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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La telangiectasia hemorr&#225;gica hereditaria &#40;HHT&#44; por sus siglas en ingl&#233;s&#44; <span class="elsevierStyleItalic">hereditary hemorrhagic telangiectasia</span>&#41;&#44; o enfermedad de Rendu-Osler-Weber&#44; es una enfermedad sist&#233;mica con herencia autos&#243;mica dominante&#46; Su incidencia mundial es de 1&#47;5&#46;000-8&#46;000 y est&#225; catalogada dentro de las enfermedades minoritarias &#40;EEMM&#41;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">1-4</span></a>&#46; Se han descrito m&#225;s de 800 mutaciones en m&#225;s de 5 genes&#44; pero la gran mayor&#237;a de ellas se localizan en los genes que codifican para la endoglina <span class="elsevierStyleItalic">&#40;ENG&#41;</span> o la activina <span class="elsevierStyleItalic">&#40;ACVRL1&#41;</span><a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; Ambas prote&#237;nas forman parte de la familia del factor transformante de crecimiento &#946;&#44; que interviene en las v&#237;as de se&#241;alizaci&#243;n vascular&#44; influyendo en la regulaci&#243;n de la angiog&#233;nesis<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">6</span></a>&#46; As&#237;&#44; alteraciones en estas prote&#237;nas dan lugar a un crecimiento vascular an&#243;malo y excesivo&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A pesar de ser una enfermedad gen&#233;tica&#44; su diagn&#243;stico es cl&#237;nico y se realiza de acuerdo con los criterios de Cura&#231;ao<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La telangiectasia es la lesi&#243;n caracter&#237;stica de la HHT y consiste en la sustituci&#243;n del lecho capilar normal por una conexi&#243;n aberrante directa entre arteriola y v&#233;nula<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">8</span></a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Las telangiectasias pueden localizarse en piel y mucosas&#44; especialmente en la mucosa nasal&#44; causando epistaxis recurrentes&#44; que es el principal s&#237;ntoma en esta enfermedad&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Al ser una enfermedad sist&#233;mica&#44; puede existir afectaci&#243;n vascular en cualquier &#243;rgano&#44; aunque mayoritariamente afecta a pulmones e h&#237;gado&#46; Esta afectaci&#243;n se sit&#250;a tanto a nivel de la microvasculatura &#40;en forma de telangiectasias&#41; como en forma de f&#237;stulas arterio-venosas &#40;AV&#41; o aneurismas en vasos de mayor tama&#241;o<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">5&#44;7&#44;9</span></a>&#46; Se recomienda realizar un cribado de estas posibles malformaciones vasculares para su detecci&#243;n precoz y manejo de acuerdo con la evidencia cient&#237;fica&#44; as&#237; como un seguimiento adecuado de los pacientes<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">10&#44;11</span></a>&#46; Aunque no existe un tratamiento curativo&#44; existen f&#225;rmacos con resultados positivos en diferentes aspectos de la enfermedad<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">12-14</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El car&#225;cter sist&#233;mico de la HHT&#44; su baja prevalencia y gran variabilidad cl&#237;nica hacen que el conocimiento de la enfermedad sea complejo&#44; especialmente en situaciones infrecuentes&#46; Este aspecto es com&#250;n en el terreno de las EEMM&#44; donde es dif&#237;cil acumular experiencia suficiente sobre el curso natural de una enfermedad y el pron&#243;stico de estos pacientes&#46; La elaboraci&#243;n de registros contribuye a superar estas dificultades&#44; representando una prioridad en el manejo de las EEMM<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">15&#44;16</span></a>&#46; El uso de registros de calidad permite adem&#225;s consensuar medidas diagn&#243;stico-terap&#233;uticas&#44; reflejar el manejo de los pacientes en la pr&#225;ctica cl&#237;nica habitual&#44; ofrecer evidencia para la elaboraci&#243;n de gu&#237;as cl&#237;nicas y generar hip&#243;tesis para la elaboraci&#243;n de ensayos cl&#237;nicos<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">16-19</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Presentamos el desarrollo del primer y &#250;nico registro de la HHT en Espa&#241;a&#44; el Registro Informatizado de la Telangiectasia Hemorr&#225;gica Hereditaria &#40;Registro RiHHTa&#41;&#44; las caracter&#237;sticas cl&#237;nicas y los aspectos diagn&#243;sticos relevantes de los primeros pacientes introducidos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todo</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dise&#241;o del Registro RiHHTa</span><p id="par0035" class="elsevierStylePara elsevierViewall">El RiHHTa es un registro multic&#233;ntrico&#44; prospectivo y observacional&#44; desarrollado dentro del Grupo de Trabajo en Enfermedades Minoritarias &#40;GTEM&#41; de la Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;&#46; Su dise&#241;o es <span class="elsevierStyleItalic">on-line</span>&#44; desde la direcci&#243;n <a id="intr0005" class="elsevierStyleInterRef" href="https://rihhta.healthincode.com/">https&#58;&#47;&#47;RiHHTa&#46;healthincode&#46;com</a>&#44; con acceso de forma individualizada para cada investigador&#44; en idiomas espa&#241;ol e ingl&#233;s &#40;por la posibilidad de internacionalizarse en un futuro&#41;&#46; Los principales objetivos de dicho registro son&#58; mejorar el manejo de los pacientes con HHT&#44; contribuir a la difusi&#243;n y el conocimiento de la enfermedad y consensuar medidas diagn&#243;stico-terap&#233;uticas entre sus miembros &#40;como forma de trabajo en red&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Para su creaci&#243;n&#44; se ha dispuesto de la colaboraci&#243;n no remunerada de la empresa de estudios gen&#233;ticos Health in Code &#40;A Coru&#241;a&#41;&#44; con amplia experiencia en registros de miocardiopat&#237;as<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Adem&#225;s&#44; permite la creaci&#243;n de informes personalizados para cada paciente&#44; de utilidad en la labor asistencial de los investigadores participantes&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pacientes y variables</span><p id="par0045" class="elsevierStylePara elsevierViewall">Los pacientes incluidos son aquellos con diagn&#243;stico cl&#237;nico de acuerdo con los criterios de Cura&#231;ao<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a> o bien con diagn&#243;stico gen&#233;tico&#44; que hayan firmado el consentimiento informado para la introducci&#243;n de sus datos en el Registro RiHHTa&#46; Est&#225; organizado por familias y las variables se dividen en 5 grandes apartados&#58; datos demogr&#225;ficos&#44; cl&#237;nicos&#44; exploraciones complementarias&#44; tratamiento y evoluci&#243;n&#46; La gravedad de las epistaxis se cuantific&#243; mediante el Epistaxis Severity Score<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">22</span></a>&#46; La valoraci&#243;n del paso de contraste mediante ecocardiograf&#237;a para detectar f&#237;stulas AV pulmonares se realiz&#243; de acuerdo a la clasificaci&#243;n de Barzilai et al&#46; en 4 grados<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">23</span></a>&#46; Para el estudio de afectaci&#243;n del tracto digestivo&#44; se siguieron las recomendaciones de practicarlo en aquellos pacientes con anemia desproporcionada al grado de epistaxis<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">La introducci&#243;n de los datos personales de los pacientes incluidos en el registro&#44; su tratamiento y comunicaci&#243;n se ajustaron a lo dispuesto en la Ley de Protecci&#243;n de Datos de Car&#225;cter Personal&#46; Para salvaguardar la identidad de los pacientes incluidos&#44; el Registro RiHHTa genera un identificador encriptado para cada paciente&#46; El dise&#241;o y el funcionamiento del Registro RiHHTa fue aprobado por el Comit&#233; de &#201;tica del Hospital Universitari de Bellvitge &#40;Barcelona&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0055" class="elsevierStylePara elsevierViewall">Los resultados fueron expresados mediante frecuencias absolutas y relativas para las variables cualitativas&#59; para las variables cuantitativas se utilizaron la media&#44; la desviaci&#243;n est&#225;ndar y el rango&#46; El an&#225;lisis descriptivo se llev&#243; a cabo para el global de la muestra&#46; La comparaci&#243;n entre grupos de la distribuci&#243;n de las variables categ&#243;ricas se realiz&#243; mediante la prueba de la chi al cuadrado&#46; La comparaci&#243;n de la distribuci&#243;n de las variables cuantitativas que no segu&#237;an una distribuci&#243;n normal se efectu&#243; mediante la prueba de la t de Student y&#44; en caso contrario&#44; se utiliz&#243; la prueba de Mann-Whitney&#46; Se consider&#243; que las diferencias eran significativas cuando p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; El an&#225;lisis estad&#237;stico fue realizado mediante el programa inform&#225;tico SPSS versi&#243;n 18&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; USA&#41;&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0060" class="elsevierStylePara elsevierViewall">El Registro RiHHTa se puso en funcionamiento el 6 de junio del 2016&#46; Desde entonces y hasta diciembre del 2017&#44; se introdujo a 152 pacientes de 104 familias&#46; De estos pacientes&#44; se ha dispuesto de datos suficientes para ser analizados de un total de 141 pacientes de 92 familias&#46; Todos los pacientes eran de raza cauc&#225;sica excepto 2&#44; de raza hispana y oriental&#46; La edad media fue de 51&#44;2 a&#241;os y 91 &#40;64&#44;5&#37;&#41; pacientes eran mujeres&#46; La comorbilidad de los pacientes se muestra en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; Cabe destacar que de los 8 &#40;5&#44;7&#37;&#41; pacientes con fibrilaci&#243;n auricular&#44; se practic&#243; un cierre de la orejuela en 2 de ellos por contraindicaci&#243;n para la anticoagulaci&#243;n&#46; Adem&#225;s&#44; casi un tercio &#40;27&#44;7&#37;&#41; de los pacientes hab&#237;a sido sometido a alguna cirug&#237;a previa y exist&#237;a historia familiar de c&#225;ncer en 17 &#40;12&#44;1&#37;&#41; pacientes&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">La forma de comienzo de la HHT fue en forma de epistaxis recurrente en 130 &#40;92&#44;2&#37;&#41; pacientes&#44; en 3 &#40;2&#44;1&#37;&#41; pacientes como absceso cerebral debido a f&#237;stulas AV pulmonares no diagnosticadas previamente y por causas diversas&#44; en el resto &#40;5&#44;7&#37;&#41;&#46; La pr&#225;ctica totalidad &#40;97&#44;2&#37;&#41; de los pacientes presentaron epistaxis recurrentes&#44; que requirieron atenci&#243;n urgente en 50 &#40;35&#44;5&#37;&#41; pacientes y transfusi&#243;n de concentrados de hemat&#237;es en 31 &#40;22&#37;&#41; de los pacientes&#46; Respecto a las telangiectasias mucocut&#225;neas&#44; presentes en 126 &#40;89&#44;4&#37;&#41; pacientes&#44; se localizaron mayoritariamente en labios&#44; lengua y pulpejo de los dedos&#46; Casi todos los afectados &#40;89&#44;4&#37;&#41; presentaron antecedentes familiares de HHT y la mayor&#237;a &#40;63&#44;8&#37;&#41; afectaci&#243;n visceral&#46; De acuerdo con los criterios de Cura&#231;ao&#44; 122 &#40;86&#44;5&#37;&#41; sujetos cumpl&#237;an 3 o m&#225;s criterios&#44; lo que constituye un diagn&#243;stico definitivo&#46; A pesar de ello&#44; la edad media al diagn&#243;stico fue de 42&#44;1 a&#241;os&#46; Las caracter&#237;sticas cl&#237;nicas de los pacientes en relaci&#243;n con la HHT se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Respecto a las pruebas de cribado&#44; no se detect&#243; paso de contraste en la ETT o este fue de grado 1 en 59 &#40;41&#44;8&#37;&#41; pacientes&#46; A pesar de ello&#44; se realiz&#243; una angio-TC tor&#225;cica a 36 de ellos&#44; de los cuales solo en 7 se detect&#243; f&#237;stula AV pulmonar&#44; que fue &#250;nica en 6 pacientes y no susceptible de embolizaci&#243;n en ning&#250;n caso&#46; Se detectaron f&#237;stulas AV pulmonares en 36 &#40;45&#44;5&#37;&#41; de los 79 pacientes estudiados mediante angio-TC pulmonar&#44; con una media de 2&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;1-14&#41; fistulas AV pulmonares por paciente&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En cuanto a la afectaci&#243;n hep&#225;tica&#44; esta se objetiv&#243; en 43 &#40;67&#44;2&#37;&#41; de los 64 pacientes a los que se les estudi&#243;&#46; Estos presentaban una tendencia a concentraciones m&#225;s elevadas de las enzimas de colestasis&#44; con unos valores de bilirrubina significativamente superiores que los individuos sin afectaci&#243;n hep&#225;tica&#46; En lo concerniente al h&#237;gado&#44; fueron m&#225;s frecuentes las telangiectasias&#44; las f&#237;stulas AV y las arterio-portales&#46; Cuando se practic&#243; angio-TC abdominal se detectaron otras afectaciones vasculares extrahep&#225;ticas en 14 &#40;10&#37;&#41; pacientes&#44; mayoritariamente pancre&#225;ticas&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Se efectu&#243; estudio gen&#233;tico a 64 &#40;45&#44;4&#37;&#41; afectados&#44; objetiv&#225;ndose mutaci&#243;n en el gen <span class="elsevierStyleItalic">ENG</span> y el <span class="elsevierStyleItalic">ACVRL1</span> en 20 &#40;31&#44;2&#37;&#41; y 44 &#40;68&#44;8&#37;&#41; pacientes&#44; respectivamente&#46; La gran mayor&#237;a &#40;64&#44;7&#37;&#41; de los que presentaban mutaciones en <span class="elsevierStyleItalic">ENG</span> mostraban afectaci&#243;n pulmonar y la pr&#225;ctica totalidad &#40;95&#44;6&#37;&#41; de los que presentaron mutaci&#243;n en <span class="elsevierStyleItalic">ACVRL1</span> ten&#237;an afectaci&#243;n hep&#225;tica&#46; Los 2 &#40;1&#44;4&#37;&#41; pacientes con un solo criterio de Cura&#231;ao y 5 de los 17 &#40;12&#44;1&#37;&#41; con solo 2 criterios pose&#237;an un estudio gen&#233;tico con mutaci&#243;n en el gen <span class="elsevierStyleItalic">ACVRL1</span>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">La afectaci&#243;n cerebral se detect&#243; tan solo en 3 &#40;3&#44;9&#37;&#41; de los sujetos estudiados&#44; sin repercusi&#243;n cl&#237;nica en ninguno de ellos&#46; Se sospecharon p&#233;rdidas digestivas en 36 pacientes&#44; de los cuales 20 &#40;55&#44;5&#37;&#41; presentaron telangiectasias en el tubo digestivo&#44; con predominio &#40;95&#37;&#41; en tracto digestivo superior&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> se reflejan los resultados de todas las exploraciones complementarias&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discusi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">El Registro RiHHTa pone en evidencia la necesidad de optimizar el diagn&#243;stico precoz de los pacientes con HHT&#46; La HHT presenta una cl&#237;nica dependiente de la edad&#44; con un desarrollo progresivo de signos y s&#237;ntomas desde la edad pedi&#225;trica hasta la cuarta d&#233;cada de vida<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">3&#44;24</span></a>&#46; A pesar de ello&#44; en una poblaci&#243;n adulta con una edad media de 51 a&#241;os&#44; la edad media al diagn&#243;stico en el Registro RiHHTa fue de 42 a&#241;os&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La recurrencia y la gravedad de las epistaxis es el factor que m&#225;s repercute en la calidad de vida de estos pacientes&#44; as&#237; como la necesidad de consultar a Urgencias y de transfusiones sangu&#237;neas&#44; como ocurri&#243; en el 35&#44;5 y el 22&#37; de los pacientes incluidos en el RiHHTa<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; Precisamente&#44; la detecci&#243;n de pacientes con epistaxis recurrentes y antecedentes familiares deber&#237;a alertar a los cl&#237;nicos sobre una posible HHT y representa una oportunidad para optimizar el diagn&#243;stico precoz de la HHT&#46; Estos 2 datos junto a un simple examen de las manos o cavidad oral detectando telangiectasias mucocut&#225;neas&#44; presentes en el 89&#44;4&#37; de los pacientes del registro RiHHTa&#44; definir&#237;a un diagn&#243;stico definitivo de HHT &#40;seg&#250;n criterios de Cura&#231;ao&#41;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Los registros en las EEMM permiten conocer situaciones poco prevalentes de una enfermedad&#44; dif&#237;cilmente reconocibles desde un &#250;nico centro<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">15-17</span></a>&#46; As&#237;&#44; en el Registro RiHHTa&#44; al menos 20 &#40;14&#44;2&#37;&#41; pacientes ten&#237;an indicaci&#243;n de anticoagulaci&#243;n &#40;10 por cardiopat&#237;a y 10 por enfermedad tromboemb&#243;lica venosa &#91;ETV&#93;&#41;&#46; La HHT no supone por s&#237; sola una contraindicaci&#243;n absoluta para la anticoagulaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">27</span></a>&#46; As&#237;&#44; en un trabajo mediante entrevistas <span class="elsevierStyleItalic">on-line</span>&#44; un 38&#37; de 150 pacientes que refer&#237;an haber recibido anticoagulaci&#243;n no manifestaron empeoramiento de sus epistaxis habituales<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">27</span></a>&#46; Sin embargo&#44; en aquellos pacientes con fibrilaci&#243;n auricular y contraindicaci&#243;n para la anticoagulaci&#243;n se recomienda la realizaci&#243;n de un cierre de la orejuela de la aur&#237;cula izquierda&#44; como se realiz&#243; en 2 casos del Registro RiHHTa<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">28</span></a>&#46; Por otro lado&#44; la anemia ferrop&#233;nica se ha relacionado con una elevaci&#243;n compensatoria del factor <span class="elsevierStyleSmallCaps">viii</span> y con un aumento del riesgo de ETV en los pacientes con HHT<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">29&#44;30</span></a>&#46; De hecho&#44; el 7&#37; de pacientes con ETV en el Registro es superior a la incidencia esperada en una poblaci&#243;n con una edad media entre 50 y 59 a&#241;os&#44; que ser&#237;a del 1&#47;1&#46;000<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">31</span></a>&#46; El Registro RiHHTa podr&#225; dar informaci&#243;n futura sobre la tolerancia de la anticoagulaci&#243;n en los pacientes con HHT en la pr&#225;ctica cl&#237;nica habitual&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La afectaci&#243;n hep&#225;tica result&#243; la manifestaci&#243;n visceral m&#225;s frecuente&#44; en consonancia con una mayor prevalencia de mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span><a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; Las mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span> definen la HHT tipo <span class="elsevierStyleSmallCaps">ii</span>&#44; con mayor prevalencia de afectaci&#243;n hep&#225;tica&#44; como ocurri&#243; en el 95&#37; de los pacientes con mutaciones en este gen incluidos en el RiHHTa<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; La forma de afectaci&#243;n hep&#225;tica m&#225;s frecuente han sido las telangiectasias&#44; que no suelen presentar s&#237;ntomas<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Los 3 tipos de afectaci&#243;n vascular identificados mediante la angio-TC abdominal implican un seguimiento y complicaciones distintas&#46; As&#237;&#44; las fistulas AV y porto-venosas pueden ocasionar signos y s&#237;ntomas de insuficiencia card&#237;aca con un &#237;ndice card&#237;aco elevado<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">32&#44;33</span></a>&#46; Sin embargo&#44; este par&#225;metro tan solo fue reportado en el Registro en la mitad de los 16 pacientes con esta afectaci&#243;n&#46; La angio-TC abdominal tambi&#233;n permiti&#243; detectar las f&#237;stulas arterio-portales que pueden ocasionar hipertensi&#243;n portal&#44; que debe buscarse durante el seguimiento&#46; Valores anal&#237;ticos alterados en la funci&#243;n hep&#225;tica&#44; se han relacionado con mayor riesgo de afectaci&#243;n hep&#225;tica cl&#237;nicamente significativa<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">34</span></a>&#46; De hecho&#44; los pacientes con afectaci&#243;n hep&#225;tica en el RiHHTa presentaban mayor elevaci&#243;n de par&#225;metros de colestasis respecto a los que no ten&#237;an esta afectaci&#243;n&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">La ETT con contraste es la prueba de elecci&#243;n para el cribado de f&#237;stulas AV pulmonares<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; Estas son m&#225;s frecuentes en los pacientes con mutaciones en el gen <span class="elsevierStyleItalic">ENG</span>&#44; que define la HHT tipo <span class="elsevierStyleSmallCaps">i</span>&#44; como ocurri&#243; en el 64&#37; de los pacientes incluidos en el RiHHTa que presentaban mutaciones en este gen<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">5</span></a>&#46; En un trabajo realizado con 95 pacientes&#44; los 24 pacientes sin paso de contraste y los 34 pacientes con grado 1&#44; de acuerdo con la Clasificaci&#243;n de Barzilai&#44; no presentaron fistulas AV en la angio-TC tor&#225;cica<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">23&#44;35</span></a>&#46; A pesar de ello&#44; en el RiHHTa se realiz&#243; innecesariamente una angio-TC tor&#225;cica a 36 de los 59 pacientes con grados 0 o 1&#46; Es necesario realizar un correcto cribado de las manifestaciones de la enfermedad que reduzcan sus complicaciones&#46; En este sentido&#44; 3 pacientes comenzaron con abscesos cerebrales como s&#237;ntoma inicial&#46; La detecci&#243;n previa de f&#237;stulas AV pulmonares hubiera permitido administrar profilaxis antibi&#243;tica ante situaciones de riesgo y valorar su embolizaci&#243;n&#44; reduciendo as&#237; el riesgo de dicha complicaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; De hecho&#44; los abscesos cerebrales&#44; presentes en 7 &#40;5&#37;&#41; pacientes del Registro RiHHTa&#44; son una complicaci&#243;n prevenible y frecuente en los individuos con HHT&#44; m&#225;s de 30 veces superior que en la poblaci&#243;n general<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">36</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Las malformaciones cerebrales presentan un comportamiento diferente&#44; ya que est&#225;n presentes desde el nacimiento<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">3</span></a>&#46; Sin embargo&#44; dada la baja prevalencia y las dificultades terap&#233;uticas&#44; no existe un elevado grado de evidencia ni recomendaciones para realizar cribado de ellas en los sujetos adultos asintom&#225;ticos con HHT<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">11&#44;37&#44;38</span></a>&#46; A pesar de ello&#44; en el Registro RiHHTa se practic&#243; estudio de malformaciones arteriovenosas cerebrales a 77 &#40;54&#44;6&#37;&#41; pacientes&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">La afectaci&#243;n del tubo digestivo es la manifestaci&#243;n m&#225;s tard&#237;a&#44; iniciando sobre la 5&#46;&#170; o 6&#46;&#170; d&#233;cadas de la vida<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">39&#44;40</span></a>&#46; Su estudio se recomienda en aquellos pacientes con anemia desproporcionada al grado de epistaxis<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">11</span></a>&#46; Esto se debe a que&#44; si bien el 80&#37; de los pacientes con HHT presentan telangiectasias en el tubo digestivo&#44; tan solo un 25-30&#37; desarrollar&#225; una afectaci&#243;n digestiva sintom&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">41&#44;42</span></a>&#46; El predominio de afectaci&#243;n a nivel gastroduodenal observado en el RiHHTa ha sido escasamente publicado y apoya la recomendaci&#243;n de iniciar el cribado con una esofagogastroduodenoscopia<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">39&#44;41&#44;42</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el Registro RiHHTa representa una iniciativa de trabajo coordinado entre sus miembros que aporta informaci&#243;n de situaciones infrecuentes y permite identificar puntos de mejora en el manejo de los pacientes con HHT&#46; Se ha detectado un uso inadecuado de la angio-TC tor&#225;cica y la utilidad de la angio-TC abdominal para poder definir subtipos de afectaci&#243;n vascular hep&#225;tica y detectar afectaci&#243;n vascular extrahep&#225;tica&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Autor&#237;a</span><p id="par0130" class="elsevierStylePara elsevierViewall">Concepci&#243;n y dise&#241;o del manuscrito&#58; Antoni Riera-Mestre&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Recogida de datos&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Rosario Sanchez Mart&#237;nez&#44; Miguel Angel Torralba Cabeza&#44; Jos&#233; Luis Patier de la Pe&#241;a&#44; Mar&#237;a Coloma Juyol Rodrigo&#44; Daniel Lopez Wolf&#44; Ana Ojeda Sosa&#44; Lorenzo Monserrat&#44; M&#243;nica L&#243;pez Rodr&#237;guez&#59; y los investigadores del Registro RiHHTa del Grupo de Trabajo de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna incluidos en el <a class="elsevierStyleCrossRef" href="#sec0050">anexo 1</a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">An&#225;lisis e interpretaci&#243;n de los datos&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Miguel Angel Torralba Cabeza&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Redacci&#243;n&#44; revisi&#243;n&#44; aprobaci&#243;n del manuscrito remitido&#58; Antoni Riera-Mestre&#44; Jos&#233; Mar&#237;a Mora Luj&#225;n&#44; Rosario Sanchez Mart&#237;nez&#44; Miguel Angel Torralba Cabeza&#44; Jos&#233; Luis Patier de la Pe&#241;a&#44; Mar&#237;a Coloma Juyol Rodrigo&#44; Daniel Lopez Wolf&#44; Ana Ojeda Sosa&#44; Lorenzo Monserrat&#44; M&#243;nica L&#243;pez Rodr&#237;guez y los investigadores del Registro RiHHTa del Grupo de Trabajo de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna incluidos en el <a class="elsevierStyleCrossRef" href="#sec0050">anexo 1</a>&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflicto de intereses</span><p id="par0150" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La telangiectasia hemorr&#225;gica hereditaria &#40;HHT&#44; por sus siglas en ingl&#233;s&#41; es una enfermedad minoritaria con herencia autos&#243;mica dominante que provoca una afectaci&#243;n vascular sist&#233;mica&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Tras la elaboraci&#243;n de un registro nacional espa&#241;ol multic&#233;ntrico&#44; denominado RiHHTa&#44; se describen las principales manifestaciones cl&#237;nicas y procedimientos diagn&#243;sticos de los primeros pacientes introducidos&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se han introducido datos de 141 pacientes&#44; de los que 91 &#40;64&#44;5&#37;&#41; eran mujeres&#46; La edad media al diagn&#243;stico fue de 42 a&#241;os&#46; Las mutaciones en el gen <span class="elsevierStyleItalic">ACVRL1</span> predominaron sobre el gen <span class="elsevierStyleItalic">ENG</span>&#46; El s&#237;ntoma inicial fue la epistaxis recurrente en 130 &#40;92&#44;2&#37;&#41; pacientes y en 3 &#40;2&#44;1&#37;&#41;&#44; el absceso cerebral&#46; Se detectaron f&#237;stulas arteriovenosas &#40;AV&#41; pulmonares en 36 &#40;45&#37;&#41; de los 79 pacientes a los que se les practic&#243; una angio-TC tor&#225;cica&#46; En 36 &#40;45&#37;&#41; de estos 79 afectados no se hab&#237;a detectado paso de contraste en la ecocardiograf&#237;a o este era grado 1&#46; En 43 &#40;67&#44;2&#37;&#41; de los 64 pacientes con una angio-TC abdominal se detectaron malformaciones vasculares hep&#225;ticas&#44; mayoritariamente telangiectasias&#44; f&#237;stulas AV y arterio-portales&#44; y extrahep&#225;ticas en 14 &#40;10&#37;&#41; sujetos&#46; Se realiz&#243; cribado de malformaci&#243;n AV cerebral a m&#225;s de la mitad de los pacientes&#44; detect&#225;ndose en un 3&#44;9&#37;&#46; La parte del tubo digestivo m&#225;s afectada fue la superior &#40;95&#37;&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El Registro RiHHTa permite identificar puntos de mejora en el manejo de los pacientes con HHT&#46; Se ha detectado un uso inadecuado de la angio-TC tor&#225;cica y la utilidad de la angio-TC abdominal para definir los subtipos de afectaci&#243;n vascular hep&#225;tica y detectar afectaci&#243;n vascular extrahep&#225;tica&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Hereditary hemorrhagic telangiectasia &#40;HHT&#41; is a rare disease with autosomal dominant inheritance that causes systemic vascular affectation&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">After development a multicentric Spanish national registry&#44; called RiHHTa&#44; main clinical manifestations and diagnostic procedures of the first patients introduced are described&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">141 patients were included&#44; of which 91 &#40;64&#46;5&#37;&#41; were women&#46; The mean age at diagnosis was 42 years&#46; Mutations in the <span class="elsevierStyleItalic">ACVRL1</span> gene predominated over the <span class="elsevierStyleItalic">ENG</span> gene&#46; The initial symptom was recurrent epistaxis in 130 &#40;92&#46;2&#37;&#41; patients and in three &#40;2&#46;1&#37;&#41;&#44; brain abscess&#46; Pulmonary arteriovenous &#40;AV&#41; fistula were detected in 36 &#40;45&#37;&#41; of the 79 patients who underwent thoracic CT angiography&#46; The contrast echocardiography detected very few bubbles &#40;grade I&#41; or none&#44; in 36 &#40;45&#37;&#41; of these 79 affected patients&#46; In 43 &#40;67&#46;2&#37;&#41; of the 64 patients with an abdominal CT angiography&#44; hepatic vascular malformations were detected&#44; mostly telangiectasias&#44; AV and arterio-portal fistula&#44; and extrahepatic in 14 &#40;10&#37;&#41; subjects&#46; More than half of the patients were screened for the presence of brain arteriovenous malformations which was found in 3&#46;9&#37; of them&#46; The upper part of the intestinal tube was the most &#40;95&#37;&#41; affected region&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The RiHHTa Registry allows improving the management of patients with HHT&#46; An inadequate use of thoracic CT angiography and the usefulness of abdominal CT angiography has been detected in order to define subtypes of hepatic vascular involvement and detect extrahepatic vascular involvement&#46;</p></span>"
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            "apendice" => "<p id="par0160" class="elsevierStylePara elsevierViewall">Coordinador del Registro RiHHTa&#58; A&#46; Riera-Mestre&#46; C&#46; Alonso Cotoner&#44; M&#46; Beneyto Florido&#44; A&#46; Fern&#225;ndez&#44; R&#46; Gil S&#225;nchez&#44; J&#46;S&#46; Garc&#237;a Morillo&#44; J&#46;F&#46; G&#243;mez Cerezo&#44; V&#46; G&#243;mez del Olmo&#44; P&#46; Iglesias&#44; M&#46;C&#46; Juyol Rodrigo&#44; N&#46; Lopez Osle&#44; M&#46; L&#243;pez Rodr&#237;guez&#44; D&#46; L&#243;pez Wolf&#44; M&#46;C&#46; Moreno de la Santa Garc&#237;a&#44; A&#46; Ojeda Sosa&#44; J&#46;L&#46; Patier de la Pe&#241;a&#44; M&#46;L&#46; Perez Garcia&#44; A&#46; Riera-Mestre&#44; R&#46; S&#225;nchez Mart&#237;nez&#44; M&#46;A&#46; Torralba Cabeza&#44; R&#46; Zarrabeitia Puente&#46;</p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Miembros del Registro RiHHTa del Grupo de Trabajo y de Enfermedades Minoritarias de la Sociedad Espa&#241;ola de Medicina Interna"
            "identificador" => "sec0050"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La HHT se define como definitiva &#40;en pacientes con 3 o m&#225;s criterios&#41;&#44; probable &#40;si se cumplen 2 criterios&#41; e improbable &#40;si cumplen uno o ninguno&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">GI&#58; gastrointestinales&#59; HHT&#58; telangiectasia hemorr&#225;gica hereditaria&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Fuente&#58; Shovlin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">7</span></a>&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Criterio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Descripci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Epistaxis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#250;ltiples&#44; en sitios caracter&#237;sticos&#58; labios&#44; cavidad oral&#44; dedos&#44; fosas nasales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lesiones viscerales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Familiar de primer grado con HHT de acuerdo con estos criterios&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">EP&#58; embolia pulmonar&#59; ETV&#58; enfermedad tromboemb&#243;lica venosa&#59; IMC&#58; &#237;ndice de masa corporal&#59; TVP&#58; trombosis venosa profunda&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top" style="border-bottom: 2px solid black">Pacientes&#44; N&#46;&#176;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top" style="border-bottom: 2px solid black">141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Caracter&#237;sticas cl&#237;nicas</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>G&#233;nero &#40;femenino&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;64&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad&#44; a&#241;os &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;2 &#40;13-89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Peso&#44; kg &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;6 &#40;45-162&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Altura&#44; cm &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">165&#44;90<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;2 &#40;147-189&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IMC&#44; kg&#47;m<span class="elsevierStyleSup">2</span> &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;8 &#40;16&#44;6-56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>IMC<span class="elsevierStyleHsp" style=""></span>&#62; 30 kg&#47;m<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Comorbilidades</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tabaquismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;12&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Extabaquismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13 &#40;9&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Alcoholismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;5&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27 &#40;19&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 &#40;4&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;15&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;18&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fibrilaci&#243;n auricular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;5&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pr&#243;tesis valvular mec&#225;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neumopat&#237;a cr&#243;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 &#40;8&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Enfermedad cerebrovascular isqu&#233;mica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Absceso cerebral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Antecedente quir&#250;rgico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;27&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Osteoporosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 &#40;7&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&#225;ncer&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Edad al diagn&#243;stico&#44; a&#241;os &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;5 &#40;7-81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Criterios de Cura&#231;ao</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;12&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45 &#40;31&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77 &#40;54&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Epistaxis recurrente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137 &#40;97&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ESS &#40;media&#177;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;5 &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Atenci&#243;n en Urgencias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;35&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;51&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Transfusi&#243;n de CCHH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Telangiectasias cut&#225;neo-mucosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 &#40;89&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Digitales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;52&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Linguales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;64&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Labiales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">95 &#40;67&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Orales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;24&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Conjuntivales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9 &#40;6&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Otras localizaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;30&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lesiones viscerales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;63&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Historia familiar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 &#40;89&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">ALT&#58; alanina aminotransferasa&#59; AST&#58; aspartato aminotransferasa&#59; AV&#44; arterio-venosa&#59; FA&#58; fosfatasa alcalina&#59; GGT&#58; gamma glutamiltranspeptidasa&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pacientes&#44; N&#46;&#176;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">An&#225;lisis de sangre &#40;media</span> &#177; <span class="elsevierStyleBold">DE&#59; rango&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hemoglobina&#44; g&#47;dl</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;4 &#40;5&#44;6-18&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Leucocitos</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">9</span></span><span class="elsevierStyleItalic">&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;1 &#40;2&#44;2-24&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Plaquetas</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#215;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">10</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">9</span></span><span class="elsevierStyleItalic">&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">265&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>88&#44;4 &#40;124-669&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">INR</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;12 &#40;0&#44;7-1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinina&#44; &#956;mol&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;2 &#40;47&#44;7-150&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Filtrado Glomerular&#44; ml&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">93&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;4 &#40;50&#44;8-150&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Ferritina&#44; mg&#47;l</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>149&#44;4 &#40;3-1137&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">IST&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;0 &#40;2-44&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Ecocardiograf&#237;a transtor&#225;cica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">86&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Grado paso burbujas</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;38&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;30&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;23&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;5&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 &#40;2&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Fracci&#243;n de eyecci&#243;n &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">67&#41;&#44; &#37; &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;4 &#40;40-80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Presi&#243;n arterial pulmonar sist&#243;lica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">32&#41;&#44; mmHg &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;42 &#40;16-66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Gasto card&#237;aco &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">23&#41;&#44; l&#47;min &#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;9 &#40;2&#44;6-11&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#205;ndice card&#237;aco &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">17&#41;&#44; l&#47;min&#47;m</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#40;media</span> &#177; <span class="elsevierStyleItalic">DE&#59; rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;2 &#40;1&#44;7-6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Mutaci&#243;n gen&#233;tica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">64&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ENG</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;31&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#47;17 &#40;64&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#47;14 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACVRL1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;68&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#47;26 &#40;30&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Afectaci&#243;n hep&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#47;23 &#40;95&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleBold">Afectaci&#243;n visceral</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">F&#237;stula AV pulmonar &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">79&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;54&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36 &#40;45&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Numero de f&#237;stulas AV &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7 &#40;1-14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Afectaci&#243;n hep&#225;tica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">64&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;32&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ALT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AST&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FA&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>GGT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>37&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Bilirrubina&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;21<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;67&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>ALT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>AST&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>FA&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">113&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>96&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>GGT&#44; U&#47;l&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>91&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Bilirrubina&#44; mg&#47;dl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;5<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tipo de afectaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Telangiectasias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas AV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas porto-venosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>F&#237;stulas arterio-portales&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hiperplasia nodular focal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hiperplasia nodular regenerativa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Otra afectaci&#243;n intraabdominal</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14 &#40;10&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pancre&#225;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Malformaci&#243;n AV cerebral &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">77&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;96&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 &#40;3&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Afectaci&#243;n tubo digestivo &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">20&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad media&#44; a&#241;os &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;9 &#40;44-83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Edad media al diagn&#243;stico&#44; a&#241;os &#40;media &#177; DE&#59; rango&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">53&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;0 &#40;27-80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Tipo de afectaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Gastro-duodenal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Gastro-duodeno-colon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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