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Vol. 224. Issue 6.
Pages 366-378 (June - July 2024)
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Vol. 224. Issue 6.
Pages 366-378 (June - July 2024)
Original article
Association between serum α-Klotho levels and osteoarthritis prevalence among middle-aged and older adults: an analysis of the NHANES 2007–2016
Asociación entre los niveles séricos de α-Klotho y la prevalencia de osteoartritis entre adultos de mediana edad y mayores: un análisis de la NHANES 2007−2016
Qi Xua,b, jiale Wangc, Hanzhi Lia, Yuwan Gaod,
Corresponding author
17320185221@163.com

Corresponding author.
a Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Nanyang Medical College, Nanyang, China
b Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China
c Department of Internal Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China
d Department of Ophthalmology, The First Affiliated Hospital of Nanyang Medical College, Nanyang, China
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Figures (2)
Tables (5)
Table 1. The demographic characteristics of participants from NHANES 2007–2016.
Table 2. Association between serum ln α-Klotho and OA.
Table 3. Threshold effect analysis.
Table 4. Subgroup analysis for the association between serum ln α-Klotho and OA.
Table 5. Univariate logistic regression associating variables with OA.
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Abstract
Background

As individuals age, the prevalence of osteoarthritis tends to increase gradually. α-Klotho is a hormone renowned for its anti-aging properties. However, the precise role of serum α-Klotho in osteoarthritis is still not fully comprehended.

Methods

We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016. Serum α-Klotho levels were measured using an enzyme-linked immunosorbent assay (ELISA). Osteoarthritis was assessed through self-reported questionnaires. Through univariate and multivariate logistic regression analyses, smooth curve fitting, threshold effect analysis, and subgroup analyses, we delved into the potential association between them.

Results

The study encompassed a cohort of 10,265 participants. In fully adjusted models of multivariate logistic regression analysis, we identified a negative correlation between serum ln α-Klotho and OA (OR = 0.77, 95% CI: 0.65−0.91, p = 0.003). When stratifying serum α-Klotho levels into tertiles, individuals in the highest tertile exhibited a 26% reduced risk of OA compared to those in the lowest tertile (OR = 0.84, 95% CI: 0.73−0.97, p = 0.014). Subsequent analyses indicated a linearly negative association. In subgroup analyses, we explored the relationship between serum ln α-Klotho and osteoarthritis across diverse populations, revealing the persistence of this association in the majority of subgroups.

Conclusion

Serum α-Klotho levels exhibit a significant negative linear correlation with the prevalence of osteoarthritis in middle-aged and elderly populations in the United States.

Keywords:
α-Klotho
Osteoarthritis
NHANES
Aging
Middle-aged and older adults
Resumen
Antecedentes

A medida que las personas envejecen, la prevalencia de la osteoartritis tiende a aumentar gradualmente. α-Klotho es una hormona conocida por sus propiedades antienvejecimiento. Sin embargo, el papel exacto de la α-Klotho sérica en la osteoartritis aún no se comprende del todo.

Métodos

Llevamos a cabo un estudio transversal utilizando datos de la Encuesta Nacional de Salud y Nutrición (NHANES) que abarca desde 2007 hasta 2016. Los niveles séricos de α-Klotho se midieron mediante un ensayo inmunoenzimático (ELISA). La osteoartritis se evaluó mediante cuestionarios autoinformados. Mediante análisis de regresión logística univariante y multivariante, ajuste suave de curvas, análisis de efecto umbral y análisis de subgrupos, se profundizó en la posible asociación entre ellos.

Resultados

El estudio abarcó una cohorte de 10.265 participantes. En modelos totalmente ajustados de análisis de regresión logística multivariante, identificamos una correlación negativa entre ln α-Klotho sérica y OA (OR = 0,77; IC 95%: 0,65−0,91; p = 0,003). Al estratificar los niveles séricos de α-Klotho en terciles, los individuos en el tercil más alto presentaban un riesgo 26% menor de padecer OA en comparación con los del tercil más bajo (OR = 0,84; IC 95%: 0,73−0,97; p = 0,014). Los análisis posteriores indicaron una asociación linealmente negativa. En análisis de subgrupos, exploramos la relación entre ln α-Klotho sérico y osteoartritis en diversas poblaciones, revelando la persistencia de esta asociación en la mayoría de los subgrupos.

Conclusiones

Los niveles séricos de α-Klotho muestran una correlación lineal negativa significativa con la prevalencia de osteoartritis en poblaciones de mediana y avanzada edad en Estados Unidos.

Palabras clave:
α-Klotho
Osteoartritis
NHANES
Envejecimiento
Adultos de mediana y avanzada edad

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