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array:22 [ "pii" => "S0014256511700042" "issn" => "00142565" "doi" => "10.1016/S0014-2565(11)70004-2" "estado" => "S300" "fechaPublicacion" => "2011-03-01" "aid" => "70004" "copyright" => "Elsevier España S.L." "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2011;211 Supl 1:15-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 597 "formatos" => array:2 [ "HTML" => 395 "PDF" => 202 ] ] "itemAnterior" => array:18 [ "pii" => "S0014256511700030" "issn" => "00142565" "doi" => "10.1016/S0014-2565(11)70003-0" "estado" => "S300" "fechaPublicacion" => "2011-03-01" "aid" => "70003" "copyright" => "Elsevier España S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Clin Esp. 2011;211 Supl 1:8-14" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 539 "formatos" => array:2 [ "HTML" => 449 "PDF" => 90 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Prevención del desarrollo de lesión orgánica en los diferentes estadios del <span class="elsevierStyleItalic">continuum</span> cardiorrenal</span>" "titulo" => "Prevención de la progresión y regresión de la lesión orgánica. Estrategias de futuro" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "8" "paginaFinal" => "14" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevention of progression and regression of target organ damage. Future strategies" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. de la Sierra" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "de la Sierra" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256511700030?idApp=WRCEE" "url" => "/00142565/00000211000000S1/v1_201302081047/S0014256511700030/v1_201302081047/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Prevención del desarrollo de lesión orgánica en los diferentes estadios del <span class="elsevierStyleItalic">continuum</span> cardiorrenal</span>" "titulo" => "Nefroprotección y riesgo vascular: prevención del daño renal en la hipertensión arterial" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "15" "paginaFinal" => "20" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.M. Galcerán Gui" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Galcerán Gui" "email" => array:1 [ 0 => "jgalceran@althaia.cat" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Nefrología, Fundación Althaia, Manresa, Universitat Internacional de Catalunya, Barcelona, España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Nephroprotection and vascular risk: prevention of renal damage in hypertension" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec18102" "palabras" => array:7 [ 0 => "Nefropatía hipertensiva" 1 => "Insuficiencia renal" 2 => "Hipertensión arterial" 3 => "Sistema renina-angiotensina" 4 => "Protección renal" 5 => "Proteinuria" 6 => "Diabetes" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec18101" "palabras" => array:7 [ 0 => "Hypertensive nephropathy" 1 => "Renal insufficiency" 2 => "Hypertension" 3 => "Renin-angiotensin system" 4 => "Renal protection" 5 => "Proteinuria" 6 => "Diabetes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de disfunción renal es elevada en la población general, y mucho más entre los pacientes con hipertensión arterial. Ello comporta un elevado riesgo no sólo de evolucionar a insuficiencia renal terminal, sino de presentar una mayor morbimortalidad cardiovascular. Las guías clínicas de enfermedad renal crónica recomiendan un control ambicioso de la presión arterial (< 130/80<span class="elsevierStyleHsp" style=""></span>mmHg o más bajo en caso de proteinuria) y la utilización de fármacos contra el sistema renina-angiotensina (SRA). Sin embargo, la evidencia de estas recomendaciones parece escasa para aquellos pacientes hipertensos que no sean diabéticos o no tengan proteinuria. Este artículo revisa dicha controversia y concluye con recomendaciones para la mejor preservación renal en los pacientes hipertensos.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Kidney dysfunction is highly prevalent in the general population and even more so among patients with hypertension, leading to a high risk not only of progression to end-stage renal insufficiency but also of greater cardiovascular morbidity and mortality. Clinical guidelines for chronic kidney disease recommend ambitious blood pressure control (< 130/80<span class="elsevierStyleHsp" style=""></span>mmHg or lower if there is proteinuria) and the use of renin-angiotensin system blockers. However, the evidence for these recommendations in patients with hypertension without diabetes or proteinuria is scarce. The present article reviews this controversy and concludes with recommendations for better renal preservation in patients with hypertension.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertensive vascular disease: description and natural history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.A. Perera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Chronic Dis" "fecha" => "1995" "volumen" => "1" "paginaInicial" => "33" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13233309" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recomendaciones sobre la utilización de ecuaciones para la estimación del filtrado glomerular en adultos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Gracia" 1 => "R. Montañés" 2 => "J. Bover" 3 => "A. Cases" 4 => "R. Deulofeu" 5 => "A.L. Martín de Francisco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nefrología" "fecha" => "2006" "volumen" => "26" "paginaInicial" => "658" "paginaFinal" => "665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17227242" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of chronic renal disease in Spain: Results of the EPIRCE study" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "On behalf of the EPIRCE Study Group" "etal" => false "autores" => array:4 [ 0 => "A. Otero" 1 => "A. De Francisco" 2 => "P. Gayoso" 3 => "F. García" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3265/Nefrologia.pre2009.Dic.5732" "Revista" => array:6 [ "tituloSerie" => "Nefrología" "fecha" => "2010" "volumen" => "30" "paginaInicial" => "78" "paginaFinal" => "86" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20038967" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal function and cardiovascular risk in patients with essential hypertension. The “FRESHA” study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Herrero" 1 => "R. Marín" 2 => "F. Fernández Vega" 3 => "M. Gorostidi" 4 => "A. Riesgo" 5 => "J. Vázquez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nefrología" "fecha" => "2006" "volumen" => "26" "paginaInicial" => "330" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16892821" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "State-specific trends in chronic kidney failure--United States, 1990–2001" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Centers for Disease Control and Prevention (CDC)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "MMWR Morb Mortal Wkly Rep" "fecha" => "2004" "volumen" => "53" "paginaInicial" => "918" "paginaFinal" => "920" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15470324" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: The Hisayama Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Nagata" 1 => "T. Ninomiya" 2 => "Y. Doi" 3 => "K. Yonemoto" 4 => "M. Kubo" 5 => "J. Hata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfq062" "Revista" => array:6 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2010" "volumen" => "25" "paginaInicial" => "2557" "paginaFinal" => "2564" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20176610" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular disease in patients with chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Wright" 1 => "A. Hutchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Vasc Health Risk Manag" "fecha" => "2009" "volumen" => "5" "paginaInicial" => "713" "paginaFinal" => "722" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19756163" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.I. Hallan" 1 => "K. Dahl" 2 => "C.M. Oien" 3 => "D.C. Grootendorst" 4 => "A. Aasberg" 5 => "J. Holmen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.39001.657755.BE" "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "2006" "volumen" => "333" "paginaInicial" => "1047" "paginaFinal" => "1054" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17062598" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Riesgo por enfermedad renal crónica: la epidemia revisada" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.M. Galcerán" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hipertens Riesgo Vasc" "fecha" => "2010" "volumen" => "27" "paginaInicial" => "183" "paginaFinal" => "186" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of Hypertensive Renal Damage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.K. Bidani" 1 => "K.A. Griffin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hipertensión" "fecha" => "2004" "volumen" => "44" "paginaInicial" => "595" "paginaFinal" => "601" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the management of chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Levin" 1 => "B. Hemmelgarn" 2 => "B. Culleton" 3 => "S. Tobe" 4 => "P. McFarlane" 5 => "M. Ruzicka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1503/cmaj.080351" "Revista" => array:6 [ "tituloSerie" => "CMAJ" "fecha" => "2008" "volumen" => "179" "paginaInicial" => "1154" "paginaFinal" => "1162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19015566" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of progression of kidney disease" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Caring for Australasians with Renal Impairment (CARI). The CARI guidelines" "etal" => false "autores" => array:5 [ 0 => "D. Harris" 1 => "M. Thomas" 2 => "D. Johnson" 3 => "K. Nicholls" 4 => "A. Gillin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nephrology (Carlton)" "fecha" => "2006" "volumen" => "11" "numero" => "Suppl 1" "paginaInicial" => "S2" "paginaFinal" => "S197" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Chronic Kidney Disease. Medicare Quality Improvement Project. Disponible en: <a class="elsevierStyleInterRef" href="http://www.fmqai.com">http:/www.fmqai.com</a>" ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of renin angiotensin system inhibition in kidney repair" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I.M. Van der Meer" 1 => "P. Cravedi" 2 => "G. Remuzzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1755-1536-3-7" "Revista" => array:5 [ "tituloSerie" => "Fibrogenesis Tissue Repair" "fecha" => "2010" "volumen" => "3" "paginaInicial" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20441574" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiotensin II induces superoxide anion production by mesangial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.A. Jaimes" 1 => "J.M. Galceran" 2 => "L. Raij" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.1998.00068.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "1998" "volumen" => "54" "paginaInicial" => "775" "paginaFinal" => "784" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9734602" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maximizing cardiorenal benefit in the management of hypertension: achieve blood pressure goals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.L. Bakris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clin Hypertens" "fecha" => "1999" "volumen" => "1" "paginaInicial" => "141" "paginaFinal" => "147" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteinuria as a modifiable risk factor for the progression of non-diabetic renal disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.H. Jafar" 1 => "P.C. Stark" 2 => "C.H. Schmid" 3 => "M. Landa" 4 => "G. Maschio" 5 => "C. Marcantoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2001.0600031131.x" "Revista" => array:6 [ "tituloSerie" => "Kidney Int" "fecha" => "2001" "volumen" => "60" "paginaInicial" => "1131" "paginaFinal" => "1140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11532109" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of kidney damage in Australian adults: The AusDiab kidney study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.J. Chadban" 1 => "E.M. Briganti" 2 => "P.G. Kerr" 3 => "D.W. Dunstan" 4 => "T.A. Welborn" 5 => "P.Z. Zimmet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "S131" "paginaFinal" => "S138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12819318" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.C. Peterson" 1 => "S. Adler" 2 => "J.M. Burkart" 3 => "T. Greene" 4 => "L.A. Hebert" 5 => "L.G. Hunsicker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "1995" "volumen" => "123" "paginaInicial" => "754" "paginaFinal" => "762" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7574193" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensive blood-pressure control in hypertensive chronic kidney disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.J. Appel" 1 => "J.T. Wright Jr." 2 => "T. Greene" 3 => "L.Y. Agodoa" 4 => "B.C. Astor" 5 => "G.L. Bakris" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0910975" "Revista" => array:6 [ "tituloSerie" => "New Engl J Med" "fecha" => "2010" "volumen" => "363" "paginaInicial" => "918" "paginaFinal" => "929" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20818902" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.M. Voyaki" 1 => "J.A. Staessen" 2 => "L. Thijs" 3 => "J.G. Wang" 4 => "A.D. Efstratopoulos" 5 => "W.H. Birkenhäger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hypertens" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "511" "paginaFinal" => "519" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11288822" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of hypertension in patients 80 years of age or older" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.S. Beckett" 1 => "R. Peters" 2 => "A.E. Fletcher" 3 => "J.A. Staessen" 4 => "L. Liu" 5 => "D. Dumitrascu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0801369" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "358" "paginaInicial" => "1887" "paginaFinal" => "1898" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18378519" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.F. Mann" 1 => "R.E. Schmieder" 2 => "M. McQueen" 3 => "L. Dyal" 4 => "H. Schumacher" 5 => "J. Pogue" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(08)61236-2" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2008" "volumen" => "372" "paginaInicial" => "547" "paginaFinal" => "553" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18707986" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Rahman" 1 => "S. Pressel" 2 => "B.R. Davis" 3 => "C. Nwachuku" 4 => "J.T. Wright Jr" 5 => "P.K. Whelton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archinte.165.8.936" "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "2005" "volumen" => "165" "paginaInicial" => "936" "paginaFinal" => "946" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15851647" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Brown" 1 => "C.R. Palmer" 2 => "A. Castaigne" 3 => "P.W. De Leeuw" 4 => "G. Mancia" 5 => "T. Rosenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(00)02527-7" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2000" "volumen" => "356" "paginaInicial" => "366" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10972368" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efecto multiplicador de glucosa y angiotensina II en la nefropatía diabética experimental" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.M. Galcerán" 1 => "G. Rehues" 2 => "M.J. Zamora" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Hipertensión" "fecha" => "2001" "volumen" => "18" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preventing Microalbuminuria in Type 2 Diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Ruggenenti" 1 => "A. Fassi" 2 => "A.P. Ilieva" 3 => "S. Bruno" 4 => "I.P. Iliev" 5 => "V. Brusegan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa042167" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "351" "paginaInicial" => "1941" "paginaFinal" => "1951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15516697" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of microalbuminuria in type 2 diabetes (roadmap trial): 6A.02" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Haller" 1 => "S. Ito" 2 => "J.L. Izzo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Hypertens" "fecha" => "2010" "volumen" => "28" "numero" => "Suppl" "paginaInicial" => "e233" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Jamerson" 1 => "M.A. Weber" 2 => "G.L. Bakris" 3 => "B. Dahlöf" 4 => "B. Pitt" 5 => "V. Shi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0806182" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "359" "paginaInicial" => "2417" "paginaFinal" => "2428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19052124" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.L. Bakris" 1 => "P.A. Sarafidis" 2 => "M.R. Weir" 3 => "B. Dahlöf" 4 => "B. Pitt" 5 => "K. Jamerson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)62100-0" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2010" "volumen" => "375" "paginaInicial" => "1173" "paginaFinal" => "1181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20170948" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00142565/00000211000000S1/v1_201302081047/S0014256511700042/v1_201302081047/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/00142565/00000211000000S1/v1_201302081047/S0014256511700042/v1_201302081047/es/main.pdf?idApp=WRCEE&text.app=https://revclinesp.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0014256511700042?idApp=WRCEE" ]
