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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Con fecha del 16 de abril de 2021&#44; el n&#250;mero de casos de COVID-19 causado por SARS-CoV-2 &#40;coronavirus de tipo 2 causante del s&#237;ndrome respiratorio agudo severo&#41; alcanz&#243; en Espa&#241;a los 3&#46;407&#46;283&#44; de los cuales&#44; 340&#46;130 &#40;9&#44;98&#37;&#41; han precisado ingreso hospitalario y 31&#46;054 &#40;0&#44;91&#37;&#41; ingreso en unidades de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El espectro cl&#237;nico de la infecci&#243;n por SARS-CoV-2 var&#237;a desde un cuadro leve caracterizado por fiebre&#44; tos&#44; seguido por expectoraci&#243;n y fatiga&#44; hasta cuadros graves en pacientes cr&#237;ticos caracterizados por sepsis&#44; coagulopat&#237;a&#44; fracaso respiratorio y desarrollo de s&#237;ndrome de distr&#233;s respiratorio del adulto<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La mortalidad acumulada en Espa&#241;a hasta el 16 de abril de 2021 ha sido de 76&#46;981 &#40;2&#44;25&#37;&#41; pacientes&#44; pero en los pacientes con ingreso en UCI&#44; la mortalidad alcanza el 31&#37;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a>&#46; Varios estudios coinciden en que los factores de riesgo asociados con el desarrollo de mortalidad incluyen edad avanzada&#44; presencia de insuficiencia renal&#44; niveles bajos de saturaci&#243;n de ox&#237;geno y valores elevados de prote&#237;na C reactiva<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La identificaci&#243;n precoz de los pacientes que van a necesitar cuidados cr&#237;ticos puede ser importante para proporcionar el tratamiento m&#225;s adecuado y optimizar los recursos disponibles&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El prop&#243;sito del presente estudio es utilizar un amplio registro nacional de pacientes con COVID-19 para desarrollar una escala de riesgo de ingreso en UCI&#44; aplicable a los pacientes que acaban de ingresar en el hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Fuente de datos</span><p id="par0030" class="elsevierStylePara elsevierViewall">La fuente de datos fue el registro SEMI-COVID-19&#44; una cohorte retrospectiva en curso que incluye la mayor parte de pacientes dados de alta o fallecidos tras su ingreso por COVID-19 confirmada en 150 hospitales de Espa&#241;a desde el 1 de marzo de 2020 hasta el 1 de septiembre de 2020<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a>&#46; La muestra estuvo formada por un total de 16&#46;298 pacientes&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Desenlace</span><p id="par0035" class="elsevierStylePara elsevierViewall">El desenlace evaluado fue el ingreso en la UCI&#44; medido desde el momento de ingreso en el hospital&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Variables predictoras</span><p id="par0040" class="elsevierStylePara elsevierViewall">Para la elaboraci&#243;n de la regla de predicci&#243;n utilizamos variables disponibles de forma rutinaria en el momento del ingreso hospitalario y que en otros estudios se asociaron con ingreso en UCI&#46; Estas variables incluyeron&#58; &#40;1&#41; demogr&#225;ficas&#44; edad y sexo&#59; &#40;2&#41; comorbilidades e &#237;ndice de comorbilidad de Charlson&#59; &#40;3&#41; signos o s&#237;ntomas&#44; incluidas disnea&#44; confusi&#243;n&#44; hemoptisis&#59; &#40;4&#41; datos de laboratorio&#44; saturaci&#243;n de ox&#237;geno en aire ambiente&#44; valor de LDH&#44; cociente neutr&#243;filos-linfocitos&#44; prote&#237;na C reactiva&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Modelo de derivaci&#243;n</span><p id="par0045" class="elsevierStylePara elsevierViewall">En el modelo de derivaci&#243;n seleccionamos de forma aleatoria dos terceras partes &#40;n &#61; 10&#46;865&#41; de la muestra&#46; Para realizar el modelo de derivaci&#243;n llevamos a cabo un an&#225;lisis de regresi&#243;n log&#237;stica m&#250;ltiple&#44; con ingreso en UCI como desenlace primario y las variables cl&#237;nicas descritas previamente como variables predictoras&#46; Utilizando los coeficientes &#946; generamos un sistema de puntuaci&#243;n que dividi&#243; a los pacientes en diferentes clases de riesgo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Modelo de validaci&#243;n</span><p id="par0050" class="elsevierStylePara elsevierViewall">El modelo de validaci&#243;n se llev&#243; a cabo utilizando la tercera parte &#40;n &#61; 5&#46;433&#41; restante de la muestra&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">An&#225;lisis estad&#237;stico</span><p id="par0055" class="elsevierStylePara elsevierViewall">Hemos seguido las recomendaciones de la gu&#237;a TRIPOD para desarrollar el modelo de an&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a>&#46; Las variables continuas se expresan como media y desviaci&#243;n est&#225;ndar y las variables categ&#243;ricas como frecuencias y porcentajes&#46; Se utiliz&#243; el test de &#967;<span class="elsevierStyleSup">2</span> para la comparaci&#243;n de variables categ&#243;ricas y la <span class="elsevierStyleItalic">t</span> de Student para la comparaci&#243;n de variables continuas entre grupos&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p &#60; 0&#44;05&#46; Se llev&#243; a cabo un an&#225;lisis de regresi&#243;n log&#237;stica m&#250;ltiple en la muestra de derivaci&#243;n para estimar la probabilidad de ingreso en UCI&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para construir el modelo de derivaci&#243;n se seleccionaron aquellas variables con valor de p inferior a 0&#44;10 obtenidas en el modelo univariante&#46; Se estimaron los <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; y su intervalo de confianza al 95&#37; &#40;IC 95&#37;&#41;&#44; a partir de los coeficientes de regresi&#243;n&#46; Se construyeron varios modelos de regresi&#243;n y se seleccion&#243; aquel que fue m&#225;s simple y explicativo basado en el test de bondad de ajuste de Hosmer y Lemeshow para trasladarlo a la cohorte de validaci&#243;n&#46; El R<span class="elsevierStyleSup">2</span> de Nagelkerke fue utilizada para estimar la proporci&#243;n de variaci&#243;n explicada por el modelo&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">El rendimiento final del modelo fue evaluado mediante la curva de caracter&#237;stica operativa del receptor &#40;ROC&#41; y el c&#225;lculo del &#225;rea bajo la curva ROC&#46; Finalmente&#44; con base en los coeficientes &#946; generamos un sistema de puntuaci&#243;n para establecer diferentes riesgos de ingreso en UCI&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico fue realizado con el <span class="elsevierStyleItalic">software</span> libre R versi&#243;n 4&#46;0&#46;2 &#40;Free Software Foundation&#44; Inc&#46; Boston&#44; MA&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Aspectos &#233;ticos</span><p id="par0075" class="elsevierStylePara elsevierViewall">Los datos personales se trataron cumpliendo la Ley 14&#47;2007 del 3 de julio&#44; de Investigaci&#243;n Biom&#233;dica&#44; as&#237; como el reglamento &#40;UE&#41; 2016&#47;679 del Parlamento Europeo y del Consejo del 27 de abril de 2016&#44; Reglamento General de Protecci&#243;n de Datos y la Ley Org&#225;nica 3&#47;2018 del 5 de diciembre sobre Protecci&#243;n de Datos Personales y Garant&#237;a de los Derechos Digitales&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El Registro SEMI-COVID fue aprobado por el Comit&#233; de &#201;tica e Investigaci&#243;n de la Provincia de M&#225;laga&#46; El departamento de Medicamentos de Uso Humano de la Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios &#40;AEMPS&#41;&#44; de conformidad con los preceptos aplicables ha calificado el estudio como &#171;estudio observacional no postautorizaci&#243;n&#187;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Caracter&#237;sticas de los pacientes ingresados en UCI</span><p id="par0085" class="elsevierStylePara elsevierViewall">Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes fueron ingresados en UCI &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Los pacientes que ingresaron en UCI eran m&#225;s j&#243;venes &#40;edad media 63&#44;3 &#177; 12&#44;3 a&#241;os&#41; que los que ingresaron en &#225;reas de hospitalizaci&#243;n convencional &#40;67&#44;7 &#177; 16&#44;4 a&#241;os&#41; &#40;p &#60; 0&#44;001&#41;&#46; El sexo var&#243;n estuvo asociado con mayor riesgo de ingreso en UCI &#40;69&#44;5 vs&#46; 56&#44;3&#37;&#44; p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Hubo comorbilidades que presentaron mayor riesgo de ingreso en UCI&#44; entre ellas&#44; la obesidad y otras que se asociaron con menor frecuencia de ingreso en UCI&#44; tales como enfermedad renal cr&#243;nica&#44; EPOC o insuficiencia card&#237;aca cr&#243;nica&#46; La condici&#243;n de fumador fue un factor de riesgo de ingreso en UCI&#46; Una mayor proporci&#243;n de pacientes que ingresaron en UCI presentaron disnea en el momento del ingreso &#40;75&#44;4 vs&#46; 56&#37;&#44; p &#60; 0&#44;001&#41;&#44; as&#237; como una menor alteraci&#243;n del nivel de conciencia &#40;8&#44;4 vs&#46; 12&#44;2&#37;&#44; p &#60; 0&#44;001&#41;&#44; mayor frecuencia de la presencia en la radiograf&#237;a de t&#243;rax de infiltrados de tipo difuso en el momento del ingreso en los pacientes que ingresaron en UCI &#40;43 vs&#46; 29&#44;3&#37; p &#60; 0&#44;001&#41; y valores m&#225;s bajos de saturaci&#243;n de ox&#237;geno &#40;SpO<span class="elsevierStyleInf">2</span>&#41; que los pacientes ingresados en &#225;reas de hospitalizaci&#243;n convencional &#40;89 vs&#46; 93&#44;3&#37;&#44; p &#60; 0&#44;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Respecto a las variables de laboratorio&#44; los pacientes ingresados en UCI mostraban un mayor cociente neutr&#243;filos-linfocitos &#40;9&#44;7 vs&#46; 7&#44;0&#44; p &#60; 0&#44;001&#41;&#44; mayor nivel de d&#237;mero D &#40;2&#46;969&#44;8 vs&#46; 1&#46;906&#44;6 ng&#47;mL&#44; p &#61; 0&#44;004&#41;&#44; glucosa &#40;138&#44;6 vs&#46; 127&#44;5 mg&#47;dL&#44; p &#60; 0&#44;001&#41;&#44; alanina aminotransferasa &#40;ALT&#41; &#40;49&#44;7 vs&#46; 40&#44;5 U&#47;L&#44; p &#60; 0&#44;001&#41;&#44; lactato deshidrogenasa &#40;501&#44;5 vs&#46; 359&#44;5 U&#47;L&#44; p &#60; 0&#44;001&#41; y prote&#237;na C reactiva &#40;130&#44;7 vs&#46; 84&#44;5 mg&#47;dL&#44; p &#60; 0&#44;001&#41;&#44; que los pacientes ingresados en &#225;reas de hospitalizaci&#243;n convencional&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Un total de 568 &#40;40&#37;&#41; de los pacientes ingresados en UCI fallecieron&#44; mientras que en las plantas de hospitalizaci&#243;n convencional hubo 2&#46;851 &#40;19&#44;2&#37;&#41; fallecimientos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Modelo predictivo</span><p id="par0105" class="elsevierStylePara elsevierViewall">Para la realizaci&#243;n del modelo predictivo dividimos la muestra de forma aleatoria en dos partes&#44; dos terceras partes correspondieron a la cohorte de derivaci&#243;n y la tercera parte restante a la cohorte de validaci&#243;n&#46; Las caracter&#237;sticas de los pacientes en ambas cohortes se describen en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">En la cohorte de derivaci&#243;n&#44; las variables con mayor asociaci&#243;n con ingreso en UCI en el an&#225;lisis univariante fueron la edad inferior a 75 a&#241;os&#44; un menor &#237;ndice de comorbilidad de Charlson&#44; la presencia de disnea&#44; taquipnea&#44; un cociente neutr&#243;filos-linfocitos superior a 5&#44; los valores de lactato deshidrogenasa superiores a 250 U&#47;L&#44; un valor de urea superior a 40 mg&#47;dL y la presencia de infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; La presencia de c&#225;ncer &#40;tumor s&#243;lido&#44; met&#225;stasis&#44; tumor hematol&#243;gico&#41; y la alteraci&#243;n del nivel de conciencia fueron factores que redujeron el riesgo de ingreso en UCI &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">En el an&#225;lisis multivariante permanecieron en el modelo la edad&#44; la presencia de disnea&#44; la puntuaci&#243;n de Charlson&#44; el cociente de neutr&#243;filos-linfocitos&#44; el valor de l&#225;ctico deshidrogenasa y los datos de la radiograf&#237;a de t&#243;rax del ingreso &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">El valor de p de la bondad de ajuste del modelo multivariante&#44; calculada mediante el estad&#237;stico de Hosmer-Lemeshow&#44; fue de 0&#44;154&#44; indicando un buen ajuste&#46; El valor R<span class="elsevierStyleSup">2</span> de Nagelkerke que muestra el poder explicativo del modelo fue de 0&#44;196&#46; La evaluaci&#243;n del rendimiento del modelo predictivo mostr&#243; un &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41; de 0&#44;780 &#40;IC 95&#37;&#58; 0&#44;763&#44; 0&#44;797&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Para una probabilidad de ingreso en UCI de 0&#44;102 &#40;punto de corte&#41;&#44; el modelo mostr&#243; una sensibilidad del 67&#44;8&#37; y una especificidad del 74&#44;6&#37; en la muestra de derivaci&#243;n&#46; En la cohorte de validaci&#243;n&#44; el AUC es 0&#44;734 y el modelo mostr&#243; una sensibilidad del 62&#44;1&#37; y una especificidad del 72&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Construcci&#243;n del sistema de puntuaci&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">Llevamos a cabo un sistema de puntuaci&#243;n basado en los coeficientes &#946; estimados en el modelo de regresi&#243;n log&#237;stica &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; La puntuaci&#243;n total individual &#40;rango de 0 a 100 puntos&#41; se obtiene sumando los puntos de cada caracter&#237;stica del paciente&#46; Este sistema de puntuaci&#243;n permite estimar la probabilidad de ingreso en UCI &#40;valor predictivo positivo&#41; con los datos obtenidos en el momento del ingreso&#44; de tal manera que&#44; para puntuaciones superiores a 75 puntos&#44; la probabilidad de ingreso en UCI es superior al 30&#37; y para puntuaciones inferiores a 50 puntos&#44; la probabilidad de ingreso en UCI es inferior al 15&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discusi&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Hemos desarrollado y validado un modelo de predicci&#243;n cl&#237;nica para identificar a los pacientes con infecci&#243;n por SARS-CoV-2 que requerir&#225;n ingreso en UCI&#46; El rendimiento del modelo de predicci&#243;n mostr&#243; un AUC de 0&#44;780 para una probabilidad de ingreso en UCI de 0&#44;102&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El riesgo de ingreso en UCI se increment&#243; de forma progresiva&#44; seg&#250;n el n&#250;mero de variables independientes que incluyeron la edad inferior a 75 a&#241;os&#44; la presencia de disnea&#44; un &#237;ndice de comorbilidad de Charlson inferior a 3&#44; un cociente neutr&#243;filos-linfocitos superior a 5&#44; los valores de lactato deshidrogenasa superiores a 250 U&#47;L y la presencia de infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; Utilizando estas variables&#44; f&#225;cilmente disponibles en el momento del ingreso hospitalario del paciente&#44; hemos construido un sistema de puntuaci&#243;n que permite asignar una probabilidad del ingreso en UCI&#46; Este estudio permite anticipar los recursos necesarios de terapia intensiva en los pacientes hospitalizados por COVID-19&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La proporci&#243;n de ingreso en UCI en la cohorte de derivaci&#243;n fue del 8&#44;9&#37; y en la cohorte de validaci&#243;n del 7&#44;7&#37;&#46; Estos valores han sido similares a los reportados por otros estudios realizados en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a>&#46; La proporci&#243;n de pacientes hospitalizados que ingresan en UCI en otros pa&#237;ses fue 16&#44;8&#37; en Italia&#44; 17&#37; en Reino Unido&#44; 11&#37; en Francia&#44; 32&#37; en EE&#46; UU&#46; y 8&#44;2&#37; en China<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9-13</span></a>&#46; Una mayor proporci&#243;n de ingreso de pacientes en UCI aplicado a nuestro modelo conllevar&#237;a un incremento del valor predictivo positivo del sistema de puntuaci&#243;n&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas demogr&#225;ficas de la poblaci&#243;n estudiada tambi&#233;n muestran diferencias por pa&#237;ses&#44; siendo la edad media alrededor de 70 a&#241;os en los estudios realizados en Europa y alrededor de los 50 a&#241;os en los estudios realizados en China&#46; Todos los estudios muestran como factores determinantes de ingreso en UCI una mayor edad y el sexo var&#243;n&#44; mayor comorbilidad y presencia de disnea&#59; entre los datos de laboratorio&#44; son signos de mal pron&#243;stico repetidos en todos los estudios un mayor cociente neutr&#243;filos-linfocitos y una mayor elevaci&#243;n de lactato deshidrogenasa<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9-13</span></a>&#46; As&#237; mismo&#44; tambi&#233;n se asocia con una mayor gravedad de la infecci&#243;n un patr&#243;n difuso&#44; bilateral con opacidades en vidrio deslustrado en la radiograf&#237;a de t&#243;rax<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El rendimiento de nuestro modelo predictivo de ingreso en UCI est&#225; en consonancia con los datos hallados por otros autores&#44; que reportan valores de AROC de 0&#44;74&#44; hasta 0&#44;88 en estudios con modelos de derivaci&#243;n y validaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">No obstante&#44; debemos ser cautelosos en la extrapolaci&#243;n de los rendimientos de los modelos cuando se aplican a otros pa&#237;ses&#44; ya que pueden mostrar diferencias&#44; en algunos casos notables<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a>&#46; Estas diferencias pueden ser por las caracter&#237;sticas demogr&#225;ficas de los sujetos estudiados&#44; el momento particular de incidencia de casos de la pandemia o las estructuras del sistema sanitario&#44; entre otras&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Entre las fortalezas&#44; el presente estudio incorpora un gran tama&#241;o muestral&#44; lo que ha permitido considerar un elevado n&#250;mero de variables en el modelo predictivo&#44; as&#237; como un an&#225;lisis robusto del modelo de derivaci&#243;n y validaci&#243;n&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Conviene interpretar este estudio como una ayuda para determinar los requerimientos de camas de unidades de cuidados intensivos en pacientes con COVID-19 grave&#46; Aunque la puntuaci&#243;n de riesgo hace referencia al deterioro cl&#237;nico relacionado con la COVID-19&#44; el beneficio del ingreso en UCI se puede ver condicionado por otros aspectos&#46; La comorbilidad del paciente&#44; la existencia de deterioro cognitivo avanzado o incapacidad para el desarrollo de las actividades b&#225;sicas de la vida diaria pueden constituir limitaciones para el ingreso en UCI en sujetos con COVID-19 grave<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Por otro lado&#44; la probabilidad de ingreso en UCI puede verse influenciada por el porcentaje de ocupaci&#243;n de sus camas en diferentes per&#237;odos de la pandemia&#46; Es posible que en per&#237;odos con buen acceso al tratamiento de soporte se decida proporcionar esta terapia a pacientes con riesgo moderado de mortalidad&#46; Por el contrario&#44; en per&#237;odos o &#225;reas con recursos m&#225;s limitados&#44; la decisi&#243;n podr&#237;a ser limitar el tratamiento intensivo de soporte a los pacientes con riesgo moderado para optimizar los recursos disponibles&#46; As&#237; mismo&#44; tampoco se ha considerado el ingreso de pacientes con COVID-19 grave en las unidades de cuidados intermedios respiratorios&#59; la disponibilidad de estas podr&#237;a alterar los resultados de validaci&#243;n de la escala&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Finalmente&#44; el desarrollo y validaci&#243;n del modelo predictivo se ha realizado en Espa&#241;a&#46; Ello podr&#237;a limitar la generalizaci&#243;n del sistema de puntuaci&#243;n a otras &#225;reas del mundo con otros sistemas sanitarios diferentes&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En resumen&#44; hemos desarrollado una regla de predicci&#243;n cl&#237;nica de ingreso en UCI para pacientes con COVID-19&#46; Las variables predictivas son f&#225;ciles de obtener en el momento del ingreso&#46; Nuestra regla de predicci&#243;n se ha validado en una amplia cohorte de pacientes y ha demostrado ser reproducible&#46; La incorporaci&#243;n de la regla en la historia m&#233;dica electr&#243;nica facilitar&#237;a su implementaci&#243;n y ayudar&#237;a a los cl&#237;nicos a adecuar correctamente el &#225;rea de ingreso de los pacientes&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Financiaci&#243;n</span><p id="par0185" class="elsevierStylePara elsevierViewall">J&#46;V&#46; Segura-Heras ha recibido ayuda competitiva del Ministerio de Econom&#237;a y Competitividad de Espa&#241;a&#44; Grant No&#46; MTM2017-83850-P&#46;</p><p id="par0590" class="elsevierStylePara elsevierViewall">La Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41; es la patrocinadora de este estudio&#46; La presente investigaci&#243;n no ha recibido ayudas espec&#237;ficas provenientes de agencias del sector p&#250;blico&#44; sector comercial o entidades sin &#225;nimo de lucro&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflictos de inter&#233;s</span><p id="par0195" class="elsevierStylePara elsevierViewall">Los autores declaran que no existe conflicto de inter&#233;s&#46;</p></span></span>"
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              "titulo" => "Caracter&#237;sticas de los pacientes ingresados en UCI"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Identificar y validar una escala de riesgo de ingreso en las unidades de cuidados intensivos &#40;UCI&#41; en pacientes hospitalizados con enfermedad por coronavirus 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos una regla de derivaci&#243;n y otra de validaci&#243;n para ingreso en UCI&#44; utilizando los datos de un registro nacional de cohortes de pacientes con infecci&#243;n confirmada por SARS-CoV-2 ingresados entre marzo y agosto del a&#241;o 2020 &#40;n &#61; 16&#46;298&#41;&#46; Analizamos variables demogr&#225;ficas&#44; cl&#237;nicas&#44; radiol&#243;gicas y de laboratorio disponibles en el ingreso hospitalario&#46; Evaluamos el rendimiento de la escala de riesgo mediante estimaci&#243;n del &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41;&#46; Utilizamos los coeficientes &#946; del modelo de regresi&#243;n para elaborar una puntuaci&#243;n &#40;0 a 100 puntos&#41; asociada con ingreso en UCI&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue de 67 a&#241;os&#59; 57&#37; varones&#46; Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes ingresaron en la UCI&#46; Las variables independientes asociadas con el ingreso en UCI fueron&#58; edad&#44; disnea&#44; &#237;ndice de comorbilidad de Charlson&#44; cociente neutr&#243;filos-linfocitos&#44; lactato deshidrogenasa e infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; El modelo mostr&#243; un AROC de 0&#44;780 &#40;IC&#58; 0&#44;763-0&#44;797&#41; en la cohorte de derivaci&#243;n y un AROC de 0&#44;734 &#40;IC&#58; 0&#44;708-0&#44;761&#41; en la cohorte de validaci&#243;n&#46; Una puntuaci&#243;n &#62; 75 se asoci&#243; con una probabilidad de ingreso en UCI superior a un 30&#37;&#44; mientras que una puntuaci&#243;n &#60; 50 redujo la probabilidad de ingreso en UCI al 15&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Una puntuaci&#243;n de predicci&#243;n simple proporcion&#243; una herramienta &#250;til para predecir la probabilidad de ingreso en la UCI con un alto grado de precisi&#243;n&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">This work aims to identify and validate a risk scale for admission to intensive care units &#40;ICU&#41; in hospitalized patients with coronavirus disease 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 &#40;n &#61; 16&#44;298&#41;&#46; We analyzed the available demographic&#44; clinical&#44; radiological&#44; and laboratory variables recorded at hospital admission&#46; We evaluated the performance of the risk score by estimating the area under the receiver operating characteristic curve &#40;AUROC&#41;&#46; Using the &#946; coefficients of the regression model&#44; we developed a score &#40;0 to 100 points&#41; associated with ICU admission&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The mean age of the patients was 67 years&#59; 57&#37; were men&#46; A total of 1&#44;420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU&#46; The variables independently associated with ICU admission were age&#44; dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-to-lymphocyte ratio&#44; lactate dehydrogenase levels&#44; and presence of diffuse infiltrates on a chest X-ray&#46; The model showed an AUROC of 0&#46;780 &#40;CI&#58; 0&#46;763-0&#46;797&#41; in the derivation cohort and an AUROC of 0&#46;734 &#40;CI&#58; 0&#46;708-0&#46;761&#41; in the validation cohort&#46; A score of greater than 75 points was associated with a more than 30&#37; probability of ICU admission while a score of less than 50 points reduced the likelihood of ICU admission to 15&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A simple prediction score was a useful tool for forecasting the probability of ICU admission with a high degree of precision&#46;</p></span>"
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            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall">Coordinador del registro SEMI-COVID-19&#58; Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SEMI-COVID-19 Miembros del Comit&#233; Cient&#237;fico&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez Huelgas&#46;</p> <p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Miembros del Grupo SEMI-COVID-19</span></p> <p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; de Bellvitge&#46; L<span class="elsevierStyleUnderline">&#8217;</span>Hospitalet de Llobregat&#44; Barcelona&#58;</span> Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio-Rivas&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; 12 de Octubre&#44; Madrid&#58;</span> Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Laura Ibarra Veganzones&#44; Luc&#237;a Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Jaime Lora-Tamayo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Rodrigo Miranda Godoy&#44; B&#225;rbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#44; Madrid&#58;</span> Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Christian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro D&#46; Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Ant&#250;nez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o M&#237;guez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Costa del Sol&#44; Marbella&#44; M&#225;laga&#58;</span> Victoria August&#237;n Bandera&#44; Javier Garc&#237;a Alegr&#237;a&#44; Nicol&#225;s Jim&#233;nez-Garc&#237;a&#44; Jairo Luque del Pino&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#44; Francisco Navarro Romero&#44; Victoria N&#250;&#241;ez Rodr&#237;guez&#44; Juli&#225;n Olalla Sierra&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Cabue&#241;es&#44; Gij&#243;n&#44; Asturias&#58;</span> Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Mar&#237;a Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Diego L&#243;pez Mart&#237;nez&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Luc&#237;a P&#233;rez Casado&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Paz&#44; Madrid&#58;</span> Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Royo Villanova&#44; Zaragoza&#58;</span> Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral Beamonte&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Geric&#243; Aseguinolaza&#44; Cristina Gallego Lezaun&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Reg&#46; U&#46; de M&#225;laga&#44; M&#225;laga&#58;</span> Mar&#237;a Mar Ayala-Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Jos&#233; Antonio Hurtado Oliver&#44; Sergio Jansen-Chaparro&#44; Mar&#237;a Dolores L&#243;pez-Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo-Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Mart&#237;n Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Iv&#225;n P&#233;rez de Pedro&#44; Araceli Pineda-Cantero&#44; Carlos Romero G&#243;mez&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Cl&#237;nico de Santiago de Compostela&#44; A Coru&#241;a&#58;</span> Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel Paez Guillan&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Dr&#46; Peset&#44; Valencia&#58;</span> Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabeth Mateo Sanch&#237;s&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Mois&#232;s Broggi&#44; Sant Joan Desp&#237;&#44; Barcelona&#58;</span> Judit Aranda Lobo&#44; Luc&#237;a Feria Casanovas&#44; Jos&#233; Loureiro Amigo&#44; Miguel Mart&#237;n Fern&#225;ndez&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicol&#225;s Rhyman&#44; Nuria V&#225;zquez Piqueras</p> <p id="par0330" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Badajoz&#44; Badajoz&#58;</span> Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; R&#237;o Hortega&#44; Valladolid&#58;</span> Irene Arroyo Jim&#233;nez&#44; Marina Cazorla Gonz&#225;lez&#44; Marta Cobos-Siles&#44; Luis Corral-Gudino&#44; Pablo Cubero-Morais&#44; Mar&#237;a Gonz&#225;lez Fern&#225;ndez&#44; Jos&#233; Pablo Miramontes Gonz&#225;lez&#44; Marina Prieto Dehesa&#44; Pablo Sanz Espinosa&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Reina Sof&#237;a&#44; C&#243;rdoba&#58;</span> Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Francisco Fuentes-Jim&#233;nez&#44; Mar&#237;a del Carmen Guerrero Mart&#237;nez&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Limia P&#233;rez&#44; Jos&#233; L&#243;pez-Miranda&#44; Laura Mart&#237;n Piedra&#44; Marta Mill&#225;n Orge&#44; Javier Pascual Vinagre&#44; Pablo P&#233;rez-Mart&#237;nez&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; &#193;ngela Rodrigo Mart&#237;nez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres-Pe&#241;a&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; S&#46; Juan de Alicante&#44; Alicante&#58;</span> Marisa Asensio Tom&#225;s&#44; David Balaz&#44; David Bonet Tur&#44; Ruth Ca&#241;izares Navarro&#44; Paloma Chazarra P&#233;rez&#44; Jes&#250;s Corbacho Redondo&#44; Eliana Damonte White&#44; Mar&#237;a Escamilla Esp&#237;nola&#44; Leticia Espinosa Del Barrio&#44; Pedro Jes&#250;s Esteve Ati&#233;nzar&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Francisco Garrido Navarro&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Ver&#243;nica Mart&#237;nez Sempere&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Rafael Pi&#241;ol Pleguezuelos&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Azucena Sempere Mira&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo&#58;</span> Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#44; Cristina Salazar Mosteiro&#44; Andrea Silva Asiain&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Pozoblanco&#44; C&#243;rdoba&#58;</span> Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Infanta Cristina&#44; Parla&#44; Madrid&#58;</span> Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Blanca Beamonte Vela&#44; Coralia Bueno Mui&#241;o&#44; Charo Bur&#243;n Fern&#225;ndez&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Pilar Cubo Romano&#44; Francesco Deodati&#44; Alejandro Estrada Santiago&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Francisco Javier Garc&#237;a S&#225;nchez&#44; Pilar Garc&#237;a de la Torre&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A&#46; Melero Bermejo&#44; Cruz Pastor Valverde&#44; Jos&#233; Luis P&#233;rez Quero&#44; Fernando Roque Rojas&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Francisco Javier Teigell Mu&#241;oz&#44; Juan Vicente de la Sota&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0400" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; G&#46; U&#46; de Elda&#44; Alicante&#58;</span> Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Santiago L&#243;pez Gil&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Nuria Ram&#237;rez Perea&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0410" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Santa Marina&#44; Bilbao&#58;</span> Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Labirua-Iturburu Ruiz&#46;</p> <p id="par0420" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; San Pedro&#44; Logro&#241;o&#44; La Rioja&#58;</span> Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Lu&#237;s Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0430" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Son Ll&#224;tzer&#44; Palma de Mallorca&#58;</span> Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0440" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; Ourense&#44; Ourense&#58;</span> Raquel Fern&#225;ndez Gonz&#225;lez&#44; Amara Gonz&#225;lez Noya&#44; Carlos Hern&#225;ndez Cer&#243;n&#44; Isabel Izuzquiza Avanzini&#44; Ana Latorre Diez&#44; Pablo L&#243;pez Mato&#44; Ana Mar&#237;a Lorenzo Vizcaya&#44; Daniel Pe&#241;a Ben&#237;tez&#44; Milagros Mar&#237;a Pe&#241;a Zemsch&#44; Luc&#237;a P&#233;rez Exp&#243;sito&#44; Marta Pose Bar&#44; Lara Rey Gonz&#225;lez&#44; Laura Rodrigo Lara&#46;</p> <p id="par0450" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Fe&#44; Valencia&#58;</span> Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0460" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Matar&#243;&#44; Barcelona&#58;</span> Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Javier Fern&#225;ndez Fern&#225;ndez&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0470" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Sagunto&#44; Valencia&#58;</span> Enrique Rodilla Sala&#44; Jos&#233; Mar&#237;a Pascual Izuel&#44; Zineb Karroud Zamrani&#46;</p> <p id="par0480" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Alto Guadalquivir&#44; And&#250;jar&#44; Ja&#233;n&#58;</span> Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0490" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Infanta Margarita&#44; Cabra&#44; C&#243;rdoba&#58;</span> Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0500" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Ferrol&#44; A Coru&#241;a&#58;</span> Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trigas Ferrin&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0510" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Marina Baixa&#44; Villajoyosa&#44; Alicante&#58;</span> Javier Ena&#44; Santiago P&#233;rez Mart&#237;n&#46;</p> <p id="par0520" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Virgen del Roc&#237;o&#44; Sevilla&#58;</span> Reyes Aparicio Santos&#44; M&#225;ximo Bernabeu-Wittel&#44; Santiago Rodr&#237;guez Su&#225;rez&#44; Mar&#237;a Nieto&#44; Luis Gim&#233;nez Miranda&#44; Rosa Mar&#237;a G&#225;mez Mancera&#44; F&#225;tima Espinosa Torre&#44; Carlos Hern&#225;ndez Quiles&#44; Concepci&#243;n Conde Guzm&#225;n&#44; Juan Delgado de la Cuesta&#44; Jara Elo&#237;sa Ternero Vega&#44; Mar&#237;a del Carmen L&#243;pez R&#237;os&#44; Pablo D&#237;az Jim&#233;nez&#44; Bosco Bar&#243;n Franco&#44; Carlos Jim&#233;nez de Juan&#44; Sonia Guti&#233;rrez Rivero&#44; Julia Lanseros Tenllado&#44; Ver&#243;nica Alfaro Lara&#44; Aurora Gonz&#225;lez Estrada&#46;</p> <p id="par0530" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; P&#250;blico de Monforte de Lemos&#44; Lugo&#58;</span> Jos&#233; L&#243;pez Castro&#44; Manuel Lorenzo L&#243;pez Reboiro&#44; Cristina Sardi&#241;a Gonz&#225;lez&#46;</p> <p id="par0540" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; General Defensa&#44; Zaragoza&#58;</span> Anyuli Gracia Guti&#233;rrez&#44; Leticia Esther Royo Trallero&#46;</p> <p id="par0550" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; A&#46; U&#46; de Salamanca&#44; Salamanca&#58;</span> Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ram&#243;n Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0560" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Palam&#243;s&#44; Girona&#58;</span> Ana Alberich Conesa&#44; Mari Cruz Almendros Rivas&#44; Miquel Hortos Alsina&#44; Jos&#233; Marchena Romero&#44; Anabel Mart&#237;n-Urda Diez-Canseco&#46;</p> <p id="par0570" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; do Salnes&#44; Vilagarc&#237;a de Arousa&#44; Pontevedra&#58;</span> Vanesa Allende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Rodr&#237;guez Ferreira&#44; Diana Sande Llovo&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0580" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; HM Montepr&#237;ncipe&#44; Boadilla del Monte&#44; Madrid&#58;</span> Jos&#233; F&#46; Varona Arche&#46;</p>"
            "etiqueta" => "Anexo&#46; 1"
            "titulo" => "Listado de miembros la red SEMI-COVID-19&#58;"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curva de caracter&#237;stica operativa del receptor para ingreso en UCI en la cohorte de derivaci&#243;n y validaci&#243;n&#46; El &#225;rea bajo la curva de caracter&#237;stica operativa del receptor fue 0&#44;781 en la cohorte de derivaci&#243;n y 0&#44;747 en la cohorte de validaci&#243;n&#46; El punto de corte que optimiza sensibilidad y especificidad fue 0&#44;087&#44; tanto en la cohorte de derivaci&#243;n como en la de validaci&#243;n&#46;</p>"
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&#44; a&#241;os&#44; media &#177; DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#44;7 &#177; 16&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;3 &#177; 12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo var&#243;n&#8212;N&#46;&#176; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;367 &#40;56&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">987 &#40;69&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dependencia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Independiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;092 &#40;82&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;377 &#40;97&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Parcialmente dependiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;461 &#40;10&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">26 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Totalmente dependiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;129 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comorbilidad&#8212;N&#46;&#176; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Fumador</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;627&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;980 &#40;70&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">876 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;567 &#40;25&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">402 &#40;29&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador activo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">717 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertensi&#243;n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;264&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;631 &#40;51&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">705 &#40;49&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;251&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;128 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">228 &#40;16&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;086&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;256&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;38&#176; C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;217 &#40;62&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;038 &#40;73&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;241&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;058 &#40;27&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">278 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Seca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;519 &#40;57&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933 &#40;65&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Con producci&#243;n de esputo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;246 &#40;15&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207 &#40;14&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anosmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;897&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;126 &#40;7&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Astenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;377 &#40;43&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;490&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anorexia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;025&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;931 &#40;20&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">262 &#40;18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;765 &#40;12&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;548&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artromialgias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;486 &#40;30&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">473 &#40;33&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ageusia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;266 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alteraci&#243;n nivel de conciencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;794 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">119 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;299 &#40;56&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;069 &#40;75&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V&#243;mitos&#47;n&#225;useas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;100 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarrea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#46;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;566 &#40;24&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">321 &#40;22&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Radiolog&#237;a&#8212;N&#46;&#176; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;789 &#40;53&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">630 &#40;44&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;567 &#40;17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrados difusos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;300 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Examen f&#237;sico&#44; media &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SpO<span class="elsevierStyleInf">2</span>&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;3 &#177; 5&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#44;0 &#177; 8&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;666&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#44;8 &#177; 21&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;8 &#177; 21&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial diast&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;9 &#177; 13&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;8 &#177; 13&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia card&#237;aca&#44; latidos&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#44;3 &#177; 17&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;8 &#177; 17&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquipnea &#40;&#60; 30 respiraciones&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;942&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4258 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">793 &#40;56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laboratorio&#44; media &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cociente neutr&#243;filos-linfocitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#177; 11&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;7 &#177; 9&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Plaquetas&#8212;x10<span class="elsevierStyleSup">9</span>&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&#46;227 &#177; 93&#46;637&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203&#46;388 &#177; 90&#46;454&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D&#237;mero D&#8212;ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;852&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;906 &#177; 10&#46;702&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;969 &#177; 11&#46;865&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5-10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactato deshidrogenasa&#44; U&#47;L</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrados difusos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">432 &#40;13&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">172 &#40;10&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">961 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">411 &#40;7&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;665&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;5&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;6&#44;88&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Taquipnea &#40;&#62; 30 respiraciones&#47;min&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409 &#40;5&#44;67&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;5&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">567 &#40;16&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Elevaci&#243;n urea &#62; 40 mg&#47;dL</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;8&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">447 &#40;10&#44;79&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183 &#40;8&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;7&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">360 &#40;7&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">159 &#40;10&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;8&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de comorbilidad de Charlson</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;649&#44; 1&#46;887&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;685&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;828&#44; 2&#46;029&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;682&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;155&#44; 2&#46;506&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;935&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;364&#44; 2&#46;822&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;313&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;659&#44; 3&#46;328&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;597&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;397&#44; 0&#44;863&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 1</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;770&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;553&#44; 1&#46;045&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 2</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Alteraci&#243;n nivel de conciencia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;511&#44; 0&#44;812&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Taquipnea&#44; &#60; 30 respiraciones&#47;min</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;327&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#46;910&#44; 3&#46;808&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Disnea</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;659&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#46;286&#44; 3&#46;104&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60; 5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5-10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;974&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactato deshidrogenasa&#44; U&#47;L</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>250-500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;591&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&#46;911 &#40;3&#46;763&#44; 6&#46;471&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Radiograf&#237;a de t&#243;rax</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;931 &#40;0&#44;728&#44; 1&#46;182&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;565&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;412&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;509 &#40;1&#46;279&#44; 1&#46;781&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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Vol. 222. Núm. 1.
Páginas 1-12 (enero 2021)
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Vol. 222. Núm. 1.
Páginas 1-12 (enero 2021)
ORIGINAL
Derivación y validación de una puntuación de riesgo de ingreso en la Unidad de Cuidados Intensivos para pacientes con COVID-19
Derivation and validation of a risk score for admission to the Intensive Care Unit in patients with COVID-19
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J. Enaa,
Autor para correspondencia
ena_jav@gva.es

Autor para correspondencia.
, J.V. Segura-Herasb, E.M. Fonseca-Aizpuruc, M.L. López-Reboirod, A. Gracia-Gutiérreze, J.A. Martín-Oterinof, A. Martín-Urda Diez-Cansecog, C. Pérez-Garcíah, J.M. Ramos-Rincóni, R. Gómez-Huelgasj, en nombre del grupo de trabajo SEMI-COVID-19
a Servicio de Medicina Interna. HospitalMarina Baixa, Alicante, España
b Instituto Universitario de Investigación «Centro de Investigación Operativa» (CIO). Universidad Miguel Hernández, Alicante, España
c Servicio de Medicina Interna. Hospital de Cabueñes, Gijón, Asturias, España
d Servicio de Medicina Interna. Hospital Público de Monforte de Lemos, Lugo, España
e Servicio de Medicina Interna. Hospital General Defensa, Zaragoza, España
f Servicio de Medicina Interna. Complejo Asistencial Universitario de Salamanca, Salamanca, España
g Servicio de Medicina Interna. Hospital de Palamós, Girona, España
h Servicio de Medicina Interna. Hospital do Salnes, Vilagarcía de Arousa, Pontevedra, España
i Departamento de Medicina Clínica. Universidad Miguel Hernández de Elche, Alicante, España
j Departamento de Medicina Interna. Hospital Regional de Málaga. Instituto de Investigación Biomédica (IBIMA). Universidad de Málaga, Málaga, España
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Tablas (4)
Tabla 1. Características de los pacientes del estudio
Tabla 2. Características de los pacientes que ingresaron en UCI en las cohortes de derivación y validación
Tabla 3. Factores independientes de ingreso en UCI en pacientes hospitalizados con COVID-19 para la cohorte de derivación. Análisis univariante
Tabla 4. Factores independientes predictivos de ingreso en UCI
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Resumen
Fundamento

Identificar y validar una escala de riesgo de ingreso en las unidades de cuidados intensivos (UCI) en pacientes hospitalizados con enfermedad por coronavirus 2019 (COVID-19).

Métodos

Realizamos una regla de derivación y otra de validación para ingreso en UCI, utilizando los datos de un registro nacional de cohortes de pacientes con infección confirmada por SARS-CoV-2 ingresados entre marzo y agosto del año 2020 (n = 16.298). Analizamos variables demográficas, clínicas, radiológicas y de laboratorio disponibles en el ingreso hospitalario. Evaluamos el rendimiento de la escala de riesgo mediante estimación del área bajo la curva de característica operativa del receptor (AROC). Utilizamos los coeficientes β del modelo de regresión para elaborar una puntuación (0 a 100 puntos) asociada con ingreso en UCI.

Resultados

La edad media de los pacientes fue de 67 años; 57% varones. Un total de 1.420 (8,7%) pacientes ingresaron en la UCI. Las variables independientes asociadas con el ingreso en UCI fueron: edad, disnea, índice de comorbilidad de Charlson, cociente neutrófilos-linfocitos, lactato deshidrogenasa e infiltrados difusos en la radiografía de tórax. El modelo mostró un AROC de 0,780 (IC: 0,763-0,797) en la cohorte de derivación y un AROC de 0,734 (IC: 0,708-0,761) en la cohorte de validación. Una puntuación > 75 se asoció con una probabilidad de ingreso en UCI superior a un 30%, mientras que una puntuación < 50 redujo la probabilidad de ingreso en UCI al 15%.

Conclusión

Una puntuación de predicción simple proporcionó una herramienta útil para predecir la probabilidad de ingreso en la UCI con un alto grado de precisión.

Palabras clave:
Epidemiologia clínica
Urgencias
Unidad de Cuidados Intensivos
Infección respiratoria
Infección viral
Modelo lineal generalizado
Abstract
Background

This work aims to identify and validate a risk scale for admission to intensive care units (ICU) in hospitalized patients with coronavirus disease 2019 (COVID-19).

Methods

We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 (n = 16,298). We analyzed the available demographic, clinical, radiological, and laboratory variables recorded at hospital admission. We evaluated the performance of the risk score by estimating the area under the receiver operating characteristic curve (AUROC). Using the β coefficients of the regression model, we developed a score (0 to 100 points) associated with ICU admission.

Results

The mean age of the patients was 67 years; 57% were men. A total of 1,420 (8.7%) patients were admitted to the ICU. The variables independently associated with ICU admission were age, dyspnea, Charlson Comorbidity Index score, neutrophil-to-lymphocyte ratio, lactate dehydrogenase levels, and presence of diffuse infiltrates on a chest X-ray. The model showed an AUROC of 0.780 (CI: 0.763-0.797) in the derivation cohort and an AUROC of 0.734 (CI: 0.708-0.761) in the validation cohort. A score of greater than 75 points was associated with a more than 30% probability of ICU admission while a score of less than 50 points reduced the likelihood of ICU admission to 15%.

Conclusion

A simple prediction score was a useful tool for forecasting the probability of ICU admission with a high degree of precision.

Keywords:
Clinical epidemiology
Critical care
Intensive care unit
Respiratory infection
Viral infection
General linear model

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