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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "73" "paginaFinal" => "74" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Fernández-Canga, M. Lamoca-Martín, C. Prada-García" "autores" => array:3 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Fernández-Canga" "email" => array:1 [ 0 => "paulafcanga@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Lamoca-Martín" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Prada-García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Complejo Asistencial Universitario de León, León, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "ASIA <span class="elsevierStyleItalic">(Autoimmune/inflammatory syndrome induced by adjuvants):</span> ¿un nuevo caso?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 722 "Ancho" => 2500 "Tamanyo" => 388417 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 40-year-old woman, with a history of asthma and atopic dermatitis, with breast implants and silicone fluid in the buttocks implanted 10 years earlier, presented generalized pruritus and skin lesions that started a year earlier, accompanied by polymyalgia, diarrhea and dyspepsia.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The examination revealed disseminated excoriated papules-plaques (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a). The skin biopsy showed a perivascular histiocytic foreign-body reaction with lipid vacuoles consistent with silicone granulomas (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b and c).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), described by Shoenfeld in 2011, is a condition that encompasses various autoinflammatory disorders after exposure to adjuvants such as silicone.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The condition can appear up to 15 years after exposure to the material and is characterized by joint pain, myalgia, chronic fatigue, local or distal granulomas, rash, eczema, urticaria and pruritus. ASIA has also been associated with neurological symptoms, various autoimmune diseases and the production of nonspecific autoantibodies.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The scarce number of published cases and its clinical variability hinders the diagnosis, which is based on ruling out other causes and requires the use of the Shoenfeld criteria: 2 major criteria or 1 major and 2 minor criteria (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The therapeutic options consist of removing the external stimulus, if possible, and employing immunomodulatory drugs.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-09-03" "fechaAceptado" => "2018-09-17" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Fernández-Canga P, Lamoca-Martín M, Prada-García C. ASIA <span class="elsevierStyleItalic">(Autoimmune/Inflammatory Syndrome Induced by Adjuvants):</span> ¿un nuevo caso? 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