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      "en" => array:1 [
        "titulo" => "Clinical characteristics during diagnosis of a prospective cohort of patients with systemic lupus erythematosus treated in Spanish Departments of Internal Medicine&#58; The RELES study"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El lupus eritematoso sist&#233;mico &#40;LES&#41; es una enfermedad autoinmune sist&#233;mica &#40;EAS&#41; que afecta fundamentalmente a mujeres j&#243;venes y condiciona un aumento de la morbimortalidad<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">1</span></a>&#46; En Espa&#241;a&#44; su prevalencia en los &#250;ltimos 40 a&#241;os ha variado entre 34&#44;1 y 91 por 100&#46;000 habitantes<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">2</span></a>&#44; lo que podr&#237;a estar relacionado con la mejor&#237;a del pron&#243;stico que se estima en hasta un 80&#37; de supervivencia a los 15 a&#241;os<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Aunque se trata de una de las EAS m&#225;s prevalentes&#44; no es f&#225;cil conseguir desde un &#250;nico centro hospitalario grandes cohortes&#46; Adem&#225;s&#44; la mayor&#237;a de las series publicadas son retrospectivas e incluyen a pacientes recogidos durante largos periodos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Los registros de pacientes y las cohortes multic&#233;ntricas son herramientas particularmente &#250;tiles para la evaluaci&#243;n de enfermedades relativamente poco frecuentes&#46; Por este motivo&#44; el Grupo de Enfermedades Autoinmunes Sist&#233;micas &#40;GEAS&#41; de la Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41; decidi&#243; en 2008 poner en marcha un estudio longitudinal&#44; nacional y multic&#233;ntrico que incluyera&#44; exclusivamente&#44; a aquellos pacientes con diagn&#243;stico reciente de LES&#44; atendidos en las consultas de los servicios de Medicina Interna&#44; al que denomin&#243; RELES &#40;Registro Espa&#241;ol de pacientes con LES&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es presentar el dise&#241;o y los objetivos a largo plazo del estudio y analizar las caracter&#237;sticas cl&#237;nicas iniciales&#44; las formas de presentaci&#243;n m&#225;s frecuentes&#44; el grado de actividad y los tratamientos recibidos en el primer mes tras el diagn&#243;stico de los pacientes incluidos en el RELES&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes y m&#233;todos</span><p id="par0025" class="elsevierStylePara elsevierViewall">RELES es un proyecto multic&#233;ntrico de cohortes&#44; observacional&#44; prospectivo&#44; de pacientes recogidos desde el inicio del diagn&#243;stico&#44; que se puso en marcha en 2008&#46; El principal objetivo del registro es conformar una cohorte observacional prospectiva de pacientes con LES&#44; con especial atenci&#243;n al papel de las complicaciones no inflamatorias en la morbimortalidad asociada a la enfermedad&#46; En este trabajo se presentan los pacientes recogidos desde enero del 2009 hasta julio del 2015&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Han participado los servicios de Medicina Interna de 38 hospitales espa&#241;oles&#46; El Comit&#233; de &#201;tica e Investigaci&#243;n Cl&#237;nica del centro coordinador &#40;Hospital Universitario Cruces&#44; Barakaldo&#41; autoriz&#243; el protocolo que posteriormente se refrend&#243; por los &#243;rganos locales de los centros participantes&#46; El estudio se realiz&#243; en conformidad con la Declaraci&#243;n de Helsinki&#46; Todos los investigadores del estudio expresaron su compromiso de confidencialidad por escrito&#46; Los pacientes firmaron el consentimiento a su entrada en el registro&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Manejo de datos y confidencialidad</span><p id="par0035" class="elsevierStylePara elsevierViewall">Los datos de todos los pacientes se cumplimentaron en un cuaderno de recogida de datos <span class="elsevierStyleItalic">online</span> y se enviaron al centro coordinador por Internet a trav&#233;s de un dominio seguro&#46; Los datos electr&#243;nicos confidenciales est&#225;n protegidos por contrase&#241;as y todas las copias en papel se guardan en lugar seguro&#46; La calidad de los datos es monitorizada y documentada mediante auditor&#237;as completas a intervalos peri&#243;dicos&#46; La informaci&#243;n recibida se almacena seg&#250;n lo establecido en la Ley Org&#225;nica de Protecci&#243;n de Datos de Car&#225;cter personal 15&#47;1999&#44; de 13 de diciembre&#46; El contenido de las bases de datos no puede ser utilizado para fines diferentes a los del propio estudio&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">La confidencialidad de los datos est&#225; asegurada mediante la asignaci&#243;n de un n&#250;mero de estudio &#250;nico para cada paciente en el momento de la inclusi&#243;n y mediante la supresi&#243;n o codificaci&#243;n de cualquier otra informaci&#243;n que pudiese identificar personas o centro hospitalario&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pacientes</span><p id="par0045" class="elsevierStylePara elsevierViewall">Para ser incluidos en el estudio&#44; los pacientes deb&#237;an cumplir de forma acumulada al menos 4 de los criterios de clasificaci&#243;n del American College of Rheumatology &#40;ACR&#41; de 1997<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">4</span></a>&#46; La visita en la que se cumpl&#237;an los 4 &#40;o m&#225;s&#41; criterios se consider&#243; el momento del diagn&#243;stico o&#44; lo que es lo mismo&#44; la primera visita del estudio&#59; ambos t&#233;rminos se utilizar&#225;n de forma indistinta a lo largo del texto&#46; Cualquier paciente diagnosticado de LES en el periodo de estudio que hubiese fallecido despu&#233;s del reclutamiento pod&#237;a ser incluido en el an&#225;lisis de los datos&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Descripci&#243;n de las variables del Registro Espa&#241;ol de Pacientes con Lupus Eritematoso Sist&#233;mico &#40;RELES&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">El estudio RELES tiene como objetivo fundamental el an&#225;lisis de la incidencia y complicaciones del LES&#44; como infecciones&#44; trombosis arteriales&#44; venosas y de peque&#241;o vaso&#44; deterioro cognitivo sintom&#225;tico&#44; osteoporosis&#44; necrosis avascular&#44; diabetes&#44; hipertensi&#243;n arterial&#44; neoplasias y menopausia precoz&#46; Otras variables que se a&#241;adieron fueron la mortalidad&#44; da&#241;o cr&#243;nico acumulado cuantificado seg&#250;n el &#237;ndice Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;SLICC&#47;ACR&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">5</span></a> y n&#250;mero de ingresos hospitalarios&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Se recogieron de forma sistem&#225;tica&#44; en el momento del diagn&#243;stico y con periodicidad anual&#44; las caracter&#237;sticas demogr&#225;ficas&#44; cl&#237;nicas y de laboratorio&#46; Las variables cl&#237;nicas incluyeron los criterios ACR de LES&#44; la presentaci&#243;n cl&#237;nica en la primera visita &#40;s&#237;ntomas activos o recogidos en la anamnesis por &#243;rganos y aparatos&#41;&#44; perfil de autoanticuerpos y diversas determinaciones anal&#237;ticas y de imagen&#44; seg&#250;n las manifestaciones del LES&#46; La actividad de la enfermedad se midi&#243; al diagn&#243;stico y de forma regular mediante el &#237;ndice Systemic Lupus Erythematosus Disease Activity Index 2000 &#40;SLEDAI 2K&#41;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">6</span></a> y el da&#241;o org&#225;nico con periodicidad anual&#46; Entre las comorbilidades se recogieron&#58; tabaquismo&#44; diabetes&#44; dislipidemia &#40;colesterol total &#62; 240<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o colesterol de baja densidad de lipoprote&#237;nas<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>130<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o triglic&#233;ridos &#62; 160<span class="elsevierStyleHsp" style=""></span>mg&#47;dL o consumo de f&#225;rmacos hipolipidemiantes&#41;&#44; hipertensi&#243;n arterial &#40;&#62; 140&#47;90<span class="elsevierStyleHsp" style=""></span>mmHg en al menos 2 ocasiones o consumo de f&#225;rmacos antihipertensivos&#41;&#44; enfermedad arterial perif&#233;rica&#44; cardiopat&#237;a isqu&#233;mica&#44; insuficiencia cardiaca&#44; enfermedad tromboemb&#243;lica y accidente vascular cerebral&#44; diagnosticados por criterios cl&#237;nicos&#44; anal&#237;ticos y de imagen habituales&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Dada la influencia de los diferentes medicamentos tanto en el curso cl&#237;nico del LES como en la morbilidad asociada&#44; cada cambio de tratamiento se registr&#243;&#44; de forma que fue posible calcular el tiempo y la dosis concreta de los f&#225;rmacos utilizados para el control del LES en un momento determinado&#46; Recientemente se ha publicado un primer an&#225;lisis de las pautas terap&#233;uticas en el primer a&#241;o de seguimiento<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">An&#225;lisis estad&#237;stico</span><p id="par0065" class="elsevierStylePara elsevierViewall">Los datos se presentan como medias &#40;desviaci&#243;n est&#225;ndar &#91;DE&#93;&#41;&#44; medianas &#40;rango intercuart&#237;lico &#91;RIC&#93;&#41; o totales con porcentajes&#46; Las caracter&#237;sticas basales entre grupos se compararon mediante la prueba de chi al cuadrado&#44; prueba exacta de Fisher&#44; t de Student o prueba de Mann-Whitney&#44; seg&#250;n fuera necesario&#46; El an&#225;lisis se realiz&#243; con el paquete estad&#237;stico SPSS 22&#46;0 para Mac OS X &#40;IBM Corp&#44; Armonk&#44; EE&#46; UU&#46;&#41;&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Resultados</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Caracter&#237;sticas demogr&#225;ficas</span><p id="par0070" class="elsevierStylePara elsevierViewall">Se incluy&#243; a 298 pacientes &#40;265 &#91;88&#44;9&#37;&#93; mujeres&#41;&#44; con una edad media al diagn&#243;stico de 40&#44;8 &#40;DE 15&#44;7&#41; a&#241;os&#46; Doscientos cincuenta y cinco &#40;85&#44;6&#37;&#41; pacientes eran de raza cauc&#225;sica&#44; 4 de raza negra&#44; 21 amerindios&#44; 4 orientales y 5 de etnia gitana&#46; La mediana de seguimiento fue 60 meses &#40;RIC 47&#44;70&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Criterios de clasificaci&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Todos los pacientes cumpl&#237;an al menos 4 de los criterios clasificatorios de LES de la ACR &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#44; con una mediana de 5 &#40;RIC 4&#44;5&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">De los criterios de clasificaci&#243;n que se cumpl&#237;an de forma acumulada en el momento del diagn&#243;stico&#44; los anticuerpos antinucleares &#40;ANA&#41; fueron los m&#225;s frecuentes &#40;98&#44;7&#37;&#41;&#44; mientras que los anti-DNA se observaron en el 62&#44;4&#37;&#46; Entre los criterios cl&#237;nicos predomin&#243; la artritis en 188 pacientes &#40;63&#44;1&#37;&#41;&#44; seguida de la fotosensibilidad en 142 &#40;47&#44;7&#37;&#41; y el rash malar en 98 &#40;32&#44;9&#37;&#41;&#46; En m&#225;s de la mitad de los pacientes &#40;51&#44;7&#37;&#41; se detect&#243; linfopenia&#46; Por el contrario&#44; los criterios neuropsiqui&#225;tricos solo aparecieron en 6 pacientes &#40;2&#37;&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Perfil cl&#237;nico e inmunol&#243;gico en la primera visita</span><p id="par0085" class="elsevierStylePara elsevierViewall">En la primera visita el 97&#44;7&#37; de los pacientes ten&#237;an ANA positivos y el 59&#44;4&#37; mostraba positividad para anti-DNA nativo &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Sesenta y cuatro pacientes &#40;21&#44;5&#37;&#41; fueron diagnosticados de nefritis en la primera visita&#46; Los &#237;ndices de actividad y cronicidad medios fueron en las nefritis clase <span class="elsevierStyleSmallCaps">iii</span> 7&#44;2 &#40;DE 3&#44;2&#41; y 6&#44;6 &#40;DE 9&#44;8&#41;&#44; y en las de clase <span class="elsevierStyleSmallCaps">iv</span> 9&#44;8 &#40;DE 4&#44;1&#41; y 3&#44;6 &#40;DE 5&#44;4&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">De los 12 pacientes que se presentaron con eventos cardiovasculares&#44; 5 &#40;40&#37;&#41; eran portadores de anticuerpos antifosfol&#237;pido &#40;AAF&#41; y 3 &#40;22&#44;5&#37;&#41; fumadores&#44; con una mediana de consumo de cigarrillos de 15 paquetes&#47;a&#241;o &#40;RIC 8-29&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">El patr&#243;n de autoanticuerpos se muestra en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; En aquellos con positividad para anticuerpos anti-DNA nativo&#44; la frecuencia de nefritis l&#250;pica fue superior &#40;26&#44;7&#37; vs&#46; 14&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#44; RR 1&#44;91&#41;&#59; as&#237; como la de anemia hemol&#237;tica &#40;13&#44;6&#37; vs&#46; 4&#44;1&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; RR 3&#44;3&#41; y linfopenia &#40;55&#44;4&#37; vs&#46; 43&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; RR 1&#44;21&#41;&#46; El resto de las manifestaciones cl&#237;nicas habituales del LES no mostraron diferencias estad&#237;sticamente significativas entre los pacientes anti-DNA nativo presente o ausente&#46; En 127 pacientes &#40;42&#44;6&#37;&#41; se detect&#243; alguno de los AAF habituales&#46; Entre estos fue m&#225;s frecuente la <span class="elsevierStyleItalic">livedo reticularis</span> &#40;14&#44;2&#37; vs&#46; 6&#44;4&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;026&#59; RR 2&#44;21&#41;&#44; el accidente isqu&#233;mico transitorio &#40;3&#44;9&#37; vs&#46; 0&#37;&#59; p 0&#44;013&#41; y la trombosis venosa profunda &#40;14&#44;2&#37; vs&#46; 2&#44;3&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; RR 6&#44;17&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">En un 20&#44;1&#37; de los pacientes se detect&#243; anti-U1RNP&#46; En estos el fen&#243;meno de Raynaud fue m&#225;s frecuente &#40;28&#44;3&#37; vs&#46; 15&#44;6&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#59; RR 1&#44;78&#41;&#46; En el 38&#44;6&#37; se encontraron anticuerpos anti-Ro y en el 16&#44;8&#37; anti-La&#46; En los pacientes con anti-Ro y&#47;o anti-La&#44; la frecuencia de s&#237;ndrome seco fue mayor &#40;26&#44;1&#37; vs&#46; 14&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#59; RR 1&#44;8&#41; y la de <span class="elsevierStyleItalic">livedo reticularis</span> menor &#40;4&#44;2&#37; vs&#46; 13&#44;5&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#59; RR 0&#44;3&#41;&#46; El 20&#37; eran portadores de anticuerpos anti-Sm&#44; pero su presencia no se asoci&#243; a ninguna manifestaci&#243;n cl&#237;nica espec&#237;fica&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El 59&#44;1&#37; de los pacientes mostraron descenso de alguno de los factores del complemento &#40;C3 o C4&#41;&#44; lo que se asoci&#243; de modo significativo con anemia hemol&#237;tica &#40;13&#44;1&#37; vs&#46; 4&#44;9&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; RR&#59; 2&#44;6&#41; y trombocitopenia &#40;19&#44;3&#37; vs&#46; 10&#44;7&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#59; RR 1&#44;8&#41;&#46; La hipocomplementemia tambi&#233;n se asoci&#243; con m&#225;s frecuencia a la nefritis l&#250;pica &#40;29&#44;1&#37; vs&#46; 10&#44;7&#37;&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#59; RR 2&#44;7&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">La mediana del SLEDAI en la primera visita fue de 9&#44;64 puntos &#40;RIC 4-13&#41;&#46; Ciento noventa y cinco pacientes &#40;65&#44;4&#37;&#41; tuvieron un SLEDAI superior o igual a 6 puntos&#46; Las diferencias cl&#237;nicas en funci&#243;n del SLEDAI se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Tratamientos previos y tras el diagn&#243;stico de lupus eritematoso sist&#233;mico &#40;LES&#41;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Se recogieron los tratamientos recibidos antes del diagn&#243;stico y 30 d&#237;as despu&#233;s del mismo &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46; Antes del diagn&#243;stico 255 &#40;85&#44;6&#37;&#41; pacientes no recib&#237;an tratamiento&#44; mientras que en los 30 d&#237;as posteriores el 85&#44;2&#37; recib&#237;a alguna medicaci&#243;n&#46; Los pacientes que ya tomaban antipal&#250;dicos en la primera visita ten&#237;an una mediana de SLEDAI inferior &#40;5 vs&#46; 8&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; Sin embargo&#44; la mediana de SLEDAI no difer&#237;a entre aquellos que tomaban o no corticoides &#40;7 vs&#46; 8&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;25&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discusi&#243;n</span><p id="par0120" class="elsevierStylePara elsevierViewall">Los registros en medicina pueden considerarse sistemas organizados de recogida y almacenamiento de informaci&#243;n sobre pacientes&#44; que nos permiten conocer mejor determinados aspectos de una enfermedad<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a>&#46; Los registros de bases de datos administrativas se han utilizado para estudiar aspectos sobre incidencia&#44; prevalencia&#44; mortalidad&#44; demograf&#237;a y algunas caracter&#237;sticas cl&#237;nicas de pacientes con LES<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">9-11</span></a>&#46; Sin embargo&#44; son las cohortes observacionales espec&#237;ficas de pacientes con LES las que han permitido un mejor conocimiento de la enfermedad&#46; Algunos ejemplos son la Hopkins Lupus Cohort<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a>&#44; la cohorte LUMINA<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">13</span></a>&#44; el registro EUROLUPUS<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a>&#44; la cohorte de la Universidad de Toronto<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> o la cohorte multic&#233;ntrica internacional SLICC<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a>&#46; De ellas se han obtenidos resultados tan importantes como la definici&#243;n por Urowitz et al&#46; en 1974 del patr&#243;n bimodal de mortalidad en el LES<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">RELES constituye la primera cohorte prospectiva y multic&#233;ntrica espa&#241;ola de pacientes recogidos en una fase inicial de la enfermedad&#44; con car&#225;cter longitudinal&#46; Las caracter&#237;sticas demogr&#225;ficas y el grado de actividad al diagn&#243;stico&#44; cuantificado por SLEDAI&#44; fueron similares a los de otras cohortes<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">13&#44;15&#44;16</span></a>&#46; En comparaci&#243;n con la serie de EUROLUPUS&#44; nuestros pacientes presentaron una mayor frecuencia de fotosensibilidad&#44; aftas orales&#44; anemia hemol&#237;tica&#44; trombocitopenia y <span class="elsevierStyleItalic">livedo reticularis</span>&#44; y menor de nefritis l&#250;pica&#44; manifestaciones neuropsiqui&#225;tricas&#44; artritis y serositis&#46; Aunque no son estudios enteramente comparables&#44; entre otras razones por la ausencia de datos relativos a la puntuaci&#243;n SLEDAI en el registro europeo&#44; s&#237; puede decirse que los pacientes de RELES se presentaron con un menor grado de afecci&#243;n org&#225;nica&#46; Este hecho puede explicarse&#44; al menos parcialmente&#44; por la tendencia en los &#250;ltimos a&#241;os a un diagn&#243;stico precoz de la enfermedad&#44; debido a un mayor &#237;ndice de sospecha cl&#237;nica y a la disponibilidad de t&#233;cnicas inmunol&#243;gicas espec&#237;ficas&#46; Un hecho diferencial m&#225;s importante es que el dise&#241;o de la cohorte EUROLUPUS no fue para pacientes con diagn&#243;stico reciente de LES&#44; por lo que las caracter&#237;sticas de los pacientes a la entrada en el estudio no reflejan&#44; como en nuestro caso&#44; las del momento inicial de la enfermedad&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En Espa&#241;a&#44; disponemos de resultados recientes de la cohorte Registro de lupus eritematoso sist&#233;mico de la Sociedad Espa&#241;ola de Reumatolog&#237;a &#40;RELESSER&#41;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">18&#44;19</span></a>&#44; un registro multic&#233;ntrico nacional que incluye a m&#225;s de 4&#46;000 pacientes&#46; Una vez m&#225;s&#44; los resultados son dif&#237;cilmente comparables&#44; ya que en este registro los datos se recogieron retrospectivamente y se incluye a pacientes en cualquier fase de la enfermedad&#46; No obstante&#44; sus promotores prev&#233;n la recogida prospectiva de variables&#44; incluyendo a los pacientes de reciente diagn&#243;stico&#44; lo que permitir&#225; establecer comparaciones sobre aspectos cl&#237;nicos y de tratamiento entre los pacientes espa&#241;oles con LES tratados en servicios de Medicina Interna y Reumatolog&#237;a&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La existencia del LES seronegativo es cada vez m&#225;s cuestionada<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a>&#44; aunque en la mayor&#237;a de las cohortes observacionales&#44; tanto las cl&#225;sicas<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> como las m&#225;s recientes<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">21</span></a>&#44; la positividad de ANA no llega al 100&#37; de los pacientes&#46; En nuestra serie&#44; 4 pacientes &#40;1&#44;3&#37;&#41; fueron ANA negativos&#44; siendo todos ellos positivos para alg&#250;n AAF&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Como en otras series&#44; la presencia de anticuerpos anti-DNA nativo en la cohorte RELES se asoci&#243; con manifestaciones graves como la nefritis y la anemia hemol&#237;tica&#46; La hipocomplementemia tambi&#233;n lo hizo con una mayor incidencia de nefritis l&#250;pica al diagn&#243;stico&#46; Los AAF se asociaron con trombosis venosa profunda y accidente isqu&#233;mico transitorio&#44; pero no con otras trombosis arteriales como cardiopat&#237;a isqu&#233;mica o infarto cerebral&#44; probablemente por el escaso n&#250;mero de pacientes con estas manifestaciones como forma de presentaci&#243;n del LES&#46; Sesenta y cuatro &#40;21&#44;5&#37;&#41; pacientes se presentaron con nefritis l&#250;pica&#44; la mayor&#237;a &#40;56&#37;&#41; fueron del tipo <span class="elsevierStyleSmallCaps">iii</span> o <span class="elsevierStyleSmallCaps">iv</span>&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">A los 30 d&#237;as del diagn&#243;stico&#44; el 68&#44;5&#37; de los pacientes estaban recibiendo antipal&#250;dicos&#46; Este porcentaje aumenta hasta el 81&#37; durante el primer a&#241;o<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">7</span></a> y se mantiene entre los pacientes con nefritis l&#250;pica y con un SLEDAI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>6&#46; Estos datos reflejan el empleo de la hidroxicloroquina como tratamiento de base del LES&#44; m&#225;s all&#225; de manifestaciones cl&#237;nicas concretas&#44; manteni&#233;ndose en los pacientes m&#225;s graves&#46; Un aspecto notorio de nuestros resultados es que los pacientes tratados con antipal&#250;dicos antes del diagn&#243;stico de LES comenzaron con una enfermedad menos activa&#44; como reflej&#243; una menor puntuaci&#243;n del SLEDAI &#40;5 vs&#46; 8 de los que no recib&#237;an antipal&#250;dicos&#41;&#46; La indicaci&#243;n de hidroxicloroquina en estos pacientes se hizo por un diagn&#243;stico previo de LES incompleto&#44; es decir&#44; pacientes con sospecha cl&#237;nica de LES&#44; que no cumplen todos los criterios requeridos para clasificarlos como tal&#46; Nuestros datos son similares a los de James et al&#46;&#44; que encontraron un efecto protector de la hidroxicloroquina&#44; traducido en un comienzo m&#225;s tard&#237;o y con menos manifestaciones de actividad&#44; como proteinuria y leucopenia&#44; en los pacientes con LES incompleto que finalmente cumplieron criterios clasificatorios<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">22</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Ciento sesenta pacientes &#40;53&#44;7&#37;&#41; fueron tratados con prednisona&#44; de los que 60 recibieron adem&#225;s de bolus de metilprednisolona&#44; ciclofosfamida intravenosa o f&#225;rmacos biol&#243;gicos desde el momento del diagn&#243;stico&#44; la mayor&#237;a por nefritis l&#250;pica y alteraciones hematol&#243;gicas&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">RELES refleja la forma de presentaci&#243;n del LES&#44; desde un punto de vista cl&#237;nico e inmunol&#243;gico&#44; en un entorno de pr&#225;ctica cl&#237;nica real y contempor&#225;nea&#46; A pesar de las limitaciones derivadas de la heterogeneidad de los centros participantes y de la ausencia de unificaci&#243;n de pruebas de laboratorio&#44; sobre todo inmunol&#243;gicas&#44; RELES constituye la primera cohorte nacional&#44; multic&#233;ntrica y prospectiva de pacientes en seguimiento desde la fase inicial del LES&#44; que nos va a permitir conocer cu&#225;les son las caracter&#237;sticas de los pacientes que se atienden en el d&#237;a a d&#237;a&#44; los factores pron&#243;sticos m&#225;s relevantes y los mejores tratamientos&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicto de intereses</span><p id="par0160" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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              "titulo" => "Perfil cl&#237;nico e inmunol&#243;gico en la primera visita"
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              "titulo" => "Tratamientos previos y tras el diagn&#243;stico de lupus eritematoso sist&#233;mico &#40;LES&#41;"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los registros de pacientes son herramientas &#250;tiles para evaluar enfermedades poco frecuentes&#46; Nuestro objetivo es presentar el &#171;Registro espa&#241;ol de pacientes con lupus eritematoso sist&#233;mico&#187; &#40;RELES&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Pacientes y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">RELES se inici&#243; en 2008&#44; como un registro multic&#233;ntrico de cohortes&#44; observacional&#44; prospectivo&#44; incluyendo a pacientes desde el momento del diagn&#243;stico&#44; cuyo objetivo es analizar la incidencia y complicaciones no inflamatorias del lupus eritematoso sist&#233;mico &#40;LES&#41;&#46; Participan los servicios de Medicina Interna de 38 hospitales espa&#241;oles&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 298 pacientes con una edad media de 40&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;7 a&#241;os&#44; de los que el 88&#44;9&#37; eran mujeres y el 85&#44;6&#37; de raza cauc&#225;sica&#46; En la primera visita&#44; predominaron las manifestaciones articulares &#40;74&#44;5&#37;&#41;&#46; Ciento setenta y siete pacientes &#40;59&#44;4&#37;&#41; mostraban positividad para anti-DNA nativo&#44; siendo superior en estos la frecuencia de nefritis l&#250;pica &#40;26&#44;7&#37; vs&#46; 14&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#59; riesgo relativo &#91;RR&#93; 1&#44;33&#41;&#44; de anemia hemol&#237;tica &#40;13&#44;6&#37; vs&#46; 4&#44;1&#37;&#44; p&#61; 0&#44;07&#59; RR 1&#44;46&#41; y linfopenia &#40;55&#44;4&#37; vs&#46; 43&#44;8&#37;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#59; RR 1&#44;21&#41;&#46; La mediana del Systemic Lupus Erythematosus Disease Activity Index 2000 &#40;SLEDAI 2K&#41; fue de 9&#44;64 puntos &#40;rango intercuart&#237;lico 4-13&#41;&#46; Los tratados con antipal&#250;dicos antes del diagn&#243;stico de LES ten&#237;an una mediana de SLEDAI en la primera visita de 5&#44; frente a 8 en los que no los tomaban &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">RELES constituye la primera cohorte de pacientes con LES recogidos desde el momento del diagn&#243;stico en Espa&#241;a&#46; La presencia de anti-DNA se ha relacionado con manifestaciones graves como nefritis y anemia hemol&#237;tica&#46; El tratamiento con antipal&#250;dicos antes del diagn&#243;stico se asoci&#243; con una enfermedad menos activa al comienzo&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patient registries are useful tools for assessing rare diseases&#46; Our objective is to present the Spanish registry of patients with systemic lupus erythematosus &#40;<span class="elsevierStyleItalic">Registro espa&#241;ol de pacientes con lupus eritematoso sist&#233;mico</span>&#44; RELES&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">RELES was started in 2008 as an observational&#44; prospective&#44; multicentre cohort registry that included patients from the time they were diagnosed&#46; The registry&#39;s objective is to analyse the incidence and noninflammatory complications of systemic lupus erythematosus &#40;SLE&#41;&#46; The departments of internal medicine of 38 Spanish hospitals participate in this registry&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 298 patients with a mean age of 40&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;7 years were included&#44; 88&#46;9&#37; of whom were women and 85&#46;6&#37; of whom were white&#46; In the first visit&#44; there was a predominance of joint manifestations &#40;74&#46;5&#37;&#41;&#46; One hundred and seventy-seven patients &#40;59&#46;4&#37;&#41; were positive for anti-native DNA&#46; In these patients&#44; there was a higher rate of lupus nephritis &#40;26&#46;7&#37; vs&#46; 14&#37;&#44; p&#61;&#46;009&#59; relative risk &#91;RR&#93;&#44; 1&#46;33&#41;&#44; haemolytic anaemia &#40;13&#46;6&#37; vs&#46; 4&#46;1&#37;&#44; p&#61;&#46;07&#59; RR&#44; 1&#46;46&#41; and lymphopenia &#40;55&#46;4&#37; vs&#46; 43&#46;8&#37;&#44; p&#61;&#46;05&#59; RR&#44; 1&#46;21&#41;&#46; The median Systemic Lupus Erythematosus Disease Activity Index 2000 &#40;SLEDAI 2<span class="elsevierStyleHsp" style=""></span>K&#41; score was 9&#46;64 points &#40;interquartile range&#44; 4-13&#41;&#46; The patients treated with antimalarial drugs before the diagnosis of SLE had a median SLEDAI score in the first visit of 5&#44; compared with 8 for those who were not treated with these drugs &#40;p&#61;&#46;02&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">RELES constitutes the first Spanish patient cohort with SLE recorded from the time of the diagnosis&#46; The presence of anti-DNA has been related to severe manifestations such as nephritis and haemolytic anaemia&#46; Treatment with antimalarial drugs before the diagnosis was associated with less active disease at the initial presentation&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">La lista completa de los investigadores RELES-GEAS consta en el <a class="elsevierStyleCrossRef" href="#sec0070">anexo 1</a>&#46;</p>"
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            "apendice" => "<p id="par0175" class="elsevierStylePara elsevierViewall">Akasbi M&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Infanta Leonor&#44; Madrid &#40;Espa&#241;a&#41;&#59; Boldova R&#46;&#44; Servicio de Medicina Interna&#44; Hospital Cl&#237;nico Universitario Lozano Blesa&#44; Zaragoza &#40;Espa&#241;a&#41;&#59; Callejas J&#46;L&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario San Cecilio&#44; Granada &#40;Espa&#241;a&#41;&#59; Caminal L&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias &#40;Espa&#241;a&#41;&#59; Canora J&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid &#40;Espa&#241;a&#41;&#59; Castillo M&#46;J&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Virgen del Roc&#237;o&#44; Sevilla &#40;Espa&#241;a&#41;&#59; Castro A&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Sant Joan de Reus&#44; Reus&#44; Tarragona &#40;Espa&#241;a&#41;&#59; Erdozain J&#46;G&#46;&#44; Servicio de Medicina Interna&#44; Hospital de Mendaro&#44; Mendaro&#44; Guip&#250;zcoa &#40;Espa&#241;a&#41;&#59; Espinosa G&#46;&#44; Servicio de Enfermedades Autoinmunes&#44; Hospital Cl&#237;nic&#44; Barcelona &#40;Espa&#241;a&#41;&#59; Fern&#225;ndez-Monr&#225;s F&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitari Sagrat Cor&#44; Barcelona &#40;Espa&#241;a&#41;&#59; Fonseca E&#46;M&#46;&#44; Servicio de Medicina Interna&#44; Hospital de Cabue&#241;es&#44; Gij&#243;n&#44; Asturias &#40;Espa&#241;a&#41;&#59; Fraile G&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Ram&#243;n y Cajal&#44; Madrid &#40;Espa&#241;a&#41;&#59; Frutos B&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario de Fuenlabrada&#44; Fuenlabrada&#44; Madrid &#40;Espa&#241;a&#41;&#59; Garc&#237;a M&#46;&#44; Unidad de Investigaci&#243;n de Enfermedades Autoinmunes&#44; Servicio de Medicina Interna&#44; BioCruces Health Research Institute&#44; Hospital Universitario Cruces&#44; Universidad del Pa&#237;s Vasco&#47;Euskal Herriko Unibertsitatea&#44; Barakaldo&#44; Vizcaya &#40;Espa&#241;a&#41;&#59; Garc&#237;a-Morales M&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario San Cecilio&#44; Granada &#40;Espa&#241;a&#41;&#59; Garc&#237;a-S&#225;nchez A&#46;I&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Infanta Leonor&#44; Madrid &#40;Espa&#241;a&#41;&#59; Gil A&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario La Paz&#44; Madrid &#40;Espa&#241;a&#41;&#59; Gonz&#225;lez-Echavarri C&#46;&#44; Unidad de Investigaci&#243;n de Enfermedades Autoinmunes&#44; Servicio de Medicina Interna&#44; BioCruces Health Research Institute&#44; Hospital Universitario Cruces&#44; Universidad del Pa&#237;s Vasco&#47;Euskal Herriko Unibertsitatea&#44; Barakaldo&#44; Vizcaya &#40;Espa&#241;a&#41;&#59; Gonz&#225;lez-Le&#243;n R&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Virgen del Roc&#237;o&#44; Sevilla &#40;Espa&#241;a&#41;&#59; Herranz M&#46;T&#46;&#44; Servicio de Medicina Interna&#44; Hospital J&#46;M&#46; Morales Meseguer&#44; Murcia &#40;Espa&#241;a&#41;&#59; Hurtado R&#46;&#44; Servicio de Medicina Interna&#44; Hospital General Universitario de Elche&#44; Elche&#44; Alicante &#40;Espa&#241;a&#41;&#59; Jim&#233;nez-Alonso J&#46;F&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Virgen de las Nieves&#44; Granada &#40;Espa&#241;a&#41;&#59; L&#243;pez-Dupla J&#46;M&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Joan XXIII&#44; Tarragona &#40;Espa&#241;a&#41;&#59; Mar&#237;n-Ballv&#233; A&#46;&#44; Servicio de Medicina Interna&#44; Hospital Cl&#237;nico Universitario Lozano Blesa&#44; Zaragoza &#40;Espa&#241;a&#41;&#59; Mart&#237;n-&#193;lvarez H&#46;&#44; Servicio de Medicina Interna&#44; Fundaci&#243;n Hospital de Alcorc&#243;n&#44; Alcorc&#243;n&#44; Madrid &#40;Espa&#241;a&#41;&#59; Mic&#243; M&#46;L&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario y Polit&#233;cnico La Fe&#44; Valencia &#40;Espa&#241;a&#41;&#59; Mitjavila F&#46;&#44; Unidad de Enfermedades Autoinmunes&#44; Servicio de Medicina Interna&#44; Hospital Universitario de Bellvitge&#44; L¿Hospitalet de Llobregat&#44; Barcelona &#40;Espa&#241;a&#41;&#59; Navarrete N&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Virgen de las Nieves&#44; Granada &#40;Espa&#241;a&#41;&#59; N&#250;&#241;ez-Cuerda E&#46;&#44; Servicio de Medicina Interna&#44; Hospital General Nuestra Se&#241;ora del Prado&#44; Talavera de la Reina&#44; Toledo &#40;Espa&#241;a&#41;&#59; Pallar&#233;s L&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Son Dureta&#44; Palma de Mallorca&#44; Islas Baleares &#40;Espa&#241;a&#41;&#59; Parra S&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Sant Joan de Reus&#44; Reus&#44; Tarragona &#40;Espa&#241;a&#41;&#59; P&#233;rez-Conesa M&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Miguel Servet&#44; Zaragoza &#40;Espa&#241;a&#41;&#59; Pinilla B&#46;&#44; Servicio de Medicina Interna&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid &#40;Espa&#241;a&#41;&#59; Rodr&#237;guez A&#46;P&#46;&#44; Servicio de Medicina Interna&#44; Complejo Hospitalario Universitario de Ourense&#44; Orense &#40;Espa&#241;a&#41;&#59; Rodr&#237;guez-Carballeira M&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Mutua de Terrasa&#44; Terrasa&#44; Barcelona &#40;Espa&#241;a&#41;&#59; Ruiz-Irastorza G&#46;&#44; Unidad de Investigaci&#243;n de Enfermedades Autoinmunes&#44; Servicio de Medicina Interna&#44; BioCruces Health Research Institute&#44; Hospital Universitario Cruces&#44; Universidad del Pa&#237;s Vasco&#47;Euskal Herriko Unibertsitatea&#44; Barakaldo&#44; Vizcaya &#40;Espa&#241;a&#41;&#59; S&#225;ez L&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Miguel Servet&#44; Zaragoza &#40;Espa&#241;a&#41;&#59; Salvador G&#46;&#44; Servicio de Medicina Interna&#44; Hospital de Manises&#44; Manises&#44; Valencia &#40;Espa&#241;a&#41;&#59; S&#225;nchez-Garc&#237;a E&#46;&#44; Unidad de Enfermedades Autoinmunes&#44; Servicio de Medicina Interna&#44; Hospital Universitario Reina Sof&#237;a&#44; C&#243;rdoba &#40;Espa&#241;a&#41;&#59; Serralta G&#46;&#44; Servicio de Medicina Interna&#44; Hospital Infanta Sof&#237;a&#44; San Sebasti&#225;n de los Reyes&#44; Madrid &#40;Espa&#241;a&#41;&#59; Sope&#241;a B&#46;&#44; Servicio de Medicina Interna&#46; Complejo Hospitalario Universitario de Vigo&#44; Pontevedra&#44; Vigo &#40;Espa&#241;a&#41;&#59; Su&#225;rez S&#46;&#44; Servicio de Medicina Interna&#44; Hospital Universitario Central de Asturias&#44; Oviedo&#44; Asturias &#40;Espa&#241;a&#41;&#59; Tolosa C&#46;&#44; Servicio de Medicina Interna&#44; Corporaci&#243; Sanit&#224;ria Parc Taul&#237;&#44; Sabadell&#44; Barcelona &#40;Espa&#241;a&#41;&#59; Villalba M&#46;V&#46;&#44; Servicio de Medicina Interna&#44; Hospital General Universitario Gregorio Mara&#241;&#243;n&#44; Madrid &#40;Espa&#241;a&#41;&#46;</p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Miembros del Grupo RELES&#58;"
            "identificador" => "sec0070"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">AAF&#58; anticuerpos antifosfol&#237;pido&#59; ANA&#58; anticuerpos antinucleares&#59; DNA&#58; &#225;cido desoxirribonucleico&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ANA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">294&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-DNA nativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">186&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Linfopenia &#40;&#60; 1&#46;500&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">154&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fotosensibilidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leucopenia &#40;&#60; 3&#46;000&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Serositis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Proteinuria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">ACV&#47;AIT&#58; accidente cerebrovascular&#47;accidente isqu&#233;mico transitorio&#59; IAM&#58; infarto agudo de miocardio&#59; SOCA&#44; s&#237;ndrome org&#225;nico cerebral agudo&#59; TEP&#58; tromboembolia pulmonar&#59; TVP&#58; trombosis venosa profunda&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artralgias&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">151&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fotosensibilidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leucopenia &#40;&#60; 3&#46;000&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aftas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Rash malar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nefritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fen&#243;meno de Raynaud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trombocitopenia &#40;&#60; 100&#46;000&#47;mm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pleuritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipotiroidismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pericarditis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lupus cut&#225;neo subagudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Livedo reticularis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anemia hemol&#237;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lupus cut&#225;neo cr&#243;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Afectaci&#243;n oftalmol&#243;gica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TVP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ACV&#47;AIT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vasculitis cut&#225;nea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neumonitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TEP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertiroidismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Valvulopat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertensi&#243;n arteria pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuropat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SOCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Convulsiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Miositis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mielitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertensi&#243;n intracraneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artropat&#237;a de Jaccoud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psicosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IAM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Corea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Manifestaciones cl&#237;nicas en la primera visita</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">aCL&#58; anticuerpo anticardiolipina&#59; AL&#58; anticoagulante l&#250;pico&#59; ANA&#58; anticuerpos antinucleares&#59; anti-B2 GP 1&#58; anticuerpo antibeta 2 glucoprote&#237;na 1&#59; FR&#58; factor reumatoide&#59; GPL&#58; unidades IgG de antifosfol&#237;pido&#59; Ig&#58; inmunoglobulina&#59; MPL&#58; unidades IgM de antifosfol&#237;pidos&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ANA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">291&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-DNA nativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">177&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-Ro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">115&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-La&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-Sm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-U1RNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C3 bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">157&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C4 bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">140&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgG negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">196&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgG bajo &#40;&#60; 40 GPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgG medio &#40;40-80 GPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgG alto &#40;&#62; 80 GPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgM negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">199&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgM bajo &#40;&#60; 40 MPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgM medio &#40;40-80 MPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">aCL IgM alto &#40;&#62; 80 MPL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-B2 GP 1 IgG &#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-B2 GP 1 IgM &#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Positividad de las pruebas inmunol&#243;gicas en la primera visita</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">AAF&#58; anticuerpos antifosfol&#237;pido&#59; ACV&#58; accidente cerebrovascular&#59; AIT&#58; accidente isqu&#233;mico transitorio&#59; ANA&#58; anticuerpos antinucleares&#59; DNA&#58; &#225;cido desoxirribonucleico&#59; FR&#58; factor reumatoide&#59; IAM&#58; infarto agudo de miocardio&#59; SOCA&#58; s&#237;ndrome org&#225;nico cerebral agudo&#59; TEP&#58; tromboembolia pulmonar&#59; TVP&#58; trombosis venosa profunda&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">SLEDAI<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">SLEDAI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Edad al diagn&#243;stico &#40;media&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Raza cauc&#225;sica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">87&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Rash malar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lupus cut&#225;neo cr&#243;nico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lupus cut&#225;neo subagudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Livedo reticularis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Alopecia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fen&#243;meno de Raynaud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vasculitis cut&#225;nea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fotosensibilidad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aftas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artralgias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">78&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Artropat&#237;a de Jaccoud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SOCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Convulsiones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psicosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mielitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuropat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertensi&#243;n intracraneal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Afectaci&#243;n oftalmol&#243;gica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertensi&#243;n arterial pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pleuritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neumonitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pericarditis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Valvulopat&#237;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anemia hemol&#237;tica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Leucopenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Linfopenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trombocitopenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TVP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TEP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ACV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AIT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertiroidismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipotiroidismo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">S&#237;ndrome seco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nefritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ANA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">97&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-DNA nativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-Ro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-La&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-Sm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anti-U<span class="elsevierStyleInf">1</span> RNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Complemento bajo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;053&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AAF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Antipal&#250;dicos previos al diagn&#243;stico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Corticoides previos al diagn&#243;stico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1319504.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Diferencias cl&#237;nicas en funci&#243;n de la puntuaci&#243;n SLEDAI al diagn&#243;stico</p>"
        ]
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          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">AAS&#58; &#225;cido acetilsalic&#237;lico&#59; AINE&#58; antiinflamatorios no esteroideos&#59; iv&#58; intravenosa&#59; LES&#58; lupus eritematoso sist&#233;mico&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">160 &#40;53&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">204 &#40;68&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;5&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;7&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;2&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Talidomida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40 &#40;13&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acenocumarol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;2&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Calcio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82 &#40;27&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vitamina D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">81 &#40;27&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bifosfonatos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;3&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Estatinas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipotensores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tacrolim&#250;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Heparina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;1&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Mortality in systemic lupus erythematosus"
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                        "paginaFinal" => "2557"
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                          0 => array:2 [
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              "identificador" => "bib0125"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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                          "autores" => array:3 [
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                            2 => "M&#46;S&#46; Anthony"
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                      ]
                    ]
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                    0 => array:1 [
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                        "paginaInicial" => "308"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16761508"
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                          ]
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                      ]
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2008"
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                        "paginaInicial" => "929"
                        "paginaFinal" => "939"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
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                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1997"
                        "volumen" => "40"
                        "paginaInicial" => "1725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9324033"
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                    ]
                  ]
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                      "titulo" => "The reliability of the Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology Damage Index in patients with systemic lupus erythematosus"
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                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1997"
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                        "paginaInicial" => "809"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9153540"
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                ]
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                      "titulo" => "Systemic lupus erythematosus disease activity index 2000"
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                        "tituloSerie" => "Clin Exp Rheumatol"
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                        "paginaInicial" => "466"
                        "paginaFinal" => "472"
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            ]
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              "identificador" => "bib0160"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lupus registries&#58; Evolution and challenges"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;J&#46; Lu"
                            1 => "D&#46;J&#46; Wallace"
                            2 => "S&#46;V&#46; Navarra"
                            3 => "M&#46;H&#46; Weisman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2008.08.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2010"
                        "volumen" => "39"
                        "paginaInicial" => "224"
                        "paginaFinal" => "245"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18992923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A&#46;R&#46;A&#46;M&#46;I&#46;S&#46; &#40;The American Rheumatism Association Medical Information System&#41;&#58; A prototypical national chronic disease data bank"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;F&#46; Fries"
                            1 => "D&#46;J&#46; McShane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "West J Med"
                        "fecha" => "1986"
                        "volumen" => "145"
                        "paginaInicial" => "798"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3492816"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ethnicity and mortality from systemic lupus erythematosus in the US"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Krishnan"
                            1 => "H&#46;B&#46; Hubert"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2005.040907"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "paginaInicial" => "1500"
                        "paginaFinal" => "1505"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16627544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic lupus erythematosus prevalence in the UK&#58; Methodological issues when using the General Practice Research Database to estimate frequency of chronic relapsing-remitting disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;L&#46; Nightingale"
                            1 => "R&#46;D&#46; Farmer"
                            2 => "C&#46;S&#46; de Vries"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/pds.1253"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pharmacoepidemiol Drug Saf"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "paginaInicial" => "144"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16700093"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hopkins Lupus Cohort &#40;1999 update&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Petri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheum Dis Clin N Am"
                        "fecha" => "2000"
                        "volumen" => "26"
                        "paginaInicial" => "199"
                        "paginaFinal" => "213"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic lupus erythematosus in a multiethnic U&#46;S&#46; cohort &#40;LUMINA&#41;&#58; XXI&#46; Disease activity&#44; damage accrual&#44; and vascular events in pre- and postmenopausal women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Fern&#225;ndez"
                            1 => "J&#46; Calvo-Al&#233;n"
                            2 => "G&#46;S&#46; Alarc&#243;n"
                            3 => "J&#46;M&#46; Roseman"
                            4 => "H&#46;M&#46; Bastian"
                            5 => "B&#46;J&#46; Fessler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.21048"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2005"
                        "volumen" => "52"
                        "paginaInicial" => "1655"
                        "paginaFinal" => "1664"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15934092"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic lupus erythematosus in Europe at the change of the millennium&#58; Lessons from the Euro-Lupus Project"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "European Working Party on Systemic Lupus Erythematosus"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Cervera"
                            1 => "M&#46; Abarca-Costalago"
                            2 => "D&#46; Abramovicz"
                            3 => "F&#46; Allegri"
                            4 => "P&#46; Annunziata"
                            5 => "A&#46;O&#46; Aydintug"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.autrev.2005.06.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Autoimmun Rev"
                        "fecha" => "2006"
                        "volumen" => "5"
                        "paginaInicial" => "180"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16483917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Contributions of observational cohort studies in systemic lupus erythematosus&#58; The University of Toronto lupus clinic experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;B&#46; Urowitz"
                            1 => "D&#46;D&#46; Gladman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rdc.2005.01.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheum Dis Clin North Am"
                        "fecha" => "2005"
                        "volumen" => "31"
                        "paginaInicial" => "211"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15922142"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Systemic Lupus International Collaborating Clinics&#47;American College of Rheumatology &#40;SLICC&#47;ACR&#41;&#46; Damage Index for Systemic Lupus Erythematosus International Comparison"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;D&#46; Gladman"
                            1 => "C&#46;H&#46; Goldsmith"
                            2 => "M&#46;B&#46; Urowitz"
                            3 => "P&#46; Bacon"
                            4 => "P&#46; Fortin"
                            5 => "E&#46; Ginzler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "373"
                        "paginaFinal" => "376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10685799"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The bimodal mortality pattern of systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;B&#46; Urowitz"
                            1 => "A&#46;A&#46; Bookman"
                            2 => "B&#46;E&#46; Koehler"
                            3 => "D&#46;A&#46; Gordon"
                            4 => "H&#46;A&#46; Smythe"
                            5 => "M&#46;A&#46; Ogryzlo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1976"
                        "volumen" => "60"
                        "paginaInicial" => "221"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1251849"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Registro nacional de pacientes con lupus eritematoso sist&#233;mico de la Sociedad Espa&#241;ola de Reumatolog&#237;a&#58; objetivos y metodolog&#237;a"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Grupo de trabajo en Enfermedades Autoinmunes Sist&#233;micas de la Sociedad Espa&#241;ola de Reumatolog&#237;a &#40;EAS-SER&#41;&#59; Unidad de Investigaci&#243;n de la Sociedad Espa&#241;ola de Reumatolog&#237;a &#40;UI-SER&#41;"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; R&#250;a-Figueroa"
                            1 => "F&#46;J&#46; L&#243;pez-Longo"
                            2 => "J&#46; Calvo-Al&#233;n"
                            3 => "M&#46; Galindo-Izquierdo"
                            4 => "E&#46; Loza"
                            5 => "M&#46;J&#46; Garc&#237;a de Yebenes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2013.04.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2014"
                        "volumen" => "10"
                        "paginaInicial" => "17"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23871155"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comprehensive description of clinical characteristics of a large systemic lupus erythematosus cohort from the Spanish Rheumatology Society Lupus Registry &#40;RELESSER&#41; with emphasis on complete versus incomplete lupus differences"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "EAS-SER &#40;Systemic Diseases Study Group of the Spanish Society of Rheumatology&#41;"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; R&#250;a-Figueroa"
                            1 => "P&#46; Richi"
                            2 => "F&#46;J&#46; L&#243;pez-Longo"
                            3 => "M&#46; Galindo"
                            4 => "J&#46; Calvo-Al&#233;n"
                            5 => "A&#46; Oliv&#233;-Marqu&#233;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "2015"
                        "volumen" => "94"
                        "paginaInicial" => "e267"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Antinuclear antibody-negative lupus as a distinct diagnostic entity &#8212;does it not longer exist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46;S&#46; Cross"
                            1 => "A&#46; Aslam"
                            2 => "S&#46;A&#46; Misbah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Q J Med"
                        "fecha" => "2004"
                        "volumen" => "97"
                        "paginaInicial" => "303"
                        "paginaFinal" => "308"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and incidence of systemic lupus erythematosus in a population-based registry of american indian and Alaska native people&#44; 2007-2009"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;D&#46; Ferucci"
                            1 => "J&#46;M&#46; Johnston"
                            2 => "J&#46;R&#46; Gaddy"
                            3 => "L&#46; Sumner"
                            4 => "J&#46;O&#46; Posever"
                            5 => "T&#46;L&#46; Choromanski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.38720"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheumatol"
                        "fecha" => "2014"
                        "volumen" => "66"
                        "paginaInicial" => "2494"
                        "paginaFinal" => "2502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24891315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; James"
                            1 => "X&#46;R&#46; Kim-Howard"
                            2 => "B&#46;F&#46; Bruner"
                            3 => "M&#46;K&#46; Jonsson"
                            4 => "M&#46;T&#46; McClain"
                            5 => "M&#46;R&#46; Arbuckle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0961203307078579"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lupus"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "paginaInicial" => "401"
                        "paginaFinal" => "409"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17664230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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        "texto" => "<p id="par0165" class="elsevierStylePara elsevierViewall">Los autores agradecen a Mar Ajubita y a todos los miembros del centro coordinador de RELES&#44; S &#38; H Medical Science Service&#44; su apoyo organizativo&#44; log&#237;stico y administrativo&#46;</p> <p id="par0170" class="elsevierStylePara elsevierViewall">Este estudio ha sido apoyado por la Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;&#46;</p>"
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ORIGINAL
Características clínicas al diagnóstico de una cohorte prospectiva de pacientes con lupus eritematoso sistémico atendidos en servicios de Medicina Interna españoles: estudio RELES
Clinical characteristics during diagnosis of a prospective cohort of patients with systemic lupus erythematosus treated in Spanish Departments of Internal Medicine: The RELES study
J. Canoraa,
Autor para correspondencia
jesus.canora@salud.madrid.org

Autor para correspondencia.
, M. Garcíab, F. Mitjavilac, G. Espinosad, S. Suáreze, R. González-Leónf, B. Sopeñag, R. Boldovah, A. Castroi, G. Ruiz-Irastorzab, en representación de los investigadores del Registro RELES-Grupo de Enfermedades Autoinmunes Sistémicas (GEAS)
a Servicio de Medicina Interna, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España
b Unidad de Investigación de Enfermedades Autoinmunes, Servicio de Medicina Interna, BioCruces Health Research Institute, Hospital Universitario Cruces, Universidad del País Vasco/Euskal Herriko Unibertsitatea, Barakaldo, Vizcaya, España
c Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Universitario de Bellvitge, L¿Hospitalet de Llobregat, Barcelona, España
d Servicio de Enfermedades Autoinmunes, Hospital Clínic, Barcelona España
e Servicio de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Asturias, España
f Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla España
g Servicio de Medicina Interna, Complejo Hospitalario Universitario de Vigo, Pontevedra, Vigo, España
h Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza España
i Servicio de Medicina Interna, Hospital Universitario Sant Joan de Reus, Reus, Tarragona, España
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