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"apellidos" => "Manzano" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0014256522000030" "doi" => "10.1016/j.rce.2021.12.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256522000030?idApp=WRCEE" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887422000285?idApp=WRCEE" "url" => "/22548874/0000022200000006/v1_202206040654/S2254887422000285/v1_202206040654/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Is it an illusion to correct vitamin D deficiency in the healthy Spanish population?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "370" "paginaFinal" => "371" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Azriel" "autores" => array:1 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Azriel" "email" => array:1 [ 0 => "sharona.azriel@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Endocrinología y Nutrición, Hospital Universitario Infanta Sofía, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Es una quimera corregir la deficiencia de vitamina D en la población sana española?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years, we have witnessed an exponential growth in interest in vitamin D. This is not just for its role in mineral metabolism and bone homeostasis through its renal and intestinal actions, but also because it is a hormone with multiple pleiotropic effects and extraskeletal systemic functions in the cardiovascular system, in innate or acquired immunomodulation, and in the regulation of cellular growth, among others.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the last two years, its relationship to SARS-CoV-2 infection has also influenced this interest. However, what is most significant is the public health impact of a high prevalence of hypovitaminosis D described in the general population.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> Despite the consensus that measurement of 25(OH)D levels reflects the body’s vitamin D status, the best biomarker that reflects sufficient levels of this vitamin and its function has not been established and nor has the most precise technique for its proper quantification. In addition, the definition of optimal 25(OH)D concentrations remains controversial.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In this regard, the National Academy of Medicine in the United States of America proposes values above 20 ng/mL for the healthy general population<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> whereas the International Osteoporosis Foundation establishes values above 30 ng/mL for patients.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Regarding these definitions, it has been described that 88% of the population has 25(OH)D concentrations below 30 ng/mL and 37% have values below 20 ng/mL.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In Spain, the situation is very similar, reaching alarming figures of 80%–100% in individuals older than 65 years when using the threshold value of less than 20 ng/mL. In the population younger than this age, the deficit has been found in 40%.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">However, it should be noted that the studies used to determine the cut-off points of 20 and 30 ng/mL measured levels of 25(OH)D via a competitive protein-binding assay and/or a radioimmunoassay, whose precision and exactness were variable at that time. This represents an important limitation and an assay-dependent definition.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Due to their hydrophobic nature, vitamin D metabolites, especially 25(OH)D, bind to carrier proteins. The principal protein is the vitamin D-binding protein, which binds to approximately 90% of its circulating concentration. Due to its high concentration in the blood but lower affinity, albumin binds the remaining 10%. A small fraction, less than 0.1% of the total, circulates freely and is unbound.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The quantification of this free fraction is not a common clinical practice, although its measurement instead of total 25(OH)D has been suggested, especially in circumstances in which the levels and/or affinities of binding proteins are physiologically altered (pregnancy), pathologically altered (liver disease, nephrotic syndrome, acute illnesses), or altered due to genetic mutations in the vitamin D carrier protein.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> These possible interferences in the measurement of the total concentration as well as racial differences may influence the overestimation of hypovitaminosis D in the population. In addition, the unbound metabolite is that which passes through cellular membranes and exercises biological actions.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Although it is common to determine the free fraction of other circulating hormones, the measurement of free 25(OH)D is a recent phenomenon due to a lack of a direct measurement method until now. With a direct immunoassay now available, the number of studies as well as their possible clinical applications are growing.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The study by Fernández-Vicente et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> evaluated vitamin D status through the analysis of total 25(OH)D and free 25(OH)D in a series of 206 healthy adults from Burgos and Valencia during two periods (March-April, period of minimum vitamin D synthesis, and October-November, months of maximum synthesis following summer). The mean concentrations of total 25(OH)D were 24.77 ng/mL in summer and 20 ng/mL in winter; they were lower in Burgos. Twenty-five percent of the cohort had sufficient vitamin D, confirming the high prevalence of hypovitaminosis D described in our country.</p><p id="par0045" class="elsevierStylePara elsevierViewall">These suboptimal results in young people, even in those from a region with a sunny climate year-round, point to the fact that the thresholds for defining vitamin D insufficiency and deficiency in the healthy population are not ideal, as the authors speculate. The recommendations of clinical practice guidelines should be reconsidered in the future as additional data become available on the standardization of 25(OH)D and data from other ongoing randomized trials.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The novelty of this work is the simultaneous quantification of free 25(OH)D and the influence of seasonality, climate, and latitude on levels of vitamin D, reporting lower free 25(OH)D concentrations in the winter in Burgos.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Additional studies that support the free fraction as the most reliable biomarker for real vitamin D status and the standardization of normal values are still necessary before widespread implementation.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Azriel S, ¿Es una quimera la deficiencia de vitamina D en la población sana española? Revista Clínica Española. 2022;222:370–371.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D deficiency 2.0: an update on the current status worldwide" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Amrein" 1 => "M. Scherkl" 2 => "M. Hoffmann" 3 => "S. Neuwersch-Sommeregger" 4 => "M. Köstenberger" 5 => "A. Tmava Berisha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41430-020-0558-y" "Revista" => array:7 [ "tituloSerie" => "Eur J Clin Nutr" "fecha" => "2020" "volumen" => "74" "numero" => "11" "paginaInicial" => "1498" "paginaFinal" => "1513" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31959942" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asystematic review of vitamin D status in populations worldwide" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Hilger" 1 => "A. Friedel" 2 => "R. Herr" 3 => "T. Rausch" 4 => "F. Roos" 5 => "D.A. Wahl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S0007114513001840" "Revista" => array:6 [ "tituloSerie" => "Br J Nutr." "fecha" => "2014" "volumen" => "111" "paginaInicial" => "23" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23930771" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recomendaciones de vitamina D para la población general" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "M. Varsavsky" 1 => "P. Rozas Moreno" 2 => "A. Becerra Fernández" 3 => "I. Luque Fernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Endocrinol Diabetes Nutr." "fecha" => "2017" "volumen" => "64" "numero" => "S1" "paginaInicial" => "7" "paginaFinal" => "14" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. Ross" 1 => "J.E. Manson" 2 => "S.A. Abrams" 3 => "J.F. Aloia" 4 => "P.M. Brannon" 5 => "S.K. Clinton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2011" "volumen" => "96" "paginaInicial" => "53" "paginaFinal" => "58" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IOF position statement: vitamin D recommendations for older adults" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Dawson-Hughes" 1 => "A. Mithal" 2 => "J.P. Bonjour" 3 => "S. Boonen" 4 => "P. Burckhardt" 5 => "G.E. Fuleihan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00198-010-1285-3" "Revista" => array:6 [ "tituloSerie" => "Osteoporos Int" "fecha" => "2010" "volumen" => "21" "paginaInicial" => "1151" "paginaFinal" => "1154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20422154" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D deficiency in Spain: a population-based cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. González-Molero" 1 => "S. Morcillo" 2 => "S. Valdes" 3 => "V. Pérez-Valero" 4 => "P. Botas" 5 => "E. Delgado" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ejcn.2010.265" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Nutr." "fecha" => "2011" "volumen" => "65" "paginaInicial" => "321" "paginaFinal" => "328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21179052" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deficiencia de vitamina D en España. ¿Realidad o mito?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Navarro Valverde" 1 => "J.M. Quesada Gómez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Osteoporos Metab Miner" "fecha" => "2014" "volumen" => "6" "numero" => "Supl 1" "paginaInicial" => "S5" "paginaFinal" => "10" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamina D libre: una determinación en aumento" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Quesada Gómez" 1 => "N. Heureux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Osteoporos Metab Miner." "fecha" => "2019" "volumen" => "11" "numero" => "1" "paginaInicial" => "30" "paginaFinal" => "34" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vitamin D testing-where are we and what is on the horizon?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N. Heureux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Adv Clin Chem." "fecha" => "2017" "volumen" => "78" "paginaInicial" => "59" "paginaFinal" => "101" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variables influyentes en los niveles de 25(OH)D total y libre en población sana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Fernández-Vicente" 1 => "A. 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Editorial
Is it an illusion to correct vitamin D deficiency in the healthy Spanish population?
¿Es una quimera corregir la deficiencia de vitamina D en la población sana española?
S. Azriel
Corresponding author
Servicio de Endocrinología y Nutrición, Hospital Universitario Infanta Sofía, Madrid, Spain