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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have read with great interest your article on the prevalence and risk factors of Chronic Obstructive Pulmonary Disease &#40;COPD&#41; in the province of Shanxi &#40;China&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; We found that authors explored significant aetiological agents of COPD&#44; such as smoking&#44; use of biomass&#44; exposure to pollution&#44; or personal history of pneumonia or bronchial infections in childhood&#46; However&#44; there was no mention of the role of genetic factors such as alpha-1 antitrypsin deficiency&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Alpha-1 antitrypsin deficiency is responsible for up to 2&#37; of all COPD cases<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Although this genetic predisposition is infrequent in China<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#44; we believe that the reason could lie in the small number of studies addressing this topic in that country&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Since alpha-1 antitrypsin deficiency has a specific augmentation therapy to reduce morbidity and mortality&#44; European guidelines and World Health Organization recommend screening patients with COPD at least once in life<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; The diagnosis of alpha-1 antitrypsin deficiency is confirmed by demonstrating low serum levels with a severe deficient genotype&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Alfa-1 antitrypsin genotyping can be carried out by drop extraction or buccal smear&#46; Both genotype methods&#44; proved by themselves to be a test fast&#44; objective&#44; specific&#44; cheap&#44; and therefore efficient<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For these reasons&#44; we advise and encourage ruling-out alpha-1 antitrypsin deficiency as a potential causative agent in patients with COPD&#46;</p></span>"
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Correspondence
DOI: 10.1016/j.rceng.2022.03.001
Response to the article A population-based survey of the prevalence and risk factors of chronic obstructive pulmonary disease in Shanxi province (China)
Respuesta al artículo Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)
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J.M. Hernández-Pérez
Corresponding author
jmherper@hotmail.com

Corresponding author.
, C.V. López-Charry
Servicio de Neumología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain

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