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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Con fecha del 16 de abril de 2021&#44; el n&#250;mero de casos de COVID-19 causado por SARS-CoV-2 &#40;coronavirus de tipo 2 causante del s&#237;ndrome respiratorio agudo severo&#41; alcanz&#243; en Espa&#241;a los 3&#46;407&#46;283&#44; de los cuales&#44; 340&#46;130 &#40;9&#44;98&#37;&#41; han precisado ingreso hospitalario y 31&#46;054 &#40;0&#44;91&#37;&#41; ingreso en unidades de cuidados intensivos &#40;UCI&#41;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El espectro cl&#237;nico de la infecci&#243;n por SARS-CoV-2 var&#237;a desde un cuadro leve caracterizado por fiebre&#44; tos&#44; seguido por expectoraci&#243;n y fatiga&#44; hasta cuadros graves en pacientes cr&#237;ticos caracterizados por sepsis&#44; coagulopat&#237;a&#44; fracaso respiratorio y desarrollo de s&#237;ndrome de distr&#233;s respiratorio del adulto<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La mortalidad acumulada en Espa&#241;a hasta el 16 de abril de 2021 ha sido de 76&#46;981 &#40;2&#44;25&#37;&#41; pacientes&#44; pero en los pacientes con ingreso en UCI&#44; la mortalidad alcanza el 31&#37;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">3</span></a>&#46; Varios estudios coinciden en que los factores de riesgo asociados con el desarrollo de mortalidad incluyen edad avanzada&#44; presencia de insuficiencia renal&#44; niveles bajos de saturaci&#243;n de ox&#237;geno y valores elevados de prote&#237;na C reactiva<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">La identificaci&#243;n precoz de los pacientes que van a necesitar cuidados cr&#237;ticos puede ser importante para proporcionar el tratamiento m&#225;s adecuado y optimizar los recursos disponibles&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El prop&#243;sito del presente estudio es utilizar un amplio registro nacional de pacientes con COVID-19 para desarrollar una escala de riesgo de ingreso en UCI&#44; aplicable a los pacientes que acaban de ingresar en el hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Fuente de datos</span><p id="par0030" class="elsevierStylePara elsevierViewall">La fuente de datos fue el registro SEMI-COVID-19&#44; una cohorte retrospectiva en curso que incluye la mayor parte de pacientes dados de alta o fallecidos tras su ingreso por COVID-19 confirmada en 150 hospitales de Espa&#241;a desde el 1 de marzo de 2020 hasta el 1 de septiembre de 2020<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">6</span></a>&#46; La muestra estuvo formada por un total de 16&#46;298 pacientes&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Desenlace</span><p id="par0035" class="elsevierStylePara elsevierViewall">El desenlace evaluado fue el ingreso en la UCI&#44; medido desde el momento de ingreso en el hospital&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Variables predictoras</span><p id="par0040" class="elsevierStylePara elsevierViewall">Para la elaboraci&#243;n de la regla de predicci&#243;n utilizamos variables disponibles de forma rutinaria en el momento del ingreso hospitalario y que en otros estudios se asociaron con ingreso en UCI&#46; Estas variables incluyeron&#58; &#40;1&#41; demogr&#225;ficas&#44; edad y sexo&#59; &#40;2&#41; comorbilidades e &#237;ndice de comorbilidad de Charlson&#59; &#40;3&#41; signos o s&#237;ntomas&#44; incluidas disnea&#44; confusi&#243;n&#44; hemoptisis&#59; &#40;4&#41; datos de laboratorio&#44; saturaci&#243;n de ox&#237;geno en aire ambiente&#44; valor de LDH&#44; cociente neutr&#243;filos-linfocitos&#44; prote&#237;na C reactiva&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Modelo de derivaci&#243;n</span><p id="par0045" class="elsevierStylePara elsevierViewall">En el modelo de derivaci&#243;n seleccionamos de forma aleatoria dos terceras partes &#40;n &#61; 10&#46;865&#41; de la muestra&#46; Para realizar el modelo de derivaci&#243;n llevamos a cabo un an&#225;lisis de regresi&#243;n log&#237;stica m&#250;ltiple&#44; con ingreso en UCI como desenlace primario y las variables cl&#237;nicas descritas previamente como variables predictoras&#46; Utilizando los coeficientes &#946; generamos un sistema de puntuaci&#243;n que dividi&#243; a los pacientes en diferentes clases de riesgo&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Modelo de validaci&#243;n</span><p id="par0050" class="elsevierStylePara elsevierViewall">El modelo de validaci&#243;n se llev&#243; a cabo utilizando la tercera parte &#40;n &#61; 5&#46;433&#41; restante de la muestra&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">An&#225;lisis estad&#237;stico</span><p id="par0055" class="elsevierStylePara elsevierViewall">Hemos seguido las recomendaciones de la gu&#237;a TRIPOD para desarrollar el modelo de an&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">7</span></a>&#46; Las variables continuas se expresan como media y desviaci&#243;n est&#225;ndar y las variables categ&#243;ricas como frecuencias y porcentajes&#46; Se utiliz&#243; el test de &#967;<span class="elsevierStyleSup">2</span> para la comparaci&#243;n de variables categ&#243;ricas y la <span class="elsevierStyleItalic">t</span> de Student para la comparaci&#243;n de variables continuas entre grupos&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p &#60; 0&#44;05&#46; Se llev&#243; a cabo un an&#225;lisis de regresi&#243;n log&#237;stica m&#250;ltiple en la muestra de derivaci&#243;n para estimar la probabilidad de ingreso en UCI&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para construir el modelo de derivaci&#243;n se seleccionaron aquellas variables con valor de p inferior a 0&#44;10 obtenidas en el modelo univariante&#46; Se estimaron los <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; y su intervalo de confianza al 95&#37; &#40;IC 95&#37;&#41;&#44; a partir de los coeficientes de regresi&#243;n&#46; Se construyeron varios modelos de regresi&#243;n y se seleccion&#243; aquel que fue m&#225;s simple y explicativo basado en el test de bondad de ajuste de Hosmer y Lemeshow para trasladarlo a la cohorte de validaci&#243;n&#46; El R<span class="elsevierStyleSup">2</span> de Nagelkerke fue utilizada para estimar la proporci&#243;n de variaci&#243;n explicada por el modelo&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">El rendimiento final del modelo fue evaluado mediante la curva de caracter&#237;stica operativa del receptor &#40;ROC&#41; y el c&#225;lculo del &#225;rea bajo la curva ROC&#46; Finalmente&#44; con base en los coeficientes &#946; generamos un sistema de puntuaci&#243;n para establecer diferentes riesgos de ingreso en UCI&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico fue realizado con el <span class="elsevierStyleItalic">software</span> libre R versi&#243;n 4&#46;0&#46;2 &#40;Free Software Foundation&#44; Inc&#46; Boston&#44; MA&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Aspectos &#233;ticos</span><p id="par0075" class="elsevierStylePara elsevierViewall">Los datos personales se trataron cumpliendo la Ley 14&#47;2007 del 3 de julio&#44; de Investigaci&#243;n Biom&#233;dica&#44; as&#237; como el reglamento &#40;UE&#41; 2016&#47;679 del Parlamento Europeo y del Consejo del 27 de abril de 2016&#44; Reglamento General de Protecci&#243;n de Datos y la Ley Org&#225;nica 3&#47;2018 del 5 de diciembre sobre Protecci&#243;n de Datos Personales y Garant&#237;a de los Derechos Digitales&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">El Registro SEMI-COVID fue aprobado por el Comit&#233; de &#201;tica e Investigaci&#243;n de la Provincia de M&#225;laga&#46; El departamento de Medicamentos de Uso Humano de la Agencia Espa&#241;ola de Medicamentos y Productos Sanitarios &#40;AEMPS&#41;&#44; de conformidad con los preceptos aplicables ha calificado el estudio como &#171;estudio observacional no postautorizaci&#243;n&#187;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Caracter&#237;sticas de los pacientes ingresados en UCI</span><p id="par0085" class="elsevierStylePara elsevierViewall">Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes fueron ingresados en UCI &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Los pacientes que ingresaron en UCI eran m&#225;s j&#243;venes &#40;edad media 63&#44;3 &#177; 12&#44;3 a&#241;os&#41; que los que ingresaron en &#225;reas de hospitalizaci&#243;n convencional &#40;67&#44;7 &#177; 16&#44;4 a&#241;os&#41; &#40;p &#60; 0&#44;001&#41;&#46; El sexo var&#243;n estuvo asociado con mayor riesgo de ingreso en UCI &#40;69&#44;5 vs&#46; 56&#44;3&#37;&#44; p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Hubo comorbilidades que presentaron mayor riesgo de ingreso en UCI&#44; entre ellas&#44; la obesidad y otras que se asociaron con menor frecuencia de ingreso en UCI&#44; tales como enfermedad renal cr&#243;nica&#44; EPOC o insuficiencia card&#237;aca cr&#243;nica&#46; La condici&#243;n de fumador fue un factor de riesgo de ingreso en UCI&#46; Una mayor proporci&#243;n de pacientes que ingresaron en UCI presentaron disnea en el momento del ingreso &#40;75&#44;4 vs&#46; 56&#37;&#44; p &#60; 0&#44;001&#41;&#44; as&#237; como una menor alteraci&#243;n del nivel de conciencia &#40;8&#44;4 vs&#46; 12&#44;2&#37;&#44; p &#60; 0&#44;001&#41;&#44; mayor frecuencia de la presencia en la radiograf&#237;a de t&#243;rax de infiltrados de tipo difuso en el momento del ingreso en los pacientes que ingresaron en UCI &#40;43 vs&#46; 29&#44;3&#37; p &#60; 0&#44;001&#41; y valores m&#225;s bajos de saturaci&#243;n de ox&#237;geno &#40;SpO<span class="elsevierStyleInf">2</span>&#41; que los pacientes ingresados en &#225;reas de hospitalizaci&#243;n convencional &#40;89 vs&#46; 93&#44;3&#37;&#44; p &#60; 0&#44;001&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Respecto a las variables de laboratorio&#44; los pacientes ingresados en UCI mostraban un mayor cociente neutr&#243;filos-linfocitos &#40;9&#44;7 vs&#46; 7&#44;0&#44; p &#60; 0&#44;001&#41;&#44; mayor nivel de d&#237;mero D &#40;2&#46;969&#44;8 vs&#46; 1&#46;906&#44;6 ng&#47;mL&#44; p &#61; 0&#44;004&#41;&#44; glucosa &#40;138&#44;6 vs&#46; 127&#44;5 mg&#47;dL&#44; p &#60; 0&#44;001&#41;&#44; alanina aminotransferasa &#40;ALT&#41; &#40;49&#44;7 vs&#46; 40&#44;5 U&#47;L&#44; p &#60; 0&#44;001&#41;&#44; lactato deshidrogenasa &#40;501&#44;5 vs&#46; 359&#44;5 U&#47;L&#44; p &#60; 0&#44;001&#41; y prote&#237;na C reactiva &#40;130&#44;7 vs&#46; 84&#44;5 mg&#47;dL&#44; p &#60; 0&#44;001&#41;&#44; que los pacientes ingresados en &#225;reas de hospitalizaci&#243;n convencional&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Un total de 568 &#40;40&#37;&#41; de los pacientes ingresados en UCI fallecieron&#44; mientras que en las plantas de hospitalizaci&#243;n convencional hubo 2&#46;851 &#40;19&#44;2&#37;&#41; fallecimientos&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Modelo predictivo</span><p id="par0105" class="elsevierStylePara elsevierViewall">Para la realizaci&#243;n del modelo predictivo dividimos la muestra de forma aleatoria en dos partes&#44; dos terceras partes correspondieron a la cohorte de derivaci&#243;n y la tercera parte restante a la cohorte de validaci&#243;n&#46; Las caracter&#237;sticas de los pacientes en ambas cohortes se describen en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">En la cohorte de derivaci&#243;n&#44; las variables con mayor asociaci&#243;n con ingreso en UCI en el an&#225;lisis univariante fueron la edad inferior a 75 a&#241;os&#44; un menor &#237;ndice de comorbilidad de Charlson&#44; la presencia de disnea&#44; taquipnea&#44; un cociente neutr&#243;filos-linfocitos superior a 5&#44; los valores de lactato deshidrogenasa superiores a 250 U&#47;L&#44; un valor de urea superior a 40 mg&#47;dL y la presencia de infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; La presencia de c&#225;ncer &#40;tumor s&#243;lido&#44; met&#225;stasis&#44; tumor hematol&#243;gico&#41; y la alteraci&#243;n del nivel de conciencia fueron factores que redujeron el riesgo de ingreso en UCI &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">En el an&#225;lisis multivariante permanecieron en el modelo la edad&#44; la presencia de disnea&#44; la puntuaci&#243;n de Charlson&#44; el cociente de neutr&#243;filos-linfocitos&#44; el valor de l&#225;ctico deshidrogenasa y los datos de la radiograf&#237;a de t&#243;rax del ingreso &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">El valor de p de la bondad de ajuste del modelo multivariante&#44; calculada mediante el estad&#237;stico de Hosmer-Lemeshow&#44; fue de 0&#44;154&#44; indicando un buen ajuste&#46; El valor R<span class="elsevierStyleSup">2</span> de Nagelkerke que muestra el poder explicativo del modelo fue de 0&#44;196&#46; La evaluaci&#243;n del rendimiento del modelo predictivo mostr&#243; un &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41; de 0&#44;780 &#40;IC 95&#37;&#58; 0&#44;763&#44; 0&#44;797&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Para una probabilidad de ingreso en UCI de 0&#44;102 &#40;punto de corte&#41;&#44; el modelo mostr&#243; una sensibilidad del 67&#44;8&#37; y una especificidad del 74&#44;6&#37; en la muestra de derivaci&#243;n&#46; En la cohorte de validaci&#243;n&#44; el AUC es 0&#44;734 y el modelo mostr&#243; una sensibilidad del 62&#44;1&#37; y una especificidad del 72&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Construcci&#243;n del sistema de puntuaci&#243;n</span><p id="par0125" class="elsevierStylePara elsevierViewall">Llevamos a cabo un sistema de puntuaci&#243;n basado en los coeficientes &#946; estimados en el modelo de regresi&#243;n log&#237;stica &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; La puntuaci&#243;n total individual &#40;rango de 0 a 100 puntos&#41; se obtiene sumando los puntos de cada caracter&#237;stica del paciente&#46; Este sistema de puntuaci&#243;n permite estimar la probabilidad de ingreso en UCI &#40;valor predictivo positivo&#41; con los datos obtenidos en el momento del ingreso&#44; de tal manera que&#44; para puntuaciones superiores a 75 puntos&#44; la probabilidad de ingreso en UCI es superior al 30&#37; y para puntuaciones inferiores a 50 puntos&#44; la probabilidad de ingreso en UCI es inferior al 15&#37; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Discusi&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Hemos desarrollado y validado un modelo de predicci&#243;n cl&#237;nica para identificar a los pacientes con infecci&#243;n por SARS-CoV-2 que requerir&#225;n ingreso en UCI&#46; El rendimiento del modelo de predicci&#243;n mostr&#243; un AUC de 0&#44;780 para una probabilidad de ingreso en UCI de 0&#44;102&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">El riesgo de ingreso en UCI se increment&#243; de forma progresiva&#44; seg&#250;n el n&#250;mero de variables independientes que incluyeron la edad inferior a 75 a&#241;os&#44; la presencia de disnea&#44; un &#237;ndice de comorbilidad de Charlson inferior a 3&#44; un cociente neutr&#243;filos-linfocitos superior a 5&#44; los valores de lactato deshidrogenasa superiores a 250 U&#47;L y la presencia de infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; Utilizando estas variables&#44; f&#225;cilmente disponibles en el momento del ingreso hospitalario del paciente&#44; hemos construido un sistema de puntuaci&#243;n que permite asignar una probabilidad del ingreso en UCI&#46; Este estudio permite anticipar los recursos necesarios de terapia intensiva en los pacientes hospitalizados por COVID-19&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">La proporci&#243;n de ingreso en UCI en la cohorte de derivaci&#243;n fue del 8&#44;9&#37; y en la cohorte de validaci&#243;n del 7&#44;7&#37;&#46; Estos valores han sido similares a los reportados por otros estudios realizados en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">8</span></a>&#46; La proporci&#243;n de pacientes hospitalizados que ingresan en UCI en otros pa&#237;ses fue 16&#44;8&#37; en Italia&#44; 17&#37; en Reino Unido&#44; 11&#37; en Francia&#44; 32&#37; en EE&#46; UU&#46; y 8&#44;2&#37; en China<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9-13</span></a>&#46; Una mayor proporci&#243;n de ingreso de pacientes en UCI aplicado a nuestro modelo conllevar&#237;a un incremento del valor predictivo positivo del sistema de puntuaci&#243;n&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas demogr&#225;ficas de la poblaci&#243;n estudiada tambi&#233;n muestran diferencias por pa&#237;ses&#44; siendo la edad media alrededor de 70 a&#241;os en los estudios realizados en Europa y alrededor de los 50 a&#241;os en los estudios realizados en China&#46; Todos los estudios muestran como factores determinantes de ingreso en UCI una mayor edad y el sexo var&#243;n&#44; mayor comorbilidad y presencia de disnea&#59; entre los datos de laboratorio&#44; son signos de mal pron&#243;stico repetidos en todos los estudios un mayor cociente neutr&#243;filos-linfocitos y una mayor elevaci&#243;n de lactato deshidrogenasa<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">9-13</span></a>&#46; As&#237; mismo&#44; tambi&#233;n se asocia con una mayor gravedad de la infecci&#243;n un patr&#243;n difuso&#44; bilateral con opacidades en vidrio deslustrado en la radiograf&#237;a de t&#243;rax<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El rendimiento de nuestro modelo predictivo de ingreso en UCI est&#225; en consonancia con los datos hallados por otros autores&#44; que reportan valores de AROC de 0&#44;74&#44; hasta 0&#44;88 en estudios con modelos de derivaci&#243;n y validaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">No obstante&#44; debemos ser cautelosos en la extrapolaci&#243;n de los rendimientos de los modelos cuando se aplican a otros pa&#237;ses&#44; ya que pueden mostrar diferencias&#44; en algunos casos notables<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">15</span></a>&#46; Estas diferencias pueden ser por las caracter&#237;sticas demogr&#225;ficas de los sujetos estudiados&#44; el momento particular de incidencia de casos de la pandemia o las estructuras del sistema sanitario&#44; entre otras&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Entre las fortalezas&#44; el presente estudio incorpora un gran tama&#241;o muestral&#44; lo que ha permitido considerar un elevado n&#250;mero de variables en el modelo predictivo&#44; as&#237; como un an&#225;lisis robusto del modelo de derivaci&#243;n y validaci&#243;n&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Conviene interpretar este estudio como una ayuda para determinar los requerimientos de camas de unidades de cuidados intensivos en pacientes con COVID-19 grave&#46; Aunque la puntuaci&#243;n de riesgo hace referencia al deterioro cl&#237;nico relacionado con la COVID-19&#44; el beneficio del ingreso en UCI se puede ver condicionado por otros aspectos&#46; La comorbilidad del paciente&#44; la existencia de deterioro cognitivo avanzado o incapacidad para el desarrollo de las actividades b&#225;sicas de la vida diaria pueden constituir limitaciones para el ingreso en UCI en sujetos con COVID-19 grave<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Por otro lado&#44; la probabilidad de ingreso en UCI puede verse influenciada por el porcentaje de ocupaci&#243;n de sus camas en diferentes per&#237;odos de la pandemia&#46; Es posible que en per&#237;odos con buen acceso al tratamiento de soporte se decida proporcionar esta terapia a pacientes con riesgo moderado de mortalidad&#46; Por el contrario&#44; en per&#237;odos o &#225;reas con recursos m&#225;s limitados&#44; la decisi&#243;n podr&#237;a ser limitar el tratamiento intensivo de soporte a los pacientes con riesgo moderado para optimizar los recursos disponibles&#46; As&#237; mismo&#44; tampoco se ha considerado el ingreso de pacientes con COVID-19 grave en las unidades de cuidados intermedios respiratorios&#59; la disponibilidad de estas podr&#237;a alterar los resultados de validaci&#243;n de la escala&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Finalmente&#44; el desarrollo y validaci&#243;n del modelo predictivo se ha realizado en Espa&#241;a&#46; Ello podr&#237;a limitar la generalizaci&#243;n del sistema de puntuaci&#243;n a otras &#225;reas del mundo con otros sistemas sanitarios diferentes&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En resumen&#44; hemos desarrollado una regla de predicci&#243;n cl&#237;nica de ingreso en UCI para pacientes con COVID-19&#46; Las variables predictivas son f&#225;ciles de obtener en el momento del ingreso&#46; Nuestra regla de predicci&#243;n se ha validado en una amplia cohorte de pacientes y ha demostrado ser reproducible&#46; La incorporaci&#243;n de la regla en la historia m&#233;dica electr&#243;nica facilitar&#237;a su implementaci&#243;n y ayudar&#237;a a los cl&#237;nicos a adecuar correctamente el &#225;rea de ingreso de los pacientes&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Financiaci&#243;n</span><p id="par0185" class="elsevierStylePara elsevierViewall">J&#46;V&#46; Segura-Heras ha recibido ayuda competitiva del Ministerio de Econom&#237;a y Competitividad de Espa&#241;a&#44; Grant No&#46; MTM2017-83850-P&#46;</p><p id="par0590" class="elsevierStylePara elsevierViewall">La Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41; es la patrocinadora de este estudio&#46; La presente investigaci&#243;n no ha recibido ayudas espec&#237;ficas provenientes de agencias del sector p&#250;blico&#44; sector comercial o entidades sin &#225;nimo de lucro&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflictos de inter&#233;s</span><p id="par0195" class="elsevierStylePara elsevierViewall">Los autores declaran que no existe conflicto de inter&#233;s&#46;</p></span></span>"
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              "titulo" => "Caracter&#237;sticas de los pacientes ingresados en UCI"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Identificar y validar una escala de riesgo de ingreso en las unidades de cuidados intensivos &#40;UCI&#41; en pacientes hospitalizados con enfermedad por coronavirus 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos una regla de derivaci&#243;n y otra de validaci&#243;n para ingreso en UCI&#44; utilizando los datos de un registro nacional de cohortes de pacientes con infecci&#243;n confirmada por SARS-CoV-2 ingresados entre marzo y agosto del a&#241;o 2020 &#40;n &#61; 16&#46;298&#41;&#46; Analizamos variables demogr&#225;ficas&#44; cl&#237;nicas&#44; radiol&#243;gicas y de laboratorio disponibles en el ingreso hospitalario&#46; Evaluamos el rendimiento de la escala de riesgo mediante estimaci&#243;n del &#225;rea bajo la curva de caracter&#237;stica operativa del receptor &#40;AROC&#41;&#46; Utilizamos los coeficientes &#946; del modelo de regresi&#243;n para elaborar una puntuaci&#243;n &#40;0 a 100 puntos&#41; asociada con ingreso en UCI&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La edad media de los pacientes fue de 67 a&#241;os&#59; 57&#37; varones&#46; Un total de 1&#46;420 &#40;8&#44;7&#37;&#41; pacientes ingresaron en la UCI&#46; Las variables independientes asociadas con el ingreso en UCI fueron&#58; edad&#44; disnea&#44; &#237;ndice de comorbilidad de Charlson&#44; cociente neutr&#243;filos-linfocitos&#44; lactato deshidrogenasa e infiltrados difusos en la radiograf&#237;a de t&#243;rax&#46; El modelo mostr&#243; un AROC de 0&#44;780 &#40;IC&#58; 0&#44;763-0&#44;797&#41; en la cohorte de derivaci&#243;n y un AROC de 0&#44;734 &#40;IC&#58; 0&#44;708-0&#44;761&#41; en la cohorte de validaci&#243;n&#46; Una puntuaci&#243;n &#62; 75 se asoci&#243; con una probabilidad de ingreso en UCI superior a un 30&#37;&#44; mientras que una puntuaci&#243;n &#60; 50 redujo la probabilidad de ingreso en UCI al 15&#37;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Una puntuaci&#243;n de predicci&#243;n simple proporcion&#243; una herramienta &#250;til para predecir la probabilidad de ingreso en la UCI con un alto grado de precisi&#243;n&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">This work aims to identify and validate a risk scale for admission to intensive care units &#40;ICU&#41; in hospitalized patients with coronavirus disease 2019 &#40;COVID-19&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We created a derivation rule and a validation rule for ICU admission using data from a national registry of a cohort of patients with confirmed SARS-CoV-2 infection who were admitted between March and August 2020 &#40;n &#61; 16&#44;298&#41;&#46; We analyzed the available demographic&#44; clinical&#44; radiological&#44; and laboratory variables recorded at hospital admission&#46; We evaluated the performance of the risk score by estimating the area under the receiver operating characteristic curve &#40;AUROC&#41;&#46; Using the &#946; coefficients of the regression model&#44; we developed a score &#40;0 to 100 points&#41; associated with ICU admission&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The mean age of the patients was 67 years&#59; 57&#37; were men&#46; A total of 1&#44;420 &#40;8&#46;7&#37;&#41; patients were admitted to the ICU&#46; The variables independently associated with ICU admission were age&#44; dyspnea&#44; Charlson Comorbidity Index score&#44; neutrophil-to-lymphocyte ratio&#44; lactate dehydrogenase levels&#44; and presence of diffuse infiltrates on a chest X-ray&#46; The model showed an AUROC of 0&#46;780 &#40;CI&#58; 0&#46;763-0&#46;797&#41; in the derivation cohort and an AUROC of 0&#46;734 &#40;CI&#58; 0&#46;708-0&#46;761&#41; in the validation cohort&#46; A score of greater than 75 points was associated with a more than 30&#37; probability of ICU admission while a score of less than 50 points reduced the likelihood of ICU admission to 15&#37;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A simple prediction score was a useful tool for forecasting the probability of ICU admission with a high degree of precision&#46;</p></span>"
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            "apendice" => "<p id="par0205" class="elsevierStylePara elsevierViewall">Coordinador del registro SEMI-COVID-19&#58; Jos&#233; Manuel Casas Rojo&#46;</p> <p id="par0210" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SEMI-COVID-19 Miembros del Comit&#233; Cient&#237;fico&#58;</span> Jos&#233; Manuel Casas Rojo&#44; Jos&#233; Manuel Ramos Rinc&#243;n&#44; Carlos Lumbreras Bermejo&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Juan Miguel Ant&#243;n Santos&#44; Ricardo G&#243;mez Huelgas&#46;</p> <p id="par0215" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Miembros del Grupo SEMI-COVID-19</span></p> <p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; de Bellvitge&#46; L<span class="elsevierStyleUnderline">&#8217;</span>Hospitalet de Llobregat&#44; Barcelona&#58;</span> Xavier Corbella&#44; Narc&#237;s Homs&#44; Abelardo Montero&#44; Jos&#233; Mar&#237;a Mora-Luj&#225;n&#44; Manuel Rubio-Rivas&#46;</p> <p id="par0230" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; 12 de Octubre&#44; Madrid&#58;</span> Paloma Agudo de Blas&#44; Coral Ar&#233;valo Ca&#241;as&#44; Blanca Ayuso&#44; Jos&#233; Bascu&#241;ana Morej&#243;n&#44; Samara Campos Escudero&#44; Mar&#237;a Carnevali Fr&#237;as&#44; Santiago Coss&#237;o Tejido&#44; Borja de Miguel Campo&#44; Carmen D&#237;az Pedroche&#44; Raquel D&#237;az Sim&#243;n&#44; Ana Garc&#237;a Reyne&#44; Laura Ibarra Veganzones&#44; Luc&#237;a Jorge Huerta&#44; Antonio Lalueza Blanco&#44; Jaime Laureiro Gonzalo&#44; Jaime Lora-Tamayo&#44; Carlos Lumbreras Bermejo&#44; Guillermo Maestro de la Calle&#44; Rodrigo Miranda Godoy&#44; B&#225;rbara Otero Perpi&#241;a&#44; Diana Paredes Ruiz&#44; Marcos S&#225;nchez Fern&#225;ndez&#44; Javier Tejada Montes&#46;</p> <p id="par0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Gregorio Mara&#241;&#243;n&#44; Madrid&#58;</span> Laura Abarca Casas&#44; &#193;lvaro Alejandre de O&#241;a&#44; Rub&#233;n Alonso Beato&#44; Leyre Alonso Gonzalo&#44; Jaime Alonso Mu&#241;oz&#44; Christian Mario Amodeo Oblitas&#44; Cristina Aus&#237;n Garc&#237;a&#44; Marta Bacete Cebri&#225;n&#44; Jes&#250;s Baltasar Corral&#44; Mar&#237;a Barrientos Guerrero&#44; Alejandro D&#46; Bendala Estrada&#44; Mar&#237;a Calder&#243;n Moreno&#44; Paula Carrascosa Fern&#225;ndez&#44; Raquel Carrillo&#44; Sabela Casta&#241;eda P&#233;rez&#44; Eva Cervilla Mu&#241;oz&#44; Agust&#237;n Diego Chac&#243;n Moreno&#44; Mar&#237;a Carmen Cuenca Carvajal&#44; Sergio de Santos&#44; Andr&#233;s Enr&#237;quez G&#243;mez&#44; Eduardo Fern&#225;ndez Carracedo&#44; Mar&#237;a Mercedes Ferreiro-Maz&#243;n Jenaro&#44; Francisco Galeano Valle&#44; Alejandra Garc&#237;a&#44; Irene Garc&#237;a Fern&#225;ndez-Bravo&#44; Mar&#237;a Eugenia Garc&#237;a Leoni&#44; Mar&#237;a G&#243;mez Ant&#250;nez&#44; Candela Gonz&#225;lez San Narciso&#44; Anthony Alexander Gurjian&#44; Lorena Jim&#233;nez Ib&#225;&#241;ez&#44; Cristina Lavilla Olleros&#44; Cristina Llamazares Mendo&#44; Sara Luis Garc&#237;a&#44; V&#237;ctor Mato Jimeno&#44; Clara Mill&#225;n Nohales&#44; Jes&#250;s Mill&#225;n N&#250;&#241;ez-Cort&#233;s&#44; Sergio Morag&#243;n Ledesma&#44; Antonio Mui&#241;o M&#237;guez&#44; Cecilia Mu&#241;oz Delgado&#44; Luc&#237;a Ordieres Ortega&#44; Susana Pardo S&#225;nchez&#44; Alejandro Parra Virto&#44; Mar&#237;a Teresa P&#233;rez Sanz&#44; Blanca Pinilla Llorente&#44; Sandra Piqueras Ruiz&#44; Guillermo Soria Fern&#225;ndez-Llamazares&#44; Mar&#237;a Toledano Mac&#237;as&#44; Neera Toledo Samaniego&#44; Ana Torres do Rego&#44; Mar&#237;a Victoria Villalba Garc&#237;a&#44; Gracia Villarreal&#44; Mar&#237;a Zurita Etayo&#46;</p> <p id="par0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Costa del Sol&#44; Marbella&#44; M&#225;laga&#58;</span> Victoria August&#237;n Bandera&#44; Javier Garc&#237;a Alegr&#237;a&#44; Nicol&#225;s Jim&#233;nez-Garc&#237;a&#44; Jairo Luque del Pino&#44; Mar&#237;a Dolores Mart&#237;n Escalante&#44; Francisco Navarro Romero&#44; Victoria N&#250;&#241;ez Rodr&#237;guez&#44; Juli&#225;n Olalla Sierra&#46;</p> <p id="par0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Cabue&#241;es&#44; Gij&#243;n&#44; Asturias&#58;</span> Ana Mar&#237;a &#193;lvarez Su&#225;rez&#44; Carlos Delgado Verg&#233;s&#44; Rosa Fern&#225;ndez-Madera Mart&#237;nez&#44; Eva Mar&#237;a Fonseca Aizpuru&#44; Alejandro G&#243;mez Carrasco&#44; Cristina Helguera Amezua&#44; Juan Francisco L&#243;pez Caleya&#44; Diego L&#243;pez Mart&#237;nez&#44; Mar&#237;a del Mar Mart&#237;nez L&#243;pez&#44; Aleida Mart&#237;nez Zapico&#44; Carmen Olabuenaga Iscar&#44; Luc&#237;a P&#233;rez Casado&#44; Mar&#237;a Luisa Taboada Mart&#237;nez&#44; Lara Mar&#237;a Tamargo Chamorro&#46;</p> <p id="par0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Paz&#44; Madrid&#58;</span> Jorge &#193;lvarez Troncoso&#44; Francisco Arnalich Fern&#225;ndez&#44; Francisco Blanco Quintana&#44; Carmen Busca Arenzana&#44; Sergio Carrasco Molina&#44; Aranzazu Castellano Candalija&#44; Germ&#225;n Daroca Bengoa&#44; Alejandro de Gea Grela&#44; Alicia de Lorenzo Hern&#225;ndez&#44; Alejandro D&#237;ez Vidal&#44; Carmen Fern&#225;ndez Capit&#225;n&#44; Mar&#237;a Francisca Garc&#237;a Iglesias&#44; Borja Gonz&#225;lez Mu&#241;oz&#44; Carmen Rosario Herrero Gil&#44; Juan Mar&#237;a Herrero Mart&#237;nez&#44; V&#237;ctor Honta&#241;&#243;n&#44; Mar&#237;a Jes&#250;s Jaras Hern&#225;ndez&#44; Carlos Lahoz&#44; Cristina Marcelo Calvo&#44; Juan Carlos Mart&#237;n Guti&#233;rrez&#44; M&#243;nica Mart&#237;nez Prieto&#44; Elena Mart&#237;nez Robles&#44; Araceli Men&#233;ndez Salda&#241;a&#44; Alberto Moreno Fern&#225;ndez&#44; Jos&#233; Mar&#237;a Mostaza Prieto&#44; Ana Noblejas Mozo&#44; Carlos Manuel O&#241;oro L&#243;pez&#44; Esmeralda Palmier Pel&#225;ez&#44; Marina Palomar Pampyn&#44; Mar&#237;a Angustias Quesada Sim&#243;n&#44; Juan Carlos Ramos Ramos&#44; Luis Ramos Ruperto&#44; Aquilino S&#225;nchez Purificaci&#243;n&#44; Teresa Sancho Bueso&#44; Raquel Sorriguieta Torre&#44; Clara Itziar Soto Abanedes&#44; Yeray Untoria Tabares&#44; Marta Varas Mayoral&#44; Julia V&#225;squez Manau&#46;</p> <p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Royo Villanova&#44; Zaragoza&#58;</span> Nicol&#225;s Alcal&#225; Rivera&#44; Anxela Crestelo Vieitez&#44; Esther del Corral Beamonte&#44; Jes&#250;s D&#237;ez Manglano&#44; Isabel Fiteni Mera&#44; Mar&#237;a del Mar Garc&#237;a Andreu&#44; Martin Geric&#243; Aseguinolaza&#44; Cristina Gallego Lezaun&#44; Claudia Josa Laorden&#44; Ra&#250;l Mart&#237;nez Murgui&#44; Marta Teresa Mat&#237;a Sanz&#46;</p> <p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Reg&#46; U&#46; de M&#225;laga&#44; M&#225;laga&#58;</span> Mar&#237;a Mar Ayala-Guti&#233;rrez&#44; Rosa Bernal L&#243;pez&#44; Jos&#233; Bueno Fonseca&#44; Ver&#243;nica Andrea Buonaiuto&#44; Luis Francisco Caballero Mart&#237;nez&#44; Lidia Cobos Palacios&#44; Clara Costo Muriel&#44; Francis de Windt&#44; Ana Teresa Fern&#225;ndez-Truchaud Christophel&#44; Paula Garc&#237;a Oca&#241;a&#44; Ricardo G&#243;mez Huelgas&#44; Javier Gorospe Garc&#237;a&#44; Jos&#233; Antonio Hurtado Oliver&#44; Sergio Jansen-Chaparro&#44; Mar&#237;a Dolores L&#243;pez-Carmona&#44; Pablo L&#243;pez Quirantes&#44; Almudena L&#243;pez Sampalo&#44; Elizabeth Lorenzo-Hern&#225;ndez&#44; Juan Jos&#233; Mancebo Sevilla&#44; Jesica Mart&#237;n Carmona&#44; Luis Miguel P&#233;rez-Belmonte&#44; Iv&#225;n P&#233;rez de Pedro&#44; Araceli Pineda-Cantero&#44; Carlos Romero G&#243;mez&#44; Michele Ricci&#44; Jaime Sanz C&#225;novas&#46;</p> <p id="par0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Cl&#237;nico de Santiago de Compostela&#44; A Coru&#241;a&#58;</span> Mar&#237;a del Carmen Beceiro Abad&#44; Mar&#237;a Aurora Freire Romero&#44; Sonia Molinos Castro&#44; Emilio Manuel Paez Guillan&#44; Mar&#237;a Pazo N&#250;&#241;ez&#44; Paula Mar&#237;a Pesqueira Font&#225;n&#46;</p> <p id="par0310" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Dr&#46; Peset&#44; Valencia&#58;</span> Juan Alberto Aguilera Ayll&#243;n&#44; Arturo Artero&#44; Mar&#237;a del Mar Carmona Mart&#237;n&#44; Mar&#237;a Jos&#233; Fabi&#225; Valls&#44; Mar&#237;a de Mar Fern&#225;ndez Garc&#233;s&#44; Ana Bel&#233;n G&#243;mez Belda&#44; Ian L&#243;pez Cruz&#44; Manuel Madrazo L&#243;pez&#44; Elisabeth Mateo Sanch&#237;s&#44; Jaume Mic&#243; Gand&#237;a&#44; Laura Piles Roger&#44; Adela Mar&#237;a Pina Belmonte&#44; Alba Viana Garc&#237;a&#46;</p> <p id="par0320" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Mois&#232;s Broggi&#44; Sant Joan Desp&#237;&#44; Barcelona&#58;</span> Judit Aranda Lobo&#44; Luc&#237;a Feria Casanovas&#44; Jos&#233; Loureiro Amigo&#44; Miguel Mart&#237;n Fern&#225;ndez&#44; Isabel Oriol Berm&#250;dez&#44; Melani Pesta&#241;a Fern&#225;ndez&#44; Nicol&#225;s Rhyman&#44; Nuria V&#225;zquez Piqueras</p> <p id="par0330" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Badajoz&#44; Badajoz&#58;</span> Rafael Arag&#243;n Lara&#44; Inmaculada Cimadevilla Fern&#225;ndez&#44; Juan Carlos Cira Garc&#237;a&#44; Gema Mar&#237;a Garc&#237;a Garc&#237;a&#44; Julia Gonz&#225;lez Granados&#44; Beatriz Guerrero S&#225;nchez&#44; Francisco Javier Monreal Peri&#225;&#241;ez&#44; Mar&#237;a Josefa Pascual P&#233;rez&#46;</p> <p id="par0340" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; R&#237;o Hortega&#44; Valladolid&#58;</span> Irene Arroyo Jim&#233;nez&#44; Marina Cazorla Gonz&#225;lez&#44; Marta Cobos-Siles&#44; Luis Corral-Gudino&#44; Pablo Cubero-Morais&#44; Mar&#237;a Gonz&#225;lez Fern&#225;ndez&#44; Jos&#233; Pablo Miramontes Gonz&#225;lez&#44; Marina Prieto Dehesa&#44; Pablo Sanz Espinosa&#46;</p> <p id="par0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Reina Sof&#237;a&#44; C&#243;rdoba&#58;</span> Antonio Pablo Arenas de Larriva&#44; Pilar Calero Espinal&#44; Javier Delgado Lista&#44; Francisco Fuentes-Jim&#233;nez&#44; Mar&#237;a del Carmen Guerrero Mart&#237;nez&#44; Mar&#237;a Jes&#250;s G&#243;mez V&#225;zquez&#44; Jos&#233; Jim&#233;nez Torres&#44; Laura Limia P&#233;rez&#44; Jos&#233; L&#243;pez-Miranda&#44; Laura Mart&#237;n Piedra&#44; Marta Mill&#225;n Orge&#44; Javier Pascual Vinagre&#44; Pablo P&#233;rez-Mart&#237;nez&#44; Mar&#237;a Elena Revelles V&#237;lchez&#44; &#193;ngela Rodrigo Mart&#237;nez&#44; Juan Luis Romero Cabrera&#44; Jos&#233; David Torres-Pe&#241;a&#46;</p> <p id="par0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; S&#46; Juan de Alicante&#44; Alicante&#58;</span> Marisa Asensio Tom&#225;s&#44; David Balaz&#44; David Bonet Tur&#44; Ruth Ca&#241;izares Navarro&#44; Paloma Chazarra P&#233;rez&#44; Jes&#250;s Corbacho Redondo&#44; Eliana Damonte White&#44; Mar&#237;a Escamilla Esp&#237;nola&#44; Leticia Espinosa Del Barrio&#44; Pedro Jes&#250;s Esteve Ati&#233;nzar&#44; Carles Garc&#237;a Cervera&#44; David Francisco Garc&#237;a N&#250;&#241;ez&#44; Francisco Garrido Navarro&#44; Vicente Giner Galva&#241;&#44; Angie G&#243;mez Uranga&#44; Javier Guzm&#225;n Mart&#237;nez&#44; Isidro Hern&#225;ndez Isasi&#44; Lourdes Lajara Villar&#44; Ver&#243;nica Mart&#237;nez Sempere&#44; Juan Manuel N&#250;&#241;ez Cruz&#44; Sergio Palacios Fern&#225;ndez&#44; Juan Jorge Peris Garc&#237;a&#44; Rafael Pi&#241;ol Pleguezuelos&#44; Andrea Ria&#241;o P&#233;rez&#44; Jos&#233; Miguel Segu&#237; Ripoll&#44; Azucena Sempere Mira&#44; Philip Wikman-Jorgensen&#46;</p> <p id="par0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo&#58;</span> Sonia Casallo Blanco&#44; Jeffrey Oskar Magallanes Gamboa&#44; Cristina Salazar Mosteiro&#44; Andrea Silva Asiain&#46;</p> <p id="par0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Pozoblanco&#44; C&#243;rdoba&#58;</span> Jos&#233; Nicol&#225;s Alcal&#225; Pedrajas&#44; Antonia M&#225;rquez Garc&#237;a&#44; In&#233;s Vargas&#46;</p> <p id="par0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Infanta Cristina&#44; Parla&#44; Madrid&#58;</span> Juan Miguel Ant&#243;n Santos&#44; Ana Bel&#233;n Barbero Barrera&#44; Blanca Beamonte Vela&#44; Coralia Bueno Mui&#241;o&#44; Charo Bur&#243;n Fern&#225;ndez&#44; Ruth Calder&#243;n Hern&#225;iz&#44; Irene Casado L&#243;pez&#44; Jos&#233; Manuel Casas Rojo&#44; Andr&#233;s Cort&#233;s Troncoso&#44; Pilar Cubo Romano&#44; Francesco Deodati&#44; Alejandro Estrada Santiago&#44; Gonzalo Garc&#237;a Casasola S&#225;nchez&#44; Elena Garc&#237;a Guijarro&#44; Francisco Javier Garc&#237;a S&#225;nchez&#44; Pilar Garc&#237;a de la Torre&#44; Mayte de Guzm&#225;n Garc&#237;a-Monge&#44; Davide Luordo&#44; Mar&#237;a Mateos Gonz&#225;lez&#44; Jos&#233; A&#46; Melero Bermejo&#44; Cruz Pastor Valverde&#44; Jos&#233; Luis P&#233;rez Quero&#44; Fernando Roque Rojas&#44; Lorea Roteta Garc&#237;a&#44; Elena Sierra Gonzalo&#44; Francisco Javier Teigell Mu&#241;oz&#44; Juan Vicente de la Sota&#44; Javier Villanueva Mart&#237;nez&#46;</p> <p id="par0400" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; G&#46; U&#46; de Elda&#44; Alicante&#58;</span> Carmen Cort&#233;s Saavedra&#44; Jennifer Fern&#225;ndez G&#243;mez&#44; Borja Gonz&#225;lez L&#243;pez&#44; Mar&#237;a Soledad Hern&#225;ndez Garrido&#44; Ana Isabel L&#243;pez Amor&#243;s&#44; Santiago L&#243;pez Gil&#44; Mar&#237;a de los Reyes Pascual P&#233;rez&#44; Nuria Ram&#237;rez Perea&#44; Andrea Torregrosa Garc&#237;a&#46;</p> <p id="par0410" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Santa Marina&#44; Bilbao&#58;</span> Mar&#237;a Areses Manrique&#44; Ainara Coduras Erdozain&#44; Ane Labirua-Iturburu Ruiz&#46;</p> <p id="par0420" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; San Pedro&#44; Logro&#241;o&#44; La Rioja&#58;</span> Diana Alegre Gonz&#225;lez&#44; Irene Ari&#241;o P&#233;rez de Zabalza&#44; Sergio Arnedo Hern&#225;ndez&#44; Jorge Collado S&#225;enz&#44; Beatriz Dendariena&#44; Marta G&#243;mez del Mazo&#44; Iratxe Mart&#237;nez de Narvajas Urra&#44; Sara Mart&#237;nez Hern&#225;ndez&#44; Estela Men&#233;ndez Fern&#225;ndez&#44; Jos&#233; Lu&#237;s Pe&#241;a Somovilla&#44; Elisa Rabad&#225;n Pejenaute&#46;</p> <p id="par0430" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Son Ll&#224;tzer&#44; Palma de Mallorca&#58;</span> Andr&#233;s de la Pe&#241;a Fern&#225;ndez&#44; Almudena Hern&#225;ndez Mili&#225;n&#46;</p> <p id="par0440" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; Ourense&#44; Ourense&#58;</span> Raquel Fern&#225;ndez Gonz&#225;lez&#44; Amara Gonz&#225;lez Noya&#44; Carlos Hern&#225;ndez Cer&#243;n&#44; Isabel Izuzquiza Avanzini&#44; Ana Latorre Diez&#44; Pablo L&#243;pez Mato&#44; Ana Mar&#237;a Lorenzo Vizcaya&#44; Daniel Pe&#241;a Ben&#237;tez&#44; Milagros Mar&#237;a Pe&#241;a Zemsch&#44; Luc&#237;a P&#233;rez Exp&#243;sito&#44; Marta Pose Bar&#44; Lara Rey Gonz&#225;lez&#44; Laura Rodrigo Lara&#46;</p> <p id="par0450" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; La Fe&#44; Valencia&#58;</span> Dafne Caba&#241;ero&#44; Mar&#237;a Calabuig Ballester&#44; Pascual C&#237;scar Fern&#225;ndez&#44; Ricardo Gil S&#225;nchez&#44; Marta Jim&#233;nez Escrig&#44; Cristina Mar&#237;n Amela&#44; Laura Parra G&#243;mez&#44; Carlos Puig Navarro&#44; Jos&#233; Antonio Todol&#237; Parra&#46;</p> <p id="par0460" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Matar&#243;&#44; Barcelona&#58;</span> Raquel Aranega Gonz&#225;lez&#44; Ramon Boixeda&#44; Javier Fern&#225;ndez Fern&#225;ndez&#44; Carlos Lopera M&#225;rmol&#44; Marta Parra Navarro&#44; Ainhoa Rex Guzm&#225;n&#44; Aleix Serrallonga Fustier&#46;</p> <p id="par0470" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Sagunto&#44; Valencia&#58;</span> Enrique Rodilla Sala&#44; Jos&#233; Mar&#237;a Pascual Izuel&#44; Zineb Karroud Zamrani&#46;</p> <p id="par0480" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Alto Guadalquivir&#44; And&#250;jar&#44; Ja&#233;n&#58;</span> Bego&#241;a Cort&#233;s Rodr&#237;guez&#46;</p> <p id="par0490" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Infanta Margarita&#44; Cabra&#44; C&#243;rdoba&#58;</span> Mar&#237;a Esther Guisado Espartero&#44; Lorena Montero Rivas&#44; Mar&#237;a de la Sierra Navas Alc&#225;ntara&#44; Raimundo Tirado-Miranda&#46;</p> <p id="par0500" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; H&#46; U&#46; de Ferrol&#44; A Coru&#241;a&#58;</span> Hortensia &#193;lvarez D&#237;az&#44; Tamara Dalama L&#243;pez&#44; Estefan&#237;a Martul Pego&#44; Carmen Mella P&#233;rez&#44; Ana Pazos Ferro&#44; Sabela S&#225;nchez Trigo&#44; Dolores Suarez Sambade&#44; Mar&#237;a Trigas Ferrin&#44; Mar&#237;a del Carmen V&#225;zquez Friol&#44; Laura Vilari&#241;o Maneiro&#46;</p> <p id="par0510" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; Marina Baixa&#44; Villajoyosa&#44; Alicante&#58;</span> Javier Ena&#44; Santiago P&#233;rez Mart&#237;n&#46;</p> <p id="par0520" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; Virgen del Roc&#237;o&#44; Sevilla&#58;</span> Reyes Aparicio Santos&#44; M&#225;ximo Bernabeu-Wittel&#44; Santiago Rodr&#237;guez Su&#225;rez&#44; Mar&#237;a Nieto&#44; Luis Gim&#233;nez Miranda&#44; Rosa Mar&#237;a G&#225;mez Mancera&#44; F&#225;tima Espinosa Torre&#44; Carlos Hern&#225;ndez Quiles&#44; Concepci&#243;n Conde Guzm&#225;n&#44; Juan Delgado de la Cuesta&#44; Jara Elo&#237;sa Ternero Vega&#44; Mar&#237;a del Carmen L&#243;pez R&#237;os&#44; Pablo D&#237;az Jim&#233;nez&#44; Bosco Bar&#243;n Franco&#44; Carlos Jim&#233;nez de Juan&#44; Sonia Guti&#233;rrez Rivero&#44; Julia Lanseros Tenllado&#44; Ver&#243;nica Alfaro Lara&#44; Aurora Gonz&#225;lez Estrada&#46;</p> <p id="par0530" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; P&#250;blico de Monforte de Lemos&#44; Lugo&#58;</span> Jos&#233; L&#243;pez Castro&#44; Manuel Lorenzo L&#243;pez Reboiro&#44; Cristina Sardi&#241;a Gonz&#225;lez&#46;</p> <p id="par0540" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; General Defensa&#44; Zaragoza&#58;</span> Anyuli Gracia Guti&#233;rrez&#44; Leticia Esther Royo Trallero&#46;</p> <p id="par0550" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">C&#46; A&#46; U&#46; de Salamanca&#44; Salamanca&#58;</span> Gloria Mar&#237;a Alonso Claudio&#44; V&#237;ctor Barreales Rodr&#237;guez&#44; Cristina Carbonell Mu&#241;oz&#44; Adela Carpio P&#233;rez&#44; Mar&#237;a Victoria Coral Orbes&#44; Daniel Encinas S&#225;nchez&#44; Sandra In&#233;s Revuelta&#44; Miguel Marcos Mart&#237;n&#44; Jos&#233; Ignacio Mart&#237;n Gonz&#225;lez&#44; Jos&#233; &#193;ngel Mart&#237;n Oterino&#44; Leticia Moralejo Alonso&#44; Sonia Pe&#241;a Balbuena&#44; Mar&#237;a Luisa P&#233;rez Garc&#237;a&#44; Ana Ram&#243;n Prados&#44; Beatriz Rodr&#237;guez-Alonso&#44; &#193;ngela Romero Alegr&#237;a&#44; Mar&#237;a S&#225;nchez Ledesma&#44; Rosa Juana Tejera P&#233;rez&#46;</p> <p id="par0560" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; de Palam&#243;s&#44; Girona&#58;</span> Ana Alberich Conesa&#44; Mari Cruz Almendros Rivas&#44; Miquel Hortos Alsina&#44; Jos&#233; Marchena Romero&#44; Anabel Mart&#237;n-Urda Diez-Canseco&#46;</p> <p id="par0570" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; do Salnes&#44; Vilagarc&#237;a de Arousa&#44; Pontevedra&#58;</span> Vanesa Allende Castro&#44; Ana Mar&#237;a Baz Lomba&#44; Ruth Brea Aparicio&#44; Marta Fern&#225;ndez Morales&#44; Jes&#250;s Manuel Fern&#225;ndez Villar&#44; Mar&#237;a Teresa L&#243;pez Monteagudo&#44; Cristina P&#233;rez Garc&#237;a&#44; Lorena Rodr&#237;guez Ferreira&#44; Diana Sande Llovo&#44; Mar&#237;a Bego&#241;a Valle Feijoo&#46;</p> <p id="par0580" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">H&#46; U&#46; HM Montepr&#237;ncipe&#44; Boadilla del Monte&#44; Madrid&#58;</span> Jos&#233; F&#46; Varona Arche&#46;</p>"
            "etiqueta" => "Anexo&#46; 1"
            "titulo" => "Listado de miembros la red SEMI-COVID-19&#58;"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Curva de caracter&#237;stica operativa del receptor para ingreso en UCI en la cohorte de derivaci&#243;n y validaci&#243;n&#46; El &#225;rea bajo la curva de caracter&#237;stica operativa del receptor fue 0&#44;781 en la cohorte de derivaci&#243;n y 0&#44;747 en la cohorte de validaci&#243;n&#46; El punto de corte que optimiza sensibilidad y especificidad fue 0&#44;087&#44; tanto en la cohorte de derivaci&#243;n como en la de validaci&#243;n&#46;</p>"
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&#44; a&#241;os&#44; media &#177; DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&#44;7 &#177; 16&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;3 &#177; 12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo var&#243;n&#8212;N&#46;&#176; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;367 &#40;56&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">987 &#40;69&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dependencia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Independiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;092 &#40;82&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;377 &#40;97&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Parcialmente dependiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;461 &#40;10&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">26 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Totalmente dependiente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;129 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;0&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comorbilidad&#8212;N&#46;&#176; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Fumador</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;627&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;980 &#40;70&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">876 &#40;64&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;567 &#40;25&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">402 &#40;29&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador activo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">717 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertensi&#243;n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;264&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;631 &#40;51&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">705 &#40;49&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;226&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;251&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;128 &#40;14&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">228 &#40;16&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;086&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;256&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;38&#176; C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;217 &#40;62&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;038 &#40;73&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;241&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;058 &#40;27&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">278 &#40;19&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Seca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;519 &#40;57&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">933 &#40;65&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Con producci&#243;n de esputo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;246 &#40;15&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207 &#40;14&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anosmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;897&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;126 &#40;7&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Astenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;377 &#40;43&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">627 &#40;44&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;490&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anorexia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;025&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;931 &#40;20&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">262 &#40;18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;765 &#40;12&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161 &#40;11&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;548&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Artromialgias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;486 &#40;30&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">473 &#40;33&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ageusia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;266 &#40;8&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alteraci&#243;n nivel de conciencia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;794 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">119 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;228&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#46;299 &#40;56&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;069 &#40;75&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V&#243;mitos&#47;n&#225;useas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;100 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">188 &#40;13&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarrea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#46;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;566 &#40;24&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">321 &#40;22&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Radiolog&#237;a&#8212;N&#46;&#176; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;061&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;789 &#40;53&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">630 &#40;44&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;567 &#40;17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrados difusos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;300 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">604 &#40;43&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Examen f&#237;sico&#44; media &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SpO<span class="elsevierStyleInf">2</span>&#44; &#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;849&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;3 &#177; 5&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89&#44;0 &#177; 8&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial sist&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;666&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&#44;8 &#177; 21&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;8 &#177; 21&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;083&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Presi&#243;n arterial diast&#243;lica&#44; mmHg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;657&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#44;9 &#177; 13&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;8 &#177; 13&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Frecuencia card&#237;aca&#44; latidos&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;831&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#44;3 &#177; 17&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;8 &#177; 17&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquipnea &#40;&#60; 30 respiraciones&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;942&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4258 &#40;29&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">793 &#40;56&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Laboratorio&#44; media &#177; DE</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cociente neutr&#243;filos-linfocitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#177; 11&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;7 &#177; 9&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Plaquetas&#8212;x10<span class="elsevierStyleSup">9</span>&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;182&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">207&#46;227 &#177; 93&#46;637&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">203&#46;388 &#177; 90&#46;454&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D&#237;mero D&#8212;ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#46;852&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;906 &#177; 10&#46;702&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;969 &#177; 11&#46;865&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5-10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactato deshidrogenasa&#44; U&#47;L</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrados difusos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">432 &#40;13&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">172 &#40;10&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">961 &#40;9&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">411 &#40;7&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;665&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;5&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;6&#44;88&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Taquipnea &#40;&#62; 30 respiraciones&#47;min&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409 &#40;5&#44;67&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">194 &#40;5&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;171&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">567 &#40;16&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Elevaci&#243;n urea &#62; 40 mg&#47;dL</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195 &#40;8&#44;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;768&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">447 &#40;10&#44;79&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183 &#40;8&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;7&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">360 &#40;7&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;903&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">159 &#40;10&#44;15&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;8&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#205;ndice de comorbilidad de Charlson</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;116&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;649&#44; 1&#46;887&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;685&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;828&#44; 2&#46;029&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;682&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;155&#44; 2&#46;506&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;935&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;364&#44; 2&#46;822&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;313&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;1&#46;659&#44; 3&#46;328&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Neoplasia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;597&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;397&#44; 0&#44;863&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;009&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 1</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;770&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;553&#44; 1&#46;045&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes mellitus tipo 2</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Alteraci&#243;n nivel de conciencia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;0&#44;511&#44; 0&#44;812&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Taquipnea&#44; &#60; 30 respiraciones&#47;min</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;327&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#46;910&#44; 3&#46;808&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Disnea</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237; vs&#46; No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;659&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;2&#46;286&#44; 3&#46;104&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#60; 5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>5-10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;974&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cociente neutr&#243;filos-linfocitos</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lactato deshidrogenasa&#44; U&#47;L</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>250-500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62; 500&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;591&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&#46;911 &#40;3&#46;763&#44; 6&#46;471&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Radiograf&#237;a de t&#243;rax</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausencia de infiltrados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado unilateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;931 &#40;0&#44;728&#44; 1&#46;182&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;565&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">0&#44;412&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;509 &#40;1&#46;279&#44; 1&#46;781&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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ORIGINAL
DOI: 10.1016/j.rce.2021.06.003
Derivación y validación de una puntuación de riesgo de ingreso en la Unidad de Cuidados Intensivos para pacientes con COVID-19
Derivation and validation of a risk score for admission to the Intensive Care Unit in patients with COVID-19
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J. Enaa,
Autor para correspondencia
ena_jav@gva.es

Autor para correspondencia.
, J.V. Segura-Herasb, E.M. Fonseca-Aizpuruc, M.L. López-Reboirod, A. Gracia-Gutiérreze, J.A. Martín-Oterinof, A. Martín-Urda Diez-Cansecog, C. Pérez-Garcíah, J.M. Ramos-Rincóni, R. Gómez-Huelgasj, en nombre del grupo de trabajo SEMI-COVID-19 ◊
a Servicio de Medicina Interna. HospitalMarina Baixa, Alicante, España
b Instituto Universitario de Investigación «Centro de Investigación Operativa» (CIO). Universidad Miguel Hernández, Alicante, España
c Servicio de Medicina Interna. Hospital de Cabueñes, Gijón, Asturias, España
d Servicio de Medicina Interna. Hospital Público de Monforte de Lemos, Lugo, España
e Servicio de Medicina Interna. Hospital General Defensa, Zaragoza, España
f Servicio de Medicina Interna. Complejo Asistencial Universitario de Salamanca, Salamanca, España
g Servicio de Medicina Interna. Hospital de Palamós, Girona, España
h Servicio de Medicina Interna. Hospital do Salnes, Vilagarcía de Arousa, Pontevedra, España
i Departamento de Medicina Clínica. Universidad Miguel Hernández de Elche, Alicante, España
j Departamento de Medicina Interna. Hospital Regional de Málaga. Instituto de Investigación Biomédica (IBIMA). Universidad de Málaga, Málaga, España
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