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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La telangiectasia hemorr&#225;gica hereditaria &#40;HHT&#44; por sus siglas en ingl&#233;s&#44; <span class="elsevierStyleItalic">hereditary hemorrhagic telangiectasia</span>&#41;&#44; o enfermedad de Rendu-Osler-Weber&#44; es una enfermedad sist&#233;mica con herencia autos&#243;mica dominante&#46; Su incidencia mundial es de 1&#47;5&#46;000-8&#46;000 y est&#225; catalogada dentro de las enfermedades minoritarias &#40;EEMM&#41;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">1-4</span></a>&#46; Se han descrito m&#225;s de 800 mutaciones en m&#225;s de 5 genes&#44; pero la gran mayor&#237;a de ellas se localizan en los genes que codifican para la endoglina <span class="elsevierStyleItalic">&#40;ENG&#41;</span> o la activina <span class="elsevierStyleItalic">&#40;ACVRL1&#41;</span><a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; Ambas prote&#237;nas forman parte de la familia del factor transformante de crecimiento &#946;&#44; que interviene en las v&#237;as de se&#241;alizaci&#243;n vascular&#44; influyendo en la regulaci&#243;n de la angiog&#233;nesis<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">6</span></a>&#46; As&#237;&#44; alteraciones en estas prote&#237;nas dan lugar a un crecimiento vascular an&#243;malo y excesivo&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A pesar de ser una enfermedad gen&#233;tica&#44; su diagn&#243;stico es cl&#237;nico y se realiza de acuerdo con los criterios de Cura&#231;ao<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La telangiectasia es la lesi&#243;n caracter&#237;stica de la HHT y consiste en la sustituci&#243;n del lecho capilar normal por una conexi&#243;n aberrante directa entre arteriola y v&#233;nula<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">8</span></a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Las telangiectasias pueden localizarse en piel y mucosas&#44; especialmente en la mucosa nasal&#44; causando epistaxis recurrentes&#44; que es el principal s&#237;ntoma en esta enfermedad&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Al ser una enfermedad sist&#233;mica&#44; puede existir afectaci&#243;n vascular en cualquier &#243;rgano&#44; aunque mayoritariamente afecta a pulmones e h&#237;gado&#46; Esta afectaci&#243;n se sit&#250;a tanto a nivel de la microvasculatura &#40;en forma de telangiectasias&#41; como en forma de f&#237;stulas arterio-venosas &#40;AV&#41; o aneurismas en vasos de mayor tama&#241;o<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">5&#44;7&#44;9</span></a>&#46; Se recomienda realizar un cribado de estas posibles malformaciones vasculares para su detecci&#243;n precoz y manejo de acuerdo con la evidencia cient&#237;fica&#44; as&#237; como un seguimiento adecuado de los pacientes<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">10&#44;11</span></a>&#46; Aunque no existe un tratamiento curativo&#44; existen f&#225;rmacos con resultados positivos en diferentes aspectos de la enfermedad<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">12-14</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El car&#225;cter sist&#233;mico de la HHT&#44; su baja prevalencia y gran variabilidad cl&#237;nica hacen que el conocimiento de la enfermedad sea complejo&#44; especialmente en situaciones infrecuentes&#46; Este aspecto es com&#250;n en el terreno de las EEMM&#44; donde es dif&#237;cil acumular experiencia suficiente sobre el curso natural de una enfermedad y el pron&#243;stico de estos pacientes&#46; La elaboraci&#243;n de registros contribuye a superar estas dificultades&#44; representando una prioridad en el manejo de las EEMM<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; El uso de registros de calidad permite adem&#225;s consensuar medidas diagn&#243;stico-terap&#233;uticas&#44; reflejar el manejo de los pacientes en la pr&#225;ctica cl&#237;nica habitual&#44; ofrecer evidencia para la elaboraci&#243;n de gu&#237;as cl&#237;nicas y generar hip&#243;tesis para la elaboraci&#243;n de ensayos cl&#237;nicos<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">16-19</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Presentamos el desarrollo del primer y &#250;nico registro de la HHT en Espa&#241;a&#44; el Registro Informatizado de la Telangiectasia Hemorr&#225;gica Hereditaria &#40;Registro RiHHTa&#41;&#44; las caracter&#237;sticas cl&#237;nicas y los aspectos diagn&#243;sticos relevantes de los primeros pacientes introducidos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todo</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dise&#241;o del Registro RiHHTa</span><p id="par0035" class="elsevierStylePara elsevierViewall">El RiHHTa es un registro multic&#233;ntrico&#44; prospectivo y observacional&#44; desarrollado dentro del Grupo de Trabajo en Enfermedades Minoritarias &#40;GTEM&#41; de la Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;&#46; Su dise&#241;o es <span class="elsevierStyleItalic">on-line</span>&#44; desde la direcci&#243;n <a id="intr0005" class="elsevierStyleInterRef" href="https://rihhta.healthincode.com/">https&#58;&#47;&#47;RiHHTa&#46;healthincode&#46;com</a>&#44; con acceso de forma individualizada para cada investigador&#44; en idiomas espa&#241;ol e ingl&#233;s &#40;por la posibilidad de internacionalizarse en un futuro&#41;&#46; Los principales objetivos de dicho registro son&#58; mejorar el manejo de los pacientes con HHT&#44; contribuir a la difusi&#243;n y el conocimiento de la enfermedad y consensuar medidas diagn&#243;stico-terap&#233;uticas entre sus miembros &#40;como forma de trabajo en red&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Para su creaci&#243;n&#44; se ha dispuesto de la colaboraci&#243;n no remunerada de la empresa de estudios gen&#233;ticos Health in Code &#40;A Coru&#241;a&#41;&#44; con amplia experiencia en registros de miocardiopat&#237;as<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Adem&#225;s&#44; permite la creaci&#243;n de informes personalizados para cada paciente&#44; de utilidad en la labor asistencial de los investigadores participantes&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pacientes y variables</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los pacientes incluidos son aquellos con diagn&#243;stico cl&#237;nico de acuerdo con los criterios de Cura&#231;ao<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a> o bien con diagn&#243;stico gen&#233;tico&#44; que hayan firmado el consentimiento informado para la introducci&#243;n de sus datos en el Registro RiHHTa&#46; Est&#225; organizado por familias y las variables se dividen en 5 grandes apartados&#58; datos demogr&#225;ficos&#44; cl&#237;nicos&#44; exploraciones complementarias&#44; tratamiento y evoluci&#243;n&#46; La gravedad de las epistaxis se cuantific&#243; mediante el Epistaxis Severity Score<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">22</span></a>&#46; La valoraci&#243;n del paso de contraste mediante ecocardiograf&#237;a para detectar f&#237;stulas AV pulmonares se realiz&#243; de acuerdo a la clasificaci&#243;n de Barzilai et al&#46; en 4 grados<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">23</span></a>&#46; Para el estudio de afectaci&#243;n del tracto digestivo&#44; se siguieron las recomendaciones de practicarlo en aquellos pacientes con anemia desproporcionada al grado de epistaxis<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">La introducci&#243;n de los datos personales de los pacientes incluidos en el registro&#44; su tratamiento y comunicaci&#243;n se ajustaron a lo dispuesto en la Ley de Protecci&#243;n de Datos de Car&#225;cter Personal&#46; Para salvaguardar la identidad de los pacientes incluidos&#44; el Registro RiHHTa genera un identificador encriptado para cada paciente&#46; El dise&#241;o y el funcionamiento del Registro RiHHTa fue aprobado por el Comit&#233; de &#201;tica del Hospital Universitari de Bellvitge &#40;Barcelona&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los resultados fueron expresados mediante frecuencias absolutas y relativas para las variables cualitativas&#59; para las variables cuantitativas se utilizaron la media&#44; la desviaci&#243;n est&#225;ndar y el rango&#46; El an&#225;lisis descriptivo se llev&#243; a cabo para el global de la muestra&#46; La comparaci&#243;n entre grupos de la distribuci&#243;n de las variables categ&#243;ricas se realiz&#243; mediante la prueba de la chi al cuadrado&#46; La comparaci&#243;n de la distribuci&#243;n de las variables cuantitativas que no segu&#237;an una distribuci&#243;n normal se efectu&#243; mediante la prueba de la t de Student y&#44; en caso contrario&#44; se utiliz&#243; la prueba de Mann-Whitney&#46; Se consider&#243; que las diferencias eran significativas cuando p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; El an&#225;lisis estad&#237;stico fue realizado mediante el programa inform&#225;tico SPSS versi&#243;n 18&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">El Registro RiHHTa se puso en funcionamiento el 6 de junio del 2016&#46; Desde entonces y hasta diciembre del 2017&#44; se introdujo a 152 pacientes de 104 familias&#46; De estos pacientes&#44; se ha dispuesto de datos suficientes para ser analizados de un total de 141 pacientes de 92 familias&#46; Todos los pacientes eran de raza cauc&#225;sica excepto 2&#44; de raza hispana y oriental&#46; La edad media fue de 51&#44;2 a&#241;os y 91 &#40;64&#44;5&#37;&#41; pacientes eran mujeres&#46; La comorbilidad de los pacientes se muestra en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Cabe destacar que de los 8 &#40;5&#44;7&#37;&#41; pacientes con fibrilaci&#243;n auricular&#44; se practic&#243; un cierre de la orejuela en 2 de ellos por contraindicaci&#243;n para la anticoagulaci&#243;n&#46; Adem&#225;s&#44; casi un tercio &#40;27&#44;7&#37;&#41; de los pacientes hab&#237;a sido sometido a alguna cirug&#237;a previa y exist&#237;a historia familiar de c&#225;ncer en 17 &#40;12&#44;1&#37;&#41; pacientes&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">La forma de comienzo de la HHT fue en forma de epistaxis recurrente en 130 &#40;92&#44;2&#37;&#41; pacientes&#44; en 3 &#40;2&#44;1&#37;&#41; pacientes como absceso cerebral debido a f&#237;stulas AV pulmonares no diagnosticadas previamente y por causas diversas&#44; en el resto &#40;5&#44;7&#37;&#41;&#46; La pr&#225;ctica totalidad &#40;97&#44;2&#37;&#41; de los pacientes presentaron epistaxis recurrentes&#44; que requirieron atenci&#243;n urgente en 50 &#40;35&#44;5&#37;&#41; pacientes y transfusi&#243;n de concentrados de hemat&#237;es en 31 &#40;22&#37;&#41; de los pacientes&#46; Respecto a las telangiectasias mucocut&#225;neas&#44; presentes en 126 &#40;89&#44;4&#37;&#41; pacientes&#44; se localizaron mayoritariamente en labios&#44; lengua y pulpejo de los dedos&#46; Casi todos los afectados &#40;89&#44;4&#37;&#41; presentaron antecedentes familiares de HHT y la mayor&#237;a &#40;63&#44;8&#37;&#41; afectaci&#243;n visceral&#46; De acuerdo con los criterios de Cura&#231;ao&#44; 122 &#40;86&#44;5&#37;&#41; sujetos cumpl&#237;an 3 o m&#225;s criterios&#44; lo que constituye un diagn&#243;stico definitivo&#46; A pesar de ello&#44; la edad media al diagn&#243;stico fue de 42&#44;1 a&#241;os&#46; Las caracter&#237;sticas cl&#237;nicas de los pacientes en relaci&#243;n con la HHT se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Respecto a las pruebas de cribado&#44; no se detect&#243; paso de contraste en la ETT o este fue de grado 1 en 59 &#40;41&#44;8&#37;&#41; pacientes&#46; A pesar de ello&#44; se realiz&#243; una angio-TC tor&#225;cica a 36 de ellos&#44; de los cuales solo en 7 se detect&#243; f&#237;stula AV pulmonar&#44; que fue &#250;nica en 6 pacientes y no susceptible de embolizaci&#243;n en ning&#250;n caso&#46; Se detectaron f&#237;stulas AV pulmonares en 36 &#40;45&#44;5&#37;&#41; de los 79 pacientes estudiados mediante angio-TC pulmonar&#44; con una media de 2&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;1-14&#41; fistulas AV pulmonares por paciente&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En cuanto a la afectaci&#243;n hep&#225;tica&#44; esta se objetiv&#243; en 43 &#40;67&#44;2&#37;&#41; de los 64 pacientes a los que se les estudi&#243;&#46; Estos presentaban una tendencia a concentraciones m&#225;s elevadas de las enzimas de colestasis&#44; con unos valores de bilirrubina significativamente superiores que los individuos sin afectaci&#243;n hep&#225;tica&#46; En lo concerniente al h&#237;gado&#44; fueron m&#225;s frecuentes las telangiectasias&#44; las f&#237;stulas AV y las arterio-portales&#46; Cuando se practic&#243; angio-TC abdominal se detectaron otras afectaciones vasculares extrahep&#225;ticas en 14 &#40;10&#37;&#41; pacientes&#44; mayoritariamente pancre&#225;ticas&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Se efectu&#243; estudio gen&#233;tico a 64 &#40;45&#44;4&#37;&#41; afectados&#44; objetiv&#225;ndose mutaci&#243;n en el gen <span class="elsevierStyleItalic">ENG</span> y el <span class="elsevierStyleItalic">ACVRL1</span> en 20 &#40;31&#44;2&#37;&#41; y 44 &#40;68&#44;8&#37;&#41; pacientes&#44; respectivamente&#46; La gran mayor&#237;a &#40;64&#44;7&#37;&#41; de los que presentaban mutaciones en <span class="elsevierStyleItalic">ENG</span> mostraban afectaci&#243;n pulmonar y la pr&#225;ctica totalidad &#40;95&#44;6&#37;&#41; de los que presentaron mutaci&#243;n en <span class="elsevierStyleItalic">ACVRL1</span> ten&#237;an afectaci&#243;n hep&#225;tica&#46; Los 2 &#40;1&#44;4&#37;&#41; pacientes con un solo criterio de Cura&#231;ao y 5 de los 17 &#40;12&#44;1&#37;&#41; con solo 2 criterios pose&#237;an un estudio gen&#233;tico con mutaci&#243;n en el gen <span class="elsevierStyleItalic">ACVRL1</span>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La afectaci&#243;n cerebral se detect&#243; tan solo en 3 &#40;3&#44;9&#37;&#41; de los sujetos estudiados&#44; sin repercusi&#243;n cl&#237;nica en ninguno de ellos&#46; Se sospecharon p&#233;rdidas digestivas en 36 pacientes&#44; de los cuales 20 &#40;55&#44;5&#37;&#41; presentaron telangiectasias en el tubo digestivo&#44; con predominio &#40;95&#37;&#41; en tracto digestivo superior&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> se reflejan los resultados de todas las exploraciones complementarias&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discusi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">El Registro RiHHTa pone en evidencia la necesidad de optimizar el diagn&#243;stico precoz de los pacientes con HHT&#46; La HHT presenta una cl&#237;nica dependiente de la edad&#44; con un desarrollo progresivo de signos y s&#237;ntomas desde la edad pedi&#225;trica hasta la cuarta d&#233;cada de vida<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">3&#44;24</span></a>&#46; A pesar de ello&#44; en una poblaci&#243;n adulta con una edad media de 51 a&#241;os&#44; la edad media al diagn&#243;stico en el Registro RiHHTa fue de 42 a&#241;os&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La recurrencia y la gravedad de las epistaxis es el factor que m&#225;s repercute en la calidad de vida de estos pacientes&#44; as&#237; como la necesidad de consultar a Urgencias y de transfusiones sangu&#237;neas&#44; como ocurri&#243; en el 35&#44;5 y el 22&#37; de los pacientes incluidos en el RiHHTa<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; Precisamente&#44; la detecci&#243;n de pacientes con epistaxis recurrentes y antecedentes familiares deber&#237;a alertar a los cl&#237;nicos sobre una posible HHT y representa una oportunidad para optimizar el diagn&#243;stico precoz de la HHT&#46; Estos 2 datos junto a un simple examen de las manos o cavidad oral detectando telangiectasias mucocut&#225;neas&#44; presentes en el 89&#44;4&#37; de los pacientes del registro RiHHTa&#44; definir&#237;a un diagn&#243;stico definitivo de HHT &#40;seg&#250;n criterios de Cura&#231;ao&#41;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los registros en las EEMM permiten conocer situaciones poco prevalentes de una enfermedad&#44; dif&#237;cilmente reconocibles desde un &#250;nico centro<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">15-17</span></a>&#46; As&#237;&#44; en el Registro RiHHTa&#44; al menos 20 &#40;14&#44;2&#37;&#41; pacientes ten&#237;an indicaci&#243;n de anticoagulaci&#243;n &#40;10 por cardiopat&#237;a y 10 por enfermedad tromboemb&#243;lica venosa &#91;ETV&#93;&#41;&#46; La HHT no supone por s&#237; sola una contraindicaci&#243;n absoluta para la anticoagulaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">27</span></a>&#46; As&#237;&#44; en un trabajo mediante entrevistas <span class="elsevierStyleItalic">on-line</span>&#44; un 38&#37; de 150 pacientes que refer&#237;an haber recibido anticoagulaci&#243;n no manifestaron empeoramiento de sus epistaxis habituales<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">27</span></a>&#46; Sin embargo&#44; en aquellos pacientes con fibrilaci&#243;n auricular y contraindicaci&#243;n para la anticoagulaci&#243;n se recomienda la realizaci&#243;n de un cierre de la orejuela de la aur&#237;cula izquierda&#44; como se realiz&#243; en 2 casos del Registro RiHHTa<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">28</span></a>&#46; Por otro lado&#44; la anemia ferrop&#233;nica se ha relacionado con una elevaci&#243;n compensatoria del factor <span class="elsevierStyleSmallCaps">viii</span> y con un aumento del riesgo de ETV en los pacientes con HHT<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">29&#44;30</span></a>&#46; De hecho&#44; el 7&#37; de pacientes con ETV en el Registro es superior a la incidencia esperada en una poblaci&#243;n con una edad media entre 50 y 59 a&#241;os&#44; que ser&#237;a del 1&#47;1&#46;000<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">31</span></a>&#46; El Registro RiHHTa podr&#225; dar informaci&#243;n futura sobre la tolerancia de la anticoagulaci&#243;n en los pacientes con HHT en la pr&#225;ctica cl&#237;nica habitual&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La afectaci&#243;n hep&#225;tica result&#243; la manifestaci&#243;n visceral m&#225;s frecuente&#44; en consonancia con una mayor prevalencia de mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span><a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; Las mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span> definen la HHT tipo <span class="elsevierStyleSmallCaps">ii</span>&#44; con mayor prevalencia de afectaci&#243;n hep&#225;tica&#44; como ocurri&#243; en el 95&#37; de los pacientes con mutaciones en este gen incluidos en el RiHHTa<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; La forma de afectaci&#243;n hep&#225;tica m&#225;s frecuente han sido las telangiectasias&#44; que no suelen presentar s&#237;ntomas<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Los 3 tipos de afectaci&#243;n vascular identificados mediante la angio-TC abdominal implican un seguimiento y complicaciones distintas&#46; As&#237;&#44; las fistulas AV y porto-venosas pueden ocasionar signos y s&#237;ntomas de insuficiencia card&#237;aca con un &#237;ndice card&#237;aco elevado<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Sin embargo&#44; este par&#225;metro tan solo fue reportado en el Registro en la mitad de los 16 pacientes con esta afectaci&#243;n&#46; La angio-TC abdominal tambi&#233;n permiti&#243; detectar las f&#237;stulas arterio-portales que pueden ocasionar hipertensi&#243;n portal&#44; que debe buscarse durante el seguimiento&#46; Valores anal&#237;ticos alterados en la funci&#243;n hep&#225;tica&#44; se han relacionado con mayor riesgo de afectaci&#243;n hep&#225;tica cl&#237;nicamente significativa<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">34</span></a>&#46; De hecho&#44; los pacientes con afectaci&#243;n hep&#225;tica en el RiHHTa presentaban mayor elevaci&#243;n de par&#225;metros de colestasis respecto a los que no ten&#237;an esta afectaci&#243;n&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">La ETT con contraste es la prueba de elecci&#243;n para el cribado de f&#237;stulas AV pulmonares<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; Estas son m&#225;s frecuentes en los pacientes con mutaciones en el gen <span class="elsevierStyleItalic">ENG</span>&#44; que define la HHT tipo <span class="elsevierStyleSmallCaps">i</span>&#44; como ocurri&#243; en el 64&#37; de los pacientes incluidos en el RiHHTa que presentaban mutaciones en este gen<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; En un trabajo realizado con 95 pacientes&#44; los 24 pacientes sin paso de contraste y los 34 pacientes con grado 1&#44; de acuerdo con la Clasificaci&#243;n de Barzilai&#44; no presentaron fistulas AV en la angio-TC tor&#225;cica<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">23&#44;35</span></a>&#46; A pesar de ello&#44; en el RiHHTa se realiz&#243; innecesariamente una angio-TC tor&#225;cica a 36 de los 59 pacientes con grados 0 o 1&#46; Es necesario realizar un correcto cribado de las manifestaciones de la enfermedad que reduzcan sus complicaciones&#46; En este sentido&#44; 3 pacientes comenzaron con abscesos cerebrales como s&#237;ntoma inicial&#46; La detecci&#243;n previa de f&#237;stulas AV pulmonares hubiera permitido administrar profilaxis antibi&#243;tica ante situaciones de riesgo y valorar su embolizaci&#243;n&#44; reduciendo as&#237; el riesgo de dicha complicaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; De hecho&#44; los abscesos cerebrales&#44; presentes en 7 &#40;5&#37;&#41; pacientes del Registro RiHHTa&#44; son una complicaci&#243;n prevenible y frecuente en los individuos con HHT&#44; m&#225;s de 30 veces superior que en la poblaci&#243;n general<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">36</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Las malformaciones cerebrales presentan un comportamiento diferente&#44; ya que est&#225;n presentes desde el nacimiento<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">3</span></a>&#46; Sin embargo&#44; dada la baja prevalencia y las dificultades terap&#233;uticas&#44; no existe un elevado grado de evidencia ni recomendaciones para realizar cribado de ellas en los sujetos adultos asintom&#225;ticos con HHT<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">11&#44;37&#44;38</span></a>&#46; A pesar de ello&#44; en el Registro RiHHTa se practic&#243; estudio de malformaciones arteriovenosas cerebrales a 77 &#40;54&#44;6&#37;&#41; pacientes&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La afectaci&#243;n del tubo digestivo es la manifestaci&#243;n m&#225;s tard&#237;a&#44; iniciando sobre la 5&#46;&#170; o 6&#46;&#170; d&#233;cadas de la vida<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">39&#44;40</span></a>&#46; Su estudio se recomienda en aquellos pacientes con anemia desproporcionada al grado de epistaxis<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; Esto se debe a que&#44; si bien el 80&#37; de los pacientes con HHT presentan telangiectasias en el tubo digestivo&#44; tan solo un 25-30&#37; desarrollar&#225; una afectaci&#243;n digestiva sintom&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">41&#44;42</span></a>&#46; El predominio de afectaci&#243;n a nivel gastroduodenal observado en el RiHHTa ha sido escasamente publicado y apoya la recomendaci&#243;n de iniciar el cribado con una esofagogastroduodenoscopia<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">39&#44;41&#44;42</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el Registro RiHHTa representa una iniciativa de trabajo coordinado entre sus miembros que aporta informaci&#243;n de situaciones infrecuentes y permite identificar puntos de mejora en el manejo de los pacientes con HHT&#46; Se ha detectado un uso inadecuado de la angio-TC tor&#225;cica y la utilidad de la angio-TC abdominal para poder definir subtipos de afectaci&#243;n vascular hep&#225;tica y detectar afectaci&#243;n vascular extrahep&#225;tica&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Autor&#237;a</span><p id="par0130" class="elsevierStylePara elsevierViewall">Concepci&#243;n y dise&#241;o del manuscrito&#58; Antoni Riera-Mestre&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Recogida de datos&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Rosario Sanchez Mart&#237;nez&#44; Miguel Angel Torralba Cabeza&#44; Jos&#233; Luis Patier de la Pe&#241;a&#44; Mar&#237;a Coloma Juyol Rodrigo&#44; Daniel Lopez Wolf&#44; Ana Ojeda Sosa&#44; Lorenzo Monserrat&#44; M&#243;nica L&#243;pez Rodr&#237;guez&#59; y los investigadores del Registro RiHHTa del Grupo de Trabajo de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna incluidos en el <a class="elsevierStyleCrossRef" href="#sec0050">anexo 1</a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">An&#225;lisis e interpretaci&#243;n de los datos&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Miguel Angel Torralba Cabeza&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Redacci&#243;n&#44; revisi&#243;n&#44; aprobaci&#243;n del manuscrito remitido&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Rosario Sanchez Mart&#237;nez&#44; Miguel Angel Torralba Cabeza&#44; Jos&#233; Luis Patier de la Pe&#241;a&#44; Mar&#237;a Coloma Juyol Rodrigo&#44; Daniel Lopez Wolf&#44; Ana Ojeda Sosa&#44; Lorenzo Monserrat&#44; M&#243;nica L&#243;pez Rodr&#237;guez y los investigadores del Registro RiHHTa del Grupo de Trabajo de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna incluidos en el <a class="elsevierStyleCrossRef" href="#sec0050">anexo 1</a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicto de intereses</span><p id="par0150" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La telangiectasia hemorr&#225;gica hereditaria &#40;HHT&#44; por sus siglas en ingl&#233;s&#41; es una enfermedad minoritaria con herencia autos&#243;mica dominante que provoca una afectaci&#243;n vascular sist&#233;mica&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Tras la elaboraci&#243;n de un registro nacional espa&#241;ol multic&#233;ntrico&#44; denominado RiHHTa&#44; se describen las principales manifestaciones cl&#237;nicas y procedimientos diagn&#243;sticos de los primeros pacientes introducidos&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se han introducido datos de 141 pacientes&#44; de los que 91 &#40;64&#44;5&#37;&#41; eran mujeres&#46; La edad media al diagn&#243;stico fue de 42 a&#241;os&#46; Las mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span> predominaron sobre el gen <span class="elsevierStyleItalic">ENG</span>&#46; El s&#237;ntoma inicial fue la epistaxis recurrente en 130 &#40;92&#44;2&#37;&#41; pacientes y en 3 &#40;2&#44;1&#37;&#41;&#44; el absceso cerebral&#46; Se detectaron f&#237;stulas arteriovenosas &#40;AV&#41; pulmonares en 36 &#40;45&#37;&#41; de los 79 pacientes a los que se les practic&#243; una angio-TC tor&#225;cica&#46; En 36 &#40;45&#37;&#41; de estos 79 afectados no se hab&#237;a detectado paso de contraste en la ecocardiograf&#237;a o este era grado 1&#46; En 43 &#40;67&#44;2&#37;&#41; de los 64 pacientes con una angio-TC abdominal se detectaron malformaciones vasculares hep&#225;ticas&#44; mayoritariamente telangiectasias&#44; f&#237;stulas AV y arterio-portales&#44; y extrahep&#225;ticas en 14 &#40;10&#37;&#41; sujetos&#46; Se realiz&#243; cribado de malformaci&#243;n AV cerebral a m&#225;s de la mitad de los pacientes&#44; detect&#225;ndose en un 3&#44;9&#37;&#46; La parte del tubo digestivo m&#225;s afectada fue la superior &#40;95&#37;&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El Registro RiHHTa permite identificar puntos de mejora en el manejo de los pacientes con HHT&#46; Se ha detectado un uso inadecuado de la angio-TC tor&#225;cica y la utilidad de la angio-TC abdominal para definir los subtipos de afectaci&#243;n vascular hep&#225;tica y detectar afectaci&#243;n vascular extrahep&#225;tica&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Hereditary hemorrhagic telangiectasia &#40;HHT&#41; is a rare disease with autosomal dominant inheritance that causes systemic vascular affectation&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">After development a multicentric Spanish national registry&#44; called RiHHTa&#44; main clinical manifestations and diagnostic procedures of the first patients introduced are described&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">141 patients were included&#44; of which 91 &#40;64&#46;5&#37;&#41; were women&#46; The mean age at diagnosis was 42 years&#46; Mutations in the <span class="elsevierStyleItalic">ACVRL1</span> gene predominated over the <span class="elsevierStyleItalic">ENG</span> gene&#46; The initial symptom was recurrent epistaxis in 130 &#40;92&#46;2&#37;&#41; patients and in three &#40;2&#46;1&#37;&#41;&#44; brain abscess&#46; Pulmonary arteriovenous &#40;AV&#41; fistula were detected in 36 &#40;45&#37;&#41; of the 79 patients who underwent thoracic CT angiography&#46; The contrast echocardiography detected very few bubbles &#40;grade I&#41; or none&#44; in 36 &#40;45&#37;&#41; of these 79 affected patients&#46; In 43 &#40;67&#46;2&#37;&#41; of the 64 patients with an abdominal CT angiography&#44; hepatic vascular malformations were detected&#44; mostly telangiectasias&#44; AV and arterio-portal fistula&#44; and extrahepatic in 14 &#40;10&#37;&#41; subjects&#46; More than half of the patients were screened for the presence of brain arteriovenous malformations which was found in 3&#46;9&#37; of them&#46; The upper part of the intestinal tube was the most &#40;95&#37;&#41; affected region&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The RiHHTa Registry allows improving the management of patients with HHT&#46; An inadequate use of thoracic CT angiography and the usefulness of abdominal CT angiography has been detected in order to define subtypes of hepatic vascular involvement and detect extrahepatic vascular involvement&#46;</p></span>"
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            "apendice" => "<p id="par0160" class="elsevierStylePara elsevierViewall">Coordinador del Registro RiHHTa&#58; A&#46; Riera-Mestre&#46; C&#46; Alonso Cotoner&#44; M&#46; Beneyto Florido&#44; A&#46; Fern&#225;ndez&#44; R&#46; Gil S&#225;nchez&#44; J&#46;S&#46; Garc&#237;a Morillo&#44; J&#46;F&#46; G&#243;mez Cerezo&#44; V&#46; G&#243;mez del Olmo&#44; P&#46; Iglesias&#44; M&#46;C&#46; Juyol Rodrigo&#44; N&#46; Lopez Osle&#44; M&#46; L&#243;pez Rodr&#237;guez&#44; D&#46; L&#243;pez Wolf&#44; M&#46;C&#46; Moreno de la Santa Garc&#237;a&#44; A&#46; Ojeda Sosa&#44; J&#46;L&#46; Patier de la Pe&#241;a&#44; M&#46;L&#46; Perez Garcia&#44; A&#46; Riera-Mestre&#44; R&#46; S&#225;nchez Mart&#237;nez&#44; M&#46;A&#46; Torralba Cabeza&#44; R&#46; Zarrabeitia Puente&#46;</p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Miembros del Registro RiHHTa del Grupo de Trabajo y de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna"
            "identificador" => "sec0050"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La HHT se define como definitiva &#40;en pacientes con 3 o m&#225;s criterios&#41;&#44; probable &#40;si se cumplen 2 criterios&#41; e improbable &#40;si cumplen uno o ninguno&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">GI&#58; gastrointestinales&#59; HHT&#58; telangiectasia hemorr&#225;gica hereditaria&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Fuente&#58; Shovlin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a>&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Criterio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Descripci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Epistaxis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#250;ltiples&#44; en sitios caracter&#237;sticos&#58; labios&#44; cavidad oral&#44; dedos&#44; fosas nasales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lesiones viscerales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Familiar de primer grado con HHT de acuerdo con estos criterios&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">EP&#58; embolia pulmonar&#59; ETV&#58; enfermedad tromboemb&#243;lica venosa&#59; IMC&#58; &#237;ndice de masa corporal&#59; TVP&#58; trombosis venosa profunda&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top" style="border-bottom: 2px solid black">Pacientes&#44; N&#46;&#176;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top" style="border-bottom: 2px solid black">141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Caracter&#237;sticas cl&#237;nicas</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>G&#233;nero &#40;femenino&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;64&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad&#44; a&#241;os &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;2 &#40;13-89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Peso&#44; kg &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;6 &#40;45-162&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Altura&#44; cm &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">165&#44;90<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;2 &#40;147-189&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IMC&#44; kg&#47;m<span class="elsevierStyleSup">2</span> &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;8 &#40;16&#44;6-56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IMC<span class="elsevierStyleHsp" style=""></span>&#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Comorbilidades</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tabaquismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;12&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Extabaquismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;9&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Alcoholismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;5&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;19&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;4&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;15&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;18&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;5&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pr&#243;tesis valvular mec&#225;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;8&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Absceso cerebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Antecedente quir&#250;rgico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;27&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Osteoporosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;7&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&#225;ncer&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad al diagn&#243;stico&#44; a&#241;os &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;5 &#40;7-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Criterios de Cura&#231;ao</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;12&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45 &#40;31&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77 &#40;54&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Epistaxis recurrente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137 &#40;97&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ESS &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Atenci&#243;n en Urgencias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;35&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;51&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Transfusi&#243;n de CCHH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Telangiectasias cut&#225;neo-mucosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 &#40;89&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Digitales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;52&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Linguales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;64&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Labiales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;67&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Orales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;24&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Conjuntivales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;6&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;30&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lesiones viscerales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;63&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Historia familiar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 &#40;89&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">ALT&#58; alanina aminotransferasa&#59; AST&#58; aspartato aminotransferasa&#59; AV&#44; arterio-venosa&#59; FA&#58; fosfatasa alcalina&#59; GGT&#58; gamma glutamiltranspeptidasa&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pacientes&#44; N&#46;&#176;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">An&#225;lisis de sangre &#40;media</span> &#177; <span class="elsevierStyleBold">DE&#59; rango&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemoglobina&#44; g&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;4 &#40;5&#44;6-18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Leucocitos</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">9</span></span><span class="elsevierStyleItalic">&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;1 &#40;2&#44;2-24&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Plaquetas</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">9</span></span><span class="elsevierStyleItalic">&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">265&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>88&#44;4 &#40;124-669&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">INR</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;12 &#40;0&#44;7-1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinina&#44; &#956;mol&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;2 &#40;47&#44;7-150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Filtrado Glomerular&#44; ml&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;4 &#40;50&#44;8-150&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Ferritina&#44; mg&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>149&#44;4 &#40;3-1137&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">IST&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;0 &#40;2-44&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Ecocardiograf&#237;a transtor&#225;cica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">86&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Grado paso burbujas</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;38&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;30&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;23&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;5&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;2&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fracci&#243;n de eyecci&#243;n &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">67&#41;&#44; &#37; &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;4 &#40;40-80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Presi&#243;n arterial pulmonar sist&#243;lica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">32&#41;&#44; mmHg &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;42 &#40;16-66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Gasto card&#237;aco &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">23&#41;&#44; l&#47;min &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9 &#40;2&#44;6-11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#205;ndice card&#237;aco &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">17&#41;&#44; l&#47;min&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;2 &#40;1&#44;7-6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Mutaci&#243;n gen&#233;tica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">64&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ENG</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;31&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#47;17 &#40;64&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#47;14 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACVRL1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;68&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#47;26 &#40;30&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#47;23 &#40;95&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Afectaci&#243;n visceral</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">F&#237;stula AV pulmonar &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">79&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;54&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;45&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Numero de f&#237;stulas AV &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;1-14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Afectaci&#243;n hep&#225;tica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">64&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;32&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ALT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AST&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FA&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>GGT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Bilirrubina&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;21<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;67&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ALT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AST&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FA&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">113&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>96&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>GGT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>91&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Bilirrubina&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tipo de afectaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Telangiectasias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas AV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas porto-venosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas arterio-portales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hiperplasia nodular focal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hiperplasia nodular regenerativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Otra afectaci&#243;n intraabdominal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pancre&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Malformaci&#243;n AV cerebral &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">77&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;96&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;3&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Afectaci&#243;n tubo digestivo &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">20&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad media&#44; a&#241;os &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;9 &#40;44-83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad media al diagn&#243;stico&#44; a&#241;os &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;0 &#40;27-80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tipo de afectaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Gastro-duodenal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Gastro-duodeno-colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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ORIGINAL
DOI: 10.1016/j.rce.2018.07.002
Registro informatizado de la telangiectasia hemorrágica hereditaria (Registro RiHHTa) en España: objetivos, métodos y resultados preliminares
Computerized registry of patients with hemorrhagic hereditary telangiectasia (RiHHTa Registry) in Spain: Objectives, methods, and preliminary results
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A. Riera-Mestrea,b,c,
Autor para correspondencia
ariera@bellvitgehospital.cat

Autor para correspondencia.
, J.M. Mora Lujána,c, R. Sanchez Martínezc,d, M.A. Torralba Cabezac,e, J.L. Patier de la Peñac,f, M.C. Juyol Rodrigoc,g, D. Lopez Wolfc,h, A. Ojeda Sosac,i, L. Monserratc,j, M. López Rodríguezc,k, en representación de los Investigadores del Registro RiHHTa ◊
a Unidad de Telangiectasia Hemorrágica Hereditaria, Servicio de Medicina Interna, Hospital Universitari de Bellvitge-IDIBELL, L‘Hospitalet de Llobregat, Barcelona, España
b Facultad de Medicina y Ciencias de la Salud, Universitat de Barcelona, Barcelona, España
c Grupo de Trabajo en Enfermedades Minoritarias, Sociedad Española de Medicina Interna
d Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, España
e Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España
f Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Madrid, España
g Servicio de Medicina Interna, Hospital Universitario Miguel Servet, Zaragoza, España
h Servicio de Medicina Interna, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España
i Servicio de Medicina Interna, Hospital Insular Universitario de Gran Canaria, Las Palmas de Gran Canaria, Las Palmas, España
j Health in Code, A Coruña, España
k Servicio de Medicina Interna, Hospital Central de la Cruz Roja, Madrid, España
Ver más
Miembros del Registro RiHHTa del Grupo de Trabajo en Enfermedades Minoritarias de la Sociedad Española de Medicina Interna
Contenido relacionado
RiHHTa, un registro clínico español ejemplo de trabajo multicéntrico en red para una enfermedad rara
Rev Clin Esp. 2018;218:479-8010.1016/j.rce.2018.08.002
L.M. Botella

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