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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de disfunci&#243;n renal es elevada en la poblaci&#243;n general&#44; y mucho m&#225;s entre los pacientes con hipertensi&#243;n arterial&#46; Ello comporta un elevado riesgo no s&#243;lo de evolucionar a insuficiencia renal terminal&#44; sino de presentar una mayor morbimortalidad cardiovascular&#46; Las gu&#237;as cl&#237;nicas de enfermedad renal cr&#243;nica recomiendan un control ambicioso de la presi&#243;n arterial &#40;&#60; 130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg o m&#225;s bajo en caso de proteinuria&#41; y la utilizaci&#243;n de f&#225;rmacos contra el sistema renina-angiotensina &#40;SRA&#41;&#46; Sin embargo&#44; la evidencia de estas recomendaciones parece escasa para aquellos pacientes hipertensos que no sean diab&#233;ticos o no tengan proteinuria&#46; Este art&#237;culo revisa dicha controversia y concluye con recomendaciones para la mejor preservaci&#243;n renal en los pacientes hipertensos&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Kidney dysfunction is highly prevalent in the general population and even more so among patients with hypertension&#44; leading to a high risk not only of progression to end-stage renal insufficiency but also of greater cardiovascular morbidity and mortality&#46; Clinical guidelines for chronic kidney disease recommend ambitious blood pressure control &#40;&#60; 130&#47;80<span class="elsevierStyleHsp" style=""></span>mmHg or lower if there is proteinuria&#41; and the use of renin-angiotensin system blockers&#46; However&#44; the evidence for these recommendations in patients with hypertension without diabetes or proteinuria is scarce&#46; The present article reviews this controversy and concludes with recommendations for better renal preservation in patients with hypertension&#46;</p>"
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Vol. 211. Núm. S1.
Prevención del desarrollo de lesión orgánica en los diferentes estadios del continuum cardiorrenal
Páginas 15-20 (marzo 2011)
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Vol. 211. Núm. S1.
Prevención del desarrollo de lesión orgánica en los diferentes estadios del continuum cardiorrenal
Páginas 15-20 (marzo 2011)
Prevención del desarrollo de lesión orgánica en los diferentes estadios del continuum cardiorrenal
Nefroprotección y riesgo vascular: prevención del daño renal en la hipertensión arterial
Nephroprotection and vascular risk: prevention of renal damage in hypertension
J.M. Galcerán Gui
Servicio de Nefrología, Fundación Althaia, Manresa, Universitat Internacional de Catalunya, Barcelona, España
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La prevalencia de disfunción renal es elevada en la población general, y mucho más entre los pacientes con hipertensión arterial. Ello comporta un elevado riesgo no sólo de evolucionar a insuficiencia renal terminal, sino de presentar una mayor morbimortalidad cardiovascular. Las guías clínicas de enfermedad renal crónica recomiendan un control ambicioso de la presión arterial (< 130/80mmHg o más bajo en caso de proteinuria) y la utilización de fármacos contra el sistema renina-angiotensina (SRA). Sin embargo, la evidencia de estas recomendaciones parece escasa para aquellos pacientes hipertensos que no sean diabéticos o no tengan proteinuria. Este artículo revisa dicha controversia y concluye con recomendaciones para la mejor preservación renal en los pacientes hipertensos.

Palabras clave:
Nefropatía hipertensiva
Insuficiencia renal
Hipertensión arterial
Sistema renina-angiotensina
Protección renal
Proteinuria
Diabetes
Abstract

Kidney dysfunction is highly prevalent in the general population and even more so among patients with hypertension, leading to a high risk not only of progression to end-stage renal insufficiency but also of greater cardiovascular morbidity and mortality. Clinical guidelines for chronic kidney disease recommend ambitious blood pressure control (< 130/80mmHg or lower if there is proteinuria) and the use of renin-angiotensin system blockers. However, the evidence for these recommendations in patients with hypertension without diabetes or proteinuria is scarce. The present article reviews this controversy and concludes with recommendations for better renal preservation in patients with hypertension.

Keywords:
Hypertensive nephropathy
Renal insufficiency
Hypertension
Renin-angiotensin system
Renal protection
Proteinuria
Diabetes

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