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such as the QT interval&#44; the QTc &#40;same interval&#44; but corrected to take into account its natural variation with the heart rhythm&#41; or the Tp-e &#40;interval from T-wave peak to T-wave end&#41; can be measured manually by a cardiologist on the ECG tracing&#44; with the help of a ruler&#44; or using a computer to magnify the tracing on digitised recordings&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Ventricular repolarisation can also be characterised by other features not directly available by visual inspection of the ECG tracings&#46; Moreover&#44; the variation over time of the repolarisation features&#44; and their spatial distribution have been shown to convey useful information on the physiology of repolarization&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> Of particular interest is the response of these features to changes in heart rate &#40;HR&#41;&#46; These indices&#44; usually driven by electrophysiological observations&#44; must be obtained by computerised methods&#44; where signal processing plays a crucial role&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">In the current issue of <span class="elsevierStyleItalic">Revista Cl&#237;nica Espa&#241;ola</span>&#44; Demirta&#351; et al&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">3</span></a> assessed in an interesting case-control study the values of some repolarisation indices quantifying repolarisation dispersion in patients with coeliac disease &#40;CD&#41;&#46; In particular&#44; Tp-e interval and the ratios Tp-e&#47;QT and Tp-e&#47;QTc were manually measured from the 12-lead ECG in 38 patients with CD and 38 age- and sex-matched controls&#46; Their results showed significantly higher values of the three indices in the CD patients with respect to the control population&#44; suggesting that CD might be associated with an increase in ventricular repolarisation dispersion&#46; 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Since a Holter recording typically includes a wide range of HR&#44; including periods with stationary HR as well as abrupt accelerations and decelerations of HR&#44; computerised analysis of Holter recordings can be used to achieve good characterisation of the repolarisation dynamics&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Non-linear models including memory have been proposed<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> to characterise the memory of different ECG parameters with respect to the HR in the previous beats&#46; Results have shown that the duration and profile of the QT dependence with HR &#40;QT&#47;RR hysteresis&#41; is highly individual-dependent while&#44; on average&#44; RR intervals of the past 150 beats &#40;approximately 2&#46;5<span class="elsevierStyleHsp" style=""></span>min&#41; are required to accurately model the QT response&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">8&#44;9</span></a> The residual of the model&#44; i&#46;e&#46; the portion of QT variation that cannot be explained by the model&#44; was also a significant risk stratifier in patients under amiodarone&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> The Tp-e was also shown to be dependent on the previous RR intervals&#44; but with a shorter memory than the QT interval&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The relative amount of change in the Tpe &#40;measured in different stable conditions&#41; with respect to the change in the RR interval &#40;denoted as &#916;&#945;&#41; has been related to the dispersion of action potential duration restitution slopes in the ventricular cells&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> This non-invasive parameter&#44; measurable in regular ambulatory recordings&#44; has been shown to discriminate between SCD victims during the four-year follow-up from survivors in a population of chronic heart failure &#40;CHF&#41; patients&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> and to be predictive of arrhythmic risk induced by sotalol&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">11</span></a> Interestingly&#44; &#916;<span class="elsevierStyleItalic">&#945;</span> was also able to identify differentially the CHF patients predisposed to death from the progression of the disease &#40;pump failure death &#91;PFD&#93;&#41;&#58; while values of &#916;<span class="elsevierStyleItalic">&#945;</span> in the higher range where predictive of SCD&#44; values of &#916;<span class="elsevierStyleItalic">&#945;</span> in the lower range were suggestive of PFD&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">12</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In a recent work&#44; we hypothesised that increased dispersion of repolarisation restitution should be better reflected in the overall morphology of the T-wave and its variation with HR&#46; A novel index called T-wave morphology restitution &#40;TMR&#41; was quantified by measuring the T-wave morphological variation between two T waves that were representative of different HR&#44; and normalised by per RR increment&#46; In the previously cited CHF population&#44; TMR was significantly higher in SCD victims than in the remaining patients&#44; with Cox analysis revealing that increased TMR was strongly associated with SCD&#44; independently of other clinical and ECG-derived variables&#46; However&#44; no association was found between this index and PFD&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">13</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The research described in the previous paragraphs was performed as a collaborative effort between clinical and engineering research groups&#46; We believe that these types of collaborations will be crucial in years to come to make advances in the management of clinical decisions based on non-invasive data&#46;</p></span>"
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        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => "P&#46; Laguna"
                            1 => "J&#46;P&#46; Mart&#237;nez"
                            2 => "E&#46; Pueyo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Proc IEEE"
                        "fecha" => "2016"
                        "volumen" => "104"
                        "paginaInicial" => "392"
                        "paginaFinal" => "515"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T&#40;p-e&#41;&#47;QT ratio as an index of arrhythmogenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Gupta"
                            1 => "C&#46; Patel"
                            2 => "H&#46; Patel"
                            3 => "S&#46; Narayanaswamy"
                            4 => "B&#46; Malhotra"
                            5 => "J&#46;T&#46; Green"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jelectrocard.2008.07.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Electrocardiol"
                        "fecha" => "2008"
                        "volumen" => "41"
                        "paginaInicial" => "567"
                        "paginaFinal" => "574"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18790499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tp-e interval and Tp-e&#47;QT ratio in patients with celiac disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:5 [
                            0 => "K&#46; Demirta&#351;"
                            1 => "&#199;&#46; Yayla"
                            2 => "M&#46; Y&#252;ksel"
                            3 => "B&#46; A&#231;ar"
                            4 => "S&#46; &#220;nal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2017"
                        "volumen" => "8"
                        "paginaInicial" => "439"
                        "paginaFinal" => "445"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Celiac disease associated with autoimmune myocarditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "A&#46; Frustaci"
                            1 => "L&#46; Cuoco"
                            2 => "C&#46; Chimenti"
                            3 => "M&#46; Pieroni"
                            4 => "G&#46; Fioravanti"
                            5 => "N&#46; Gentiloni"
                            6 => "A&#46; Maseri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "105"
                        "paginaInicial" => "8"
                        "paginaFinal" => "2611"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11772868"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dilated cardiomyopathy in celiac disease&#58; role of carnitine deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Uslu"
                            1 => "H&#46; Demir"
                            2 => "T&#46; Karagoz"
                            3 => "I&#46;N&#46; Saltik-Temizel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Gastroenterol Belg"
                        "fecha" => "2010"
                        "volumen" => "73"
                        "paginaInicial" => "530"
                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21299168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An analysis of the time-relations of electrocardiograms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Bazett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Heart"
                        "fecha" => "1920"
                        "volumen" => "7"
                        "paginaInicial" => "353"
                        "paginaFinal" => "370"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Problems of heart rate correction in assessment of drug-induced QT interval prolongation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Malik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cardiovasc Electrophysiol"
                        "fecha" => "2001"
                        "volumen" => "12"
                        "paginaInicial" => "411"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11332559"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46; Pueyo"
                            1 => "P&#46; Smetana"
                            2 => "P&#46; Caminal"
                            3 => "A&#46; Bay&#233;s de Luna"
                            4 => "M&#46; Malik"
                            5 => "P&#46; Laguna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1109/TBME.2004.828050"
                      "Revista" => array:6 [
                        "tituloSerie" => "IEEE Trans Biomed Eng"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "1511"
                        "paginaFinal" => "1520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15376499"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Modeling and quantification of repolarization feature dependency on heart rate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Minchol&#233;"
                            1 => "E&#46; Zacur"
                            2 => "E&#46; Pueyo"
                            3 => "P&#46; Laguna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3414/ME13-02-0040"
                      "Revista" => array:6 [
                        "tituloSerie" => "Methods Inf Med"
                        "fecha" => "2014"
                        "volumen" => "53"
                        "paginaInicial" => "324"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25077546"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Ram&#237;rez"
                            1 => "A&#46; Minchol&#233;"
                            2 => "J&#46; Bolea"
                            3 => "P&#46; Laguna"
                            4 => "E&#46; Pueyo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "XL international conference on computing in cardiology"
                        "paginaInicial" => "1"
                        "paginaFinal" => "4"
                        "serieFecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ECG-based estimation fo dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Minchol&#233;"
                            1 => "A&#46; Bueno-Orovio"
                            2 => "P&#46; Laguna"
                            3 => "E&#46; Pueyo"
                            4 => "B&#46; Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jelectrocard.2015.06.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Electrocardiol"
                        "fecha" => "2015"
                        "volumen" => "48"
                        "paginaInicial" => "867"
                        "paginaFinal" => "873"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26117457"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "Available at&#58; <span class="elsevierStyleInterRef" id="intr0005" href="https://zaguan.unizar.es/record/60873/files/TESIS-2017-029.pdf">https&#58;&#47;&#47;zaguan&#46;unizar&#46;es&#47;record&#47;60873&#47;files&#47;TESIS-2017-029&#46;pdf</span> &#91;accessed 23&#46;08&#46;17&#93;"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of cardiac death risk by analysis of ventricular repolarization restitution from the electrocardiogram signal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Ram&#237;rez"
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                        ]
                      ]
                    ]
                  ]
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                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T-Wave morphology restitution predicts sudden cardiac death in patients with chronic heart failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Ram&#237;rez"
                            1 => "M&#46; Orini"
                            2 => "A&#46; Minchol&#233;"
                            3 => "V&#46; Monasterio"
                            4 => "I&#46; Cygankiewicz"
                            5 => "A&#46; Bay&#233;s de Luna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/JAHA.116.005310"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Heart Assoc"
                        "fecha" => "2017"
                        "volumen" => "6"
                        "paginaInicial" => "e005310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28526702"
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                      ]
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                ]
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            ]
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Editorial
Measuring ventricular repolarisation dynamics from ambulatory electrocardiography as non-invasive cardiac risk indices
Medición de la dinámica de repolarización ventricular mediante electrocardiografía ambulatoria, como índices de riesgo cardiaco no invasivos
J.P. Martíneza,b,
Autor para correspondencia
, P. Lagunaa,b
a Instituto de Investigación en Ingeniería de Aragón, IIS-Aragón, Universidad de Zaragoza, Zaragoza, Aragón, Spain
b Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain
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