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Original article
Available online 7 May 2023
Lactate/albumin ratio prognostic value for mortality in patients older than 65 years with complicated urinary tract infection
Valor pronóstico del cociente lactato/albúmina para la mortalidad en pacientes mayores de 65 años con infección urinaria complicada
Manuel Madrazoa, Ian López-Cruza, Laura Pilesa, Juan Alberolaa,
Corresponding author

Corresponding author.
, Jaume Micó Gandiaa, Jose M. Eirosb, Arturo Arteroa
a Doctor Peset University Hospital, Valencia, Spain
b Río Hortega University Hospital, Universidad de Valladolid, Spain
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Received 14 December 2022. Accepted 12 April 2023
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Figures (1)
Tables (2)
Table 1. Epidemiological and clinical characteristics and outcomes of complicated community-acquired urinary tract infection in patients according to lactate-albumin ratio.
Table 2. Performance of LAR, qSOFA and SOFA for 30-day mortality in patients with complicated community-acquired urinary tract infection.
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Lactate to albumin ratio (LAR) is an emerging sepsis biomarker that has been tested for mortality in patients with sepsis of different focus. Our goal is to evaluate the prognostic value of LAR in patients admitted to the hospital due to complicated urinary tract infections.


Prospective observational study of patients older than 65 years diagnosed with UTI. Area under the ROC curve, sensibility, and specificity to predict 30-day mortality were calculated for LAR, qSOFA and SOFA.


341 UTI cases were analyzed. 30-day mortality (20.2% vs. 6.7%, p < 0.001) and longer hospital stay (5 [4–8] vs. 4 [3–7], p 0.018) were associated with LAR ≥ 0.708. LAR has no statistically significant differences compared to qSOFA and SOFA for predicting 30-day mortality (AUROC 0.737 vs. 0.832 and 0.777 respectively, p 0.119 and p 0.496). The sensitivity of LAR was similar to the sensitivity of qSOFA and SOFA (60.8% vs. 84.4% and 82.2, respectively, p 0.746 and 0.837). However, its specificity was lower than the specificity of qSOFA (60.8% vs. 75%, p 0.003), but similar to the specificity of SOFA (60.8% vs. 57.8%, p 0.787).


LAR has no significant differences with other well-stablished scores in sepsis, such as qSOFA and SOFA, to predict 30-day mortality in patients with complicated UTI.

Prognostic scores

El cociente lactato/albúmina (LAR) es un biomarcador emergente de sepsis que se ha evaluado para determinar la mortalidad en pacientes con sepsis de distinto foco. Nuestro objetivo es evaluar el valor pronóstico de LAR en pacientes ingresados en el hospital por infecciones urinarias complicadas.


Estudio observacional prospectivo de pacientes mayores de 65 años diagnosticados de ITU. Se calcularon y compararon el área bajo la curva ROC, la sensibilidad y la especificidad para predecir la mortalidad a 30 días para LAR, qSOFA y SOFA.


Se analizaron 341 casos de ITU. La mortalidad a 30 días (20,2% frente a 6,7%, p < 0,001) y la mayor estancia hospitalaria (5 [4–8] frente a 4 [3–7], p 0,018) se asociaron con LAR ≥ 0,708. LAR no presenta diferencias estadísticamente significativas en comparación con qSOFA y SOFA para predecir la mortalidad a 30 días (AUROC 0,737 frente a 0,832 y 0,777 respectivamente, p 0,119 y p 0,496). La sensibilidad de LAR fue similar a la de qSOFA y SOFA (60,8% frente a 84,4% y 82,2, respectivamente, p 0,746 y 0,837). Sin embargo, su especificidad fue inferior a la del qSOFA (60,8% frente a 75%, p 0,003), pero similar a la del SOFA (60,8% frente a 57,8%, p 0,787).


LAR no presenta diferencias significativas con otras puntuaciones bien establecidas en sepsis, como qSOFA y SOFA, para predecir la mortalidad a 30 días en pacientes con ITU complicada.

Palabras clave:
Puntuaciones pronósticas


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