Association between arterial stiffness and fat mass in patients with obesity

Asociación entre rigidez arterial y masa grasa en pacientes con obesidad

S. Tolosa-Álvareza, J.C. Arévalo-Loridoa,

Corresponding author

[e-mail]

Corresponding author.

, J.F. Sánchez-Muñoz-Torrerob, A. Pijierro-Amadora, L. Nevado López-Alegríaa, J. Carretero-Gómeza

a Servicio de Medicina Interna, Hospital Universitario de Badajoz, Badajoz, Spain

b Servicio de Medicina Interna, Hospital San Pedro de Alcántara, Cáceres, Spain

Abstract

Objective

The aim is to observe whether body composition in patients with high-risk obesity (body mass index >35 or between 30 and 34.9kg/m2 with a waist circumference greater than 102cm in men or greater than 88cm in women) is related with vascular disease.

Methods

This is a cross-sectional study of patients with high-risk obesity. Their fat mass was measured through bioimpedance and arterial stiffness through pulse wave velocity (PWV). Tertiles of patients were analyzed according to PWV distribution.

Results

A total of 59 patients were analyzed. As PWV increased, BMI (p=0.02) and fat mass content (p<0.00) increased. There was also a significant increase in inflammation indicators.

Conclusions

In patients with high-risk obesity, there were differences in their body composition which were associated with changes in arterial stiffness and inflammatory burden.

Keywords:

Obesity

Arterial stiffness

Bioimpedance

Resumen

Objetivo

Comprobar si la composición corporal en los pacientes con obesidad de riesgo alto (índice de masa corporal >35 o entre 30 y 34,9kg/m2 con un perímetro abdominal mayor de 102cm en varones o mayor de 88cm en mujeres) se relaciona con la enfermedad vascular.

Métodos

Estudio transversal de pacientes con obesidad de riesgo alto. Se mide su masa grasa mediante bioimpedancia y la rigidez arterial mediante la velocidad de la onda de pulso (VOP). Se analizan los terciles de pacientes según la distribución de la VOP.

Resultados

Se ha estudiado a 59 pacientes. Con incrementos de la VOP, aumentan el IMC (p=0,02) y el contenido de masa grasa (p<0,00). Existe, además, un incremento significativo de los indicadores de inflamación.

Conclusiones

En pacientes con obesidad de riesgo alto existen diferencias relativas a su composición corporal que se asocian a modificaciones de su rigidez arterial y de su carga inflamatoria.

Palabras clave:

Obesidad

Rigidez arterial

Bioimpedancia