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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 40-year-old woman&#44; with a history of asthma and atopic dermatitis&#44; with breast implants and silicone fluid in the buttocks implanted 10 years earlier&#44; presented generalized pruritus and skin lesions that started a year earlier&#44; accompanied by polymyalgia&#44; diarrhea and dyspepsia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The examination revealed disseminated excoriated papules-plaques &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#41;&#46; The skin biopsy showed a perivascular histiocytic foreign-body reaction with lipid vacuoles consistent with silicone granulomas &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b and c&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Autoimmune&#47;inflammatory syndrome induced by adjuvants &#40;ASIA&#41;&#44; described by Shoenfeld in 2011&#44; is a condition that encompasses various autoinflammatory disorders after exposure to adjuvants such as silicone&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The condition can appear up to 15 years after exposure to the material and is characterized by joint pain&#44; myalgia&#44; chronic fatigue&#44; local or distal granulomas&#44; rash&#44; eczema&#44; urticaria and pruritus&#46; ASIA has also been associated with neurological symptoms&#44; various autoimmune diseases and the production of nonspecific autoantibodies&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The scarce number of published cases and its clinical variability hinders the diagnosis&#44; which is based on ruling out other causes and requires the use of the Shoenfeld criteria&#58; 2 major criteria or 1 major and 2 minor criteria &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The therapeutic options consist of removing the external stimulus&#44; if possible&#44; and employing immunomodulatory drugs&#46;</p></span>"
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Medicine in Image
DOI: 10.1016/j.rceng.2018.12.003
ASIA (Autoimmune/inflammatory syndrome induced by adjuvants): A new case?
ASIA (Autoimmune/inflammatory syndrome induced by adjuvants): ¿un nuevo caso?
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P. Fernández-Canga
Corresponding author
paulafcanga@gmail.com

Corresponding author.
, M. Lamoca-Martín, C. Prada-García
Servicio de Dermatología, Complejo Asistencial Universitario de León, León, Spain

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