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        "titulo" => "Efecto de un equipo multidisciplinar &#40;c&#243;digo TEP&#41; en el pron&#243;stico de los pacientes con tromboembolia de pulm&#243;n aguda sintom&#225;tica"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Use of advanced treatment according to whether patients did or did not receive care from the PERT team&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0010" class="elsevierStylePara elsevierViewall">Pulmonary embolism &#40;<span class="elsevierStyleBold">PE</span>&#41; is a frequent cause of morbidity and mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> In fact&#44; venous thromboembolism &#40;<span class="elsevierStyleBold">VTE</span>&#41; ranks third among the causes of cardiovascular mortality&#44; following acute myocardial infarction and stroke&#46; While some studies suggest that the short-term prognosis for PE patients has improved in recent years&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> mortality remains high for patients with severe disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The prognostic stratification of patients with acute symptomatic PE has become an essential condition for selecting the optimal therapeutic option &#40;anticoagulation or reperfusion therapy&#41; and treatment location &#40;home&#44; hospital ward&#44; under monitoring&#44; or the Intensive Care Unit&#41; for said patients&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Various prognostic tools and algorithms have been published in the last decade with the aim of classifying these patients&#8217; risk&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;9</span></a> However&#44; experience using these algorithms is needed&#44; and some studies suggest that the prognostic efficacy of said tools depends on the experience of the physicians using them&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Adhering to the evidence-based recommendations from the clinical practice guidelines is associated with increased survival in patients with PE&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> However&#44; the scientific evidence backing the use of new reperfusion therapies &#40;mechanical and pharmacomechanical&#41; is weak and fundamentally limited to non-randomised studies that used surrogate outcomes and featured small patient numbers&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;13</span></a> What&#8217;s more&#44; the selection of ideal candidates for this type of therapy depends on clinical experience&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">For these very reasons&#44; in recent years multidisciplinary teams &#40;pulmonary embolism response teams or PERT&#41; have been created for treating patients with acute symptomatic PE&#46; The goal is to combine the experience of different specialists to aid in consensual decision-making regarding early diagnosis and treatment for these patients&#46; While some of these groups have published their experiences&#44; the clinical benefits of multidisciplinary management of patients with acute symptomatic pulmonary embolism have not been sufficiently demonstrated&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#8211;16</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The main aim of this study was to evaluate the effect of multidisciplinary care &#40;PERT team&#41; versus regular care &#40;non-multidisciplinary&#41; on short-term mortality for patients with acute symptomatic PE&#46; The secondary objectives were to evaluate the effects on PE-related mortality&#44; on the use of reperfusion therapies and on the length of hospital stays&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Design</span><p id="par0035" class="elsevierStylePara elsevierViewall">A retrospective study including consecutive patients diagnosed with acute symptomatic PE admitted to a tertiary university hospital between January 2007 and December 2022&#46; The study was approved by the local ethics committee and all patients gave consent prior to participation&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and selection criteria</span><p id="par0040" class="elsevierStylePara elsevierViewall">This registry includes consecutive adult patients diagnosed with acute symptomatic PE via objective testing&#46; The PE diagnosis was confirmed via computed tomography angiography &#40;CTA&#41; findings of a partial intraluminal filling defect surrounded by contrast agent or full occlusion of a pulmonary artery in the two consecutive CT cohorts&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Pulmonary embolism diagnosis via ventilation-perfusion scintigraphy &#40;<span class="elsevierStyleBold">V&#47;Q</span> scan&#41; was performed in cases of high probability defined according to the PIOPED criteria<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> &#40;at least one segmental perfusion defect or two subsegmental defects with normal ventilation&#41;&#44; or for cases with suspected PE&#44; unconclusive scintigraphy and ultrasound of lower limbs&#44; diagnosis showing a compressibility defect of the venous lumen as a sign of deep vein thrombosis &#40;<span class="elsevierStyleBold">DVT</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Patients who could not be monitored for at least one month from the date of diagnosis and asymptomatic patients who were incidentally diagnosed with PE were excluded&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In this study&#44; we defined treated patients as those patients who received multidisciplinary care from the PERT team&#46; The controls were patients with the same distribution of baseline variables &#40;that is&#44; the same baseline probability of dying&#41; who receive regular care &#40;that is&#44; non-multidisciplinary&#41;&#46; Activation of the PERT team was determined by the head of the multidisciplinary team in all cases&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Intervention &#40;PERT team&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Multidisciplinary care via the PERT team was first offered at our hospital in 2017&#46; The team is made up of a cardiologist&#44; a vascular surgeon&#44; an intensive care physician&#44; an internist&#44; a pulmonologist&#44; a radiologist and an emergency medicine physician&#46; The team is typically activated via the on-call Pulmonary team and the pulmonologist from the PERT team&#46; While multidisciplinary care could be given to any patient diagnosed with PE&#44; it is typically provided for patients with high-risk PE or intermediate-high risk PE&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Study variables</span><p id="par0055" class="elsevierStylePara elsevierViewall">At the time of inclusion in the registry&#44; the following data were collected&#58; demographic&#44; clinical and analytical data including&#44; but not limited to&#44; age&#44; sex&#44; weight&#44; height&#44; comorbidities &#40;cancer&#44; ischaemic heart disease&#44; heart failure&#44; sleep apnoea&#41; venous thromboembolism &#40;<span class="elsevierStyleBold">VTE</span>&#41; risk factors &#40;prior surgery&#44; immobilisation&#44; history of VTE&#41;&#44; clinical signs and symptoms &#40;heart rate&#44; systolic blood pressure &#91;<span class="elsevierStyleBold">SBP</span>&#93;&#44; oxygen saturation &#91;<span class="elsevierStyleBold">satO<span class="elsevierStyleInf">2</span></span>&#93;&#41;&#44; PE severity scales &#40;Simplified <span class="elsevierStyleItalic">pulmonary embolism severity index</span> &#91;<span class="elsevierStyleBold">PESI</span>&#93;&#41;&#44; imaging tests &#40;CT angiography of the chest&#44; transthoracic echocardiogram&#44; lower limb compression ultrasound&#41; and lab testing at the time of admission &#40;haemoglobin&#44; leukocytes&#44; platelets&#44; serum creatinine&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Episodes analysed</span><p id="par0060" class="elsevierStylePara elsevierViewall">We defined the primary assessment parameter as all-cause mortality in the month post-PE diagnosis&#46; The secondary parameters were mortality due to PE&#44; objectively confirmed non-fatal thromboembolic recurrence&#44; non-fatal major bleeding&#44; and the use of advanced therapies during the month post-diagnosis&#46; The length of hospital stays was also analysed&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The recurrent PE diagnosis was confirmed via the presence of at least one new intraluminal filling defect in the CT angiography of the chest&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Major bleeding was defined as clinically relevant bleeding accompanied by one or more of the following criteria&#58; drop in haemoglobin of at least 2&#8239;g&#47;dL&#59; need for transfusion of at least 2 units of pack red blood cells&#59; haemodynamic compromise with need for emergency intervention &#40;administration of fluids or blood products&#44; inotropic support&#44; surgery&#44; or other invasive procedures&#41;&#59; intracranial or retroperitoneal bleeding or bleeding in any other critical organ&#44; or fatal bleeding&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Follow-up</span><p id="par0070" class="elsevierStylePara elsevierViewall">Follow-up was conducted via review of hospital databases&#44; medical histories&#44; and death certificates&#44; as well as outpatient appointments and telephone interviews when necessary&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">The categorical variables are presented as percentages and were compared using the chi-squared test&#46; The continuous variables are expressed as mean&#8239;&#177;&#8239;standard deviation or median &#40;interquartile range&#41; and were compared using Student&#8217;s t-test or the Mann-Whitney U test &#40;for variables without a normal distribution&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">To minimise possible selection bias&#44; the effect of multidisciplinary management on mortality was analysed in both the entire study group as well as a 1&#58;1 matched population according to the following variables&#58; age &#40;&#62;80 years v&#46; &#8804;80 years&#41;&#44; heart rate &#40;&#8805;110&#47;min vs&#46;&#8239;&#60;&#8239;110&#47;min&#41;&#44; SBP &#40;&#60;100&#8239;mmHg vs&#46; &#8805;100&#8239;mmHg&#41;&#44; satO<span class="elsevierStyleInf">2</span> &#40;&#60;90&#37; vs&#46; &#8805;90&#37;&#41;&#44; cardiac troponin &#40;elevated vs&#46; normal&#41; and transthoracic echocardiogram &#40;right ventricular &#91;RV&#93; dysfunction vs&#46; no RV dysfunction&#41;&#46; After matching&#44; the effect of multidisciplinary management was assessed via a GEE repeated measures model in which each cluster was made up of the treated patient and their matched pair&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We conducted various sensitivity analyses&#46; First&#44; we examined the effect of multidisciplinary management on mortality in the first 10 days following PE diagnosis&#46; Second&#44; we matched patients 1&#58;2 &#40;in other words&#44; each patient seen by the PERT team was matched with two patients who received regular care protocols&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We used Stata&#44; version 17&#46;1 &#40;StataCorp&#44; College Station&#44; Texas&#41; for Windows&#44; to perform the matching &#40;&#8220;calipmatch&#8221;&#41; and for all other analyses&#46; For statistical significance we considered a <span class="elsevierStyleItalic">p</span>-value of &#60;0&#46;05&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">The final sample was 2&#44;902 patients &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; A total of 92&#37; of the patients &#40;2&#44;669&#47;2&#44;902&#41; were diagnosed via CT angiography of the chest&#44; 321 &#40;11&#46;1&#37;&#41; via high-probability V&#47;Q scintigraphy&#44; and 138 &#40;4&#46;8&#37;&#41; had negative chest scans and DVT confirmed via lower limb ultrasound&#46; Some patients had multiple simultaneous positive diagnostic tests&#46; A total of 223 patients were seen &#40;7&#46;7&#37;&#59; 95&#37; confidence interval &#91;<span class="elsevierStyleBold">CI</span>&#93;&#44; 6&#46;7&#37;&#8211;8&#46;7&#37;&#41; by the PERT team&#46; The mean number &#40;standard deviation&#41; of specialists call on was 2&#46;2 &#40;0&#46;55&#41; and the median &#40;interquartile range&#41; was 2 &#40;2&#8722;2&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Unmatched cohort</span><p id="par0100" class="elsevierStylePara elsevierViewall">The characteristics of the patients included in the study are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The number of patients treated with inferior vena cava filters was low &#40;2&#46;9&#37;&#59; 83 out of 2&#44;902 patients&#41;&#46; A total of 7&#46;8&#37; &#40;227 out of 2&#44;902 patients&#41; were treated with thrombolytics&#46; Patients treated by the PERT team were less frequently male&#44; but more frequently had a history of COPD and heart failure &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The presentation of PE was more severe in patients cared for by the PERT team&#46; They more frequently presented a positive score on the simplified pulmonary embolism severity index &#40;<span class="elsevierStyleBold">PESI</span>&#41;&#46; They more commonly presented with syncope&#44; tachycardia&#44; hypotension&#44; desaturation&#44; and RV dysfunction than patients with PE treated according to normal protocols &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Clinical information was available for 98&#46;8&#37; of the patients &#40;2&#44;866&#47;2&#44;902 patients&#41; after the 30-day follow-up period&#46; Of the 2&#44;902 patients&#44; 241 &#40;8&#46;3&#37;&#59; 95&#37; CI&#44; 7&#46;3&#37;&#8211;9&#46;4&#37;&#41; died during the first 30 days of follow-up &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Eighty-eight patients &#40;36&#46;5&#37;&#41; died due to the actual PE&#44; 62 &#40;25&#46;7&#37;&#41; due to cancer&#44; 23 &#40;9&#46;5&#37;&#41; to infection&#44; 17 to lung disease &#40;7&#46;1&#37;&#41;&#44; 10 &#40;4&#46;1&#37;&#41; to bleeding&#44; 9 &#40;3&#46;7&#37;&#41; to heart failure and 32 &#40;13&#46;3&#37;&#41; due to other causes&#46; Of the patients treated by the PERT team&#44; 20 &#40;9&#46;0&#37;&#59; 95&#37; CI&#44; 5&#46;6&#37;&#8211;13&#46;5&#37;&#41; died during the first 30 days of follow-up&#46; Of the patients who received regular treatment&#44; 221 &#40;8&#46;2&#37;&#59; 95&#37; CI&#44; 7&#46;2&#37;&#8211;9&#46;4&#37;&#41; died within the first 30 days of follow-up &#40;absolute difference &#91;AD&#93;&#44; 0&#46;8&#37;&#59; 95&#37; CI&#44;-2&#46;7&#37;&#8211;5&#46;6&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">For the unmatched cohort&#44; the distribution of secondary outcomes according to treatment group is shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; With regards to treatment&#44; the patients seen by the PERT team received percutaneous thrombectomy with greater frequency &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;01&#41; and an inferior vena cava filter with less frequency &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#60;&#8239;0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; There were no differences between the 2 compared groups in terms of the use of fibrinolysis&#44; vasoactive drugs&#44; or the need for orotracheal intubation&#46; The median hospital stay was 7 days<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;11</span></a> in the PERT team treatment group and 8 days<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;13</span></a> in the regular treatment group &#40;<span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239;0&#46;27&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Matched cohort</span><p id="par0115" class="elsevierStylePara elsevierViewall">Matching of the patients treated by the PERT team or who received regular clinical practice was performed and 414 patients were successfully matched &#40;207 patients in each group&#41;&#46; The absolute standardised differences for the primary demographic and clinical variables of interest upon analysing all the patients are almost completely reduced &#40;except for a history of COPD and CHF&#41; when analysing the matched patient group &#40;Table S1&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In the matched cohort&#44; management by the PERT team was not associated with a statistically significant reduction in all-cause mortality &#40;odds ratio &#91;OR&#93;&#44; 1&#46;09&#59; 95&#37; CI&#44; 0&#46;63&#8211;1&#46;89&#41; or PE-related death &#40;OR&#44; 1&#46;30&#59; 95&#37; CI&#44; 0&#46;47&#8211;3&#46;62&#41; in the month after diagnosis of PE&#46; The percent of non-fatal thrombotic recurrences was lower in patients treated by the PERT team&#59; however&#44; the difference was not statistically significant &#40;OR&#44; 0&#46;59&#59; 95&#37; CI&#44; 0&#46;21&#8211;1&#46;68&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Sensitivity analysis</span><p id="par0125" class="elsevierStylePara elsevierViewall">When analysing mortality during the first 10 days of follow-up&#44; PERT team management was not associated with a statistically significant reduction in all-cause mortality &#40;6&#46;3&#37; vs&#46; 3&#46;9&#37;&#59; OR&#44; 1&#46;67&#59; 95&#37; CI&#44; 0&#46;66&#8211;4&#46;20&#41; or PE-related death &#40;4&#46;4&#37; vs&#46; 1&#46;9&#37;&#59; OR&#44; 2&#46;31&#59; 95&#37; CI&#44; 0&#46;69&#8211;7&#46;74&#41;&#46; When matching 1&#58;2&#44; the results were similar for all-cause mortality during the month after PE diagnosis &#40;OR&#44; 1&#46;09&#59; 95&#37; CI&#44; 0&#46;62&#8211;1&#46;89&#41;&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discussion</span><p id="par0130" class="elsevierStylePara elsevierViewall">This study assessed the effectiveness of multidisciplinary care &#40;via the PERT team&#41; in a broad cohort of patients with acute symptomatic PE&#46; In our series&#44; management of patients with acute symptomatic PE by a PERT team did not significantly reduce early mortality &#40;all-cause or PE-related&#41;&#46; Multidisciplinary care significantly increased the indication for percutaneous thrombectomy in these patients and no significant differences in hospital stay length were observed&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">In our experience&#44; the most severe presentations of PE were found in patients who received multidisciplinary care&#46; As previously described in the literature&#44; patients treated by the PERT team more frequently belonged to intermediate-high risk and high-risk groups&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> It is possible that the presence of a multidisciplinary team has improved assessments of the severity of patients with acute symptomatic PE and that prognostic tests are more frequently requested to classify said patients &#40;i&#46;e&#46;&#44; prognostic scales&#44; cardiac troponins&#44; transthoracic echocardiogram&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#8211;25</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">While one recent analysis suggests that multidisciplinary case reduces the use of advanced treatments for PE&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> most studies and two recent meta-analyses show the opposite&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> In our series&#44; the indication for thrombectomy was significantly more frequent in patients treated by the multidisciplinary team than among those treated according to normal care&#44; though this difference did not translate into a difference in hospital stay length&#46; The presence of a higher percent of intermediate-high and high-risk patients and the availability of new advanced therapies for PE could explain these findings&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">The clinical practice guidelines suggest multidisciplinary care for patients with acute symptomatic PE&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> One study including 769 patients hospitalised for PE reported that the PERT team &#40;n&#8239;&#61;&#8239;426&#41; reduced early mortality in a statistically significant manner &#40;8&#46;5&#37; vs&#46; 4&#46;7&#37;&#59; <span class="elsevierStyleItalic">p</span>&#8239;&#61;&#8239; 0&#46;03&#41;&#46; However&#44; most studies and the most recent meta-analyses have not been able to show a reduction in mortality among patients with PE who received care from multidisciplinary teams&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> Nor were we able to observe any reduction in mortality in our cohort&#44; even after matching with patients with a similarly severe baseline&#46; When limiting the analyses to the subgroup of patients with intermediate-high or high-risk PE &#40;data not shown&#41;&#44; we were still not able to demonstrate a significant reduction in all-cause mortality or PE-related mortality&#46; It is possible that the study design &#40;retrospective&#41; and a small sample size could explain these results&#46; In addition&#44; the PERT teams&#8217; composition and implementation is not standardised&#44; and this heterogeneity could influence the conflicting findings in the literature&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The study does present some limitations&#46; First&#44; though the researchers collected all the variables prospectively&#44; this is a retrospective analysis and is subject to biases that are inherent to this type of study&#46; The possibility of unmeasured confounding factors that influenced the results cannot be ruled out&#46; However&#44; an exact matching technique was used to overcome this limitation&#46; The propensity analysis did not allow us to eliminate the differences between the two groups for some covariates &#40;i&#46;e&#46;&#44; recent bleeding&#44; COPD&#44; or CHF&#41;&#46; However&#44; for small sample sizes&#44; the standardised differences &#62;20&#37; for some covariates did not impair the validity of the model&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> What&#39;s more&#44; the similar results from the sensitivity analyses reinforce the validity of the results&#46; Lastly&#44; the size of the matched cohorts was small and increased the risk of the study not identifying a statistically significant difference in mortality &#40;that is&#44; type II error&#41;&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">In conclusion&#44; our results show that multidisciplinary care of patients with acute symptomatic PE is not associated with a significant reduction in early mortality&#46; The results should be considered exploratory and generators of hypotheses&#46; Well-designed prospective studies are needed to evaluate the effect of multidisciplinary care on PE prognosis&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicts of interest</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors have nothing to declare with the exception of D&#46;J&#46;&#44; who reports having received remuneration for conferences from Bristol-Myers-Squibb&#44; Pfizer and Sanofi&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Funding</span><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleGrantSponsor" id="gs0005">IV Grant Merck Health Foundation</span> for Research in Health Outcomes&#46;</p></span></span>"
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              "titulo" => "Patients and selection criteria"
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          "clase" => "keyword"
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            0 => "Pulmonary embolism"
            1 => "Prognosis"
            2 => "Multidisciplinary team"
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          "clase" => "keyword"
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          "palabras" => array:3 [
            0 => "Tromboembolia de pulm&#243;n"
            1 => "Pron&#243;stico"
            2 => "Equipo multidisciplinar"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The effect of a pulmonary embolism response team &#40;<span class="elsevierStyleBold">PERT</span>&#41; in the short-term prognosis of patients with acute symptomatic pulmonary embolism &#40;<span class="elsevierStyleBold">PE</span>&#41; lacks clarity&#46; We therefore aimed at evaluating the effect of a PERT team on short-term mortality among patients with acute PE&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We retrospectively reviewed consecutive patients with acute symptomatic PE enrolled in a single-center registry between 2007 and 2022&#46; We used propensity score matching to compare treatment effects for patients with similar predicted probabilities of receiving management by the PERT team&#46; The primary outcome was all-cause mortality within 30 days following the diagnosis of PE&#46; The secondary outcome was 30-day PE-related mortality&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Of the 2&#44;902 eligible patients who had acute symptomatic PE&#44; 223 &#40;7&#46;7&#37;&#59; 95&#37; confidence interval &#91;<span class="elsevierStyleBold">CI</span>&#93;&#44; 6&#46;7&#37;&#8211;8&#46;7&#37;&#41; were managed by the PERT team&#46; Two hundred and seven patients who were treated by the PERT were matched with 207 patients who were not&#46; Matched pairs did not show a statistically significant lower all-cause &#40;odds ratio &#91;<span class="elsevierStyleBold">OR</span>&#93;&#44; 1&#46;09&#59; 95&#37; CI&#44; 0&#46;63&#8211;1&#46;89&#41; or PE-related death &#40;OR&#44; 1&#46;30&#59; 95&#37; CI&#44; 0&#46;47&#8211;3&#46;62&#41; for PERT management compared with no PERT management through 30 days after diagnosis of PE&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that multidisciplinary care of patients with acute symptomatic PE by a PERT team is not associated with a significant reduction in short-term all-cause or PE-related mortality&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
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            "identificador" => "abst0010"
            "titulo" => "Methods"
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            "titulo" => "Results"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">No se han aclarado suficientemente los beneficios del manejo multidisciplinar &#40;c&#243;digo TEP&#41; de los pacientes con tromboembolia de pulm&#243;n &#40;<span class="elsevierStyleBold">TEP</span>&#41; aguda sintom&#225;tica&#46; El objetivo de este estudio fue evaluar el efecto sobre la mortalidad a corto plazo del c&#243;digo TEP comparado con la atenci&#243;n habitual&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Realizamos un estudio retrospectivo que incluy&#243; a todos los pacientes con diagn&#243;stico de TEP aguda sintom&#225;tica ingresados en un hospital terciario Universitario entre 2007 y 2022&#46; Mediante un an&#225;lisis de emparejamiento exacto 1&#58;1&#44; los pacientes atendidos por un equipo multidisciplinar para el manejo de la TEP &#40;c&#243;digo TEP&#41; fueron emparejados con otros que recibieron la atenci&#243;n habitual &#40;es decir&#44; no multidisciplinar&#41; para la TEP&#46; El evento primario de eficacia fue la mortalidad por cualquier causa durante los 30 primeros d&#237;as despu&#233;s del diagn&#243;stico&#46; El evento secundario de eficacia fue la mortalidad por la propia TEP durante el mismo per&#237;odo de tiempo&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">De los 2&#46;902 pacientes con diagn&#243;stico de TEP aguda sintom&#225;tica incluidos en este estudio&#44; 223 &#40;7&#44;7&#37;&#59; intervalo de confianza &#91;<span class="elsevierStyleBold">IC</span>&#93; del 95&#37;&#44; 6&#44;7&#37;&#8211;8&#44;7&#37;&#41; fueron manejados por el c&#243;digo TEP&#46; Se emparejaron 207 pacientes manejados por el c&#243;digo TEP con 207 pacientes manejados de forma habitual&#46; En la cohorte emparejada&#44; la atenci&#243;n multidisciplinar a los pacientes con TEP aguda sintom&#225;tica no se asoci&#243; a una reducci&#243;n significativa de la mortalidad por cualquier causa &#40;<span class="elsevierStyleItalic">odds ratio</span> &#91;<span class="elsevierStyleBold">OR</span>&#93;&#44; 1&#44;09&#59; IC del 95&#37;&#44; 0&#44;63&#8722;1&#44;89&#41; o por la propia TEP &#40;OR&#44; 1&#44;30&#59; IC del 95&#37;&#44; 0&#44;47&#8722;3&#44;62&#41; en el mes posterior al diagn&#243;stico de la TEP&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">La atenci&#243;n multidisciplinar a los pacientes con TEP aguda sintom&#225;tica no se asoci&#243; a una reducci&#243;n significativa de la mortalidad precoz&#46;</p></span>"
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            "apendice" => "<p id="par0175" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
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            "titulo" => "Supplementary data"
            "identificador" => "sec0090"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow chart&#46;</p>"
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        "etiqueta" => "Figure 2"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Use of advanced treatment according to whether patients did or did not receive care from the PERT team&#46;</p>"
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          "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; PE&#44; pulmonary embolism&#59; VTE&#44; venous thromboembolism&#59; COPD&#44; chronic obstructive pulmonary disease&#59; CHF&#44; congestive heart failure&#59; SBP&#44; systolic blood pressure&#59; PESI&#44; pulmonary embolism severity index&#59; ESC&#44; European Society of Cardiology&#59; RV&#44; right ventricle&#59; BNP&#44; B-type natriuretic peptide&#59; SD&#44; standard deviation&#46;</p>"
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Age &#62;80 years&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">742 &#40;27&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;242 &#40;46&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cancer<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Recent surgery<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;6&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">222 &#40;8&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;37&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;10&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">334 &#40;12&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Immobilization<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;20&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">552 &#40;20&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comorbidities&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Recent major bleeding<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">218 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;12&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">213 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>CHF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;8&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141 &#40;5&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Signs and symptoms&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Syncope&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;25&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">426 &#40;15&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chest pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;40&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;127 &#40;42&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyspnoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;87&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;930 &#40;72&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Heart rate &#8805;110&#47;minute&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;33&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">587 &#40;21&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Haemoglobin oxygen saturation &#60;90&#37; &#40;n&#8239;&#61;&#8239;2&#44;711&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#47;221 &#40;39&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">725&#47;2490 &#40;29&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SBP &#60;100&#8239;mmHg &#40;n&#8239;&#61;&#8239;2&#44;858&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#47;223 &#40;16&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">222&#47;2635 &#40;8&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Simplified PESI&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;17&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">812 &#40;30&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183 &#40;82&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;867 &#40;69&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ESC severity classification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Low risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;17&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">812 &#40;30&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Low-intermediate risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;43&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;573 &#40;58&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Intermediate-high risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;27&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">189 &#40;7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>High risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;11&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Echocardiogram and cardiac biomarkers&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>RV dysfunction &#40;n&#8239;&#61;&#8239;1&#44;585&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">213&#47;215 &#40;99&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">737&#47;1370 &#40;53&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Elevated cardiac troponin &#40;n&#8239;&#61;&#8239;2&#44;304&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#47;219 &#40;36&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">687&#47;2085 &#40;32&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Elevated BNP &#40;n&#8239;&#61;&#8239;1&#44;444&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">144&#47;208 &#40;69&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">590&#47;1236 &#40;47&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lab testing&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Elevated creatinine &#40;&#62;2&#8239;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;1&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99 &#40;3&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Thrombocytopenia &#40;&#60;100&#8239;&#215;&#8239;10<span class="elsevierStyleSup">9</span>&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Haemoglobin&#44; g&#47;dL &#40;mean &#177; SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;4 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;3 &#40;2&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
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            1 => array:3 [
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              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Non-surgical patients bedridden for &#8805;4 days in the month prior to PE diagnosis&#46;</p>"
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of 2&#44;902 patients with acute PE according to whether or not they received care from the PERT team&#46;</p>"
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          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; PE&#58; pulmonary embolism&#59; CI&#58; confidence interval&#46;</p>"
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            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total N&#8239;&#61;&#8239;2&#44;902&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PERT team N&#8239;&#61;&#8239;223&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No PERT team N&#8239;&#61;&#8239;2&#44;679&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Absolute difference &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">All-cause mortality&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">241 &#40;8&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;9&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">221 &#40;8&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#37; &#40;&#8722;2&#46;7&#37;&#8211;5&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mortality due to PE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88 &#40;3&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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