including cTn <span class="elsevierStyleSmallCaps">II</span>concentrations&#46; Using multiple logistic regression&#44; 3 predictors of ACS were identified&#58; a history of coronary artery disease&#44; hyperlipidemia and a score on the Geleijnse scale &#8805;6 points&#46; The area under the receiver operating characteristic &#40;ROC&#41; curve for the final model was 0&#46;90 &#40;95&#37; confidence interval &#91;95&#37; CI&#93; 0&#46;85&#8211;0&#46;93&#41;&#46; The authors proposed a decision point of 5 points for assigning the diagnosis of ACS&#44; which achieved a sensitivity of 76&#46;7&#37; &#40;95&#37; CI 68&#8211;84&#37;&#41; and a specificity of 91&#46;8&#37; &#40;95&#37; CI 87&#8211;95&#37;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Despite the interesting approach&#44; there are several aspects of the study that deserve mention&#46; Firstly&#44; although assignment of the final diagnosis by consensus is the standard methodology in this type of study&#44; a previous study showed that&#44; despite an acceptable agreement &#40;<span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;79&#59; 95&#37; CI 0&#46;73&#8211;0&#46;85&#41; between 2 groups of evaluators &#40;one local and another central&#41; in assigning the final diagnosis&#44; up to 34&#37; of the patients were reassigned in the central evaluation to a diagnostic category other than that performed in the local assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> The lack of absolute agreement in the assignment is intrinsic to the methodology employed&#44; but the final assignment of the conflicting cases&#44; in one category or another&#44; could affect the results and&#44; as a result&#44; their interpretation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Secondly&#44; the authors used a contemporary method for determining the cTn level&#44; with a decision point of 0&#46;30<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;corresponding to the value above the 99th percentile&#41;&#46; Nevertheless&#44; the European Society of Cardiology guidelines recommend the use of high-sensitivity cTn&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> an immunoassay that measures very low cTn concentrations with the analytical quality recommended in the successive definitions of AMI<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> &#40;a coefficient of variation &#60;10&#37; in the concentration corresponding to the 99th percentile&#41;&#46; This increased analytical sensitivity has 2 consequences&#46; On one hand&#44; it increases the diagnosis of AMI at the expense of a lower number of unstable angina cases&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> On the other&#44; it increases the number of patients with high biomarker concentrations in situations other than AMI&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> Regardless of the patient&#39;s final diagnosis&#44; high cTn values are associated with higher mortality in the follow-up&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;13</span></a> although a strategy for these patients has not yet been determined&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Thirdly&#44; based on the ROC curve values&#44; the authors proposed a decision point for the use of the scale analyzed with diagnostic intent&#46; Strategies with &#60;1&#37; of false negatives are considered useful for proposing discharges to home for patients with nontraumatic chest pain&#44; without needing additional studies&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> For this reason&#44; additional studies are needed to check the scale&#39;s validity and its inclusion in a decision-making algorithm&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the study by Montero-P&#233;rez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> shows the need to accurately identify patients with unstable angina&#46; The study shows us a new tool based on clinical parameters&#44; which is easy to implement and could facilitate the diagnosis and standardize the decision-making process&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Alqu&#233;zar-Arb&#233; A&#44; Lopez Barbeito B&#46; Escalas cl&#237;nicas&#58; una herramienta para el diagn&#243;stico de angina inestable&#46; Rev Clin Esp&#46; 2018&#59;218&#58;72&#8211;73&#46;</p>"
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Editorial
Clinical scales: Tools for the diagnosis of unstable angina
Escalas clínicas: una herramienta para el diagnóstico de angina inestable
A. Alquézar-Arbéa,
Corresponding author
aalquezar@santpau.cat

Corresponding author.
, B. Lopez Barbeitob,c
a Servei Urgències, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
b Àrea D’Urgències, Hospital Clínic Provincial, Barcelona, Spain
c Miembro del grupo de trabajo del Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS) «Urgencias: procesos y patologías»
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        "titulo" => "Escalas cl&#237;nicas&#58; una herramienta para el diagn&#243;stico de angina inestable"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Coronary artery disease is the leading cause of death worldwide&#44; and its most typical presentation is acute coronary syndrome &#40;ACS&#41;&#44; which usually manifests as nontraumatic chest pain&#46; ACS includes 3 entities<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a>&#58; 1&#41; acute myocardial infarction &#40;AMI&#41; with ST-segment elevation&#44; whose diagnosis is established by the presence of specific electrocardiogram &#40;ECG&#41; abnormalities&#59; 2&#41; AMI without ST-segment elevation&#44; whose diagnosis requires the demonstration of changes in concentration &#40;both significant increases and decreases&#41; in the serial measurements of cardiac troponin &#40;cTn&#41;&#59; and 3&#41; unstable angina&#44; in which myocardial ischemia occurs&#44; which can be accompanied by ECG changes but with no significant changes in serial cTn readings&#46; The diagnosis of this last entity is the most complex and usually requires additional studies such as stress testing and computed angiotomography&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">For most patients with an initial clinical suspicion of ACS&#44; this entity is eventually ruled out&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> at the cost of extended observation times and various additional examinations&#46; It is therefore essential to have strategies that enable clinicians to quickly differentiate patients with chest pain but no ACS from those who do have ACS&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Numerous strategies have been proposed to identify patients without ACS&#44; strategies based on the medical history and additional examinations&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> combinations of biomarkers and risk scales<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> and even the implementation of imaging tests&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> In the study by Montero-P&#233;rez et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> published in this issue of <span class="elsevierStyleSmallCaps">Revista Cl&#237;nica Espa&#241;ola</span>&#44; the authors proposed a clinical scale for the patient group with suspected ACS&#44; in which the ECG and biomarkers are not conclusive&#46; The aim of the scale is to discern which of these patients have unstable angina or pain of noncoronary origin&#46; To this end&#44; the study prospectively included 286 patients treated for chest pain in an emergency department of a tertiary hospital&#44; with normal ECG results and no cTn increase&#46; The final diagnosis was ACS in 103 patients &#40;36&#37;&#41; and was conducted by consensus of at least 2 physicians&#44; based on clinical data and additional tests&#44; including cTn <span class="elsevierStyleSmallCaps">II</span>concentrations&#46; Using multiple logistic regression&#44; 3 predictors of ACS were identified&#58; a history of coronary artery disease&#44; hyperlipidemia and a score on the Geleijnse scale &#8805;6 points&#46; The area under the receiver operating characteristic &#40;ROC&#41; curve for the final model was 0&#46;90 &#40;95&#37; confidence interval &#91;95&#37; CI&#93; 0&#46;85&#8211;0&#46;93&#41;&#46; The authors proposed a decision point of 5 points for assigning the diagnosis of ACS&#44; which achieved a sensitivity of 76&#46;7&#37; &#40;95&#37; CI 68&#8211;84&#37;&#41; and a specificity of 91&#46;8&#37; &#40;95&#37; CI 87&#8211;95&#37;&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Despite the interesting approach&#44; there are several aspects of the study that deserve mention&#46; Firstly&#44; although assignment of the final diagnosis by consensus is the standard methodology in this type of study&#44; a previous study showed that&#44; despite an acceptable agreement &#40;<span class="elsevierStyleItalic">k</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;79&#59; 95&#37; CI 0&#46;73&#8211;0&#46;85&#41; between 2 groups of evaluators &#40;one local and another central&#41; in assigning the final diagnosis&#44; up to 34&#37; of the patients were reassigned in the central evaluation to a diagnostic category other than that performed in the local assessment&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">7</span></a> The lack of absolute agreement in the assignment is intrinsic to the methodology employed&#44; but the final assignment of the conflicting cases&#44; in one category or another&#44; could affect the results and&#44; as a result&#44; their interpretation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Secondly&#44; the authors used a contemporary method for determining the cTn level&#44; with a decision point of 0&#46;30<span class="elsevierStyleHsp" style=""></span>ng&#47;mL &#40;corresponding to the value above the 99th percentile&#41;&#46; Nevertheless&#44; the European Society of Cardiology guidelines recommend the use of high-sensitivity cTn&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> an immunoassay that measures very low cTn concentrations with the analytical quality recommended in the successive definitions of AMI<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> &#40;a coefficient of variation &#60;10&#37; in the concentration corresponding to the 99th percentile&#41;&#46; This increased analytical sensitivity has 2 consequences&#46; On one hand&#44; it increases the diagnosis of AMI at the expense of a lower number of unstable angina cases&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> On the other&#44; it increases the number of patients with high biomarker concentrations in situations other than AMI&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> Regardless of the patient&#39;s final diagnosis&#44; high cTn values are associated with higher mortality in the follow-up&#44;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12&#44;13</span></a> although a strategy for these patients has not yet been determined&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Thirdly&#44; based on the ROC curve values&#44; the authors proposed a decision point for the use of the scale analyzed with diagnostic intent&#46; Strategies with &#60;1&#37; of false negatives are considered useful for proposing discharges to home for patients with nontraumatic chest pain&#44; without needing additional studies&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> For this reason&#44; additional studies are needed to check the scale&#39;s validity and its inclusion in a decision-making algorithm&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; the study by Montero-P&#233;rez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> shows the need to accurately identify patients with unstable angina&#46; The study shows us a new tool based on clinical parameters&#44; which is easy to implement and could facilitate the diagnosis and standardize the decision-making process&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Alqu&#233;zar-Arb&#233; A&#44; Lopez Barbeito B&#46; Escalas cl&#237;nicas&#58; una herramienta para el diagn&#243;stico de angina inestable&#46; Rev Clin Esp&#46; 2018&#59;218&#58;72&#8211;73&#46;</p>"
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Original language: English
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