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Robledo-Sánchez, C. Delgado Mucientes, P. Manchado López" "autores" => array:3 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Robledo-Sánchez" "email" => array:1 [ 0 => "robledosanchezaitana@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Delgado Mucientes" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Manchado López" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma agresivo tipo animal en varón de 79 años" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 949 "Ancho" => 1300 "Tamanyo" => 148096 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present the case of a 79-year-old man with a history of colon adenocarcinoma. The patient consulted for a lesion on the back that appeared a year ago, which had grown and bled. The physical examination revealed a blackish swelling measuring 2.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3.5<span class="elsevierStyleHsp" style=""></span>cm on the back (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a), as well as numerous surrounding bluish satellite lesions and skin infiltration (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b). Adjacent to the main swelling, we palpated a subcutaneous nodule with a normal skin color. There was no clinical evidence of axillary adenopathies. A skin biopsy of the nodule revealed intraepidermal melanocytic proliferation, with irregular and convergent thecal groups (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>c). The invasive component consisted of cell masses that dissected the dermal collagen throughout its thickness. The melanocytes had epithelioid and fusocellular morphology, with a high degree of cytoplasmic pigmentation. The maximum thickness (Breslow index) was 5<span class="elsevierStyleHsp" style=""></span>mm. We also observed extensive mitosis and ulceration but no signs of vascular invasion or regression. The extension study using brain and chest-abdomen-pelvis computed tomography showed adenopathies in the left axilla, with irregular contours due to capsular infiltration and a subcutaneous node of pathological appearance, with a hypodense area of central necrosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>d). Extirpation was performed with extensive margins of the main lesion and satellitosis. Selective sentinel node biopsy was not performed because we did not consider it indicated. After 6 months, the patient showed rapid disease progression and died due to hepatic and brain metastases.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-02-13" "fechaAceptado" => "2018-03-16" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Robledo-Sánchez A, Delgado Mucientes C, Manchado López P. Melanoma agresivo tipo animal en varón de 79 años. Rev Clin Esp. 2018;218:445–446.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 949 "Ancho" => 1300 "Tamanyo" => 148096 ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack373877" "titulo" => "Acknowledgements" "texto" => "<p id="par0010" class="elsevierStylePara elsevierViewall">We would like to thank Gerardo Martínez García for his collaboration in performing the histopathology images.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/22548874/0000021800000008/v1_201810300615/S2254887418300857/v1_201810300615/en/main.assets" "Apartado" => array:4 [ "identificador" => "71811" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Medicine in images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22548874/0000021800000008/v1_201810300615/S2254887418300857/v1_201810300615/en/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2254887418300857?idApp=WRCEE" ]
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Medicine in Images
Aggressive animal-type melanoma in a 79-year-old man
Melanoma agresivo tipo animal en varón de 79 años
A. Robledo-Sánchez
, C. Delgado Mucientes, P. Manchado López
Corresponding author
Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain