Medicine in Images
Breast plasmacytoma as a manifestation prior to relapse of multiple myeloma
Plasmocitoma mamario como manifestación previa a recaída de mieloma múltiple
E. López Rodríguez
, R.M. Álvarez Pérez, J.M. Jiménez-Hoyuela García
Corresponding author
Servicio de Medicina Nuclear. Hospital Universitario Virgen del Rocío, Sevilla, Spain
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López Rodríguez, R.M. Álvarez Pérez, J.M. Jiménez-Hoyuela García" "autores" => array:3 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "López Rodríguez" "email" => array:1 [ 0 => "estefania.lr.86@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "R.M." "apellidos" => "Álvarez Pérez" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Jiménez-Hoyuela García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Medicina Nuclear. Hospital Universitario Virgen del Rocío, Sevilla, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Plasmocitoma mamario como manifestación previa a recaída de mieloma múltiple" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 776 "Ancho" => 1255 "Tamanyo" => 86097 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 34-year-old woman was diagnosed with multiple myeloma in 2014, with complete response. In December 2017, the patient underwent positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- <span class="elsevierStyleSmallCaps">d</span>-glucose integrated with computed tomography (<span class="elsevierStyleSup">18</span>F-FDG PET/CT) for an evaluation prior to a possible allogeneic transplant, which revealed as the only finding a hypermetabolic nodule in the right breast (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). An assessment was therefore recommended to rule out malignancy. Histopathology confirmed the presence of infiltration by multiple myeloma. Faced with the presence of a breast plasmacytoma, the decision was made to perform allogeneic transplantation and subsequent radiation therapy. A check-up PET/CT was requested to assess the treatment response of the breast plasmacytoma, which revealed metabolic progression of the disease with involvement of muscle, supradiaphragmatic and infradiaphragmatic lymph nodes, liver, kidneys and bone (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). The patient was started on systemic chemotherapy. Once the treatment was completed, the patient underwent a new PET/CT, which showed a partial metabolic response of the lesions (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). After changing the treatment line and after several hospitalizations for infectious conditions, the patient ultimately died.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Breast plasmacytoma is a rare entity but is most common in women with a mean age of 53 years.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The disease can be its own presentation or occur during the course of already diagnosed multiple myeloma.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> As was the case with our patient, breast plasmacytoma can also precede a systemic relapse of a treated disease in remission. It is therefore important to consider this finding because it can be a manifestation prior to the relapse of multiple myeloma.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-15" "fechaAceptado" => "2019-03-18" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López Rodríguez E., Álvarez Pérez R.M., Jiménez-Hoyuela García J.M. Plasmocitoma mamario como manifestación previa a recaída de mieloma multiple. Rev Clin Esp. 2021;221:243–244.</p>" ] ] "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1199 "Ancho" => 1255 "Tamanyo" => 94675 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 776 "Ancho" => 1255 "Tamanyo" => 86097 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bilateral breast plasmacytoma: a clinical case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.R. Fischer" 1 => "F. Higashi" 2 => "Q. Crusoe Ede" 3 => "V.T. Hungria" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bjhh.2016.03.003" "Revista" => array:7 [ "tituloSerie" => "Rev Bras Hematol Hemoter" "fecha" => "2016" "volumen" => "38" "numero" => "2" "paginaInicial" => "166" "paginaFinal" => "169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27208578" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasmablastic plasmacytoma of the breast" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.K. Le" 1 => "D. Metter" 2 => "J.R. Krause" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/08998280.2017.11929587" "Revista" => array:7 [ "tituloSerie" => "Proc (Bayl Univ Med Cent)." "fecha" => "2017" "volumen" => "30" "numero" => "2" "paginaInicial" => "203" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28405083" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000022100000004/v2_202104080754/S2254887419302413/v2_202104080754/en/main.assets" "Apartado" => array:4 [ "identificador" => "71811" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Medicine in images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000022100000004/v2_202104080754/S2254887419302413/v2_202104080754/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887419302413?idApp=WRCEE" ]
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