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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">First of all&#44; I would like to thank the authors for their attention to the article&#46; Alpha-1 antitrypsin deficiency &#40;AATD&#41; is indeed an important genetic risk factor for chronic obstructive pulmonary disease &#40;COPD&#41;&#46; Although AATD is caused by a single genetic variant&#44; the clinical manifestations of the disease are variable<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In 2001&#44; Professor Zhu analysed the status of AATD in China and pointed out that AATD might not be an important factor for the development of COPD in Chinese patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Moreover&#44; a family history of emphysema and&#47;or liver disease should rise the diagnosis of AATD&#46; Family testing for AATD is the most cost-effective and successful strategy to find patients who may benefit from lifestyle interventions or therapy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Family history was first questioned in our study&#44; but no positive family members were found&#46; Routine testing for AATD was not carried out&#46; With the updating of current detection methods and the reduction of detection costs&#44; AATD should be taken into account in future studies&#46;</p></span>"
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DOI: 10.1016/j.rceng.2022.03.002
Counter-reply to the letter in response to the article A population-based survey of the prevalence and risk factors of chronic obstructive pulmonary disease in Shanxi province (China)
Contrarréplica a la carta de respuesta al artículo Encuesta poblacional sobre la prevalencia y los factores de riesgo de la enfermedad pulmonar obstructiva crónica en la provincia de Shanxi (China)
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R. Wang, J. Xu, Y. Wang
Corresponding author
wry0526@163.com

Corresponding author.
Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, Taiyuan, Shanxi Province, China

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