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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background and objectives</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Blood donation is suggested to increase the risk of Restless Legs Syndrome &#40;RLS&#41;&#46; This study aims to assess the prevalence of RLS in Spanish blood donors and determined its potential correlation with iron metabolism parameters&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study of 129 blood donors &#40;54&#46;3&#37; men&#44; 39&#46;44 years&#8201;&#177;&#8201;11&#46;0&#41; that underwent a physical examination&#44; blood analysis &#40;hemoglobin&#44; ferritin&#44; transferrin saturation index and soluble transferrin receptor&#41; and a RLS screening questionnaire followed by a prospective follow-up study including a clinical phone interview&#46; A multivariate logistic regression model was performed to examine the association between RLS and other variables&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Eighty-four &#40;65&#46;1&#37;&#41; participants were repeat blood donors &#40;mean of 2&#46;11 donations&#47;year&#41; at inclusion and 61 &#40;47&#46;4&#37;&#41; at follow-up &#40;mean of 2&#46;09 donations&#47;year&#41;&#46; Non-anemic iron deficiency &#40;ferritin&#8201;&#60;&#8201;50&#8201;&#181;g&#47;L&#41; was high in women p&#8201;&#60;&#8201;0&#46;001 and in repeat donors &#40;p&#8201;&#61;&#8201;0&#46;003&#41;&#46; The prevalence of RLS was 14&#46;1&#37; at inclusion increasing prospectively &#40;19&#46;5&#37;&#59; p&#8201;&#61;&#8201;0&#46;065&#41;&#46; On multivariate analysis&#44; gender was the only variable significantly associated with a RLS diagnosis&#44; being higher in women &#40;OR 5&#46;1&#59; 95&#37; CI 1&#46;71-15&#46;3&#59; p&#8201;&#61;&#8201;0&#46;003&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Despite the high prevalence of non-anemic iron deficiency there was no association between ferritin&#44; soluble transferrin receptor concentration values and RLS diagnosis&#46; Gender was associated with RLS diagnosis regardless of other variables&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes y objetivos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Hay especialistas que sugieren que la donaci&#243;n de sangre aumenta el riesgo de s&#237;ndrome de piernas inquietas &#40;SPI&#41;&#46; Este estudio pretende evaluar la prevalencia del SPI en donantes de sangre espa&#241;oles y determinar su posible correlaci&#243;n con par&#225;metros del metabolismo del hierro&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materiales y m&#233;todos</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohorte prospectivo de 129 donantes de sangre &#40;54&#44;3&#37; hombres&#44; 39&#44;44 a&#241;os&#8201;&#177;&#8201;11&#44;0&#41; a los que se les realiz&#243; una exploraci&#243;n f&#237;sica&#44; un an&#225;lisis de sangre &#40;hemoglobina&#44; ferritina&#44; &#237;ndice de saturaci&#243;n de transferrina y receptor soluble de transferrina&#41; y un cuestionario de cribado de SPI seguido de un estudio de seguimiento prospectivo que incluy&#243; una entrevista cl&#237;nica telef&#243;nica&#46; Se realiz&#243; un modelo de regresi&#243;n log&#237;stica multivariante para examinar la asociaci&#243;n entre el SPI y otras variables&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Ochenta y cuatro &#40;65&#44;1&#37;&#41; participantes eran donantes de sangre repitientes &#40;media de 2&#44;11 donaciones&#47;a&#241;o&#41; en la inclusi&#243;n y 61 &#40;47&#44;4&#37;&#41; en el seguimiento &#40;media de 2&#44;09 donaciones&#47;a&#241;o&#41;&#46; La deficiencia de hierro no an&#233;mica &#40;ferritina&#8201;&#60;&#8201;50&#8201;&#181;g&#47;L&#41; fue alta en mujeres p&#8201;&#60;&#8201;0&#44;001 y en donantes repitientes &#40;p&#8201;&#61;&#8201;0&#44;003&#41;&#46; La prevalencia de RLS fue del 14&#44;1&#37; en la inclusi&#243;n aumentando prospectivamente &#40;19&#44;5&#37;&#59; p&#8201;&#61;&#8201;0&#44;065&#41;&#46; En el an&#225;lisis multivariado&#44; el g&#233;nero fue la &#250;nica variable significativamente asociada con un diagn&#243;stico de RLS&#44; siendo mayor en mujeres &#40;OR 5&#44;1&#59; IC 95&#37; 1&#44;71-15&#44;3&#59; p&#8201;&#61;&#8201;0&#44;003&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">A pesar de la alta prevalencia de deficiencia de hierro no an&#233;mica no hubo asociaci&#243;n entre los valores de ferritina&#44; concentraci&#243;n del receptor soluble de transferrina y el diagn&#243;stico de RLS&#46; El g&#233;nero se asoci&#243; con el diagn&#243;stico de s&#237;ndrome de piernas inquietas independientemente de otras variables&#46;</p></span>"
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Original article
DOI: 10.1016/j.rceng.2024.10.009
Pre-proof, online 1 November 2024
Prospective study of restless legs syndrome in a blood donors’ sample
Estudio prospectivo del síndrome de piernas inquietas en una muestra de donantes de sangre
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Laura Lillo-Trigueroa, Alejandro Del Castillo-Ruedab, José María Bellónc, Rosa Peraita-Adradosd,
Corresponding author
rosa-peraita@telefonica.net

Corresponding author at: Sleep Unit—Clinical Neurophysiology Service, University General Hospital and Research Institute Gregorio Marañón, University Complutense of Madrid (UCM), Dr. Esquerdo, 46, Madrid 28007, Spain.
a Neurology and Sleep Unit, Ruber International Hospital, Madrid, Spain
b Internal Medicine Department, University General Hospital and Research Institute Gregorio Marañón, University Complutense of Madrid (UCM), Madrid, Spain
c Biostatistics, Research Institute Gregorio Marañón, University Complutense of Madrid (UCM), Madrid, Spain
d Sleep and Epilepsy Unit—Clinical Neurophysiology Service, University General Hospital and Research Institute Gregorio Marañón, University Complutense of Madrid (UCM), Madrid, Spain

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Highlighted articles
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Revista Clínica Española
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The value of multi-modal ultrasound in the assessment of...
Rev Clin Esp. 2024;224:437-44
Adverse cardiovascular, obstetric and perinatal events...
Rev Clin Esp. 2024;224:337-45
How to detect non-institutionalized older patients at risk...
Rev Clin Esp. 2024;224:217-24
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