Journal Information
Vol. 224. Issue 7.
Pages 474-478 (August - September 2024)
Share
Share
Download PDF
More article options
Visits
1
Vol. 224. Issue 7.
Pages 474-478 (August - September 2024)
Brief Original
Bronchiectasis, lymphadenopathies related to BAFF overexpression and lymphoplasmacytic cystitis as adverse events associated with prolonged use of rituximab in systemic autoimmune rheumatic diseases
Bronquiectasias, adenopatías relacionadas con la sobreexpresión de BAFF y cistitis linfoplasmocítica como eventos adversos asociados al uso prolongado de rituximab en enfermedades reumáticas autoinmunes sistémicas
Visits
1
C.A. Cañasa,b,c,
Corresponding author
cacanas@icesi.edu.co

Corresponding author.
, I. Posso-Osorioa,b,c, V. Pérez-Uribec, V. Erazo-Martínezd
a Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Calle 18 No. 122 -135, Cali 760031, Colombia
b Universidad Icesi, Facultad de Ciencias de la Salud, Calle 18 No. 122 -135, Cali 760031, Colombia
c Fundación Valle del Lili, Unidad de Reumatología, Cra 98 No. 18 - 49, Cali 760032, Colombia
d Fundación Valle del Lili, Centro de Investigaciones Clínicas, Cra 98 No. 18 - 49, Cali 760032, Colombia
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Tables (1)
Table 1. Possible adverse events in a cohort of 178 patients with long-term rituximab (RTX) use, type of AE, number of cases, and severity.
Abstract
Background

The long-term use of rituximab (RTX) has been gaining ground in the treatment of systemic autoimmune diseases. The adverse events (AEs) associated with its use different to infections are being reported.

Methods

A cohort of patients with SAIDs treated at a high-complexity center in Cali (southwestern Colombia) with follow-up from January 2008 to December 2022 were examined to search for potential AEs associated with prolonged use of RTX.

Results

From 178 patients with long-term use of RTX 3 (1.68%) had lymphadenopathies with lymphoid follicular hyperplasia related to BAFF overexpression, 4 (2.24%) with bronchiectasis, and 4 (2.24%) with lymphoplasmacytic cystitis.

Conclusion

Bronchiectasis, lymphoid follicular hyperplasia related to BAFF overexpression, and lymphoplasmacytic cystitis may be life-threatening long-term AEs in patients with prolonged use of RTX.

Keywords:
Anti-CD 20
Side effects
Long-term adverse events
Hypogammaglobulinemia
Resumen
Introducción

El uso a largo plazo de rituximab (RTX) ha ido ganando terreno en el tratamiento de varias enfermedades autoinmunes. Los eventos adversos (EA) asociados con su uso diferente a infecciones se han empezado a reporter.

Métodos

Se examinó a una cohorte de pacientes con EAS tratados en un centro de alta complejidad en Cali (suroccidente de Colombia) con seguimiento desde enero de 2008 hasta diciembre de 2022 para buscar posibles EA asociados al uso prolongado de RTX.

Resultados

De 178 pacientes con uso prolongado de RTX 3 (1.68%) presentaron adenopatías con hiperplasia folicular linfoide relacionada con la sobreexpresión BAFF, 4 (2.24%) con bronquiectasias) y 4 (2.24%) con cistitis linfoplasmocítica.

Conclusión

Las bronquiectasias, la hiperplasia folicular linfoide relacionada con la sobreexpresión de BAFF y la cistitis linfoplasmocítica pueden ser EA a largo plazo en pacientes con uso prolongado de RTX.

Palabras clave:
Anti-CD 20
Efectos secundarios
Eventos adversos a largo plazo
Hipogammaglobulinemia

Article

These are the options to access the full texts of the publication Revista Clínica Española (English Edition)
Member
Si es usted socio de FESEMI siga los siguientes pasos:

Diríjase desde aquí a la web de la >>>FESEMI<<< e inicie sesión mediante el formulario que se encuentra en la barra superior, pulsando sobre el candado.

Una vez autentificado, en la misma web de FESEMI, en el menú superior, elija la opción deseada.

>>>FESEMI<<<

Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Clínica Española (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Revista Clínica Española (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?