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Brief Original
DOI: 10.1016/j.rceng.2020.10.006
Available online 14 May 2021
CURB-65 as a predictor of 30-day mortality in patients hospitalized with COVID-19 in Ecuador: COVID-EC study
CURB-65 como predictor de mortalidad a 30 días enpacientes hospitalizados con COVID-19 en Ecuador: estudio COVID-EC
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J. Carriela,f,
Corresponding author
jorge.carriel84@gmail.com

Corresponding author.
, R. Muñoz-Jaramillob, O. Bolaños-Ladinezc, F. Heredia-Villacresesc, J. Menéndez-Sanchónd, J. Martin-Delgadoe, COVID EC Researh Group 1
a Servicio de Medicina Interna, Hospital Universitario La Zarzuela, Madrid, Spain
b Servicio de Gastroenterología, Hospital IESS Ceibos, Guayaquil, Ecuador
c Servicio de Medicina Intensiva, Servicio de Cardiología, Hospital Clínica San Francisco, Guayaquil, Ecuador
d Servicio de Medicina Interna, Hospital General Guasmo Sur, Guayaquil, Ecuador
e Grupo de Investigación Atenea, Fundación para el Fomento de la Investigación Sanitaria y Biomédica, San Juan de Alicante, Alicante, Spain
f Instituto de Investigación e Innovación en Salud integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador
Received 14 July 2020. Accepted 14 October 2020
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Table 1. Univariate and multivariate analysis of independent factors associated with morality.
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Abstract
Objective

This article aims to assess the utility of CURB-65 in predicting 30-day mortality in adult patients hospitalized with COVID-19.

Methods

This work is a cohort study conducted between March 1 and April 30, 2020 in Ecuador.

Results

A total of 247 patients were included (mean age 60 ± 14 years, 70% men, overall mortality 41.3%). Patients with CURB-65 ≥ 2 had a higher mortality rate (57 vs. 17%, p < .001) that was associated with other markers of risk: advanced age, hypertension, overweight/obesity, kidney failure, hypoxemia, requirement for mechanical ventilation, or onset of respiratory distress.

Conclusions

CURB-65  ≥ 2 was associated with higher 30-day mortality on the univariate (Kaplan–Meier estimator) and multivariate (Cox regression) analysis.

Keywords:
Pneumonia
Coronavirus
SARS-CoV-2
COVID-19
CURB-65
Mortality
Resumen
Objetivo

Valorar la utilidad del CURB-65 para predecir la mortalidad a 30 días en pacientes adultos hospitalizados con COVID-19.

Métodos

Cohorte realizada entre el 1 de marzo y el 30 de abril de 2020 en Ecuador.

Resultados

Se incluyeron 247 pacientes (edad media 60 ± 14 años, 70% varones, mortalidad global 41,3%). Los pacientes con CURB-65 ≥ 2 presentaron mayor mortalidad (57 vs. 17%, p < 0,001), en asociación con otros marcadores de riesgo: edad avanzada, hipertensión arterial, sobrepeso/obesidad, fracaso renal, hipoxemia, requerimiento de ventilación mecánica o desarrollo de distrés respiratorio.

Conclusiones

En el análisis univariado (Kaplan–Meier) y multivariado (regresión de Cox) el CURB-65 ≥ 2 se relacionó con una mayor mortalidad a 30 días.

Palabras clave:
Neumonía
Coronavirus
SARS-CoV-2
COVID-19
CURB-65
Mortalidad

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