Publish in this journal
Journal Information
Vol. 217. Issue 7.
Pages 387-393 (October 2017)
Share
Share
Download PDF
More article options
ePub
Visits
...
Vol. 217. Issue 7.
Pages 387-393 (October 2017)
Original article
Incidence of cancer in outpatients with chronic obstructive pulmonary disease
Incidencia de cáncer en pacientes ambulatorios con enfermedad pulmonar obstructiva crónica
Visits
...
J.M. Figueira Gonçalvesa,
Corresponding author
juanmarcofigueira@gmail.com

Corresponding author.
, R. Dorta Sáncheza, L.I. Pérez Méndezb,c, L. Pérez Negrína, I. García-Talaveraa, A. Pérez Rodrígueza, D. Díaz Péreza, P. Viña Manriquea, C. Guzmán Sáenza
a Pneumology and Thoracic Surgery Service, University Hospital Nuestra Sen¿ora de Candelaria, Santa Cruz de Tenerife, Spain
b Department of Clinical Epidemiology and Biostatistics, Research Unit, University Hospital Nuestra Sen¿ora de Candelaria and Primary Care Management, Santa Cruz de Tenerife, Spain
c CIBER de Enfermedades Respiratorias, Instituto de Salud CArlos III, Madrid, Spain
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Tables (2)
Table 1. Clinical and demographic characteristics of the patients with chronic obstructive pulmonary disease.
Table 2. Factors that increase the risk of cancer in patients with chronic obstructive pulmonary disease.
Show moreShow less
Abstract
Introduction

The relationship between chronic obstructive pulmonary disease (COPD) and the overall incidence of cancer is poorly understood. The aim of this study was to analyze the incidence of cancer (pulmonary and extrapulmonary sites) in patients with COPD followed up in a specialized outpatient unit, and to assess the relationship to the degree of airflow obstruction.

Methodology

A prospective observational study was conducted with a cohort of 308 patients with COPD followed up at pulmonology outpatient clinics from January 2012 to December 2015. The neoplasms diagnosed during this period were divided into a pulmonary and an extrapulmonary group.

Results

The overall yearly incidence rates of cancer, lung cancer and extrapulmonary cancer cases per 1000 patients with COPD were 10.3, 3.4 and 7.3 cases, respectively. The most frequent cancer types were lung cancer (31%), genitourinary tract cancer (29%) and gastrointestinal cancer (21%). Mild to moderate stages (grade I–II of the 2009 GOLD classification) and the increase in the pack-year index (PYI) were related to an increase in the onset of neoplasia, with an odds ratio (OR) of 2.16 (95% confidence interval [95% CI]: 1.087–4.309; p=.026) and 1.01 (95% CI: 1.002–1.031; p=.023), respectively.

Conclusion

The incidence of extrapulmonary cancer in patients with COPD was twice that of lung cancer; stages I–II of the 2009 GOLD classification and the PYI were significantly related to the onset of neoplasia.

Keywords:
Chronic obstructive pulmonary disease (COPD)
Incidence
Cancer
Resumen
Introducción

La relación entre la enfermedad pulmonar obstructiva crónica (EPOC) y la incidencia global de cáncer es poco conocida. El objetivo del estudio fue analizar la incidencia de cáncer (tanto de localización pulmonar como extrapulmonar) en pacientes con EPOC en seguimiento en una consulta ambulatoria especializada, así como valorar su relación con el grado de obstrucción al flujo aéreo.

Metodología

Estudio observacional prospectivo de una cohorte de 308 pacientes con EPOC en seguimiento en consultas ambulatorias de neumología durante el periodo comprendido entre enero de 2012 y diciembre de 2015. Las neoplasias diagnosticadas en este periodo se dividieron en pulmonares y extrapulmonares.

Resultados

Las tasas de incidencia global de cáncer, de cáncer de pulmón (CP) y de cáncer extrapulmonar fueron de 10,3, 3,4 y 7,3 casos por 1.000 pacientes EPOC-año, respectivamente. Los tumores más frecuentes fueron el CP (31%), los del tracto genitourinario (29%) y digestivo (21%). Los estadios leve-moderado (gradosI-II de la GOLD 2009) y el incremento del índice paquetes-año (IPA) se relacionaron con un aumento en la aparición de neoplasias con un odds ratio (OR) de 2,16 (intervalo de confianza al 95% [IC95%]: 1,087-4,309; p=0,026) y 1,01 (IC95%:1,002-1,031; p=0,023), respectivamente.

Conclusión

La incidencia de cáncer de localización extrapulmonar en pacientes con EPOC duplica a la de CP. Los estadiosI-II de la GOLD 2009 y el IPA se relacionan de forma significativa con la aparición de neoplasias.

Palabras clave:
Enfermedad pulmonar obstructiva crónica (EPOC)
Incidencia
Cáncer

Article

These are the options to access the full texts of the publication Revista Clínica Española (English Edition)
Member
Si es usted socio de FESEMI siga los siguientes pasos:

Diríjase desde aquí a la web de la >>>FESEMI<<< e inicie sesión mediante el formulario que se encuentra en la barra superior, pulsando sobre el candado.

Una vez autentificado, en la misma web de FESEMI, en el menú superior, elija la opción deseada.

>>>FESEMI<<<

Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Clínica Española (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Idiomas
Revista Clínica Española (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?