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and hemorrhagic complications and limited physical activity &#40;for both treatments&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Anticoagulant therapy compliance is a highly relevant aspect&#44; considering the risk that the incorrect taking of medication entails&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> Numerous studies have evaluated VKA treatment compliance&#59; however&#44; our understanding of compliance with DOAs is highly limited&#44; with more than a quarter of patients presenting suboptimal compliance&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> In terms of patient satisfaction&#44; the results so far are conflicting&#44; showing dissatisfaction due to problems of anxiety and depression&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">5</span></a> In other cases the results show a lower burden and greater perceived benefit&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In this issue&#44; the results of an interesting article by Barrios et al&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">8</span></a> are presented&#46; The authors compared the quality of life&#44; treatment compliance and satisfaction between patients with anticoagulated AF taking VKA or dabigatran&#44; which was the first DOA introduced into clinical practice&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">9</span></a> The authors included more than 1000 patients treated in outpatient cardiology clinics&#46; Quality of life was assessed using the AF-QoL test&#44; which has been validated in Spain for this disease&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> The results showed that the patients treated with dabigatran had a better quality-of-life score at 6 months of follow-up&#44; results that differed from the reference clinical trial on dabigatran &#40;RELY&#41; that observed no differences in quality of life between the two treatment groups at 1 year of follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> The benefit of dabigatran observed in this new study could be an accurate reflection of clinical practice&#44; where the follow-up conditions are significantly different from those of a clinical trial&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Moreover&#44; the article by Barrios et al&#46; also analyzed the degree of compliance with these 2 groups of anticoagulants&#46; It is important to note that compliance with dabigatran was very high during the 6 months of follow-up &#40;approximately 90&#37;&#41;&#44; which was significantly greater than that of VKA &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; The authors note&#44; however&#44; that the follow-up period might have been too short and that the results might have been lower if the follow-up had been extended a year or more&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The study&#39;s most controversial issue is the assessment of the study patients&#8217; degree of satisfaction&#46; While most studies have estimated this parameter with a test that assesses the degree of patient wellbeing&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> the present study measured it indirectly&#44; using a survey directed at the physicians responsible for the patients&#46; The survey was developed <span class="elsevierStyleItalic">ad hoc</span> for this study&#44; which collected the physician&#39;s perception of the patients&#8217; satisfaction with the treatment&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Despite these limitations&#44; the study by Barrios et al&#46; throws light on additional important aspects that have seldom been studied on anticoagulant therapy in patients with AF&#44; such as quality of life and treatment compliance&#46; The information provided by this study is a further test of the superiority of DOAs over VKA in cases of nonvalvular AF&#46; We congratulate the authors for their contribution&#46; Nevertheless&#44; these results should be corroborated in future studies&#46;</p></span>"
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Editorial
Quality of life, compliance and satisfaction of patients with atrial fibrillation who are undergoing anticoagulant treatment
Calidad de vida, adherencia y satisfacción en pacientes con fibrilación auricular en tratamiento anticoagulante
M. Montero-Pérez-Barqueroa,
Corresponding author
fm1mopem@uco.es

Corresponding author.
, L. Manzanob
a Servicio de Medicina Interna, IMIBIC/Hospital Universitario Reina Sofía, Universidad de Córdoba, Córdoba, Spain
b Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Universidad de Alcalá (IRYCIS), Madrid, Spain
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