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array:23 [ "pii" => "S2254887415000788" "issn" => "22548874" "doi" => "10.1016/j.rceng.2015.05.003" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1162" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2015;215:380-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 50 "formatos" => array:2 [ "HTML" => 49 "PDF" => 1 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S0014256515001770" "issn" => "00142565" "doi" => "10.1016/j.rce.2015.05.003" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1162" "copyright" => "Elsevier España, S.L.U. y Sociedad Española de Medicina Interna (SEMI)" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2015;215:380-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 226 "formatos" => array:2 [ "HTML" => 102 "PDF" => 124 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Echinococcosis: A 15-year epidemiological, clinical and outcome overview" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "380" "paginaFinal" => "384" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Equinococosis: epidemiología, clínica y resultados en una panorámica de 15 años" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C.A. Amado-Diago, M. Gutiérrez-Cuadra, C. Armiñanzas, F. Arnaíz de las Revillas, M. Gómez-Fleitas, M.C. Fariñas" "autores" => array:6 [ 0 => array:2 [ "nombre" => "C.A." "apellidos" => "Amado-Diago" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Gutiérrez-Cuadra" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Armiñanzas" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Arnaíz de las Revillas" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Gómez-Fleitas" ] 5 => array:2 [ "nombre" => "M.C." "apellidos" => "Fariñas" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2254887415000788" "doi" => "10.1016/j.rceng.2015.05.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887415000788?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256515001770?idApp=WRCEE" "url" => "/00142565/0000021500000007/v1_201510020911/S0014256515001770/v1_201510020911/en/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2254887415000648" "issn" => "22548874" "doi" => "10.1016/j.rceng.2015.05.002" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1160" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2015;215:385-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 36 "formatos" => array:2 [ "HTML" => 35 "PDF" => 1 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Dabigatran: Experience in standard clinical practice" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "385" "paginaFinal" => "390" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dabigatrán: experiencia en la práctica clínica habitual" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Álvarez-Otero, J. de la Fuente-Aguado, J.C. Arias-Castaño, L. González-González, R. Puerta-Louro, S. Araújo-Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Álvarez-Otero" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "de la Fuente-Aguado" ] 2 => array:2 [ "nombre" => "J.C." "apellidos" => "Arias-Castaño" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "González-González" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Puerta-Louro" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Araújo-Fernández" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0014256515001757" "doi" => "10.1016/j.rce.2015.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256515001757?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887415000648?idApp=WRCEE" "url" => "/22548874/0000021500000007/v1_201510020909/S2254887415000648/v1_201510020909/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2254887415000636" "issn" => "22548874" "doi" => "10.1016/j.rceng.2015.06.001" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "1156" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2015;215:371-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 50 "formatos" => array:2 [ "HTML" => 46 "PDF" => 4 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Scientific production and bibliometric impact of a representative group of Spanish internists with established research careers" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "371" "paginaFinal" => "379" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Producción científica e impacto bibliométrico de un grupo representativo de internistas españoles con trayectoria investigadora consolidada" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1858 "Ancho" => 3326 "Tamanyo" => 422841 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Example of the temporal evolution of the scientific output and impact markers of one of the evaluated researchers who best fit the model in this study (researcher 16). The best-fit line was derived using a second-degree polynomial regression model.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Burbano Santos, Ò. Miró, F.J. Martín-Sánchez, C. Fernández Pérez, J. Casademont" "autores" => array:5 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Burbano Santos" ] 1 => array:2 [ "nombre" => "Ò." "apellidos" => "Miró" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "Martín-Sánchez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernández Pérez" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Casademont" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0014256515001496" "doi" => "10.1016/j.rce.2015.04.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256515001496?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887415000636?idApp=WRCEE" "url" => "/22548874/0000021500000007/v1_201510020909/S2254887415000636/v1_201510020909/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Echinococcosis: A 15-year epidemiological, clinical and outcome overview" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "380" "paginaFinal" => "384" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C.A. Amado-Diago, M. Gutiérrez-Cuadra, C. Armiñanzas, F. Arnaíz de las Revillas, M. Gómez-Fleitas, M.C. Fariñas" "autores" => array:6 [ 0 => array:3 [ "nombre" => "C.A." "apellidos" => "Amado-Diago" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Gutiérrez-Cuadra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Armiñanzas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Arnaíz de las Revillas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "M." "apellidos" => "Gómez-Fleitas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:4 [ "nombre" => "M.C." "apellidos" => "Fariñas" "email" => array:1 [ 0 => "mcfarinas@humv.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Service of Pneumology, Hospital Universitario Marqués de Valdecilla, , Santander, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "General Surgery Department, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Equinococosis: epidemiología, clínica y resultados en una panorámica de 15 años" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Hydatidosis or cystic echinococcosis (CE) is a parasitic zoonosis caused by <span class="elsevierStyleItalic">Echinococcus</span>, whose larval stages infect various carnivores that act as definitive hosts for the parasite.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleItalic">Echinococcus granulosus</span> is the main cause of human hydatid infections.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a> It has a life cycle that involves dogs, sheep and sometimes other animals,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2–5</span></a> in which the eggs of the parasite are excreted in their feces and later ingested by humans.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">CE has a worldwide distribution, with greater prevalence in temperate zones.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2,7–9</span></a> In Spain, the autonomous regions of Castilla y León, La Rioja, Navarra, Aragón, and the Mediterranean coast are the areas where it is most commonly diagnosed.<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">2,10</span></a> Risk factors proposed for CE acquisition include low socioeconomic level, residing in rural areas and contact with dogs, which are in turn in contact with livestock or offal of other carnivores.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">6,11</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical signs and symptoms of EC may be related to the mass effect of the cyst, its superinfection or hypersensitivity reaction secondary to its rupture.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">12,13</span></a> Because of its slow growth, diagnosis is usually made in adulthood<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a> by combining clinical symptoms with imaging tests and serological techniques.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a> Ultrasound is a key diagnostic tool due to its accessibility and safety. The World Health Organization (WHO) has proposed a classification based on ultrasound images of the cyst for diagnosis, prognosis and treatment of CE.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> Serology, which has good sensitivity but more limited specificity, provides good results in combination with imaging techniques.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1,15</span></a> There is no universal consensus on the management of CE. Treatment is based on three pillars: medical treatment (mainly albendazole), surgery, and percutaneous drainage. The choice of the most appropriate approach is based on the patient's clinical symptoms and the characteristics of the cysts.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study was to describe the epidemiological and clinical characteristics of CE diagnosed in the twenty-first century in Cantabria, an autonomous region of northern Spain, as well as to compare the outcome of patients according to whether they received treatment or not.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Materials and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">From January 1, 1997 to December 31, 2011, the medical records of all patients diagnosed with CE during their admission to the Hospital Universitario Marqués de Valdecilla (a tertiary, 1000-bed teaching hospital, and the reference center for infectious diseases of the Region of Cantabria) were reviewed.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The following variables were collected: age, gender, nationality, address, occupation, reason for hospitalization, assigned ward and disease history, temperature, heart rate, blood pressure, symptoms and organs involved, hemoglobin levels, white blood cell count and platelet count, serum creatinine, urea, serum levels of sodium, potassium and glucose, serology and cultures, radiological examinations, type of treatment, duration of hospitalization and outcome. Follow-up time of patients after discharge was at least 1 year. Presence or absence of recurrence, complications and mortality were recorded. Recurrence was defined as readmission of the patient to the hospital for persistence or exacerbation of clinical symptoms of CE, provided that the first episode had occurred within the study period. Incidence of disease was calculated according to inhabitants served by the Hospital Universitario Marqués de Valdecilla.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Patient diagnoses were classified into the 3 categories proposed by WHO<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a>: (a) possible case: any patient with a compatible clinical or epidemiological history, and image findings or serology positive for CE; (b) probable case: any patient with a compatible clinical and epidemiological history, and imaging findings and two positive serological tests, and (c) confirmed case: in addition to the above, confirmation by microscopy or molecular biology techniques of the presence of the parasite or its components in surgical or percutaneous samples, or changes in WHO staging of the cyst,<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">14</span></a> either spontaneously or after treatment.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Statistical analysis</span><p id="par0040" class="elsevierStylePara elsevierViewall">All data were included in the SPSS statistical software package (Statistical Package for Social Sciences, Chicago, IL, USA) for later processing. Quantitative data were expressed as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation (SD) or absolute value (percentage). Student's <span class="elsevierStyleItalic">t</span>-test or the Mann–Whitney <span class="elsevierStyleItalic">U</span> test were used to detect differences between two groups of quantitative variables, and the chi-square (<span class="elsevierStyleItalic">χ</span><span class="elsevierStyleSup">2</span>) test was used to compare qualitative variables. A logistic regression analysis was performed, considering “death” as the dependent variable and including the variables showing statistical significance between the two groups (treated vs. untreated) in the univariate analysis.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">A total of 76 cases of hydatidosis (58% men) were diagnosed during the study period. The characteristics of these patients are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. Their mean age was 57.8 years (SD: 19.1 years; range: 14.9–92.7), and was slightly higher in women (57.4 vs. 58.4 years, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.834). The majority of diagnoses of CE were made in 2005, in which 8 cases (10.5%) were recorded. The yearly average incidence was 1.08 cases/100,000 inhabitants. Sixty-two cases (80%) were from the province of Cantabria, 5 (6%) from the rest of Spain, and 3 (4%) belonged to other nationalities. In 6 (8%) patients the origin was unknown. Within Cantabria, 29 patients (46%) were from rural areas and 33 from urban areas (54%). Hydatidosis was a casual finding in 43 patients (56%) during an imaging or surgical examination for another reason, whereas 27 patients (35.5%) presented abdominal pain as the initial symptom. Of the 76 cases of CE, 50 (65.8%) were classified as confirmed, 1 (1.3%) as probable, and 25 (32.9) as possible.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">The liver was the primary location of hydatidosis in 71 patients (94%), and the lung in five cases (6%). In 70 patients (92%) involvement was only present at the primary location. In six patients, infection had spread to other sites: in three to the lungs (4%), in two to the peritoneum (3%) and in one case to both the lungs and the vertebrae (1%). Cysts were calcified in 24 patients (31.6%).</p><p id="par0055" class="elsevierStylePara elsevierViewall">An imaging test was performed in 74 patients (95%): ultrasound was obtained in 61 patients (80%), and computed tomography (CT) scans in 56 (74%). In 39 patients, both examinations were performed, and lesions which were undetected by ultrasonography were observed with CT in 5 patients (13%). Serology was performed in 30 patients (39%), of which 13 (43%) had a positive result. Among patients with negative serology, 13 (76%) had liver cysts and 1 (6%) had lung cysts. In 3 patients (18%) cysts were present in multiple organs.</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Treatment</span><p id="par0060" class="elsevierStylePara elsevierViewall">Fifty-five patients (72%) received some form of treatment for CE. Of these, 2 (3.6%) patients received only medical treatment; 27 (49%) only surgical treatment; 3 (5.4%) medical treatment combined with cyst drainage; and 23 (42%) combined medical and surgical treatment. Medical treatment involved the use of albendazole, whereas the surgical technique used in all cases was pericystectomy. Of patients who underwent surgery treatment, 8 (13%) had surgical complications: 3 (5.4%) developed abscesses, 3 (5.4%) surgical site infections, 1 (1%) obstruction due to peritoneal adhesions and 1 (1%) hemorrhage.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Among the 21 (28%) patients who did not receive any treatment, 16 (76%) did not have clinical symptoms at the time of diagnosis, and 5 (24%) had comorbidities that contraindicated medical or surgical treatment. There were no differences in age, gender, degree of diagnostic confirmation and calcification between both groups.</p><p id="par0070" class="elsevierStylePara elsevierViewall">There were 8 (11.8%) cases of recurrence. Of these, 6 (75%) patients had received medical and surgical treatment, whereas 1 (12.5%) had received only surgical treatment, and another (12.5%) combined medical and surgical treatment.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Outcome</span><p id="par0075" class="elsevierStylePara elsevierViewall">During the 15-year-period covered by the study, 24 (31.2%) patients with CE died, with a mean age of 69 years (SD: 15.3; range: 25–87 years). Those patients had been older than those still living (53 years; SD: 18.6; range: 15–92 years) (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001). Average survival after diagnosis of those patients who died was 6.4 years (SD: 10.8; range: 1.5–56 years). The main known causes of death were neoplasms in 6 (25%) patients and pneumonia in 3 (12.5%). In 10 of the 24 patients who died (42%), the cause of death was not determined. Hydatidosis could not be established as the cause of death in any case.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Mortality was significantly higher in the untreated vs. the treated patient group (57% vs. 22%, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.003). Treated patients were significantly younger (51 vs. 76 years, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) and with a higher percentage of symptomatic cases (58% vs. 24%, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.007). There was also a predominance of men (71% vs. 53%, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.140) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Of the patients who received treatment, 9 (16%) had calcified cysts, a characteristic that was also observed in 15 (71.4%) of the patients who did not receive treatment (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Absence of hydatidosis treatment was correlated to mortality in the non-adjusted analysis, as well as other characteristics such as the presence of calcified cysts and recurrence of disease (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). All were more frequent in older patients. After adjustment by age, gender, recurrence, degree of diagnostic confirmation and calcification, the differences were not significant (OR: 0.83; CI: 0.09–7.50; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.867).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">During a 15-year-period, 76 patients diagnosed with CE were recorded in a university hospital. Patients were predominantly male and had a mean age of almost 58 years. When these results were compared with other studies, it was found that distribution by gender varied widely in the different publications. Thus, two studies conducted in other Spanish regions showed similar proportions to ours, and mean ages also agreed.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">12,16</span></a> However, other series found no differences by gender,<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">10,17</span></a> or even a trend to a higher proportion of women, as occurs in a study conducted in Yemen,<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">18</span></a> where the patients were also much younger. These authors point out that the variation in distribution by gender found in the different publications may have been influenced by social and cultural factors as the person usually in charge of the animals transmitting the disease was obviously more exposed.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Most of the patients studied were from Spain, with anecdotal cases of hydatidosis in foreign patients, unlike other Spanish publications where the number of foreigners is much larger.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> It is striking that there were more patients from urban than rural areas, contrary to what is suggested by the epidemiology of the disease<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">6,11</span></a> and other studies published in Spain.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> However, this was also reported in a study published in Romania,<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> where the distribution of the disease was slightly higher in the urban area, despite a much higher incidence rate of the disease in the rural area (5.1 vs. 2.5/100,000 inhabitants).</p><p id="par0100" class="elsevierStylePara elsevierViewall">More than half of the diagnosed cases of hydatidosis were made coincidentally in the context of imaging or surgical examinations done for other reasons, as in the study by Pardo et al.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a> Less than half of the patients had clinical symptoms, the most common being abdominal pain, one of the most characteristic symptoms.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">12,16</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The main diagnostic tool of CE was imaging testing, as confirmed in other studies.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">16</span></a> Ultrasound was the most commonly used technique, though it sometimes failed to detect lesions visible on CT. Nearly all patients had cysts at a single location, the liver being the most frequently affected organ. Both characteristics are consistent with published studies.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">1,2,10,12,16–18</span></a> Cysts were calcified in a third of our patients, suggesting they were inactive.</p><p id="par0110" class="elsevierStylePara elsevierViewall">A third of patients received no treatment and in those who did (72%), treatment was mainly surgical, alone or in combination with medical treatment (49% and 42% of total treatments initiated, respectively). These figures are higher than those published in other studies, which in many cases do not reach two thirds of patients who received surgical treatment.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">12,16</span></a> In our case, the main reasons for not initiating treatment were the absence of clinical symptoms or excessive comorbidity. This difference is shown when the treated and untreated patient groups are compared, as the latter had a significantly older mean age and a higher proportion of asymptomatic patients.</p><p id="par0115" class="elsevierStylePara elsevierViewall">During the 15-year study period, 31.2% of the patients diagnosed with hydatidosis died. Mean age was significantly higher in those who did. The primary causes of death were neoplasms and pneumonia. In nearly a third of patients, the reason for death was unknown, and in none of the cases was the cause of death attributed to hydatidosis. This is probably why our mortality rate is higher than in other studies, where no deaths<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">17</span></a> or very few<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">12</span></a> were recorded. A recent study has reported a considerable mortality, but it is very low in comparison to our results.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">19</span></a> These differences may be related to total observation time for each study. Our study included mortality for any cause and over a very long follow-up period, while in the other studies the observation period was limited to the time of diagnosis and the postoperative period. However, although mortality in our patients was significantly higher in the untreated patient group, the logistic regression study indicated that this result might have been influenced by other factors, primarily age. That seems also to be the explanation for why some factors, such as the presence of calcified cysts or recurrences, theoretically linked with a better prognosis, were related to death. These characteristics were more frequent in older patients, and we were evaluating mortality for any cause.</p><p id="par0120" class="elsevierStylePara elsevierViewall">This study has several limitations. First, its retrospective nature. Secondly, all our patients were admitted to the same hospital; this could be a selection bias because our series may not represent the situation of all patients with hydatidosis which prevents establishing the actual incidence of the disease. However, ours represents one of the largest series analyzing the epidemiological, clinical and outcome during this century.</p><p id="par0125" class="elsevierStylePara elsevierViewall">In summary, echinococcosis, a disease of mandatory declaration in our country, still represents a high economic burden. Our study reveals that surgery is the most used treatment. The mortality of patients in our series was high, but not directly related to hydatidosis. There were fewer deaths in treated patients, though their younger age should be taken into account. Our results suggest the need to design current multicenter prospective studies to determine the actual risk of hydatidosis in developed countries and establish definite indications of treatment.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres563523" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec580065" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres563522" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Resultados" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec580066" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analysis" ] ] ] 6 => array:3 [ "identificador" => "sec0020" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Treatment" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Outcome" ] ] ] 7 => array:2 [ "identificador" => "sec0035" "titulo" => "Discussion" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-01-24" "fechaAceptado" => "2015-05-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec580065" "palabras" => array:3 [ 0 => "Hydatidosis" 1 => "Echinococcosis" 2 => "Zoonotic parasitic diseases" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec580066" "palabras" => array:3 [ 0 => "Hidatidosis" 1 => "Equinococosis" 2 => "Enfermedades zoonóticas parasitarias" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the epidemiological and clinical characteristics and mortality of patients with cystic echinococcosis (CE) in northern Spain.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective study of the medical records of patients diagnosed with CE and hospitalized from 1997 to 2011 in a University Hospital.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 76 patients (44 men) were diagnosed with CE. The mean age was 57.8 years (SD: 19.1 years; range: 14.9–92.7). The yearly average incidence was 1.08 cases/100,000 inhabitants. The highest incidence was registered in patients aged 70–79 years (22.7% of all cases). Liver was the main organ involved (92.1%), followed by lung (6.6%) and peritoneum (1.3%). Fifty-five patients (72%) received treatment: 2 (3.6%) medical treatment with albendazole, 27 (49%) surgical treatment, 3 (5.4%) medical treatment combined with cyst drainage, and 23 (42%) combined medical and surgical treatment. Eight patients had a recurrence. Twenty-four (31.2%) patients died. No patient's death was attributed directly to hydatidosis, though mortality was significantly higher in the untreated vs. the treated patient group (57% vs. 22%, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.003).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Hydatidosis treatment and diagnostic approaches remain heterogeneous. The liver continues being the main organ affected. Mortality was higher in patients who did not receive treatment. However, this result might have been influenced by other factors, mainly age.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar las características epidemiológicas y clínicas y la mortalidad de los pacientes con equinococosis quística (EQ) en el norte de España.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Pacientes y métodos: Estudio retrospectivo de las historias clínicas de los pacientes diagnosticados de EQ, ingresados entre los años 1997 y 2011 en un Hospital Universitario.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron de hidatidosis un total de 76 pacientes (44 varones). La media de edad fue de 57,8 años (DE: 19,1 años; rango: 14,9–92,7). El promedio de incidencia anual fue de 1,08 casos/100.000 habitantes. La incidencia más alta se registró entre los pacientes con una edad comprendida entre 70 y 79 años (22,7% de los casos). El hígado fue el principal órgano afectado (92,1%), seguido del pulmón (6,6%) y el peritoneo (1,3%). Recibieron tratamiento 55 pacientes (72%): 2 (3,6%) tratamiento médico (albendazol), 27 (49%) tratamiento quirúrgico, 3 (5,4%) tratamiento médico combinado con drenaje del quiste y 23 (42%) tratamiento médico y quirúrgico combinados. Presentaron recurrencias 8 pacientes, y fallecieron 24 (31,2%). Ninguno de los pacientes falleció por una causa atribuible a hidatidosis, aunque la mortalidad fue significativamente mayor en el grupo de los no tratados respecto al de los tratados (57% vs. 22%, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,003).</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La aproximación diagnóstica y terapéutica de la hidatidosis continúa siendo heterogénea. El hígado sigue siendo el principal órgano afectado. La mortalidad fue mayor en los pacientes que no recibieron tratamiento, si bien este resultado puede estar influido por otros factores, principalmente la edad.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Resultados" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>76 \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Age (years, SD)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57.8 (19.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Gender (male (%))</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 (58%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Population</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Urban Cantabria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (44.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Rural Cantabria \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 (37%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other places in Spain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (6.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Foreigners \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Clinical symptoms, n (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Asymptomatic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43 (56%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Abdominal pain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (36%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fever \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Location, n (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Liver \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71 (93.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lung \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (6.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Calcified cysts, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (31.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Positive serology, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (17.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Diagnosis, n (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Possible \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25 (32.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Probable \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Confirmed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">50 (65.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Treatment, n (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Only medical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (2.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Only surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (35.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Medical<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (30.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Medical<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>drainage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (3.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>None \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (27.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Recurrence, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (10.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Deaths, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (31.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Cause of death, n (%)</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hydatidosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (3.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neoplasm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (7.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (6.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unknown \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (13%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab913735.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the study population.</p>" ] ] 1 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>55 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No treatment<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>21 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age (years, SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">76 (11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Sex (male [%]) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29 (53%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (71%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.140 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Prior hydatidosis, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.000 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Asymptomatic patients, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 (58%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Liver cysts, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (93%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">20 (95%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.576 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Calcified cysts, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (16%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (71%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Positive serology, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.496 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Confirmed diagnosis, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49 (89%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Recurrence, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (15%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Death, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (22%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (57%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab913736.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients with hydatidosis according to whether they received specific treatment or not.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">OR: odds ratio; CI: confidence interval.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR (CI) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.06 (1.02–1.10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Male gender \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.25 (0.80–6.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.125 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Symptomatic patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.51 (0.19–1.38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.188 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Confirmed diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.28 (0.10–0.78) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Calcified cysts \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.33 (1.20–9.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Recurrence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.70 (0.13–3.74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.637 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Hydatidosis treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.21 (0.07–0.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab913737.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Factors associated with mortality.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0100" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Writing Panel for the WHO-IWGE" "etal" => false "autores" => array:3 [ 0 => "E. Brunetti" 1 => "P. Kern" 2 => "D.A. Vuitton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.actatropica.2009.11.001" "Revista" => array:7 [ "tituloSerie" => "Acta Trop" "fecha" => "2010" "volumen" => "114" "paginaInicial" => "1" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19931502" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674913013730" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0105" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Worldwide epidemiology of liver hydatidosis including the Mediterranean area" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Grosso" 1 => "S. Gruttadauria" 2 => "A. Biondi" 3 => "S. Marventano" 4 => "A. Mistretta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v18.i13.1425" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2012" "volumen" => "18" "paginaInicial" => "1425" "paginaFinal" => "1437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22509074" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0110" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progress in control of cystic echinococcosis in La Rioja, Spain: decline in infection prevalences in human and animal hosts and economic costs and benefits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Jiménez" 1 => "A. Pérez" 2 => "H. Gil" 3 => "P. Schantz" 4 => "E. Ramalle" 5 => "R. Juste" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Trop" "fecha" => "2002" "volumen" => "83" "paginaInicial" => "213" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12204394" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0115" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dog echinococcosis in northern Spain: comparison of coproantigen and serum antibody assays with coprological exam" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Benito" 1 => "D. Carmena" 2 => "L. Joseph" 3 => "J. Martínez" 4 => "J.A. Guisantes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vetpar.2006.06.011" "Revista" => array:6 [ "tituloSerie" => "Vet Parasitol" "fecha" => "2006" "volumen" => "142" "paginaInicial" => "102" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16863681" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0120" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hydatidosis: epidemiological, clinical, diagnostic and therapeutic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Armiñanzas" 1 => "M. Gutiérrez-Cuadra" 2 => "M.C. Fariñas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Quimioter" "fecha" => "2015" "volumen" => "28" "paginaInicial" => "116" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26032995" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0125" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review of the epidemiology of echinococcosis in domestic and wild animals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Otero-Abad" 1 => "P.R. Torgerson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pntd.0002249" "Revista" => array:5 [ "tituloSerie" => "PLoS Negl Trop Dis" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "e2249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23755310" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0130" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The present situation of echinococcosis in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Romig" 1 => "A. Dinkel" 2 => "U. Mackemstedt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.parint.2005.11.028" "Revista" => array:6 [ "tituloSerie" => "Parasitol Int" "fecha" => "2006" "volumen" => "55" "paginaInicial" => "S187" "paginaFinal" => "S191" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16352465" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0135" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of <span class="elsevierStyleItalic">Echinococcus multilocularis</span> and <span class="elsevierStyleItalic">E. granulosus</span> in central Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Eckert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Parassitologia" "fecha" => "1997" "volumen" => "39" "paginaInicial" => "337" "paginaFinal" => "344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9802089" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0140" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echinococcosis/hydatidosis: a severe threat in Mediterranean countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Dakkak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vetpar.2010.08.009" "Revista" => array:6 [ "tituloSerie" => "Vet Parasitol" "fecha" => "2010" "volumen" => "174" "paginaInicial" => "2" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20888694" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0145" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hydatidosis in the province of Salamanca (Spain): should we let down our guard" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Pardo" 1 => "A. Muro" 2 => "I. Galindo" 3 => "M. Cordero" 4 => "A. Carpio" 5 => "M. Siles-Lucas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Enferm Infecc Microbiol Clin" "fecha" => "2005" "paginaInicial" => "266" "paginaFinal" => "269" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0150" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepatic echinococcosis: clinical and therapeutic aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Nunnari" 1 => "M.R. Pinzone" 2 => "S. Gruttadauria" 3 => "B.M. Celesia" 4 => "G. Madeddu" 5 => "G. Malaguarnera" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v18.i13.1448" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2012" "volumen" => "18" "paginaInicial" => "1448" "paginaFinal" => "1458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22509076" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0155" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary super-infection of hydatid cyst. Clinical setting and microbiology in 37 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Belhassen García" 1 => "J. Pardo Lledías" 2 => "I. Galindo Pérez" 3 => "V. Velasco Tirado" 4 => "L. Fuentes Pardo" 5 => "L. Muñoz Bellvís" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4269/ajtmh.2010.09-0375" "Revista" => array:6 [ "tituloSerie" => "Am J Trop Med Hyg" "fecha" => "2010" "volumen" => "82" "paginaInicial" => "376" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20207859" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0160" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic and alveolar echinococcosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Stojkovic" 1 => "T. Junghanss" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/B978-0-444-53490-3.00026-1" "Revista" => array:6 [ "tituloSerie" => "Handb Clin Neurol" "fecha" => "2013" "volumen" => "114" "paginaInicial" => "327" "paginaFinal" => "334" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23829922" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0165" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International classification of ultrasound images in cystic echinococcosis for application in clinical and field epidemiological settings" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "WHO Informal Working Group" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Trop" "fecha" => "2003" "volumen" => "85" "paginaInicial" => "253" "paginaFinal" => "261" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12606104" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0170" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review on diagnostic and preventive aspects of cystic echinococcosis and human cysticercosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Giri" 1 => "S.C. Parija" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/2229-5070.105174" "Revista" => array:6 [ "tituloSerie" => "Trop Parasitol" "fecha" => "2012" "volumen" => "2" "paginaInicial" => "99" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23767016" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0195" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Casos de hidatidosis en el Departamento de Salud 2 de la Comunidad Valenciana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Moreno" 1 => "C.J. Téllez" 2 => "F.J. Pardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Quimioter" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "62" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19544098" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0200" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human cystic echinococcosis in two south-western and central-western Romanian counties: a 7-year epidemiological and clinical overview" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Moldovan" 1 => "A.M. Neghina" 2 => "C. Calma" 3 => "I. Marincu" 4 => "R. Neghina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.actatropica.2011.10.003" "Revista" => array:6 [ "tituloSerie" => "Acta Trop" "fecha" => "2012" "volumen" => "121" "paginaInicial" => "26" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22019934" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0205" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cases of hydatidosis in patients referred to Governmental hospitals for cyst removal in Sana’a City, Republic of Yemen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.A. Al-Shibani" 1 => "S.M. Al-Eryani" 2 => "A.A. Azazy" 3 => "A.M. Al-Mekhlafi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Trop Biomed" "fecha" => "2012" "volumen" => "29" "paginaInicial" => "18" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22543599" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0190" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study of hydatidosis-attributed mortality in endemic area" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Belhassen-García" 1 => "A. Romero-Alegria" 2 => "V. Velasco-Tirado" 3 => "M. Alonso-Sardón" 4 => "A. Lopez-Bernus" 5 => "L. Alvela-Suarez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0091342" "Revista" => array:6 [ "tituloSerie" => "PLOS ONE" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e91342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24632824" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674904014137" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000021500000007/v1_201510020909/S2254887415000788/v1_201510020909/en/main.assets" "Apartado" => array:4 [ "identificador" => "1901" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000021500000007/v1_201510020909/S2254887415000788/v1_201510020909/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887415000788?idApp=WRCEE" ]
