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climbing stairs and sneezing&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">OVFs are not harmless for the patient and promote future fractures&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a> both vertebral and nonvertebral&#44; and are associated with greater mortality and poorer quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> Studies have estimated that an OVF quadruples the risk of a new OVF and doubles the risk of an osteoporotic fracture of the femoral neck&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The risk of new fractures is 7&#8211;10&#37; during the first year after the onset of the fracture and rises to 18&#37; at 2&#8239;years of the fracture&#46; In individuals older than 75 years&#44; the risk increases to 25&#37; at 2&#8239;years of the fracture<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;17&#44;18</span></a> and is higher for women&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> An early and accurate diagnosis is therefore essential for starting treatment as soon as possible&#46; The dorsal-lumbar hinge is the most affected area&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Morbidity and mortality</span><p id="par0030" class="elsevierStylePara elsevierViewall">A US population study conducted with patients older than 65 years with OVF showed an increase in mortality in this group twice that of the control group&#44; with survival rates of 50&#37; at 3 years&#44; 30&#37; at 5 years and only 10&#37; at 7 years&#46; The patients&#8217; mean age was 80 years&#44; and the increase in mortality was higher in men&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Similar results were obtained from an Australian cohort that also showed that mortality was not higher after OVF in older patients with fractures compared with the younger patients&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Pain is the first manifestation but is only present in a third of fractures&#44; and only 10&#37; of patients with pain consult for it in medical centers&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a> Pain is secondary to the same fracture&#59; apart from the pain in the paravertebral area&#44; patients with multiple fractures can present pain due to the impact of the ribs on the pelvic bones&#46; Another common manifestation is the patients&#8217; loss of stature&#44; many times attributed to other causes&#44; such as age-associated degenerative processes&#46; A documented loss &#62;2&#8239;cm in the past year or a loss of 4&#8211;6&#8239;cm from the height recorded in their youth should alert clinicians to the presence of an OVF&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One of the characteristics of OVFs is the rare involvement of the medullary canal &#40;&#60;1&#37;&#41;&#44; possibly due to the fact that the posterior wall of the vertebral body and the posterior arch are unaffected&#46; Spinal injuries&#44; if they occur&#44; are secondary to the posterior displacement of a fragment of the vertebral body&#46; Neurological symptoms concomitant with pain should raise suspicion about other etiologies&#46; Impairment above T5 is also rare&#46; Fractures in the first dorsal or cervical vertebra are therefore rarely secondary to osteoporosis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The presence of multiple fractures can also result in restrictive lung disease due to a reduction in the thoracic cavity&#44; gastroesophageal transit disorders due to diaphragmatic compensation with abdominal cavity reduction&#44; and physical activity limitations due to pain&#44; with the consequent acceleration of bone waste&#44; increased sarcopenia and physical dependency and can also increase the number of falls due to loss of equilibrium&#46; Likewise&#44; medical complications secondary to immobility can appear&#44; such as pressure ulcers and venous embolism&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Screening for osteoporotic vertebral fractures</span><p id="par0050" class="elsevierStylePara elsevierViewall">The International Osteoporosis Foundation considers the early detection of OVFs an essential element in preventing new fractures&#44; both OVFs and osteoporotic nonvertebral fractures&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Various research studies have recently been published<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;23</span></a> on algorithms for the early detection of asymptomatic OVFs&#46; The main predictors are advanced age&#44; poorer bone mineral density&#44; the use of corticosteroids and the loss of stature&#46; In terms of the bone densitometry values in the lumbar spine as predictors of fractures&#44; there is disagreement among the studies&#44; although a higher prevalence of osteopenia instead of osteoporosis has been observed in the lumbar spine of patients with OVFs&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Given that vertebral fractures are the most common osteoporotic fracture&#44; early and accurate detection should be conducted to decrease the risk of new fractures and to properly establish secondary prevention&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">National and international societies on osteoporosis and frailty fractures do not recommend universal screening for vertebral fractures using spine radiography&#46; Screening is recommended only for patients with symptoms suggestive of OVF or for elderly patients with other previous osteoporotic fractures or densitometric osteoporosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> The recent guidelines of the National Osteoporosis Foundation and International Society for Clinical Densitometry include the recommendations shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> for the search for vertebral fractures&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;25</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Once a first screening for OVFs has been conducted and potential fractures have been identified&#44; repeating the imaging test is advised only if there is a documented loss of height or new onset dorsal-lumbar pain &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Classification of vertebral fractures</span><p id="par0075" class="elsevierStylePara elsevierViewall">OVFs are classified into 3 groups according to their morphology&#58; anterior wedging &#40;reduced anterior diameter of the vertebral body&#41;&#44; biconcave &#40;reduced middle diameter&#41; or compressed &#40;reduced anterior&#44; middle and posterior diameters&#41;&#46; On very rare occasions&#44; the posterior arch of the vertebra is affected and usually does not affect the medullary canal&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The first vertebral fracture assessment methods in spinal radiographs were quantitative and based on the vertebral form&#46; One of the best known of these methods is by Eastell and Melton&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> which is based on vertebral body size abnormalities compared with populational standards&#44; although the method offers low sensitivity and specificity&#46; In 1993&#44; Genant developed a semiquantitative system for classifying OVFs&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> defining 3 groups according to the percentage reduction in vertebral body diameters compared with the adjoining vertebras that showed no structural abnormalities&#46; This method classified fractures with a 20&#8211;25&#37; reduction of one of these diameters as grade 1 or mild fracture&#44; fractures with a 25&#8211;40&#37; reduction as grade 2 or moderate and fractures with a &#62;40&#37; reduction as grade 3 or severe&#46; This method does not use populational reference values&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Jiang et al&#46; subsequently described an algorithm-based qualitative &#40;ABQ&#41; identification system for fractures&#44; which is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Various studies have compared the identification of OVFs using the 3 methods&#44; showing a low correlation between results&#46; However&#44; the Genant semiquantitative system identified the most fractures &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Recently published studies have recommended starting the detection of OVFs with the Genant semiquantitative method&#46; For grade 1 OVFs&#44; the studies recommend applying the ABQ method&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#8211;32</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diagnostic methods for vertebral fractures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Spine radiography</span><p id="par0100" class="elsevierStylePara elsevierViewall">Spine radiography is the gold standard technique and the easiest for detecting OVFs&#46; However&#44; it has certain limitations&#44; the first of which is its operator-dependency&#44; wherein the obliquity at which the radiography is performed can create false images&#46; The second limitation is the difficulty in interpreting the images&#44; if there are deformities such as inadequate curvature&#44; osteoarthritis&#44; developmental disorders &#40;Scheuermann&#8217;s disease&#41;&#44; disc degeneration and Schmorl nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> Lastly&#44; although this technique helps diagnose moderate and severe vertebral fractures&#44; mild fractures can go unnoticed&#44; especially in the dorsal-cervical area&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Two projections need to be performed&#58; a dorsal centered on D7 and a lumbar centered on L2&#44; although a radiography in anteroposterior projection can be useful in some cases&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Lateral chest radiography is a widely used technique and is useful for detecting OVFs in asymptomatic patients&#44; visualizing the dorsal spine and the dorsal-lumbar hinge area&#44; which is the area most affected by vertebral fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> Retrospective studies conducted in internal medicine and emergency departments that have assessed the detection of OVFs in lateral chest radiographs have achieved a detection rate of 50&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;35&#44;36</span></a> The technique has low sensitivity and specificity&#44; especially during the acute phase of the fracture&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Vertebral morphometry</span><p id="par0115" class="elsevierStylePara elsevierViewall">Vertebral morphometry &#40;or vertebral fracture assessment&#41; came into use in the 1990s and is a program incorporated into bone densitometry that enables the concomitant assessment of the spine&#46; Thus&#44; the same examination can obtain more information and avoid radiography&#44; thereby sparing the patient from unnecessary radiation&#46; The technique is estimated to use &#60;1&#37; of the radiation of conventional radiography &#40;3&#8239;&#181;Sv&#41; and has been shown to be a cost-effective technique&#46; In each vertebral body&#44; the program automatically creates 6 points that can be manually adjusted by a technician if they do not fit the diameters of the vertebral bodies&#46; Their interpretation uses Genant&#8217;s semiquantitative method<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> and assesses the standard deviations of the diameters compared with adjacent healthy vertebras&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The technique has a sensitivity of 70&#8211;93&#37; and a specificity of 95&#37; in detecting moderate to severe fractures<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;38</span></a> &#40;especially of T4 to L4&#41; but has poorer detection of mild fractures&#46; The resolution of the cervical spine is poor compared with other techniques&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39&#44;40</span></a> Vertebral morphometry helps diagnose 94&#37; of grade 2 and 3 fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">A study sponsored by the National Health and Nutrition Examination Survey reported a prevalence of 5&#46;4&#37; for OVFs in patients older than 40 years detected through vertebral morphometry&#44; 59&#37; of which were moderate and severe&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Other techniques&#58; computed tomography of the spine&#44; magnetic resonance imaging of the spine&#44; bone scintigraphy&#44; positron emission tomography</span><p id="par0130" class="elsevierStylePara elsevierViewall">Computed tomography with axial or sagittal slices has low sensitivity for detecting fractures&#44; is operator-dependent and is not cost-effective for diagnosing fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Clinical studies of chest and abdomen computed tomography have observed that a considerable number of mild OVFs were not diagnosed by radiologists&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Magnetic resonance imaging and bone scintigraphy are useful examinations soon after a fracture&#44; given that OVFs might not be visible in spine radiography&#46; These examinations can help reveal abnormalities that indicate that the fracture is acute&#44; they can help assess the elapsed time&#44; especially when there is no associated trauma&#44; and assess the need for surgery for the fracture&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Magnetic resonance imaging is the technique that shows abnormalities the earliest&#46; A reduced signal in the T1 and T2 sequences is observed when there is bone marrow edema and can help assess impairment of the medullary canal&#46; In bone scintigraphy&#44; an image suggestive of a fracture will be observed 7 days after the trauma&#44; with a linear image located in the affected vertebra&#46; The technique can also help perform a complete assessment of the entire skeleton&#46; Scintigraphy is a highly sensitive but poorly specific technique for osteoporotic fractures&#44; given that uptake is observed in all fractures regardless of their etiology&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">45&#8211;47</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Fluorodeoxyglucose positron emission tomography can help differentiate between OVFs and pathological fractures due to high fluorodeoxyglucose uptake in the latter&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Treatment</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pain treatment</span><p id="par0150" class="elsevierStylePara elsevierViewall">Acute mechanical pain&#44; if it occurs&#44; usually lasts 6&#8211;12 weeks and is treated with conventional analgesics &#40;according to the World Health Organization scale&#41;&#44; muscle relaxants and rest&#46; If the pain does not decrease&#44; the patient can be started on more potent morphine derivatives&#44; especially during the first 2 weeks of treatment&#46; Opioids and rest are not exempt from complications&#44; especially in the elderly population&#46; Follow-up should therefore be conducted&#46; It has been reported that parathyroid hormone analogues can have an analgesic effect in OVFs&#44; although compared with oral bisphosphonates&#44; this improvement is not significant&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The lumbar corset is a temporary treatment to help patients during the acute phase of a vertebral fracture&#46; The prolonged use of a lumbar corset is counterproductive&#44; because it limits the recovery of paravertebral extensor muscles and can worsen common comorbidities in these patients&#46; There are rigid and semirigid lumbar corsets&#46; The rigid corsets offer good support but are poorly tolerated by elderly individuals&#46; In these cases&#44; a good alternative is a CAMP semirigid corset with shoulder straps&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Surgical techniques</span><p id="par0160" class="elsevierStylePara elsevierViewall">There are 2 techniques&#58; percutaneous vertebroplasty and kyphoplasty&#46; Percutaneous vertebroplasty was the first established minimally invasive technique &#40;1987&#41; consisting of an injection of radiopaque cement into the vertebral body&#46; Kyphoplasty was validated in 1998 and consists of inserting a balloon into the interior of the fractured vertebral body and filling it with cement&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Both techniques are limited to patients with poorly controlled pain despite analgesic treatment and are always performed within the first 4 months of the fracture&#46; Kyphoplasty is limited to the first weeks of the fracture and especially in compression fractures&#46; When the fractures are subacute or chronic&#44; the use of both techniques is more controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50&#44;51</span></a> A multidisciplinary assessment of each case is necessary&#44; particularly when deciding on the best treatment with all the available clinical information&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">This is a surgical procedure that is not exempt from complications &#40;2&#8211;4&#37;&#41;&#44; which include infections&#44; cement embolism&#44; hypotension and spinal cord impairment due to protrusion&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> There is controversy as to whether the technique predisposes to new OVFs&#44; but recent published meta-analyses have shown no such relationship&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Treatment for osteoporosis</span><p id="par0175" class="elsevierStylePara elsevierViewall">Drug treatment for osteoporosis helps reduce vertebral fractures in patients with risk factors and acts as secondary prevention of new fractures&#46; The treatment is effective&#44; and in some cases can decrease the risk of OVF by up to 70&#37;&#46; There are antiresorptive drugs &#40;oral and intravenous bisphosphonates and subcutaneous denosumab&#41;&#44; anabolic agents &#40;subcutaneous teriparatide&#41; and selective estrogen receptor modulators &#40;raloxifene and bazedoxifene&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;24</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The treatment of choice for patients with more than 2&#8239;OVFs and for patients who present an OVF along with nonvertebral fractures is subcutaneous teriparatide&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0185" class="elsevierStylePara elsevierViewall">OVFs are highly prevalent in the elderly population and have major clinical and functional consequences&#46; Historically&#44; the problem has received little interest&#46; Understanding the importance of the disease and its consequences can help improve our patients&#8217; quality of life&#46; There are simple and accessible tools currently available for all clinicians for the early detection of these fractures&#46; Cost-effective prevention strategies for decreasing the high rates of osteoporotic fractures need to be established&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">Aina Capdevila Reniu received funding from &#8220;Ajut a la Recerca Josep Font&#8221; Clinic Hospital of Barcelona&#44; Spain&#46;</p></span></span>"
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          "titulo" => "Background"
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          "identificador" => "sec0010"
          "titulo" => "Imminent risk of fractures"
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          "titulo" => "Screening for osteoporotic vertebral fractures"
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          "titulo" => "Classification of vertebral fractures"
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              "identificador" => "sec0045"
              "titulo" => "Other techniques&#58; computed tomography of the spine&#44; magnetic resonance imaging of the spine&#44; bone scintigraphy&#44; positron emission tomography"
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    "fechaRecibido" => "2019-05-28"
    "fechaAceptado" => "2019-09-05"
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            0 => "Vertebral fracture"
            1 => "Osteoporosis"
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            3 => "Vertebral morphometry"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Vertebral fractures are the most prevalent osteoporotic fractures and are paradoxically the most underdiagnosed&#46; While only one-third of patients have acute pain&#44; they can present other associated chronic complications&#46; Vertrebal fractures are associated with the onset of new fractures&#44; both vertebral and nonvertebral&#46; Radiography of the dorsal-lumbar spine is a useful tool for detecting them but depends on the subjective interpretation of the physician conducting the assessment&#46; New techniques&#44; such as vertebral morphometry&#44; have recently demonstrated greater efficacy in detecting v vertebral fractures and are performed concomitantly with bone densitometry&#46; Knowing how to identify vertebral fractures is essential for the secondary prevention of new fractures and improving our patients&#8217; quality of life&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las fracturas vertebrales son las fracturas osteopor&#243;ticas m&#225;s prevalentes y parad&#243;jicamente siguen siendo tambi&#233;n las m&#225;s infradiagnosticadas&#46; Solo un tercio de los pacientes presentan dolor agudo&#44; pero tambi&#233;n pueden presentar otras complicaciones cr&#243;nicas asociadas&#46; Las fracturas vertebrales se asocian a la aparici&#243;n de nuevas fracturas tanto vertebrales como no vertebrales&#46; La radiograf&#237;a de columna dorso-lumbar es una buena herramienta para su detecci&#243;n&#44; pero es una t&#233;cnica que depende de la interpretaci&#243;n subjetiva del m&#233;dico que la valora&#46; Recientemente nuevas t&#233;cnicas&#44; como la morfometr&#237;a vertebral&#44; que se realiza de forma concomitante a la densitometr&#237;a &#243;sea&#44; han demostrado una mayor eficacia en la detecci&#243;n de fracturas vertebrales&#46; Identificar las fracturas vertebrales es primordial para la prevenci&#243;n secundaria de nuevas fracturas y para mejorar la calidad de vida de nuestros pacientes&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Capdevila-Reniu A&#44; Navarro-L&#243;pez M&#44; L&#243;pez-Soto A&#46; Fracturas vertebrales osteopor&#243;ticas&#58; un reto diagn&#243;stico en el siglo XXI&#46; Rev Clin Esp&#46; 2021&#59;221&#58;118&#8211;124&#46;</p>"
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                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1 SD and &#8805;70 years &#40;women&#41; or &#8805;80 years &#40;men&#41;&#44;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1 SD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1&#46;5 SD and age 65&#8211;69 years &#40;women&#41; or 70&#8211;79 years &#40;men&#41;&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Age &#8805;70 years &#40;women&#41; or &#8805;80 years &#40;men&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Loss of more than 4&#8239;cm of height compared with baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Fracture due to a low-impact fall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Loss of more than 4&#8239;cm of height compared with baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Previous medical history of vertebral fracture&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Loss of more than 2&#8239;cm in the past few months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Treatment with corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Long-term glucocorticoid therapy&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Recommendations of the National Osteoporosis Foundation &#40;NOF&#41; and International Society for Clinical Densitometry &#40;ISCD&#41; for finding osteoporotic vertebral fractures&#46;</p>"
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                  \t\t\t\t">Greater ease interpreting the results&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Operator-dependent&nbsp;\t\t\t\t\t\t\n
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                    0 => array:2 [
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              "referencia" => array:1 [
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                            1 => "S&#46;A&#46; Steel"
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                    0 => array:2 [
                      "doi" => "10.1007/s00198-007-0548-0"
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                      "titulo" => "En nombre del grupo de trabajo en osteoporosis de la Sociedad Espa&#241;ola de Medicina Interna &#40;SEMI&#41;&#46; Prevalencia de fracturas vertebrales en pacientes con fractura de cadera"
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                      "doi" => "10.1016/j.jocd.2015.08.004"
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                  "contribucion" => array:1 [
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                          "autores" => array:6 [
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                            3 => "G&#46; Girotti"
                            4 => "M&#46; Mazzochin"
                            5 => "B&#46;M&#46; Zanforlini"
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              "etiqueta" => "7"
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                  "contribucion" => array:1 [
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                      "titulo" => "Osteoporosis in the European Union&#58; medical management&#44; epidemiology and economic burden&#46; A report prepared in collaboration with the International Osteoporosis Foundation &#40;IOF&#41; and the European Federation of Pharmaceutical Industry Associations &#40;EFPIA&#41;"
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                            1 => "A&#46; Svedbom"
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                      "doi" => "10.1007/s11657-013-0136-1"
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                      "titulo" => "The population-based prevalence of osteoporotic vertebral fracture and densitometric osteoporosis in postmenopausal women over 50 in Valencia&#44; Spain &#40;the FRAVO Study&#41;"
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                            2 => "G&#46; Sanf&#233;lix-Gimeno"
                            3 => "S&#46; Peir&#243;"
                            4 => "M&#46; Graells-Ferrer"
                            5 => "M&#46; Vega-Mart&#237;nez"
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                  "host" => array:1 [
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                      "doi" => "10.1016/j.bone.2010.06.015"
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                        "paginaInicial" => "610"
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Review
Osteoporotic vertebral fractures: A diagnostic challenge in the 21st century
Fracturas vertebrales osteoporóticas: un reto diagnóstico en el siglo XXI
A. Capdevila-Reniua,
Corresponding author
aicapdev@clinic.ub.es

Corresponding author.
, M. Navarro-Lópeza,b, A. López-Sotoa,b
a Servicio de Medicina Interna, Unidad de Geriatria, Hospital Clínic de Barcelona, Barcelona, Spain
b Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Vertebral morphometry showing wedge fracture of T11 and L4 according to the Genant semiquantitative assessment&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Background</span><p id="par0005" class="elsevierStylePara elsevierViewall">Osteoporosis is the most prevalent metabolic bone disease worldwide&#44; especially due to the increased life expectancy of the population&#46; According to the World Health Organization&#44; osteoporosis affects 3&#46;5 million people in Spain&#46; The estimated incidence of osteoporosis in Catalonia is 10&#46;91 per 1000 individuals older than 50 years per year&#44; and a significant increase is predicted due to the aging of the population&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The osteoporotic vertebral fracture &#40;OVF&#41; is the most common vertebral fracture&#44; which&#44; according to the European Prospective Osteoporosis Study&#44; has an estimated incidence rate of 1&#44;400&#44;000 fractures per year&#44; equivalent to 20&#8211;25&#37; of postmenopausal women older than 50 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> A national study showed a OVF rate of 62&#46;6&#37; in postmenopausal patients admitted for concomitant osteoporotic hip fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> OVFs are more common in elderly patients&#44; with a prevalence &#62;40&#37; for patients older than 80 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> The epidemiological studies FRAVO in women and Camargo in men&#44; both conducted in Spain&#44; reported a OVF incidence rate of 21&#46;3&#37; in women and in men older than 50 years and a higher rate &#40;46&#37;&#41; in women &#8805;75 years compared with men of the same age &#40;32&#46;6&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Despite the high percentage of especially elderly patients with OVF&#44; this number is underestimated because most OVFs are undiagnosed and go unnoticed by the patient and attending doctor&#44; to the point where it has been considered the &#8220;silent epidemic of the 21st century&#8221;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The 2014 clinical guidelines of the National Osteoporosis Foundation consider the presence of a vertebral fracture compatible with the diagnosis of osteoporosis&#44; as is the case for any nonvertebral fracture of osteoporotic characteristics&#44; even in the absence of densitometric osteoporosis&#44; and is therefore an indication for drug treatment to improve the secondary prevention of new osteoporotic fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Imminent risk of fractures</span><p id="par0020" class="elsevierStylePara elsevierViewall">OVFs are caused by a fall from the patient&#8217;s height or lower or through low-impact effort such as crouching&#44; climbing stairs and sneezing&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">OVFs are not harmless for the patient and promote future fractures&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#8211;13</span></a> both vertebral and nonvertebral&#44; and are associated with greater mortality and poorer quality of life&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">14&#44;15</span></a> Studies have estimated that an OVF quadruples the risk of a new OVF and doubles the risk of an osteoporotic fracture of the femoral neck&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> The risk of new fractures is 7&#8211;10&#37; during the first year after the onset of the fracture and rises to 18&#37; at 2&#8239;years of the fracture&#46; In individuals older than 75 years&#44; the risk increases to 25&#37; at 2&#8239;years of the fracture<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12&#44;17&#44;18</span></a> and is higher for women&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> An early and accurate diagnosis is therefore essential for starting treatment as soon as possible&#46; The dorsal-lumbar hinge is the most affected area&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Morbidity and mortality</span><p id="par0030" class="elsevierStylePara elsevierViewall">A US population study conducted with patients older than 65 years with OVF showed an increase in mortality in this group twice that of the control group&#44; with survival rates of 50&#37; at 3 years&#44; 30&#37; at 5 years and only 10&#37; at 7 years&#46; The patients&#8217; mean age was 80 years&#44; and the increase in mortality was higher in men&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Similar results were obtained from an Australian cohort that also showed that mortality was not higher after OVF in older patients with fractures compared with the younger patients&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Pain is the first manifestation but is only present in a third of fractures&#44; and only 10&#37; of patients with pain consult for it in medical centers&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;6&#44;7</span></a> Pain is secondary to the same fracture&#59; apart from the pain in the paravertebral area&#44; patients with multiple fractures can present pain due to the impact of the ribs on the pelvic bones&#46; Another common manifestation is the patients&#8217; loss of stature&#44; many times attributed to other causes&#44; such as age-associated degenerative processes&#46; A documented loss &#62;2&#8239;cm in the past year or a loss of 4&#8211;6&#8239;cm from the height recorded in their youth should alert clinicians to the presence of an OVF&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">One of the characteristics of OVFs is the rare involvement of the medullary canal &#40;&#60;1&#37;&#41;&#44; possibly due to the fact that the posterior wall of the vertebral body and the posterior arch are unaffected&#46; Spinal injuries&#44; if they occur&#44; are secondary to the posterior displacement of a fragment of the vertebral body&#46; Neurological symptoms concomitant with pain should raise suspicion about other etiologies&#46; Impairment above T5 is also rare&#46; Fractures in the first dorsal or cervical vertebra are therefore rarely secondary to osteoporosis&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The presence of multiple fractures can also result in restrictive lung disease due to a reduction in the thoracic cavity&#44; gastroesophageal transit disorders due to diaphragmatic compensation with abdominal cavity reduction&#44; and physical activity limitations due to pain&#44; with the consequent acceleration of bone waste&#44; increased sarcopenia and physical dependency and can also increase the number of falls due to loss of equilibrium&#46; Likewise&#44; medical complications secondary to immobility can appear&#44; such as pressure ulcers and venous embolism&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Screening for osteoporotic vertebral fractures</span><p id="par0050" class="elsevierStylePara elsevierViewall">The International Osteoporosis Foundation considers the early detection of OVFs an essential element in preventing new fractures&#44; both OVFs and osteoporotic nonvertebral fractures&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Various research studies have recently been published<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#44;23</span></a> on algorithms for the early detection of asymptomatic OVFs&#46; The main predictors are advanced age&#44; poorer bone mineral density&#44; the use of corticosteroids and the loss of stature&#46; In terms of the bone densitometry values in the lumbar spine as predictors of fractures&#44; there is disagreement among the studies&#44; although a higher prevalence of osteopenia instead of osteoporosis has been observed in the lumbar spine of patients with OVFs&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Given that vertebral fractures are the most common osteoporotic fracture&#44; early and accurate detection should be conducted to decrease the risk of new fractures and to properly establish secondary prevention&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">National and international societies on osteoporosis and frailty fractures do not recommend universal screening for vertebral fractures using spine radiography&#46; Screening is recommended only for patients with symptoms suggestive of OVF or for elderly patients with other previous osteoporotic fractures or densitometric osteoporosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> The recent guidelines of the National Osteoporosis Foundation and International Society for Clinical Densitometry include the recommendations shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> for the search for vertebral fractures&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;25</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Once a first screening for OVFs has been conducted and potential fractures have been identified&#44; repeating the imaging test is advised only if there is a documented loss of height or new onset dorsal-lumbar pain &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Classification of vertebral fractures</span><p id="par0075" class="elsevierStylePara elsevierViewall">OVFs are classified into 3 groups according to their morphology&#58; anterior wedging &#40;reduced anterior diameter of the vertebral body&#41;&#44; biconcave &#40;reduced middle diameter&#41; or compressed &#40;reduced anterior&#44; middle and posterior diameters&#41;&#46; On very rare occasions&#44; the posterior arch of the vertebra is affected and usually does not affect the medullary canal&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">The first vertebral fracture assessment methods in spinal radiographs were quantitative and based on the vertebral form&#46; One of the best known of these methods is by Eastell and Melton&#44;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> which is based on vertebral body size abnormalities compared with populational standards&#44; although the method offers low sensitivity and specificity&#46; In 1993&#44; Genant developed a semiquantitative system for classifying OVFs&#44;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> defining 3 groups according to the percentage reduction in vertebral body diameters compared with the adjoining vertebras that showed no structural abnormalities&#46; This method classified fractures with a 20&#8211;25&#37; reduction of one of these diameters as grade 1 or mild fracture&#44; fractures with a 25&#8211;40&#37; reduction as grade 2 or moderate and fractures with a &#62;40&#37; reduction as grade 3 or severe&#46; This method does not use populational reference values&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Jiang et al&#46; subsequently described an algorithm-based qualitative &#40;ABQ&#41; identification system for fractures&#44; which is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">28&#44;29</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Various studies have compared the identification of OVFs using the 3 methods&#44; showing a low correlation between results&#46; However&#44; the Genant semiquantitative system identified the most fractures &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Recently published studies have recommended starting the detection of OVFs with the Genant semiquantitative method&#46; For grade 1 OVFs&#44; the studies recommend applying the ABQ method&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#8211;32</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diagnostic methods for vertebral fractures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Spine radiography</span><p id="par0100" class="elsevierStylePara elsevierViewall">Spine radiography is the gold standard technique and the easiest for detecting OVFs&#46; However&#44; it has certain limitations&#44; the first of which is its operator-dependency&#44; wherein the obliquity at which the radiography is performed can create false images&#46; The second limitation is the difficulty in interpreting the images&#44; if there are deformities such as inadequate curvature&#44; osteoarthritis&#44; developmental disorders &#40;Scheuermann&#8217;s disease&#41;&#44; disc degeneration and Schmorl nodes&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> Lastly&#44; although this technique helps diagnose moderate and severe vertebral fractures&#44; mild fractures can go unnoticed&#44; especially in the dorsal-cervical area&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Two projections need to be performed&#58; a dorsal centered on D7 and a lumbar centered on L2&#44; although a radiography in anteroposterior projection can be useful in some cases&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Lateral chest radiography is a widely used technique and is useful for detecting OVFs in asymptomatic patients&#44; visualizing the dorsal spine and the dorsal-lumbar hinge area&#44; which is the area most affected by vertebral fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> Retrospective studies conducted in internal medicine and emergency departments that have assessed the detection of OVFs in lateral chest radiographs have achieved a detection rate of 50&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">30&#44;35&#44;36</span></a> The technique has low sensitivity and specificity&#44; especially during the acute phase of the fracture&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Vertebral morphometry</span><p id="par0115" class="elsevierStylePara elsevierViewall">Vertebral morphometry &#40;or vertebral fracture assessment&#41; came into use in the 1990s and is a program incorporated into bone densitometry that enables the concomitant assessment of the spine&#46; Thus&#44; the same examination can obtain more information and avoid radiography&#44; thereby sparing the patient from unnecessary radiation&#46; The technique is estimated to use &#60;1&#37; of the radiation of conventional radiography &#40;3&#8239;&#181;Sv&#41; and has been shown to be a cost-effective technique&#46; In each vertebral body&#44; the program automatically creates 6 points that can be manually adjusted by a technician if they do not fit the diameters of the vertebral bodies&#46; Their interpretation uses Genant&#8217;s semiquantitative method<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> and assesses the standard deviations of the diameters compared with adjacent healthy vertebras&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The technique has a sensitivity of 70&#8211;93&#37; and a specificity of 95&#37; in detecting moderate to severe fractures<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;38</span></a> &#40;especially of T4 to L4&#41; but has poorer detection of mild fractures&#46; The resolution of the cervical spine is poor compared with other techniques&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39&#44;40</span></a> Vertebral morphometry helps diagnose 94&#37; of grade 2 and 3 fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">A study sponsored by the National Health and Nutrition Examination Survey reported a prevalence of 5&#46;4&#37; for OVFs in patients older than 40 years detected through vertebral morphometry&#44; 59&#37; of which were moderate and severe&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Other techniques&#58; computed tomography of the spine&#44; magnetic resonance imaging of the spine&#44; bone scintigraphy&#44; positron emission tomography</span><p id="par0130" class="elsevierStylePara elsevierViewall">Computed tomography with axial or sagittal slices has low sensitivity for detecting fractures&#44; is operator-dependent and is not cost-effective for diagnosing fractures&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Clinical studies of chest and abdomen computed tomography have observed that a considerable number of mild OVFs were not diagnosed by radiologists&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Magnetic resonance imaging and bone scintigraphy are useful examinations soon after a fracture&#44; given that OVFs might not be visible in spine radiography&#46; These examinations can help reveal abnormalities that indicate that the fracture is acute&#44; they can help assess the elapsed time&#44; especially when there is no associated trauma&#44; and assess the need for surgery for the fracture&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Magnetic resonance imaging is the technique that shows abnormalities the earliest&#46; A reduced signal in the T1 and T2 sequences is observed when there is bone marrow edema and can help assess impairment of the medullary canal&#46; In bone scintigraphy&#44; an image suggestive of a fracture will be observed 7 days after the trauma&#44; with a linear image located in the affected vertebra&#46; The technique can also help perform a complete assessment of the entire skeleton&#46; Scintigraphy is a highly sensitive but poorly specific technique for osteoporotic fractures&#44; given that uptake is observed in all fractures regardless of their etiology&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">45&#8211;47</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Fluorodeoxyglucose positron emission tomography can help differentiate between OVFs and pathological fractures due to high fluorodeoxyglucose uptake in the latter&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Treatment</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pain treatment</span><p id="par0150" class="elsevierStylePara elsevierViewall">Acute mechanical pain&#44; if it occurs&#44; usually lasts 6&#8211;12 weeks and is treated with conventional analgesics &#40;according to the World Health Organization scale&#41;&#44; muscle relaxants and rest&#46; If the pain does not decrease&#44; the patient can be started on more potent morphine derivatives&#44; especially during the first 2 weeks of treatment&#46; Opioids and rest are not exempt from complications&#44; especially in the elderly population&#46; Follow-up should therefore be conducted&#46; It has been reported that parathyroid hormone analogues can have an analgesic effect in OVFs&#44; although compared with oral bisphosphonates&#44; this improvement is not significant&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">48&#44;49</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The lumbar corset is a temporary treatment to help patients during the acute phase of a vertebral fracture&#46; The prolonged use of a lumbar corset is counterproductive&#44; because it limits the recovery of paravertebral extensor muscles and can worsen common comorbidities in these patients&#46; There are rigid and semirigid lumbar corsets&#46; The rigid corsets offer good support but are poorly tolerated by elderly individuals&#46; In these cases&#44; a good alternative is a CAMP semirigid corset with shoulder straps&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Surgical techniques</span><p id="par0160" class="elsevierStylePara elsevierViewall">There are 2 techniques&#58; percutaneous vertebroplasty and kyphoplasty&#46; Percutaneous vertebroplasty was the first established minimally invasive technique &#40;1987&#41; consisting of an injection of radiopaque cement into the vertebral body&#46; Kyphoplasty was validated in 1998 and consists of inserting a balloon into the interior of the fractured vertebral body and filling it with cement&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Both techniques are limited to patients with poorly controlled pain despite analgesic treatment and are always performed within the first 4 months of the fracture&#46; Kyphoplasty is limited to the first weeks of the fracture and especially in compression fractures&#46; When the fractures are subacute or chronic&#44; the use of both techniques is more controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">50&#44;51</span></a> A multidisciplinary assessment of each case is necessary&#44; particularly when deciding on the best treatment with all the available clinical information&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">This is a surgical procedure that is not exempt from complications &#40;2&#8211;4&#37;&#41;&#44; which include infections&#44; cement embolism&#44; hypotension and spinal cord impairment due to protrusion&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> There is controversy as to whether the technique predisposes to new OVFs&#44; but recent published meta-analyses have shown no such relationship&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#44;54</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Treatment for osteoporosis</span><p id="par0175" class="elsevierStylePara elsevierViewall">Drug treatment for osteoporosis helps reduce vertebral fractures in patients with risk factors and acts as secondary prevention of new fractures&#46; The treatment is effective&#44; and in some cases can decrease the risk of OVF by up to 70&#37;&#46; There are antiresorptive drugs &#40;oral and intravenous bisphosphonates and subcutaneous denosumab&#41;&#44; anabolic agents &#40;subcutaneous teriparatide&#41; and selective estrogen receptor modulators &#40;raloxifene and bazedoxifene&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;24</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">The treatment of choice for patients with more than 2&#8239;OVFs and for patients who present an OVF along with nonvertebral fractures is subcutaneous teriparatide&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0185" class="elsevierStylePara elsevierViewall">OVFs are highly prevalent in the elderly population and have major clinical and functional consequences&#46; Historically&#44; the problem has received little interest&#46; Understanding the importance of the disease and its consequences can help improve our patients&#8217; quality of life&#46; There are simple and accessible tools currently available for all clinicians for the early detection of these fractures&#46; Cost-effective prevention strategies for decreasing the high rates of osteoporotic fractures need to be established&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0190" class="elsevierStylePara elsevierViewall">Aina Capdevila Reniu received funding from &#8220;Ajut a la Recerca Josep Font&#8221; Clinic Hospital of Barcelona&#44; Spain&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
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        1 => array:2 [
          "identificador" => "xpalclavsec1326358"
          "titulo" => "Keywords"
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        2 => array:3 [
          "identificador" => "xres1454561"
          "titulo" => "Resumen"
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        3 => array:2 [
          "identificador" => "xpalclavsec1326357"
          "titulo" => "Palabras clave"
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        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Background"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Imminent risk of fractures"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Morbidity and mortality"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Screening for osteoporotic vertebral fractures"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Classification of vertebral fractures"
        ]
        9 => array:3 [
          "identificador" => "sec0030"
          "titulo" => "Diagnostic methods for vertebral fractures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Spine radiography"
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            1 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Vertebral morphometry"
            ]
            2 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Other techniques&#58; computed tomography of the spine&#44; magnetic resonance imaging of the spine&#44; bone scintigraphy&#44; positron emission tomography"
            ]
          ]
        ]
        10 => array:3 [
          "identificador" => "sec0050"
          "titulo" => "Treatment"
          "secciones" => array:3 [
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              "identificador" => "sec0055"
              "titulo" => "Pain treatment"
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            1 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Surgical techniques"
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            2 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Treatment for osteoporosis"
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        11 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conclusions"
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        12 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Funding"
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        13 => array:1 [
          "titulo" => "References"
        ]
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-05-28"
    "fechaAceptado" => "2019-09-05"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:4 [
            0 => "Vertebral fracture"
            1 => "Osteoporosis"
            2 => "Radiography"
            3 => "Vertebral morphometry"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:4 [
            0 => "Fractura vertebral"
            1 => "Osteoporosis"
            2 => "Radiograf&#237;a"
            3 => "Morfometr&#237;a vertebral"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Vertebral fractures are the most prevalent osteoporotic fractures and are paradoxically the most underdiagnosed&#46; While only one-third of patients have acute pain&#44; they can present other associated chronic complications&#46; Vertrebal fractures are associated with the onset of new fractures&#44; both vertebral and nonvertebral&#46; Radiography of the dorsal-lumbar spine is a useful tool for detecting them but depends on the subjective interpretation of the physician conducting the assessment&#46; New techniques&#44; such as vertebral morphometry&#44; have recently demonstrated greater efficacy in detecting v vertebral fractures and are performed concomitantly with bone densitometry&#46; Knowing how to identify vertebral fractures is essential for the secondary prevention of new fractures and improving our patients&#8217; quality of life&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las fracturas vertebrales son las fracturas osteopor&#243;ticas m&#225;s prevalentes y parad&#243;jicamente siguen siendo tambi&#233;n las m&#225;s infradiagnosticadas&#46; Solo un tercio de los pacientes presentan dolor agudo&#44; pero tambi&#233;n pueden presentar otras complicaciones cr&#243;nicas asociadas&#46; Las fracturas vertebrales se asocian a la aparici&#243;n de nuevas fracturas tanto vertebrales como no vertebrales&#46; La radiograf&#237;a de columna dorso-lumbar es una buena herramienta para su detecci&#243;n&#44; pero es una t&#233;cnica que depende de la interpretaci&#243;n subjetiva del m&#233;dico que la valora&#46; Recientemente nuevas t&#233;cnicas&#44; como la morfometr&#237;a vertebral&#44; que se realiza de forma concomitante a la densitometr&#237;a &#243;sea&#44; han demostrado una mayor eficacia en la detecci&#243;n de fracturas vertebrales&#46; Identificar las fracturas vertebrales es primordial para la prevenci&#243;n secundaria de nuevas fracturas y para mejorar la calidad de vida de nuestros pacientes&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Capdevila-Reniu A&#44; Navarro-L&#243;pez M&#44; L&#243;pez-Soto A&#46; Fracturas vertebrales osteopor&#243;ticas&#58; un reto diagn&#243;stico en el siglo XXI&#46; Rev Clin Esp&#46; 2021&#59;221&#58;118&#8211;124&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Vertebral morphometry showing wedge fracture of T11 and L4 according to the Genant semiquantitative assessment&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">NOF&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ISCD&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1 SD and &#8805;70 years &#40;women&#41; or &#8805;80 years &#40;men&#41;&#44;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1 SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T-score&#8239;&#60;&#8239;&#8722;1&#46;5 SD and age 65&#8211;69 years &#40;women&#41; or 70&#8211;79 years &#40;men&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#8805;70 years &#40;women&#41; or &#8805;80 years &#40;men&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#8805;50 years and one of the following&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Loss of more than 4&#8239;cm of height compared with baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fracture due to a low-impact fall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Loss of more than 4&#8239;cm of height compared with baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Loss of more than 2&#8239;cm in the past few months&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Treatment with corticosteroids&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Long-term glucocorticoid therapy&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Recommendations of the National Osteoporosis Foundation &#40;NOF&#41; and International Society for Clinical Densitometry &#40;ISCD&#41; for finding osteoporotic vertebral fractures&#46;</p>"
        ]
      ]
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Lateral dorsal-lumbar radiography&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vertebral morphometry&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Easy availability&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Available along with bone densitometry&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Short time for performing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Requires more time to perform&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Operator-dependent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Standardized technique&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Difficulty interpreting the results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Greater ease interpreting the results&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Operator-dependent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Operator-dependent&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Standard radiation for radiographs&nbsp;\t\t\t\t\t\t\n
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?