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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Background</span><p id="par0025" class="elsevierStylePara elsevierViewall">Infectious spondylitis &#40;IS&#41;&#44; also known as vertebral osteomyelitis or spondylodiscitis&#44; is an uncommon disease &#40;3&#8211;5&#37; of cases of osteomyelitis&#41;&#44; with a incidence that varies between 2&#46;2 and 9 cases&#47;100&#44;000 inhabitants&#47;year&#44; according to published Spanish series&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a> Patients with IE are mostly men between the ages of 50 and 70 years with predisposing factors such as spinal surgery&#44; prior bacteremia and parenteral drug use &#40;PDU&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a> The incidence of IS has increased in recent years due to the availability of better diagnostic methods and the increase in nosocomial infections&#44; the rates of spinal surgery and the number of patients with immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> IS is produced by hematogenous dissemination &#40;with a extraspinal focus&#41;&#44; by direct external inoculation &#40;spinal or trauma surgery&#41; or by contiguity &#40;from a close infectious focus&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> The clinical condition is fairly nonspecific&#44; often leading to a delay in the diagnosis&#44; which at times requires the implementation of invasive techniques or surgery to determine the causal microorganism&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The microorganism most often involved is <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;<span class="elsevierStyleItalic">S&#46; aureus</span>&#41;&#44; followed by Gram-negative bacilli&#46; In our community and in a not too distant past&#44; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;<span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#41; and <span class="elsevierStyleItalic">Brucella melitensis</span> were common&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#44;8</span></a> IS can cause pain-related conditions and neurological deficits&#44; at times irreversible&#44; and its mortality is approximately 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The Spanish publications of case series of IS have been few in recent years&#44; during which IS appears to have undergone significant changes in its clinical&#8211;epidemiological characteristics&#46; The aim of this study was to describe the epidemiological&#44; clinical and etiological characteristics and outcomes of patients who have presented IS in 2 hospitals of Palma de Mallorca&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">A series of retrospective cases conducted in 2 hospitals on the island of Mallorca that cover a population of approximately 550&#44;000 inhabitants&#46; We included all patients over 15 years of age with a diagnosis of IS from January 1&#44; 2003 to October 31&#44; 2013&#46; The data were obtained from the diagnostic coding database of the department of clinical archives and documentation of the 2 hospitals&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A diagnosis of IS was established when there was a compatible clinical condition &#40;lumbar pain&#44; fever and muscle pain during the physical examination&#41;&#44; supported by an imaging technique&#58; &#40;a&#41; plain radiography with vertebral endplate disintegration&#44; reduced joint space or vertebral body destruction&#59; &#40;b&#41; computed axial tomography &#40;CT scan&#41; with subchondral bone destruction&#44; loss of cortical margin of the vertebral endplate or periosteal reaction&#59; &#40;c&#41; magnetic resonance imaging &#40;MRI&#41; with reduced signal of the vertebra and intervertebral disc on T1&#44; increased signal of the vertebra and disc in T2&#44; loss of definition of the vertebral endplate&#59; and &#40;d&#41; bone scintigraphy with tecnecio-99 &#40;GO <span class="elsevierStyleSup">99</span>mTc&#41;&#46; In terms of the etiological diagnosis&#44; we assessed any isolates in blood or in a sample of the focus obtained during surgery or percutaneous puncture&#46; A diagnosis of spondylitis tuberculous was considered the presence of symptoms and radiological compatible findings&#44; along with positive direct smears for bacilli or <span class="elsevierStyleItalic">M&#46; tuberculosis</span> isolates in Lowenstein-Jensen medium with no other bacterial isolate&#46; We also considered a positive PCR for <span class="elsevierStyleItalic">M&#46; tuberculosis</span> of any microbiological sample&#44; a positive tuberculin test or QuantiFERON &#8211; TB Gold<span class="elsevierStyleSup">&#174;</span>&#44; along with clinical and radiological improvement after starting tuberculostatic treatment&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The following variables were collected&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Demographic&#58; 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in cases where sequelae were detected&#44; mortality or related overall according to the discretion of the researchers provided there was a direct relationship between the infection and death&#46;</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">A basic statistical analysis was conducted using frequency calculation for each qualitative variable and the mean&#44; standard deviation &#40;SD&#41;&#44; median and interquartile range &#40;IQR&#41; for the quantitative variables&#46; We then performed a univariate analysis on the qualitative variables using the chi-squared test &#40;Fisher&#39;s test for those cases that required it&#41;&#44; as well as a risk estimate using the odds ratio calculation with its 95&#37; confidence intervals &#40;95&#37; CI&#41;&#46; For the comparison of quantitative variables&#44; we used Student&#39;s <span class="elsevierStyleItalic">t</span>-test&#46; The level of statistical significance was established at &#46;05 &#40;in all hypothesis testing&#44; the null hypothesis was rejected with an error type I or an alpha error &#60;0&#46;05&#41;&#46; All calculations were performed with the statistical bundle SPSS 12&#46;0 for Windows&#46; The confidentiality of the recorded data was ensured&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">A total of 51 cases of IS were recorded&#59; 37 &#40;72&#46;5&#37;&#41; were of men and 14 were of women &#40;27&#46;5&#37;&#41;&#46; The median age was 66 years &#40;IQR&#58; 22&#8211;85&#41;&#44; and 28 patients &#40;54&#46;9&#37;&#41; were older than 65 years&#46; The cumulative incidence was 9 cases&#47;10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#44; and the mean annual incidence was 5&#46;1 cases&#47;year&#44; with the distribution shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Twenty-three patients &#40;45&#46;1&#37;&#41; presented bacteremia in the 30 days prior to the bone infection diagnosis&#46; The origin of the bacteremia was urinary in 10 &#40;43&#46;5&#37;&#41; patients&#44; catheter in 5 &#40;21&#46;7&#37;&#41; patients&#44; respiratory in 3 &#40;13&#37;&#41; patients&#44; endocardial in 3 &#40;13&#37;&#41; patients and skin or soft tissue in 2 &#40;8&#46;7&#37;&#41; patients&#46; Six patients &#40;11&#46;8&#37;&#41; were PDU and 6 &#40;11&#46;8&#37;&#41; had undergone prior spinal surgery&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The comorbidities present in the patients included in this study are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The median Charlson comorbidity index was 2&#46;8 points &#40;range&#58; 0&#8211;13&#41;&#46; Four &#40;7&#46;8&#37;&#41; patients had severe dependence &#40;Barthel index &#60;35 points&#41;&#44; 9 &#40;17&#46;6&#37;&#41; had mild to moderate dependence &#40;&#62;40 points&#41; and 38 &#40;74&#46;5&#37;&#41; were independent&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">The most common presentation was spondylodiscitis in 48 &#40;94&#46;1&#37;&#41; cases&#44; while 2 &#40;3&#46;9&#37;&#41; cases presented spondylitis without discitis&#44; and 1 &#40;1&#46;9&#37;&#41; presented posterior segment infection &#40;vertebral arches and spinous process&#41;&#46; The most common location was the lumbar spine in 30 &#40;58&#46;8&#37;&#41; patients&#44; dorsal in 15 &#40;29&#46;4&#37;&#41; and cervical in 6 &#40;11&#46;8&#37;&#41;&#46; All patients showed a single focal involvement&#44; except for one patient who had cervical and dorsal involvement&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The most common symptom was fever &#40;35 cases&#59; 68&#46;8&#37;&#41;&#44; while 14 &#40;27&#46;5&#37;&#41; patients reported radicular pain&#46; During the examination&#44; 32 &#40;62&#46;7&#37;&#41; patients experienced focal pain on palpation in the area of the lesion&#44; and 10 &#40;19&#46;6&#37;&#41; patients experienced paralysis&#44; paresis or paresthesia&#46; The mean elapsed time from symptom onset to diagnosis was 80&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#46;1 days&#46; Leukocytosis was detected &#40;&#8805;11&#44;000 leukocytes&#47;L&#41; in 22 &#40;43&#46;1&#37;&#41; cases&#44; the median CRP was 14 &#40;1&#8211;320&#41; mg&#47;dL&#44; and the median ESR was 48 &#40;10&#8211;40&#41; mm&#47;h&#46; Thirty-eight &#40;74&#46;5&#37;&#41; plain spine radiographs were performed&#44; 23 &#40;60&#46;5&#37;&#41; of which revealed pathological findings&#46; CT scans were performed on 34 &#40;66&#46;6&#37;&#41; patients&#44; 32 of which revealed pathological findings &#40;94&#46;1&#37;&#41;&#46; MRIs were performed on 46 &#40;90&#46;2&#37;&#41; patients&#44; all of them revealing pathological findings &#40;100&#37;&#41;&#46; GO <span class="elsevierStyleSup">99</span>mTc was performed on 12 &#40;23&#46;5&#37;&#41; patients&#44; with normal results on 2 occasions &#40;16&#46;7&#37;&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The IS had a hematogenous origin in 36 &#40;70&#46;6&#37;&#41; patients&#44; was due to contiguity in 4 &#40;7&#46;8&#37;&#41; patients&#44; was postsurgical or post-trauma in 3 &#40;5&#46;9&#37;&#41; patients and was of unknown origin in 8 &#40;15&#46;7&#37;&#41; patients&#46; Forty-four &#40;86&#46;3&#37;&#41; cases were caused by pyogenic bacteria&#59; <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was isolated in 4 &#40;7&#46;8&#37;&#41; cases&#46; In 3 &#40;5&#46;9&#37;&#41; cases&#44; the causal microorganism could not be determined despite performing a percutaneous puncture on the lesion&#46; For the patients without microbiological isolates&#44; the time to diagnosis was 283&#46;3 days &#40;10&#8211;420&#41;&#44; much longer than the 67&#46;4 &#40;1&#8211;450&#41; days required by the patients with a confirmed etiology &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Statistically significant differences were not found however in terms of treatment time and sequelae&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The causal agents involved are listed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The most common microorganism was <span class="elsevierStyleItalic">S&#46; aureus</span> in 23 &#40;52&#46;3&#37;&#41; patients of whom 2 were methicillin-resistant &#40;MRSA&#41;&#44; followed by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in 6 &#40;13&#46;7&#37;&#41; patients&#44; <span class="elsevierStyleItalic">E&#46; coli</span> in 5 &#40;11&#46;4&#37;&#41;&#44; <span class="elsevierStyleItalic">Salmonella</span> and other enterobacteriaceae in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Enterococcus faecalis</span> in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Bacteroides fragilis</span> in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Streptococcus spp&#46;</span> in 2 &#40;4&#46;5&#37;&#41; and coagulase-negative staphylococci in 2 &#40;4&#46;5&#37;&#41; patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Serologies for <span class="elsevierStyleItalic">Brucella</span> &#40;Rose Bengal and total antibodies&#41; were conducted for 10 &#40;5&#46;1&#37;&#41; patients&#44; all of which were negative&#46; In 6 of the 10 &#40;60&#37;&#41; cases&#44; the tuberculin test yielded positive results&#46; A QuantiFERON-TB Gold<span class="elsevierStyleSup">&#174;</span> test was performed in 2 &#40;3&#46;9&#37;&#41; cases&#44; which yielded a positive result in only 1 case&#59; the CRP for <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was positive in only 1 case&#46; Microorganisms were isolated in 7 &#40;87&#46;5&#37;&#41; of the 8 patients who underwent surgery&#44; in 11 &#40;50&#37;&#41; of the 22 who underwent percutaneous puncture and in 27 &#40;65&#46;8&#37;&#41; of the 41 for whom blood cultures were performed&#46; Significant differences were detected when comparing the characteristics of patients with pyogenic germs vs&#46; those for whom no germ could be identified&#46; The former group had a shorter time to diagnosis &#40;61&#46;9 vs&#46; 129&#46;33 days&#59; 95&#37; CI 80&#46;9&#8211;363&#46;3&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41; and shorter treatment &#40;40&#46;6 vs&#46; 87&#46;7 days&#59; 95&#37; CI 14&#46;7&#8211;120&#46;1&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; The main differences between the cases of IS included in this study according to whether they had a pyogenic or tuberculous etiology are listed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Empiric antibiotic treatment was monotherapy for 18 &#40;35&#46;3&#37;&#41; patients&#44; double therapy for 20 &#40;39&#46;2&#37;&#41; and triple therapy for 4 &#40;7&#46;8&#37;&#41; patients&#46; No empiric treatment was administered to 9 &#40;17&#46;6&#37;&#41; patients&#46; The empirically administered antibiotics were cloxacillin in 15 cases &#40;21&#46;1&#37;&#41;&#44; vancomycin in 12 &#40;16&#46;9&#37;&#41;&#44; aminoglycosides in 9 &#40;12&#46;7&#37;&#41;&#44; other penicillins in 9 &#40;12&#46;7&#37;&#41;&#44; cephalosporins in 8 &#40;11&#46;3&#37;&#41;&#44; rifampicin on 5 &#40;7&#37;&#41;&#44; carbapenems in 4 &#40;5&#46;6&#37;&#41;&#44; quinolones in 3 &#40;4&#46;2&#37;&#41;&#44; linezolid in 2 &#40;2&#46;8&#37;&#41;&#44; tuberculostatic agents in 2 &#40;2&#46;8&#37;&#41;&#44; daptomycin in 1 &#40;1&#46;4&#37;&#41; and teicoplanin in 1 &#40;1&#46;4&#37;&#41; case&#46; The treatment was changed for 42 &#40;82&#46;3&#37;&#41; patients&#46; For 11 of these patients &#40;26&#46;2&#37;&#41;&#44; the treatment was adjusted based on the results of the antibiogram&#59; the reason for changing treatment in the remaining patients was not reported or specified in the comments of the medical history&#46; The antibiotics most frequently used as targeted treatment were quinolones in 17 &#40;24&#46;3&#37;&#41; cases&#44; cloxacillin in 14 &#40;20&#37;&#41;&#44; rifampicin in 13 &#40;18&#46;6&#37;&#41;&#44; cephalosporins in 7 &#40;10&#37;&#41;&#44; other penicillins in 6 &#40;8&#46;6&#37;&#41;&#44; aminoglycosides in 4 &#40;5&#46;7&#37;&#41;&#44; carbapenems in 3 &#40;4&#46;3&#37;&#41;&#44; vancomycin in 3 &#40;4&#46;3&#37;&#41;&#44; linezolid in 1 &#40;1&#46;4&#37;&#41;&#44; clindamycin in 1 &#40;1&#46;4&#37;&#41; and teicoplanin in 1 &#40;1&#46;4&#37;&#41; case&#46; Of the 6 &#40;11&#46;7&#37;&#41; patients who underwent empirical treatment with tuberculostatic agents&#44; <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was isolated in 4&#46; No IS-causing microorganism could be isolated in the 2 remaining patients&#44; although they progressed favorably with no complications during the follow-up&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The mean total treatment time was 78&#46;92 days &#40;SD&#44; 66&#46;4&#41;&#46; Antibiotic treatment was administered intravenously for 29&#46;64 days &#40;SD&#44; 16&#46;1&#41; and orally for 71&#46;61 days &#40;SD&#44; 75&#46;3&#41;&#46; The cases of IS of tuberculosis origin were treated for 212 days &#40;SD&#44; 75&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Twelve patients &#40;23&#46;5&#37;&#41; required some type of surgical management&#59; 5 &#40;41&#46;6&#37;&#41; for abscess draining&#44; 5 &#40;41&#46;6&#37;&#41; for spinal decompression&#44; 1 &#40;8&#46;3&#37;&#41; due to treatment failure and 1 &#40;8&#46;3&#37;&#41; for diagnostic purposes&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">During the acute phase&#44; 12 patients &#40;23&#46;5&#37;&#41; developed paravertebral abscesses&#44; 8 &#40;15&#46;7&#37;&#41; developed epidural abscesses and 3 &#40;5&#46;9&#37;&#41; developed psoas abscesses&#46; Seven patients &#40;13&#46;7&#37;&#41; presented long-term residual neurological deficits and 6 &#40;11&#46;8&#37;&#41; maintained chronic pain&#46; Thirty-six patients &#40;70&#46;6&#37;&#41; were clinically cured&#44; 4 &#40;7&#46;8&#37;&#41; presented sequelae despite demonstrating microbiological healing&#44; and another 6 &#40;11&#46;8&#37;&#41; died&#44; although only one of them died for reasons directly related to the infection&#46; Due to an inability to maintain clinical follow-up&#44; we were not able to determine the outcome of 5 &#40;9&#46;8&#37;&#41; patients&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The patients who presented acute complications or long-term sequela presented comorbidities &#40;median Charlson&#39;s index of 4 points &#91;IQR 0&#8211;13&#93; vs&#46; 2 points &#91;IQR 0&#8211;11&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;068&#41;&#44; neurological symptoms at symptom onset &#40;14 &#91;58&#46;3&#37;&#93; vs&#46; 3 &#91;11&#46;1&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41; and required surgery &#40;10 &#91;83&#46;3&#37;&#93; vs&#46; 2 &#91;6&#46;2&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41;&#44; with a greater frequency than the other patients who did not present acute complications or long-term sequelae&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">This study describes the main clinical and epidemiological characteristics of 51 cases of IS that required hospitalization and were treated in 2 hospital centers in Mallorca between 2003 and 2013&#46; This study represents the third largest Spanish series&#44; in terms of the number of included patients&#44; published in the last 10 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2&#44;6&#44;9&#44;10</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In our study&#44; the incidence of IS was 9 cases<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#44; the same rate reported more recently by Ruiz Mart&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> and similar to the largest series reported in Spain by Colmenero et al&#46;&#44; <a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> who observed an incidence of 7 cases<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#46; These results indicate that despite the increase in the incidence reported by a number of authors&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> the incidence in our community has not changed significantly&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The disease antecedents that have classically been related to IS&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> such as diabetes mellitus&#44; liver disease&#44; neoplasms and immunosuppression&#44; are also the most common in our series&#46; Although 54&#46;9&#37; of the patients were older than 65 years&#44; as can be deduced from the estimates of the Charlson and Barthel indices&#44; they did not present a significant degree of comorbidity&#44; and 74&#46;5&#37; of the patients were completely independent&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The most common location for IS was lumbar&#46; The clinical condition was characterized by the presence of fever&#44; focal pain in the lesion and&#44; in a significant minority of cases &#40;19&#46;6&#37;&#41;&#44; focal neurological impairment in the form of paralysis&#44; paresis&#44; algias or paresthesia&#46; This high percentage could be related to the delay from symptom onset to diagnosis that occurred in our series&#46; The additional tests included detecting the presence of leukocytosis&#44; increased PCR and ESR&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The diagnostic sensitivities of the spine imaging tests were 60&#46;5&#37; for the plain radiology&#44; 83&#46;3&#37; for the GO <span class="elsevierStyleSup">99</span>mTc&#44; 94&#46;1&#37; for the CT scan and 100&#37; for the MRI&#44; results very similar to those reported previously&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2&#44;9</span></a> except for the plain radiography&#44; which could be due to the difficulty in interpreting the often nonspecific radiological changes&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The origin of the IS was mostly hematogenous&#46; In our series&#44; only 3 patients had previously undergone surgery&#44; which differs from previous observations&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> In most cases&#44; the IS was caused by pyogenic germs &#40;86&#46;3&#37;&#41;&#44; with monobacterial isolates in all cases&#46; The most common microorganism was <span class="elsevierStyleItalic">S&#46; aureus</span> &#40;52&#46;3&#37;&#41;&#44; coinciding with the findings of other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;6&#44;10</span></a> The presence of MRSA was not a noteworthy aspect of our series &#40;only 2 cases had MRSA&#41;&#44; in contrast to that observed in other series that found increases in its incidence&#44; which were hypothetically related to hospital care&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> Although the incidence in 2012 of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> infection in all of its clinical forms in the Balearic Islands was 12&#46;8 cases per 100&#44;000 inhabitants&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> the number of cases of tuberculous IS has been low&#44; given that the latest case was diagnosed in 2008&#46; It is worth noting that in our series there was no case of IS caused by <span class="elsevierStyleItalic">Brucella</span> and that since 2010 the Balearic Islands have been considered by the European Union as a territory unscathed by bovine and caprine brucellosis&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Our results support the diagnostic yield of percutaneous punctures and&#44; when necessary&#44; surgical approaches&#44; enabling accurate microbiological diagnoses to be reached&#44; which in turn enable the most appropriate treatment to be administered&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">In our series&#44; 17&#46;6&#37; of the cases started antibiotherapy empirically until the microorganism responsible for the infection was identified&#46; In the majority of cases&#44; empiric antibiotherapy was likely started due to the presence of fever and nonspecific symptoms&#44; a situation that could have been accompanied by reduced diagnostic yields&#46; Although the current trend is to decrease the antibiotic treatment duration&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a> there is controversy given that the duration depends fundamentally on the microbiological isolate&#44; the presence of bacteremia&#44; the presence of endocarditis&#44; paravertebral abscesses that require drainage&#44; the patient&#39;s general condition&#44; etc&#46; To start empiric antibiotherapy&#44; it is important to characterize the various clinical conditions&#46; In our study&#44; the comparisons performed between the various etiologies show that spondylodiscitis of pyogenic origin has a higher frequency of previous bacteremia and is diagnosed earlier than spondylodiscitis of tuberculosis or unidentified origin&#46; We also have no randomized clinical trials&#44; and the current recommendations range from 6 weeks<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> to 3 months&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a> with an intravenous treatment duration of at least 4 weeks&#46; In our study&#44; the patients underwent treatment for 78&#46;92 days&#44; of which intravenous administration used 29&#46;64 days&#46; All patients with IS of tuberculosis origin underwent treatment for at least 6 months&#44; according to the recommendations of the treatment guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">In our series&#44; almost half of the patients presented localized complications during the acute phase&#46; As occurred in other series&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a> mortality was low&#44; although morbidity was high given that chronic pain or residual neurological deficits were detected in almost a quarter of the cases during follow-up&#44; which compromised the patients&#8217; quality of life&#46; It is possible that a greater index of suspicion and a shorter delay in the diagnosis of IS could reduce these types of complications&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Our study&#39;s limitations include its retrospective nature&#46; Selecting cases according to the coding of the discharge report could have led us to underestimate the number of cases&#44; due to errors in the preparation or coding of the report&#46; However&#44; it seems fairly unlikely given the characteristics of IS&#46; The intervention by various specialists from 2 hospital centers&#44; with no homogeneous diagnostic and therapeutic criteria&#44; could have affected our results&#46; The collection of samples using percutaneous puncture was conducted by different physicians in the department of radiology and was guided by ultrasonography or CT&#46; We therefore cannot ensure that the method for collecting samples was the same in all cases&#46; We cannot rule out the fact that during the follow-up &#40;after discharge&#41; a number of patients were treated in other hospital centers&#44; both public and private&#44; although this number is probably low given that the participating hospitals are the centers that treat the largest percentage of the population in Mallorca&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">We can conclude that the incidence of IS has not changed significantly over the last decade&#44; a fact that can be observed mainly in patients with associated comorbidity &#40;although without a high degree of dependence&#41;&#46; The main etiology of IS is <span class="elsevierStyleItalic">S&#46; Aureus</span>&#44; which usually presents a long diagnostic delay and&#44; although it causes low mortality&#44; frequently causes disabling sequelae&#46; The selective performance of percutaneous punctures&#44; accompanied by blood cultures&#44; improves the diagnostic performance&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "clase" => "keyword"
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          "identificador" => "xpalclavsec539982"
          "palabras" => array:6 [
            0 => "Enfermedades &#243;seas"
            1 => "Infecciosas"
            2 => "Espondilitis"
            3 => "Discitis"
            4 => "Tuberculosis espinal"
            5 => "Tuberculosis osteoarticular"
          ]
        ]
      ]
    ]
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Vertebral osteomyelitis &#40;VO&#41; is a rare entity&#44; although its incidence has increased in recent years&#46; The objective is to describe the patients with this infection in our environment and a comparison with other published series&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective review was conducted of epidemiological&#44; clinical&#44; microbiological&#44; treatment&#44; complications and evolution data of patients with VO during 10 years &#40;2004&#8211;2014&#41; in two hospitals of Mallorca&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">51 cases&#44; median age 66 &#40;range 22&#8211;85&#41; years&#44; 37 &#40;72&#46;5&#37;&#41; men with a mean onset of symptoms of 80&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#46;1 days&#46; In thirty-six &#40;70&#46;6&#37;&#41; cases the origin of infection was considered hematogenous&#44; although previous bacteremia was documented in 23 &#40;45&#37;&#41; cases&#44; being of urinary in 10 &#40;43&#46;5&#37;&#41; cases&#46; Clinically at the moment of diagnosis 35 &#40;68&#46;8&#37;&#41; had fever&#44; 32 &#40;62&#46;7&#37;&#41; pain&#44; 14 &#40;27&#46;5&#37;&#41; irradiated nerve pain and 10 &#40;19&#46;6&#37;&#41; paralysis&#47;paresia&#46; MRI was the most performed radiological test 46 &#40;90&#46;2&#37;&#41;&#44; being pathological in all cases&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> 23 &#40;52&#46;3&#37;&#41; was the most common microbiological isolates&#46; At the moment of the diagnosis&#44; blood cultures were positive in 27 &#40;65&#46;8&#37;&#41; of 41 cases and 11 &#40;50&#37;&#41; of 22 percutaneous puncture was positive&#46; Paraspinal&#44; epidural or psoas abscesses were observed in 23 &#40;45&#46;1&#37;&#41;&#44; neurological deficit in 7 &#40;13&#46;7&#37;&#41; and chronic pain in 6 &#40;11&#46;8&#37;&#41;&#46; One patient &#40;1&#46;9&#37;&#41; died in relation with infection&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Diagnosis was delayed in most cases&#46; Previous bacteremia being main predisposing factor and hematogenous origin the main source of infection&#46; <span class="elsevierStyleItalic">S&#46; aureus</span> was the most isolated&#46; Percutaneous puncture together with blood cultures increase etiologic diagnosis&#46; A high percentage of patients had complications or sequelae&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La espondilitis infecciosa &#40;EI&#41; es una entidad poco frecuente cuya incidencia ha aumentado en los &#250;ltimos a&#241;os&#46; El objetivo de este estudio ha sido describir los casos con EI y realizar una comparaci&#243;n con el resto de series publicadas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo donde se describen datos epidemiol&#243;gicos&#44; microbiol&#243;gicos y cl&#237;nicos de los pacientes diagnosticados de EI durante un periodo de 10 a&#241;os &#40;2004-2014&#41; en 2 hospitales de Mallorca&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; un total de 51 pacientes&#44; con una edad mediana de 66 a&#241;os &#40;rango 22-85&#41;&#46; El 72&#44;5&#37; &#40;37&#47;51&#41; fueron varones&#46; El tiempo medio transcurrido desde el inicio de la cl&#237;nica hasta el diagn&#243;stico fue de 80&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#44;1 d&#237;as&#46; En 36 ocasiones &#40;70&#44;6&#37;&#41; el origen fue hemat&#243;geno&#46; El factor predisponente m&#225;s frecuente fue presentar bacteriemia previa &#40;10 &#91;43&#44;5&#37;&#93; de origen urinario&#41;&#46; Presentaron fiebre 35 pacientes &#40;68&#44;8&#37;&#41;&#44; dolor 32 &#40;62&#44;7&#37;&#41;&#44; radiculalgia 14 &#40;27&#44;5&#37;&#41; y par&#225;lisis&#47;paresia 10 &#40;19&#44;6&#37;&#41;&#46; La prueba diagn&#243;stica m&#225;s utilizada fue la resonancia magn&#233;tica &#40;46 &#91;90&#44;2&#37;&#93;&#41;&#44; resultando patol&#243;gica en todos los casos&#46; El microorganismo etiol&#243;gico m&#225;s frecuente fue <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;23 &#91;52&#44;3&#37;&#93;&#41;&#46; Los hemocultivos resultaron positivos en 27&#47;41 ocasiones &#40;65&#44;8&#37;&#41; y la punci&#243;n percut&#225;nea en 11&#47;22 &#40;50&#37;&#41;&#46; Veintitr&#233;s pacientes &#40;45&#44;1&#37;&#41; desarrollaron abscesos paravertebrales&#44; epidurales o del psoas&#44; 7 &#40;13&#44;7&#37;&#41; d&#233;ficits neurol&#243;gicos residuales y 6 &#40;11&#44;8&#37;&#41; dolor cr&#243;nico&#46; Un paciente &#40;1&#44;9&#37;&#41; falleci&#243; por motivos relacionados con la infecci&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La EI es poco frecuente&#46; Su origen usualmente es hemat&#243;geno&#46; La bacteriemia previa es el factor predisponente m&#225;s importante&#46; El diagn&#243;stico es habitualmente tard&#237;o&#44; siendo <span class="elsevierStyleItalic">Staphylococcus aureus</span> el germen implicado con mayor frecuencia&#46; La realizaci&#243;n de punciones percut&#225;neas acompa&#241;ando a los hemocultivos aumenta la rentabilidad diagn&#243;stica&#46;</p></span>"
        "secciones" => array:4 [
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            "titulo" => "Introducci&#243;n"
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            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as&#58; Raya Cruz M&#44; Vilchez Rueda HH&#44; Marinescu CI&#44; Saras&#237;bar Ezcurra H&#44; Riera Jaume M&#44; Payeras Cifre A&#46; Espondilitis infecciosa en Baleares&#58; an&#225;lisis de 51 casos&#46; Rev Clin Esp&#46; 2015&#59;215&#58;251&#8211;257&#46;</p>"
      ]
    ]
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Annual incidence of cases of spondylodiscitis in Mallorca &#40;2004&#8211;2013&#41;&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Antecedent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sex &#40;male&#47;female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37 &#40;72&#46;5&#41;&#47;14 &#40;27&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;23&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neoplastic disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic liver disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic respiratory disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;11&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Peripheral arterial disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ischemic heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemiplegia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gastroduodenal ulcer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acquired immune deficiency syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hematologic neoplastic disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Connective tissue disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Microbiological isolate&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percutaneous sample&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Surgical sample&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Staphylococcus aureus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;36&#46;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;27&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Coagulase-negative staphylococci&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Streptococcus</span> spp&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Salmonella</span> and other Enterobacteriaceae&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Enterococcus faecalis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;2&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Bacteroides fragilis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Isolated pyogenic microorganisms in the 51 cases of spondylodiscitis included in the study&#46;</p>"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Differences between the cases of pyogenic and tuberculous etiology in the 51 cases of spondylodiscitis included in the study&#46;</p>"
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        "texto" => array:1 [
          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">What we know&#63;</span><p id="par0010" class="elsevierStylePara elsevierViewall">Infectious spondylitis is a low-incidence disease&#46; Few series with multiple cases have been published in recent years&#44; and it is possible that significant changes are occurring in its clinical&#8211;epidemiological characteristics&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">What this article provides&#63;</span><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of infectious spondylitis in our community remains stable&#46; The main etiological agent of this disease is <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#46; The involvement of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> is very low and that of <span class="elsevierStyleItalic">Brucella melitensis</span> has disappeared completely&#46; The selective performance of percutaneous punctures&#44; accompanied by blood cultures&#44; has appreciably improved diagnostic performance&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The Editors</p></span></span>"
        ]
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                    ]
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Original article
Infectious spondylitis in the Balearic Islands: An analysis of 51 cases
Espondilitis infecciosa en Baleares: análisis de 51 casos
M. Raya Cruza,
Corresponding author
manuelraya@hotmail.com

Corresponding author.
, H.H. Vilchez Ruedab, C.I. Marinescub, H. Sarasíbar Ezcurrac, M. Riera Jaumeb, A. Payeras Cifrea
a Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital Son Llàtzer, Palma de Mallorca, Spain
b Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital Son Espases, Palma de Mallorca, Spain
c Servicio de Radiodiagnóstico, Hospital Son Llàtzer, Palma de Mallorca, Spain
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        "titulo" => "Espondilitis infecciosa en Baleares&#58; an&#225;lisis de 51 casos"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Annual incidence of cases of spondylodiscitis in Mallorca &#40;2004&#8211;2013&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="tb0005"></elsevierMultimedia></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Background</span><p id="par0025" class="elsevierStylePara elsevierViewall">Infectious spondylitis &#40;IS&#41;&#44; also known as vertebral osteomyelitis or spondylodiscitis&#44; is an uncommon disease &#40;3&#8211;5&#37; of cases of osteomyelitis&#41;&#44; with a incidence that varies between 2&#46;2 and 9 cases&#47;100&#44;000 inhabitants&#47;year&#44; according to published Spanish series&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a> Patients with IE are mostly men between the ages of 50 and 70 years with predisposing factors such as spinal surgery&#44; prior bacteremia and parenteral drug use &#40;PDU&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a> The incidence of IS has increased in recent years due to the availability of better diagnostic methods and the increase in nosocomial infections&#44; the rates of spinal surgery and the number of patients with immunosuppression&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a> IS is produced by hematogenous dissemination &#40;with a extraspinal focus&#41;&#44; by direct external inoculation &#40;spinal or trauma surgery&#41; or by contiguity &#40;from a close infectious focus&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> The clinical condition is fairly nonspecific&#44; often leading to a delay in the diagnosis&#44; which at times requires the implementation of invasive techniques or surgery to determine the causal microorganism&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> The microorganism most often involved is <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;<span class="elsevierStyleItalic">S&#46; aureus</span>&#41;&#44; followed by Gram-negative bacilli&#46; In our community and in a not too distant past&#44; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> &#40;<span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#41; and <span class="elsevierStyleItalic">Brucella melitensis</span> were common&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">7&#44;8</span></a> IS can cause pain-related conditions and neurological deficits&#44; at times irreversible&#44; and its mortality is approximately 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The Spanish publications of case series of IS have been few in recent years&#44; during which IS appears to have undergone significant changes in its clinical&#8211;epidemiological characteristics&#46; The aim of this study was to describe the epidemiological&#44; clinical and etiological characteristics and outcomes of patients who have presented IS in 2 hospitals of Palma de Mallorca&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patients and methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">A series of retrospective cases conducted in 2 hospitals on the island of Mallorca that cover a population of approximately 550&#44;000 inhabitants&#46; We included all patients over 15 years of age with a diagnosis of IS from January 1&#44; 2003 to October 31&#44; 2013&#46; The data were obtained from the diagnostic coding database of the department of clinical archives and documentation of the 2 hospitals&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">A diagnosis of IS was established when there was a compatible clinical condition &#40;lumbar pain&#44; fever and muscle pain during the physical examination&#41;&#44; supported by an imaging technique&#58; &#40;a&#41; plain radiography with vertebral endplate disintegration&#44; reduced joint space or vertebral body destruction&#59; &#40;b&#41; computed axial tomography &#40;CT scan&#41; with subchondral bone destruction&#44; loss of cortical margin of the vertebral endplate or periosteal reaction&#59; &#40;c&#41; magnetic resonance imaging &#40;MRI&#41; with reduced signal of the vertebra and intervertebral disc on T1&#44; increased signal of the vertebra and disc in T2&#44; loss of definition of the vertebral endplate&#59; and &#40;d&#41; bone scintigraphy with tecnecio-99 &#40;GO <span class="elsevierStyleSup">99</span>mTc&#41;&#46; In terms of the etiological diagnosis&#44; we assessed any isolates in blood or in a sample of the focus obtained during surgery or percutaneous puncture&#46; A diagnosis of spondylitis tuberculous was considered the presence of symptoms and radiological compatible findings&#44; along with positive direct smears for bacilli or <span class="elsevierStyleItalic">M&#46; tuberculosis</span> isolates in Lowenstein-Jensen medium with no other bacterial isolate&#46; We also considered a positive PCR for <span class="elsevierStyleItalic">M&#46; tuberculosis</span> of any microbiological sample&#44; a positive tuberculin test or QuantiFERON &#8211; TB Gold<span class="elsevierStyleSup">&#174;</span>&#44; along with clinical and radiological improvement after starting tuberculostatic treatment&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The following variables were collected&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Demographic&#58; age&#44; sex and date of admission&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">Predisposing factors&#58; PDU&#44; spinal surgery&#44; previous bacteremia&#44; associated comorbidities according to the Charlson classification and functional state assessed with the Barthel index&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Clinical manifestations&#58; days elapsed from symptom onset to diagnosis&#44; presence of lumbar pain&#44; fever&#44; pain during the physical examination or neurological symptoms &#40;radicular pain&#44; paresthesia&#44; paresis or paralysis&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0065" class="elsevierStylePara elsevierViewall">Results of additional tests&#58; leukocyte count&#44; erythrocyte sedimentation rate &#40;ESR&#41;&#44; C-reactive protein &#40;CRP&#41;&#44; performance of simple radiology&#44; CT scan&#44; MRI or GO <span class="elsevierStyleSup">99</span>mTc&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Microbiological data&#58; results of blood cultures&#44; samples obtained using percutaneous puncture or surgery at the IS focus&#44; recent bacteremia in the last month and&#44; in the case of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> infection&#44; we also collected the results of the tuberculin test&#44; CRP for <span class="elsevierStyleItalic">M&#46; tuberculosis</span> or the <span class="elsevierStyleItalic">QuantiFERON &#8211; TB Gold</span><span class="elsevierStyleSup">&#174;</span>&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#46;</span><p id="par0075" class="elsevierStylePara elsevierViewall">Treatment&#58; We assessed the antibiotic treatment&#44; both empiric and targeted and treatment duration&#44; whether intravenous or oral&#44; and recorded the reasons for any change in antibiotic treatment&#46; We also recorded the need and reasons for surgical treatment &#40;including the diagnostic method&#44; medical treatment failure&#44; abscess drainage and bone marrow pressure&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7&#46;</span><p id="par0080" class="elsevierStylePara elsevierViewall">Evolution in the acute phase&#58; presence of chronic cutaneous fistulae and epidural&#44; paravertebral or psoas abscesses&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8&#46;</span><p id="par0085" class="elsevierStylePara elsevierViewall">Follow-up during the first year&#58; presence of sequelae in the form of residual chronic pain or neurological deficiency&#44; as well as the evolution to clinical or microbiological healing&#44; in cases where sequelae were detected&#44; mortality or related overall according to the discretion of the researchers provided there was a direct relationship between the infection and death&#46;</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">A basic statistical analysis was conducted using frequency calculation for each qualitative variable and the mean&#44; standard deviation &#40;SD&#41;&#44; median and interquartile range &#40;IQR&#41; for the quantitative variables&#46; We then performed a univariate analysis on the qualitative variables using the chi-squared test &#40;Fisher&#39;s test for those cases that required it&#41;&#44; as well as a risk estimate using the odds ratio calculation with its 95&#37; confidence intervals &#40;95&#37; CI&#41;&#46; For the comparison of quantitative variables&#44; we used Student&#39;s <span class="elsevierStyleItalic">t</span>-test&#46; The level of statistical significance was established at &#46;05 &#40;in all hypothesis testing&#44; the null hypothesis was rejected with an error type I or an alpha error &#60;0&#46;05&#41;&#46; All calculations were performed with the statistical bundle SPSS 12&#46;0 for Windows&#46; The confidentiality of the recorded data was ensured&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="par0095" class="elsevierStylePara elsevierViewall">A total of 51 cases of IS were recorded&#59; 37 &#40;72&#46;5&#37;&#41; were of men and 14 were of women &#40;27&#46;5&#37;&#41;&#46; The median age was 66 years &#40;IQR&#58; 22&#8211;85&#41;&#44; and 28 patients &#40;54&#46;9&#37;&#41; were older than 65 years&#46; The cumulative incidence was 9 cases&#47;10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#44; and the mean annual incidence was 5&#46;1 cases&#47;year&#44; with the distribution shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Twenty-three patients &#40;45&#46;1&#37;&#41; presented bacteremia in the 30 days prior to the bone infection diagnosis&#46; The origin of the bacteremia was urinary in 10 &#40;43&#46;5&#37;&#41; patients&#44; catheter in 5 &#40;21&#46;7&#37;&#41; patients&#44; respiratory in 3 &#40;13&#37;&#41; patients&#44; endocardial in 3 &#40;13&#37;&#41; patients and skin or soft tissue in 2 &#40;8&#46;7&#37;&#41; patients&#46; Six patients &#40;11&#46;8&#37;&#41; were PDU and 6 &#40;11&#46;8&#37;&#41; had undergone prior spinal surgery&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The comorbidities present in the patients included in this study are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The median Charlson comorbidity index was 2&#46;8 points &#40;range&#58; 0&#8211;13&#41;&#46; Four &#40;7&#46;8&#37;&#41; patients had severe dependence &#40;Barthel index &#60;35 points&#41;&#44; 9 &#40;17&#46;6&#37;&#41; had mild to moderate dependence &#40;&#62;40 points&#41; and 38 &#40;74&#46;5&#37;&#41; were independent&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">The most common presentation was spondylodiscitis in 48 &#40;94&#46;1&#37;&#41; cases&#44; while 2 &#40;3&#46;9&#37;&#41; cases presented spondylitis without discitis&#44; and 1 &#40;1&#46;9&#37;&#41; presented posterior segment infection &#40;vertebral arches and spinous process&#41;&#46; The most common location was the lumbar spine in 30 &#40;58&#46;8&#37;&#41; patients&#44; dorsal in 15 &#40;29&#46;4&#37;&#41; and cervical in 6 &#40;11&#46;8&#37;&#41;&#46; All patients showed a single focal involvement&#44; except for one patient who had cervical and dorsal involvement&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The most common symptom was fever &#40;35 cases&#59; 68&#46;8&#37;&#41;&#44; while 14 &#40;27&#46;5&#37;&#41; patients reported radicular pain&#46; During the examination&#44; 32 &#40;62&#46;7&#37;&#41; patients experienced focal pain on palpation in the area of the lesion&#44; and 10 &#40;19&#46;6&#37;&#41; patients experienced paralysis&#44; paresis or paresthesia&#46; The mean elapsed time from symptom onset to diagnosis was 80&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#46;1 days&#46; Leukocytosis was detected &#40;&#8805;11&#44;000 leukocytes&#47;L&#41; in 22 &#40;43&#46;1&#37;&#41; cases&#44; the median CRP was 14 &#40;1&#8211;320&#41; mg&#47;dL&#44; and the median ESR was 48 &#40;10&#8211;40&#41; mm&#47;h&#46; Thirty-eight &#40;74&#46;5&#37;&#41; plain spine radiographs were performed&#44; 23 &#40;60&#46;5&#37;&#41; of which revealed pathological findings&#46; CT scans were performed on 34 &#40;66&#46;6&#37;&#41; patients&#44; 32 of which revealed pathological findings &#40;94&#46;1&#37;&#41;&#46; MRIs were performed on 46 &#40;90&#46;2&#37;&#41; patients&#44; all of them revealing pathological findings &#40;100&#37;&#41;&#46; GO <span class="elsevierStyleSup">99</span>mTc was performed on 12 &#40;23&#46;5&#37;&#41; patients&#44; with normal results on 2 occasions &#40;16&#46;7&#37;&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The IS had a hematogenous origin in 36 &#40;70&#46;6&#37;&#41; patients&#44; was due to contiguity in 4 &#40;7&#46;8&#37;&#41; patients&#44; was postsurgical or post-trauma in 3 &#40;5&#46;9&#37;&#41; patients and was of unknown origin in 8 &#40;15&#46;7&#37;&#41; patients&#46; Forty-four &#40;86&#46;3&#37;&#41; cases were caused by pyogenic bacteria&#59; <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was isolated in 4 &#40;7&#46;8&#37;&#41; cases&#46; In 3 &#40;5&#46;9&#37;&#41; cases&#44; the causal microorganism could not be determined despite performing a percutaneous puncture on the lesion&#46; For the patients without microbiological isolates&#44; the time to diagnosis was 283&#46;3 days &#40;10&#8211;420&#41;&#44; much longer than the 67&#46;4 &#40;1&#8211;450&#41; days required by the patients with a confirmed etiology &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Statistically significant differences were not found however in terms of treatment time and sequelae&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">The causal agents involved are listed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; The most common microorganism was <span class="elsevierStyleItalic">S&#46; aureus</span> in 23 &#40;52&#46;3&#37;&#41; patients of whom 2 were methicillin-resistant &#40;MRSA&#41;&#44; followed by <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> in 6 &#40;13&#46;7&#37;&#41; patients&#44; <span class="elsevierStyleItalic">E&#46; coli</span> in 5 &#40;11&#46;4&#37;&#41;&#44; <span class="elsevierStyleItalic">Salmonella</span> and other enterobacteriaceae in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Enterococcus faecalis</span> in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Bacteroides fragilis</span> in 2 &#40;4&#46;5&#37;&#41;&#44; <span class="elsevierStyleItalic">Streptococcus spp&#46;</span> in 2 &#40;4&#46;5&#37;&#41; and coagulase-negative staphylococci in 2 &#40;4&#46;5&#37;&#41; patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Serologies for <span class="elsevierStyleItalic">Brucella</span> &#40;Rose Bengal and total antibodies&#41; were conducted for 10 &#40;5&#46;1&#37;&#41; patients&#44; all of which were negative&#46; In 6 of the 10 &#40;60&#37;&#41; cases&#44; the tuberculin test yielded positive results&#46; A QuantiFERON-TB Gold<span class="elsevierStyleSup">&#174;</span> test was performed in 2 &#40;3&#46;9&#37;&#41; cases&#44; which yielded a positive result in only 1 case&#59; the CRP for <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was positive in only 1 case&#46; Microorganisms were isolated in 7 &#40;87&#46;5&#37;&#41; of the 8 patients who underwent surgery&#44; in 11 &#40;50&#37;&#41; of the 22 who underwent percutaneous puncture and in 27 &#40;65&#46;8&#37;&#41; of the 41 for whom blood cultures were performed&#46; Significant differences were detected when comparing the characteristics of patients with pyogenic germs vs&#46; those for whom no germ could be identified&#46; The former group had a shorter time to diagnosis &#40;61&#46;9 vs&#46; 129&#46;33 days&#59; 95&#37; CI 80&#46;9&#8211;363&#46;3&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41; and shorter treatment &#40;40&#46;6 vs&#46; 87&#46;7 days&#59; 95&#37; CI 14&#46;7&#8211;120&#46;1&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; The main differences between the cases of IS included in this study according to whether they had a pyogenic or tuberculous etiology are listed in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Empiric antibiotic treatment was monotherapy for 18 &#40;35&#46;3&#37;&#41; patients&#44; double therapy for 20 &#40;39&#46;2&#37;&#41; and triple therapy for 4 &#40;7&#46;8&#37;&#41; patients&#46; No empiric treatment was administered to 9 &#40;17&#46;6&#37;&#41; patients&#46; The empirically administered antibiotics were cloxacillin in 15 cases &#40;21&#46;1&#37;&#41;&#44; vancomycin in 12 &#40;16&#46;9&#37;&#41;&#44; aminoglycosides in 9 &#40;12&#46;7&#37;&#41;&#44; other penicillins in 9 &#40;12&#46;7&#37;&#41;&#44; cephalosporins in 8 &#40;11&#46;3&#37;&#41;&#44; rifampicin on 5 &#40;7&#37;&#41;&#44; carbapenems in 4 &#40;5&#46;6&#37;&#41;&#44; quinolones in 3 &#40;4&#46;2&#37;&#41;&#44; linezolid in 2 &#40;2&#46;8&#37;&#41;&#44; tuberculostatic agents in 2 &#40;2&#46;8&#37;&#41;&#44; daptomycin in 1 &#40;1&#46;4&#37;&#41; and teicoplanin in 1 &#40;1&#46;4&#37;&#41; case&#46; The treatment was changed for 42 &#40;82&#46;3&#37;&#41; patients&#46; For 11 of these patients &#40;26&#46;2&#37;&#41;&#44; the treatment was adjusted based on the results of the antibiogram&#59; the reason for changing treatment in the remaining patients was not reported or specified in the comments of the medical history&#46; The antibiotics most frequently used as targeted treatment were quinolones in 17 &#40;24&#46;3&#37;&#41; cases&#44; cloxacillin in 14 &#40;20&#37;&#41;&#44; rifampicin in 13 &#40;18&#46;6&#37;&#41;&#44; cephalosporins in 7 &#40;10&#37;&#41;&#44; other penicillins in 6 &#40;8&#46;6&#37;&#41;&#44; aminoglycosides in 4 &#40;5&#46;7&#37;&#41;&#44; carbapenems in 3 &#40;4&#46;3&#37;&#41;&#44; vancomycin in 3 &#40;4&#46;3&#37;&#41;&#44; linezolid in 1 &#40;1&#46;4&#37;&#41;&#44; clindamycin in 1 &#40;1&#46;4&#37;&#41; and teicoplanin in 1 &#40;1&#46;4&#37;&#41; case&#46; Of the 6 &#40;11&#46;7&#37;&#41; patients who underwent empirical treatment with tuberculostatic agents&#44; <span class="elsevierStyleItalic">M&#46; tuberculosis</span> was isolated in 4&#46; No IS-causing microorganism could be isolated in the 2 remaining patients&#44; although they progressed favorably with no complications during the follow-up&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The mean total treatment time was 78&#46;92 days &#40;SD&#44; 66&#46;4&#41;&#46; Antibiotic treatment was administered intravenously for 29&#46;64 days &#40;SD&#44; 16&#46;1&#41; and orally for 71&#46;61 days &#40;SD&#44; 75&#46;3&#41;&#46; The cases of IS of tuberculosis origin were treated for 212 days &#40;SD&#44; 75&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Twelve patients &#40;23&#46;5&#37;&#41; required some type of surgical management&#59; 5 &#40;41&#46;6&#37;&#41; for abscess draining&#44; 5 &#40;41&#46;6&#37;&#41; for spinal decompression&#44; 1 &#40;8&#46;3&#37;&#41; due to treatment failure and 1 &#40;8&#46;3&#37;&#41; for diagnostic purposes&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">During the acute phase&#44; 12 patients &#40;23&#46;5&#37;&#41; developed paravertebral abscesses&#44; 8 &#40;15&#46;7&#37;&#41; developed epidural abscesses and 3 &#40;5&#46;9&#37;&#41; developed psoas abscesses&#46; Seven patients &#40;13&#46;7&#37;&#41; presented long-term residual neurological deficits and 6 &#40;11&#46;8&#37;&#41; maintained chronic pain&#46; Thirty-six patients &#40;70&#46;6&#37;&#41; were clinically cured&#44; 4 &#40;7&#46;8&#37;&#41; presented sequelae despite demonstrating microbiological healing&#44; and another 6 &#40;11&#46;8&#37;&#41; died&#44; although only one of them died for reasons directly related to the infection&#46; Due to an inability to maintain clinical follow-up&#44; we were not able to determine the outcome of 5 &#40;9&#46;8&#37;&#41; patients&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The patients who presented acute complications or long-term sequela presented comorbidities &#40;median Charlson&#39;s index of 4 points &#91;IQR 0&#8211;13&#93; vs&#46; 2 points &#91;IQR 0&#8211;11&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;068&#41;&#44; neurological symptoms at symptom onset &#40;14 &#91;58&#46;3&#37;&#93; vs&#46; 3 &#91;11&#46;1&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41; and required surgery &#40;10 &#91;83&#46;3&#37;&#93; vs&#46; 2 &#91;6&#46;2&#37;&#93;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41;&#44; with a greater frequency than the other patients who did not present acute complications or long-term sequelae&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">This study describes the main clinical and epidemiological characteristics of 51 cases of IS that required hospitalization and were treated in 2 hospital centers in Mallorca between 2003 and 2013&#46; This study represents the third largest Spanish series&#44; in terms of the number of included patients&#44; published in the last 10 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2&#44;6&#44;9&#44;10</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">In our study&#44; the incidence of IS was 9 cases<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#44; the same rate reported more recently by Ruiz Mart&#237;n et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> and similar to the largest series reported in Spain by Colmenero et al&#46;&#44; <a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> who observed an incidence of 7 cases<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">6</span> inhabitants&#47;year&#46; These results indicate that despite the increase in the incidence reported by a number of authors&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> the incidence in our community has not changed significantly&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The disease antecedents that have classically been related to IS&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> such as diabetes mellitus&#44; liver disease&#44; neoplasms and immunosuppression&#44; are also the most common in our series&#46; Although 54&#46;9&#37; of the patients were older than 65 years&#44; as can be deduced from the estimates of the Charlson and Barthel indices&#44; they did not present a significant degree of comorbidity&#44; and 74&#46;5&#37; of the patients were completely independent&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">The most common location for IS was lumbar&#46; The clinical condition was characterized by the presence of fever&#44; focal pain in the lesion and&#44; in a significant minority of cases &#40;19&#46;6&#37;&#41;&#44; focal neurological impairment in the form of paralysis&#44; paresis&#44; algias or paresthesia&#46; This high percentage could be related to the delay from symptom onset to diagnosis that occurred in our series&#46; The additional tests included detecting the presence of leukocytosis&#44; increased PCR and ESR&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The diagnostic sensitivities of the spine imaging tests were 60&#46;5&#37; for the plain radiology&#44; 83&#46;3&#37; for the GO <span class="elsevierStyleSup">99</span>mTc&#44; 94&#46;1&#37; for the CT scan and 100&#37; for the MRI&#44; results very similar to those reported previously&#44;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2&#44;9</span></a> except for the plain radiography&#44; which could be due to the difficulty in interpreting the often nonspecific radiological changes&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The origin of the IS was mostly hematogenous&#46; In our series&#44; only 3 patients had previously undergone surgery&#44; which differs from previous observations&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a> In most cases&#44; the IS was caused by pyogenic germs &#40;86&#46;3&#37;&#41;&#44; with monobacterial isolates in all cases&#46; The most common microorganism was <span class="elsevierStyleItalic">S&#46; aureus</span> &#40;52&#46;3&#37;&#41;&#44; coinciding with the findings of other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;6&#44;10</span></a> The presence of MRSA was not a noteworthy aspect of our series &#40;only 2 cases had MRSA&#41;&#44; in contrast to that observed in other series that found increases in its incidence&#44; which were hypothetically related to hospital care&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> Although the incidence in 2012 of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> infection in all of its clinical forms in the Balearic Islands was 12&#46;8 cases per 100&#44;000 inhabitants&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a> the number of cases of tuberculous IS has been low&#44; given that the latest case was diagnosed in 2008&#46; It is worth noting that in our series there was no case of IS caused by <span class="elsevierStyleItalic">Brucella</span> and that since 2010 the Balearic Islands have been considered by the European Union as a territory unscathed by bovine and caprine brucellosis&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Our results support the diagnostic yield of percutaneous punctures and&#44; when necessary&#44; surgical approaches&#44; enabling accurate microbiological diagnoses to be reached&#44; which in turn enable the most appropriate treatment to be administered&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">In our series&#44; 17&#46;6&#37; of the cases started antibiotherapy empirically until the microorganism responsible for the infection was identified&#46; In the majority of cases&#44; empiric antibiotherapy was likely started due to the presence of fever and nonspecific symptoms&#44; a situation that could have been accompanied by reduced diagnostic yields&#46; Although the current trend is to decrease the antibiotic treatment duration&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a> there is controversy given that the duration depends fundamentally on the microbiological isolate&#44; the presence of bacteremia&#44; the presence of endocarditis&#44; paravertebral abscesses that require drainage&#44; the patient&#39;s general condition&#44; etc&#46; To start empiric antibiotherapy&#44; it is important to characterize the various clinical conditions&#46; In our study&#44; the comparisons performed between the various etiologies show that spondylodiscitis of pyogenic origin has a higher frequency of previous bacteremia and is diagnosed earlier than spondylodiscitis of tuberculosis or unidentified origin&#46; We also have no randomized clinical trials&#44; and the current recommendations range from 6 weeks<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">17</span></a> to 3 months&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">18</span></a> with an intravenous treatment duration of at least 4 weeks&#46; In our study&#44; the patients underwent treatment for 78&#46;92 days&#44; of which intravenous administration used 29&#46;64 days&#46; All patients with IS of tuberculosis origin underwent treatment for at least 6 months&#44; according to the recommendations of the treatment guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">In our series&#44; almost half of the patients presented localized complications during the acute phase&#46; As occurred in other series&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1&#44;2</span></a> mortality was low&#44; although morbidity was high given that chronic pain or residual neurological deficits were detected in almost a quarter of the cases during follow-up&#44; which compromised the patients&#8217; quality of life&#46; It is possible that a greater index of suspicion and a shorter delay in the diagnosis of IS could reduce these types of complications&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Our study&#39;s limitations include its retrospective nature&#46; Selecting cases according to the coding of the discharge report could have led us to underestimate the number of cases&#44; due to errors in the preparation or coding of the report&#46; However&#44; it seems fairly unlikely given the characteristics of IS&#46; The intervention by various specialists from 2 hospital centers&#44; with no homogeneous diagnostic and therapeutic criteria&#44; could have affected our results&#46; The collection of samples using percutaneous puncture was conducted by different physicians in the department of radiology and was guided by ultrasonography or CT&#46; We therefore cannot ensure that the method for collecting samples was the same in all cases&#46; We cannot rule out the fact that during the follow-up &#40;after discharge&#41; a number of patients were treated in other hospital centers&#44; both public and private&#44; although this number is probably low given that the participating hospitals are the centers that treat the largest percentage of the population in Mallorca&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">We can conclude that the incidence of IS has not changed significantly over the last decade&#44; a fact that can be observed mainly in patients with associated comorbidity &#40;although without a high degree of dependence&#41;&#46; The main etiology of IS is <span class="elsevierStyleItalic">S&#46; Aureus</span>&#44; which usually presents a long diagnostic delay and&#44; although it causes low mortality&#44; frequently causes disabling sequelae&#46; The selective performance of percutaneous punctures&#44; accompanied by blood cultures&#44; improves the diagnostic performance&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "clase" => "keyword"
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            0 => "Bone diseases"
            1 => "Infectious"
            2 => "Spondylitis"
            3 => "Discitis"
            4 => "Spinal tuberculosis"
            5 => "Osteoarticular tuberculosis"
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            0 => "Enfermedades &#243;seas"
            1 => "Infecciosas"
            2 => "Espondilitis"
            3 => "Discitis"
            4 => "Tuberculosis espinal"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Vertebral osteomyelitis &#40;VO&#41; is a rare entity&#44; although its incidence has increased in recent years&#46; The objective is to describe the patients with this infection in our environment and a comparison with other published series&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective review was conducted of epidemiological&#44; clinical&#44; microbiological&#44; treatment&#44; complications and evolution data of patients with VO during 10 years &#40;2004&#8211;2014&#41; in two hospitals of Mallorca&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">51 cases&#44; median age 66 &#40;range 22&#8211;85&#41; years&#44; 37 &#40;72&#46;5&#37;&#41; men with a mean onset of symptoms of 80&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#46;1 days&#46; In thirty-six &#40;70&#46;6&#37;&#41; cases the origin of infection was considered hematogenous&#44; although previous bacteremia was documented in 23 &#40;45&#37;&#41; cases&#44; being of urinary in 10 &#40;43&#46;5&#37;&#41; cases&#46; Clinically at the moment of diagnosis 35 &#40;68&#46;8&#37;&#41; had fever&#44; 32 &#40;62&#46;7&#37;&#41; pain&#44; 14 &#40;27&#46;5&#37;&#41; irradiated nerve pain and 10 &#40;19&#46;6&#37;&#41; paralysis&#47;paresia&#46; MRI was the most performed radiological test 46 &#40;90&#46;2&#37;&#41;&#44; being pathological in all cases&#46; <span class="elsevierStyleItalic">Staphylococcus aureus</span> 23 &#40;52&#46;3&#37;&#41; was the most common microbiological isolates&#46; At the moment of the diagnosis&#44; blood cultures were positive in 27 &#40;65&#46;8&#37;&#41; of 41 cases and 11 &#40;50&#37;&#41; of 22 percutaneous puncture was positive&#46; Paraspinal&#44; epidural or psoas abscesses were observed in 23 &#40;45&#46;1&#37;&#41;&#44; neurological deficit in 7 &#40;13&#46;7&#37;&#41; and chronic pain in 6 &#40;11&#46;8&#37;&#41;&#46; One patient &#40;1&#46;9&#37;&#41; died in relation with infection&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Diagnosis was delayed in most cases&#46; Previous bacteremia being main predisposing factor and hematogenous origin the main source of infection&#46; <span class="elsevierStyleItalic">S&#46; aureus</span> was the most isolated&#46; Percutaneous puncture together with blood cultures increase etiologic diagnosis&#46; A high percentage of patients had complications or sequelae&#46;</p></span>"
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          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction"
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            "identificador" => "abst0010"
            "titulo" => "Methods"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La espondilitis infecciosa &#40;EI&#41; es una entidad poco frecuente cuya incidencia ha aumentado en los &#250;ltimos a&#241;os&#46; El objetivo de este estudio ha sido describir los casos con EI y realizar una comparaci&#243;n con el resto de series publicadas&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo donde se describen datos epidemiol&#243;gicos&#44; microbiol&#243;gicos y cl&#237;nicos de los pacientes diagnosticados de EI durante un periodo de 10 a&#241;os &#40;2004-2014&#41; en 2 hospitales de Mallorca&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; un total de 51 pacientes&#44; con una edad mediana de 66 a&#241;os &#40;rango 22-85&#41;&#46; El 72&#44;5&#37; &#40;37&#47;51&#41; fueron varones&#46; El tiempo medio transcurrido desde el inicio de la cl&#237;nica hasta el diagn&#243;stico fue de 80&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>125&#44;1 d&#237;as&#46; En 36 ocasiones &#40;70&#44;6&#37;&#41; el origen fue hemat&#243;geno&#46; El factor predisponente m&#225;s frecuente fue presentar bacteriemia previa &#40;10 &#91;43&#44;5&#37;&#93; de origen urinario&#41;&#46; Presentaron fiebre 35 pacientes &#40;68&#44;8&#37;&#41;&#44; dolor 32 &#40;62&#44;7&#37;&#41;&#44; radiculalgia 14 &#40;27&#44;5&#37;&#41; y par&#225;lisis&#47;paresia 10 &#40;19&#44;6&#37;&#41;&#46; La prueba diagn&#243;stica m&#225;s utilizada fue la resonancia magn&#233;tica &#40;46 &#91;90&#44;2&#37;&#93;&#41;&#44; resultando patol&#243;gica en todos los casos&#46; El microorganismo etiol&#243;gico m&#225;s frecuente fue <span class="elsevierStyleItalic">Staphylococcus aureus</span> &#40;23 &#91;52&#44;3&#37;&#93;&#41;&#46; Los hemocultivos resultaron positivos en 27&#47;41 ocasiones &#40;65&#44;8&#37;&#41; y la punci&#243;n percut&#225;nea en 11&#47;22 &#40;50&#37;&#41;&#46; Veintitr&#233;s pacientes &#40;45&#44;1&#37;&#41; desarrollaron abscesos paravertebrales&#44; epidurales o del psoas&#44; 7 &#40;13&#44;7&#37;&#41; d&#233;ficits neurol&#243;gicos residuales y 6 &#40;11&#44;8&#37;&#41; dolor cr&#243;nico&#46; Un paciente &#40;1&#44;9&#37;&#41; falleci&#243; por motivos relacionados con la infecci&#243;n&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La EI es poco frecuente&#46; Su origen usualmente es hemat&#243;geno&#46; La bacteriemia previa es el factor predisponente m&#225;s importante&#46; El diagn&#243;stico es habitualmente tard&#237;o&#44; siendo <span class="elsevierStyleItalic">Staphylococcus aureus</span> el germen implicado con mayor frecuencia&#46; La realizaci&#243;n de punciones percut&#225;neas acompa&#241;ando a los hemocultivos aumenta la rentabilidad diagn&#243;stica&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as&#58; Raya Cruz M&#44; Vilchez Rueda HH&#44; Marinescu CI&#44; Saras&#237;bar Ezcurra H&#44; Riera Jaume M&#44; Payeras Cifre A&#46; Espondilitis infecciosa en Baleares&#58; an&#225;lisis de 51 casos&#46; Rev Clin Esp&#46; 2015&#59;215&#58;251&#8211;257&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Annual incidence of cases of spondylodiscitis in Mallorca &#40;2004&#8211;2013&#41;&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Antecedent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Frequency &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Sex &#40;male&#47;female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37 &#40;72&#46;5&#41;&#47;14 &#40;27&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;23&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Neoplastic disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic liver disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic respiratory disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;11&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic heart failure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Peripheral arterial disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;9&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ischemic heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Chronic cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemiplegia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gastroduodenal ulcer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Acquired immune deficiency syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;7&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hematologic neoplastic disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Connective tissue disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comorbidities present in the 51 cases of spondylodiscitis included in the study&#46;</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Microbiological isolate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Blood cultures&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percutaneous sample&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Surgical sample&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Staphylococcus aureus</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;36&#46;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;27&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Escherichia coli</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Coagulase-negative staphylococci&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Streptococcus</span> spp&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;4&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Salmonella</span> and other Enterobacteriaceae&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Enterococcus faecalis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;2&#46;4&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Bacteroides fragilis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;9&#46;1&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;34&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">In 3 cases&#44; the organism was isolated in blood cultures and in the surgical sample&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">In 3 cases <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span> was isolated in blood cultures by bacteremia prior to the current episode&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">In 1 case&#44; <span class="elsevierStyleItalic">Enterococcus faecalis</span> was isolated in blood cultures by bacteremia prior to the current episode&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">In 1 case&#44; the organism was isolated in the surgical sample and in the percutaneous puncture</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Isolated pyogenic microorganisms in the 51 cases of spondylodiscitis included in the study&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pyogenic&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tuberculous&#44; <span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value and 95&#37; confidence interval&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;001 &#40;11&#46;44&#8211;43&#46;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Diagnosis time &#8805;60 days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#40;27&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;007 &#40;1&#46;01&#8211;1&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Previous bacteremia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;52&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;045 &#40;0&#46;71&#8211;0&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Days of treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001 &#40;118&#46;1&#8211;214&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;40&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;038 &#40;1&#46;04&#8211;1&#46;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Differences between the cases of pyogenic and tuberculous etiology in the 51 cases of spondylodiscitis included in the study&#46;</p>"
        ]
      ]
      4 => array:5 [
        "identificador" => "tb0005"
        "tipo" => "MULTIMEDIATEXTO"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "texto" => array:1 [
          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">What we know&#63;</span><p id="par0010" class="elsevierStylePara elsevierViewall">Infectious spondylitis is a low-incidence disease&#46; Few series with multiple cases have been published in recent years&#44; and it is possible that significant changes are occurring in its clinical&#8211;epidemiological characteristics&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">What this article provides&#63;</span><p id="par0015" class="elsevierStylePara elsevierViewall">The incidence of infectious spondylitis in our community remains stable&#46; The main etiological agent of this disease is <span class="elsevierStyleItalic">Staphylococcus aureus</span>&#46; The involvement of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> is very low and that of <span class="elsevierStyleItalic">Brucella melitensis</span> has disappeared completely&#46; The selective performance of percutaneous punctures&#44; accompanied by blood cultures&#44; has appreciably improved diagnostic performance&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The Editors</p></span></span>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:19 [
            0 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Espondilodiscitis infecciosas en un &#225;rea sanitaria gallega&#44; 1983&#8211;2003"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; G&#243;mez Rodr&#237;guez"
                            1 => "Y&#46; Penelas-Cort&#233;s Bellas"
                            2 => "J&#46; Ib&#225;&#241;ez Ru&#225;n"
                            3 => "M&#46; Gonz&#225;lez P&#233;rez"
                            4 => "M&#46;L&#46; S&#225;nchez Lorenzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Med Intern"
                        "fecha" => "2004"
                        "volumen" => "21"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteomielitis vertebral hemat&#243;gena&#46; Experiencia en un hospital comarcal"
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