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chronic diseases&#44; defined by the World Health Organization &#40;WHO&#41; as long-acting&#44; generally noncommunicable and slow progression diseases&#46; These noncommunicable chronic diseases are currently the leading cause of death worldwide&#46; Many of these diseases share the same risk factors and are related to pronounced lifestyle changes &#40;e&#46;g&#46;&#44; tobacco consumption&#44; physical inactivity&#44; alcohol abuse and unhealthy diets&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The 4 main types of chronic diseases are cardiovascular disease&#44; cancer&#44; chronic respiratory disease and diabetes&#46; These diseases already disproportionately affect low-income and medium-income countries where almost 75&#37; of the 28 million annually recorded deaths are due to these diseases&#46; These diseases occur in all age groups and regions and are usually associated with the oldest age groups&#46; However&#44; the evidence shows that more than 16 million of the deaths attributed to these diseases occur in individuals younger than 70 years and that 82&#37; of these premature deaths occur in low-income and medium-income countries&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">1</span></a> Children&#44; adults and the elderly are all vulnerable to risk factors that promote chronic diseases&#46; According to Margaret Chan&#44; director general of the World Health Organization &#40;WHO&#41;&#44; chronic diseases are a slow-motion catastrophe&#46; Although their development is slow&#44; the lifestyles that feed this epidemic are propagating at an impressive speed&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aging of the population is a recent fact in Spain&#46; Until the 1950s&#44; individuals older than 65 years represented 7&#37; of the population&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">3&#44;4</span></a> In the past 40 years&#44; this percentage has grown uninterrupted and will represent 25&#37; by 2025&#46; Although Spain has achieved one of longest life expectancies in the world&#44; especially for women&#44; there are other countries in our community that exceed Spain&#39;s life expectancy with good health&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">3&#8211;5</span></a> Good health is one of the pillars of an economically and socially prosperous society&#44; and achieving life-years free of disability must be one of our healthcare goals&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The increase in age directly affects individuals with chronic diseases&#44; due to the addition and accumulation of these diseases over the course of life&#46; In advanced age&#44; there is a propensity to inflammation&#44; mitochondrial dysfunction and epigenetic disorders that lead to a loss of functional reserve in various organs and systems &#40;neurological&#44; cardiovascular&#44; musculoskeletal&#44; respiratory&#44; renal-urological&#44; immune&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">6</span></a> This loss&#44; rooted in the biological determinants of the aging process&#44; leads to greater susceptibility to chronic diseases such as dementia&#44; ischemic heart disease&#44; heart failure&#44; osteoporosis&#44; osteoarthritis&#44; respiratory diseases and chronic renal disease&#46; There is also a progressive development of functional impairment&#44; which causes a loss of quality of life&#44; increased disability&#44; drug interactions&#44; multiple hospitalizations and increased mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">The concepts of multimorbidity and polypathology</span><p id="par0030" class="elsevierStylePara elsevierViewall">The most common chronic condition in adults is the coexistence of numerous chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">7</span></a> Several terms have been designated to define this condition&#44; depending on the language used&#58; &#8220;multimorbidity&#8221; in English and &#8220;pluripatolog&#237;a&#8221; &#40;polypathology&#41; in Spanish&#46; In any case&#44; this type of patient with multiple chronic diseases is not the exception but rather the rule&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">8</span></a> It would therefore be appropriate that the condition of &#8220;multiple chronic conditions&#8221; be included as another diagnosis in the International Classification of Diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The term &#8220;multimorbidity&#8221; was first coined in 1976 by Brandlmeier&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">9</span></a> In a 2008 report&#44; the WHO defined the term as the simultaneous presence of 2 or more chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">10</span></a> In 2015&#44; the term was translated to 10 European languages for use in family medicine&#44; defining the term &#8220;multimorbidity&#8221; in Spanish as &#8220;any combination of a chronic disease with at least one other disease &#40;acute or chronic&#41; or a biopsychosocial factor &#40;associated or not&#41; or a risk factor&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">11</span></a> &#8220;Multimorbidity&#8221; can modify health results and lead to greater disability&#44; poorer quality of life and frailty&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In September 2016&#44; the National Institute for Health and Care Excellence defined the term &#8220;multimorbidity&#8221; as the presence of 2 or more long-standing health conditions&#44; which can include the following&#58; defined physical and mental health disorders&#44; such as diabetes and schizophrenia&#59; complex conditions such as frailty and chronic pain&#59; and sensory deficits such as reduced visual or auditory acuity&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">12</span></a> In short&#44; 2 or more long-term physical health conditions or a mental disease and another physical disease&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The US has lately been using the expression &#8220;patients with high needs and high costs&#8221; to refer to individuals with 3 or more chronic diseases and functional dependence&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">13&#44;14</span></a> The concept of &#8220;polypathology&#8221; &#40;or that of multimorbidity&#41; can be understood&#44; from a strict perspective&#44; as the coexistence of 2 or more chronic diseases with no other requirements&#46; In 2002&#44; this concept was defined differently in Andalusia as follows&#58; the condition in which an individual experiences 2 or more diseases among 8 clinical categories included in a list of common defined chronic diseases with certain severity or complexity &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">15&#44;16</span></a> In other words&#44; to meet this definition&#44; a person needs to have several chronic diseases&#59; however&#44; not all individuals with several chronic diseases meet the criteria for a polypathological patient&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Moreover&#44; the concept of &#8220;complex chronic patient&#8221; has been coined to refer to patients who have 2 or more chronic progressive diseases&#44; with frequent exacerbations or complex societal situations&#44; which cause an impairment in autonomy and functional capacity and result in frequent use of healthcare services&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">17</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The Spanish Ministry of Health&#44; Social Services and Equality&#44; in its strategy for attention on chronicity in the Spanish National Health System&#44; textually defines<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">18</span></a> a&#41; &#8220;polypathology&#8221; if there are 2 or more coexisting chronic diseases&#59; b&#41; &#8220;comorbidity&#8221;&#44; when any disease is associated with a main nosological entity&#44; both acute and chronic&#44; modulating its diagnosis and treatment&#59; and c&#41; &#8220;complex chronic patient&#8221; as an individual who presents greater complexity in their management by having changing needs that require continuous reassessments and requires the orderly use of various healthcare levels and&#44; in some cases&#44; healthcare and social services&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In short&#44; there is no consensus on the terms or concepts when referring to this type of patient&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Magnitude of the problem&#46; consequences</span><p id="par0065" class="elsevierStylePara elsevierViewall">The number of chronic diseases present in a person increases progressively with age&#44; such that individuals 80 years or older have a mean of over 4 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a> In a study conducted in Scotland&#44; the number of chronic diseases was greater than 8 among individuals older than 85 years&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">20</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The presence of several chronic diseases in an individual is very common&#46; A document by the Organization for Economic Cooperation and Development listed a number of examples&#58; heart failure is the only entity in only 3&#37; of patients&#44; stroke in 6&#37;&#44; atrial fibrillation in 7&#37;&#44; ischemic heart disease in 9&#37;&#44; diabetes in 14&#37;&#44; chronic obstructive pulmonary disease in 18&#37; and dementia in 5&#37;&#46; By contrast&#44; individuals with heart failure&#44; stroke&#44; diabetes and dementia who have 3 or more chronic diseases represent 74&#37;&#44; 62&#37;&#44; 47&#37; and 64&#37;&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a> It can therefore be emphatically stated that the most common chronic situation is the presence of several chronic diseases in a single individual&#46; This report highlighted that the number of chronic diseases increases with age and inversely with the individual&#39;s socioeconomic status&#46; As the number of these diseases increases&#44; the degree of polypharmacy and medical errors increases&#44; especially if the care is provided by various physicians or specialists &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">In a systematic review&#44; the prevalence of multimorbidity in elderly individuals varied between 55&#37; and 98&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">22</span></a> Advanced age&#44; female sex and low socioeconomic level were the factors associated with multimorbidity&#44; whose main consequences were disability&#44; functional impairment&#44; poor quality of life and high healthcare costs&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In various studies conducted at the state and regional level&#44; the estimated prevalence of polypathological patients was 1&#46;38&#37; of the general population and 5&#37; of those older than 65 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">18&#44;23</span></a> Depending on their characteristics&#44; it is estimated that between 38&#37; and 60&#37; of patients hospitalized In internal medicine departments have multiple diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">24</span></a> In recent years&#44; the prevalence of polypathology has increased dramatically in orthopedic surgery and trauma units &#40;due mainly to hip fractures in the elderly&#41; and in urology units due to prostate disease&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The standard profile of a hospitalized polypathological patient is a 78-year-old individual&#44; with a mean of 2&#46;4 diseases in the clinical categories of the Andalusian classification &#40;69&#37; with 2 categories&#59; 31&#37; with &#8805;3 categories&#41;&#44; predominantly cardiovascular&#44; respiratory&#44; neurological or renal type&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">25</span></a> These are also polymedicated patients&#44; with an average of 8 drugs&#44; with greater functional dependence at hospital discharge and at 1 year &#40;decrease in Barthel index of 11&#8211;20 points&#41;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">25&#44;26</span></a> and greater mortality compared with nonpolypathological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">27</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Impact of polypathology&#47;multimorbidity on healthcare management</span><p id="par0090" class="elsevierStylePara elsevierViewall">For many years&#44; public health organizations worldwide have stated the urgent need to change the way in which we address health promotion and disease care&#46; The evidence that social determinants of health &#40;housing&#44; education&#44; food and hygiene&#41; are the main risk factors for contracting disease&#44; the overwhelming logic of &#8220;prevention is better than cure&#8221; and the &#8220;tsunami&#8221; of chronic diseases have resulted in a multitude of warnings and recommendations on the risk of financial ruin run by healthcare systems and the states themselves&#46; Since 2000&#44; the WHO has developed strategies and action plans to prevent and control chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">28</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In 2011&#44; the United Nations&#44; in a high-level general assembly in which the heads of member states met&#44; put forth the &#8220;Declaration on the Prevention and Control of Non-communicable Diseases&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">29</span></a> All member states agreed that chronic diseases undermine social and economic development worldwide&#44; are a threat for the economies of many states&#44; promote poverty&#44; increase inequalities among countries and populations and represent a threat to achieving the &#8220;Millennium Development Goals&#8221;&#44; placing this topic among the priorities of political agendas&#46; In their political declaration&#44; the UN established the global objective &#8220;25 by 25&#8221;&#59; i&#46;e&#46;&#44; to reduce by 25&#37; the premature mortality associated with chronic diseases by 2025&#46; The declaration also urged the inclusion of prevention for these diseases as a priority in all national and international programs&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In 2006&#44; the European Union prepared a &#8220;European Strategy for the Prevention and Control of Noncommunicable Diseases&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">30</span></a> In December 2010&#44; The Council of the European Union adopted a number of conclusions for the development of action plans to decrease the impact of chronic diseases in Europe&#46; Chronic diseases were considered a priority for the present and future of research and the design of intervention programs&#46; The member states and the European Commission were requested to urgently implement specific and coordinated measures to confront this problem&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">31</span></a> More specifically&#44; the Council invited the member states to implement patient-focused policies to promote health&#44; primary and secondary prevention and the treatment and care of chronic diseases&#44; in cooperation with the responsible politicians and&#44; especially&#44; with the patient associations&#46; The Council also invited the states to identify and exchange information on best practices in this setting and assess the incidence&#44; prevalence and impact of this collection of diseases&#46; A project funded by the European Union was created to care for individuals with multiple diseases &#40;Improving care for people with multiple chronic conditions in Europe&#44; ICARE4EU&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">32</span></a> with the objective of assessing and promoting innovation and improvement in the care of patients with several chronic diseases&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All the recommendations of international organizations advocate the need to facilitate access for all citizens to healthcare and to control risk factors&#44; creating environments that promote health and health prevention and that prevent inequality&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">33</span></a> Universal coverage is the only measure that&#44; by itself&#44; can profoundly improve social equity&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">34</span></a> Additionally&#44; all the recommendations urge changes in the way health care is provided&#46; Due to the fact that communicable diseases have been the predominant type until the 1950s&#44; care has traditionally been based on the disease and generally provided reactively by hospital specialists&#44; with their actions based on the symptoms and focused on treatment&#46; Although the pattern of diseases and the type of patient have changed&#44; the healthcare systems continue acting in the same manner as in the past&#46; Patients with several diseases are treated by several specialists who take care of the acute episode and the organ for which they are exclusively responsible&#46; The specialists do not interrelate and do not cover the individual&#39;s biopsychosocial needs&#46; Thus&#44; examinations and treatments are unnecessarily multiplied&#44; with the subsequent increase in their adverse effects and the prescription cascade to solve them&#46; There is no coordinated and proactive action to prevent decompensations&#44; and patients are admitted and readmitted over and over&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The new focus of the healthcare model should be based on the &#8220;Comprehensive Care Model&#8221;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">35</span></a>&#58; a&#41; focused on the individual and not on the disease&#44; b&#41; based in primary care and not in the hospital&#44; c&#41; focused on the needs of the population and not on those of the individual patient&#44; d&#41; organized for proactive and planned care&#44; not reactive in the face of symptoms and e&#41; focused on promotion and prevention&#44; not treatment&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Care must be integrated across time&#44; places and health problems&#46; The healthcare team members must collaborate with each other and with the patients and their relatives to achieve the treatment objectives&#46; The implemented plans and strategies should be focused on the patient&#39;s needs&#44; values and preferences&#46; Collectively&#44; health professionals must be able to provide a complete range of healthcare services&#44; from prevention and rehabilitation to end-of-life care&#46; Thus&#44; integrated healthcare models that go beyond specific diseases and that place the individual as the main objective provide a viable solution for introducing efficient and effective care&#46; Several specific recommendations have been developed in our setting for this patient group&#44; both by healthcare administrations and scientific societies &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">15&#44;36&#8211;39</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Challenges in healthcare systems</span><p id="par0120" class="elsevierStylePara elsevierViewall">Polypathology&#47;multimorbidity is much more than the sum of the individual diseases&#44; given that it adopts complex disease patterns that require diagnostic and therapeutic approaches that are substantially different from traditional practices focused on a single disease&#46; Strengthening primary care and improving coordination and integration between primary care and hospital care and the health and social care would improve the intervention for individuals with polypathology&#46; Healthcare systems face various challenges in promoting this change&#44; challenges that are discussed below&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Research</span><p id="par0125" class="elsevierStylePara elsevierViewall">We need to generate quality measures for the care of individuals with multiple chronic diseases&#44; focused on the performance of the healthcare system for individuals with more needs&#46; Most of the current registries are directed toward individuals with specific diseases&#46; The development of specific indicators for individuals with multiple diseases could help measure efficiency and compare results between various systems&#44; departments and healthcare models&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Clinical practice guidelines</span><p id="par0130" class="elsevierStylePara elsevierViewall">The current guidelines provide relevant recommendations on specific diseases&#46; Guidelines need to be prepared for patients with several diseases that are usually associated &#40;clusters of diseases&#41;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">40</span></a> typically with a significant burden of therapeutic compliance &#40;lifestyle&#44; complex treatments&#44; visits to various practitioners&#44; etc&#46;&#41;&#46; The guidelines need to also consider the patient&#39;s prognosis and recommendations in the various stages over the course of the patient&#39;s life cycle&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Information systems</span><p id="par0135" class="elsevierStylePara elsevierViewall">Information systems need to be improved to achieve integration of all the patient&#39;s data&#44; which should be accessible to any healthcare or social professional and to the patients themselves&#46; These information systems should also facilitate the exploitation of results so that the organization of the various healthcare systems can be compared&#44; opening new lines of research&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Communication technology</span><p id="par0140" class="elsevierStylePara elsevierViewall">New technology can improve coordination among the various healthcare settings and with the patients themselves&#46; Online health technologies offer a promising solution for providing better care and support for individuals &#40;and their caregivers&#41; who have multiple diseases and complex care needs&#46; These technologies can include electronic medical records&#44; telemonitoring systems&#44; web portals and mobile health technologies &#40;&#8220;mHealth&#8221;&#41;&#44; which help exchange information among healthcare providers&#44; patients and their families&#46; There are various experiences&#44; such as in Ontario &#40;Canada&#41;&#44; Scotland and Kaiser Permanente in Colorado &#40;US&#41; where electronic health tools have been adopted for individuals with multimorbidity and complex care needs&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">41</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Healthy aging</span><p id="par0145" class="elsevierStylePara elsevierViewall">The unprecedented demographic change is revealing the shortcomings of the healthcare and social systems&#46; For 2050&#44; the WHO predicts that the number of people older than 60 years will double&#44; that more than 1 in every 5 individuals will be older than 60 years and that 80&#37; will live in countries with medium to low incomes&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The elderly are not all equal&#59; some need permanent assistance for basic activities of life while others&#44; conversely&#44; will maintain a good functional level&#46; Individual factors influence this condition&#44; such as age-related changes&#44; behavior&#44; genetics and diseases&#44; as do environmental factors&#44; such as housing&#44; healthcare devices&#44; social facilities and transport&#46; A change is therefore needed in how we see aging and the elderly&#44; creating adapted environments&#44; suiting the healthcare systems to their needs and establishing long-term care systems&#46; We will thus achieve healthy aging&#44; which consists of being able to do those things that we value&#44; for as long as possible&#44; ensuring an appropriate retirement through the pension system&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Policies should therefore be established with sufficient potential to mitigate the demographic changes in society and help elderly individuals continue as active and productive citizens&#44; either through flexible work&#44; gradual retirement and ongoing learning&#59; in short&#44; as volunteers or caregivers&#46; Investment in this field will be highly rewarding for society&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Health promotion and disease prevention</span><p id="par0160" class="elsevierStylePara elsevierViewall">The social determinants of health are the socioeconomic&#44; political&#44; cultural and environmental conditions in which individuals live and grow&#46; These determinants create risk factors that in turn promote the presence of chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">43</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">There are many ways to promote and preserve health&#44; some of which are found at the border of the competencies of the healthcare sector&#46; The circumstances in which individuals grow&#44; work and age influence in considerable measure the form in which individuals live and die&#46; Education&#44; housing&#44; diet and employment all affect health&#46; Reducing inequalities in these aspects will in turn decrease the inequalities resulted from the acquisition of diseases and in the access to healthcare&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Healthcare systems should promote Antonovsky&#39;s &#8220;salutogenic model&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">44</span></a> i&#46;e&#46;&#44; those individual or group factors that promote the creation of health&#59; resilience or the capacity to resist and adapt<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">45</span></a> and health asset maps&#46; A health asset is any factor or resource that strengthens the ability of individuals&#44; groups or populations to maintain or improve their health and wellbeing&#46; These assets can act in the individual&#44; family or community as protective elements to counter stressful conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">46</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Integration of healthcare and social services</span><p id="par0175" class="elsevierStylePara elsevierViewall">The method for integrating healthcare and social services represents a significant challenge for most countries&#46; Individuals with multiple chronic diseases are more predisposed to disability and therefore need assistance in their daily activities&#46; Traditionally&#44; this type of social care has not been a part of healthcare itself&#44; which multiplies the need for resources and services&#46; Greater mesointegration results in better health results at lower costs&#44; as has been shown by the impact of the US Program for All-Inclusive Care for the Elderly &#40;PACE&#41;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">47</span></a> and the Canadian System of Integrated Services for Aged Persons &#40;SIPA&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">48</span></a> Legislation was recently passed in Scotland on the integration of healthcare and social services&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">49</span></a> The Spanish Ministry of Health has established the basis for social and healthcare coordination&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">50</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding and universal coverage</span><p id="par0180" class="elsevierStylePara elsevierViewall">The WHO&#44; in its report &#8220;Health Systems Financing&#46; The path to universal coverage&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">51</span></a> indicated that 20&#8211;40&#37; of healthcare expenditures are lost due to inefficiencies in the system itself&#46; Initiatives were proposed to achieve proper financing&#58; 1&#41; increase the efficiency in revenue collection&#44; preventing evasion and inefficient collection&#44; thereby increasing the funds for providing services&#59; 2&#41; re-establish the priorities of state budgets given that governments often give relatively low importance to health care when creating budgets&#59; 3&#41; provide innovative financing&#58; with increased taxes on foreign exchange transactions&#44; solidarity taxes on a variety of products and services&#44; taxes on products that are harmful for health such as tobacco&#44; alcohol&#44; sugary drinks and food with high salt content or trans-fatty acids&#46; These taxes will thereby decrease the consumption of unhealthy products&#44; promoting health and generating revenue to devote to healthcare&#59; and 4&#41; provide development assistance for healthcare in global solidarity for low-income countries&#46; If countries immediately meet their current international commitments&#44; external financing for health for low-income countries would more than double immediately&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Reducing unnecessary expenditures in drug products and the more appropriate use of these drugs could save the system up to 5&#37; of the total healthcare expenditure&#46; To increase the efficiency of the system&#44; we need to get the most out of healthcare technologies and services&#44; improve hospital efficiency&#44; reduce medical errors&#44; critically assess the necessary healthcare services and eliminate unnecessary expenditures&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Professionals</span><p id="par0190" class="elsevierStylePara elsevierViewall">A focus on public health promotion needs to be one of the fundamental values of healthcare practitioners&#46; Investments should be directed toward developing methodologies for integration that favor a general approach and not a subspecialized and fragmented approach to health problems&#46; Instruments need to be developed in relation to the health results of patient groups &#40;e&#46;g&#46;&#44; those who require home care&#44; who are institutionalized&#44; who have many needs and entail high costs&#41;&#44; which are more useful than those related to individual diseases&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Healthcare practitioners have not followed the changes in their patients&#44; the patients&#8217; needs and their health problems&#46; It is important to include multimorbidity&#47;polypathology in medical education&#44; as well as the necessary skills for improving the care for this type of patient&#46; Healthcare practitioners need to be trained in a&#41; the shared decision-making process&#59; b&#41; in providing value to the patient&#44; avoiding overdiagnosis and overtreatment&#44; including the use of preventive drugs in individuals with limited life expectancy&#59; c&#41; the training of teams&#59; d&#41; helping patients and caregivers to acquire greater responsibility for their health&#59; e&#41; preventing disability&#59; and f&#41; end-of-life care&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Background"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "The concepts of multimorbidity and polypathology"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Magnitude of the problem&#46; consequences"
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          "titulo" => "Impact of polypathology&#47;multimorbidity on healthcare management"
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          "titulo" => "Challenges in healthcare systems"
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              "titulo" => "Research"
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              "titulo" => "Information systems"
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              "identificador" => "sec0045"
              "titulo" => "Communication technology"
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            4 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Healthy aging"
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            5 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "Health promotion and disease prevention"
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              "titulo" => "Integration of healthcare and social services"
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            7 => array:2 [
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              "titulo" => "Funding and universal coverage"
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    "fechaRecibido" => "2016-10-20"
    "fechaAceptado" => "2017-01-12"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec830142"
          "palabras" => array:5 [
            0 => "Polypathology"
            1 => "Multimorbidity"
            2 => "Challenges of healthcare systems"
            3 => "Aging"
            4 => "Chronic diseases"
          ]
        ]
      ]
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          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:5 [
            0 => "Pluripatolog&#237;a"
            1 => "Multimorbilidad"
            2 => "Retos de los sistemas sanitarios"
            3 => "Envejecimiento"
            4 => "Enfermedades cr&#243;nicas"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Improvements in living conditions and scientific advances have led to an unprecedented demographic change&#46; The curing of numerous acute diseases and the growing adoption of unhealthy lifestyles have caused a pandemic of cumulative chronic diseases that constitute the leading cause of death worldwide&#46; Currently&#44; the most common situation is the coexistence of multiple chronic diseases &#40;or polypathology&#41;&#46; This situation undermines socio-economic development and increases inequality&#46; This results in an overriding need to change the way in which health and disease are addressed&#46; Healthcare systems are not prepared to meet the needs of complex polypathological patients&#46; In this article&#44; we summarize the challenges facing healthcare systems and states&#44; as well as the main recommendations from the organizations responsible for healthcare&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La mejor&#237;a de las condiciones de vida y los avances cient&#237;ficos han propiciado un cambio demogr&#225;fico sin precedentes&#46; La curaci&#243;n de muchas enfermedades agudas y la adopci&#243;n creciente de estilos de vida no saludables han provocado una pandemia de enfermedades cr&#243;nicas acumulativas que constituyen la primera causa de mortalidad mundial&#46; Lo m&#225;s frecuente&#44; actualmente&#44; es la coexistencia de m&#250;ltiples enfermedades cr&#243;nicas o pluripatolog&#237;a&#46; Esta situaci&#243;n socava el desarrollo socioecon&#243;mico y aumenta las desigualdades&#46; Ello condiciona una necesidad imperiosa de cambiar el modo de abordar la salud y la enfermedad&#46; Los sistemas sanitarios no est&#225;n preparados para satisfacer las necesidades de los pacientes pluripatol&#243;gicos complejos&#46; En el presente art&#237;culo se resumen los desaf&#237;os a los que se enfrentan los sistemas sanitarios y los propios estados&#44; as&#237; como las principales recomendaciones de los organismos responsables de la salud de las personas&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Please cite this article as&#58; Rom&#225;n P&#44; Ruiz-Cantero A&#46; La pluripatolog&#237;a&#44; un fen&#243;meno emergente y un reto para los sistemas sanitarios&#46; Rev Clin Esp&#46; 2017&#59;217&#58;229&#8211;237&#46;</p>"
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        "etiqueta" => "Figure 1"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients with several diseases&#46; Abbreviations&#58; AF&#44; atrial fibrillation&#59; AHT&#44; arterial hypertension&#59; COPD&#44; chronic obstructive pulmonary disease&#59; dis&#44; diseases&#59; HF&#44; heart failure&#59; IHD&#44; ischemic heart disease&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Own preparation&#46; Modified from Bruce Guthrie&#44; Sally Wyke&#44; Jane Gunn&#44; Marjan van den Akker and Stewart Mercer by OECD&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a></p>"
        ]
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        "mostrarDisplay" => false
        "figura" => array:1 [
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        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Number of medical errors according to the number of specialists who treated a patient&#46; Abbreviations&#58; AUS&#44; Australia&#59; CAN&#44; Canada&#59; FR&#44; France&#59; GER&#44; Germany&#59; NL&#44; The Netherlands&#59; NZ&#44; New Zealand&#59; UK&#44; United Kingdom&#59; US&#44; United States&#46;</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Own preparation&#46; Modified from the 2008 Commonwealth Fund International Health Policy Survey of Sicker Adults&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">21</span></a></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A&#46;1&#46; Heart failure that in a clinically stable state has been in NYHA class <span class="elsevierStyleSmallCaps">ii</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;symptoms with regular physical activity&#41;<br><span class="elsevierStyleHsp" style=""></span>A&#46;2&#46; Ischemic heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>B&#46;1&#46; Vasculitis and systemic autoimmune diseases<br><span class="elsevierStyleHsp" style=""></span>B&#46;2&#46; Chronic kidney disease defined by a glomerular filtration rate<span class="elsevierStyleHsp" style=""></span>&#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;m or proteinuria<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&#44; maintained for 3 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&#46;1&#46; Chronic respiratory disease that in a clinically stable state has occurred with&#58;<br>dyspnea grade <span class="elsevierStyleSmallCaps">ii</span> of the MRC scale<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> &#40;dyspnea at normal pace on a level surface&#41; or FEV1<span class="elsevierStyleHsp" style=""></span>&#60;65&#37;&#44; or Sat O<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8804;90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category D</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>D&#46;1&#46; Chronic inflammatory bowel disease<br><span class="elsevierStyleHsp" style=""></span>D&#46;2&#46; Chronic liver disease with hepatocellular insufficiency<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> or portal hypertension<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> data&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category E</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>E&#46;1&#46; Stroke<br><span class="elsevierStyleHsp" style=""></span>E&#46;2&#46; Neurological disease with permanent motor deficit that restricts basic activities of daily life &#40;Barthel index<span class="elsevierStyleHsp" style=""></span>&#60;60&#41;<br><span class="elsevierStyleHsp" style=""></span>E&#46;3&#46; Neurological disease with permanent cognitive impairment&#44; at least moderate &#40;Pfeiffer with 5 or more errors&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category F</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>F&#46;1&#46; Symptomatic peripheral arteriopathy<br><span class="elsevierStyleHsp" style=""></span>F&#46;2&#46; Diabetes mellitus with proliferative retinopathy or symptomatic neuropathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category G</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>G&#46;1&#46; Chronic anemia due to gastrointestinal losses or acquired blood disorder not responsive to curative treatment&#44; which&#160;presents Hb levels<span class="elsevierStyleHsp" style=""></span>&#60;10<span class="elsevierStyleHsp" style=""></span>mg&#47;dL in 2 measurements separated&#160;by more than 3 months<br><span class="elsevierStyleHsp" style=""></span>G&#46;2&#46; Solid or hematologically neoplasm not responsive to treatment with intent to heal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category H</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>H&#46;1&#46; Chronic osteoarticular disease that by itself restricts basic activities of daily life &#40;Barthel index<span class="elsevierStyleHsp" style=""></span>&#60;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Number of inclusion categories&#58; 2&#8211;3&#8211;4&#8211;5&#8211;6&#8211;7&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Slight restriction of physical activity&#46; Normal physical activity causes dyspnea&#44; angina&#44; fatigue or palpitations&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Albumin&#47;creatinine index &#62;300<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#44; microalbuminuria &#62;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL in urine sample or albumin &#62;300<span class="elsevierStyleHsp" style=""></span>mg&#47;day in 24<span class="elsevierStyleHsp" style=""></span>h urine or &#62;200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;min&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Unable to maintain the pace of another individual of the same age &#40;walking on a level surface&#41; due to respiratory difficulty or having to stop and rest when walking on a level surface at their own pace&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">INR<span class="elsevierStyleHsp" style=""></span>&#62;1&#46;7&#59; albumin<span class="elsevierStyleHsp" style=""></span>&#60;3&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; bilirubin<span class="elsevierStyleHsp" style=""></span>&#62;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p>"
            ]
            4 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "e"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Defined as the presence of clinical&#44; laboratory&#44; ultrasound or endoscopic data&#46;</p> <p class="elsevierStyleNotepara" id="npar0030"><span class="elsevierStyleItalic">Source</span>&#58; Care of polypathological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">15</span></a></p>"
            ]
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Definition of polypathological patient&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Organization&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Title&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ministry of Health and Social Policy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Polypathological patient unit&#46; Standards and Recommendations<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">36</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Andalusia<br>Ministry of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Care of polypathological patients<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Andalusia<br>Ministry of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Care of polypathological patients&#46; 2nd Edition<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Navarra&#46;<br>Department of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Navarra strategy for the comprehensive care of chronically ill and polypathological patients<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">37</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spanish Society of Internal Medicine &#40;SEMI&#41;<br>Spanish Society of Family and Community Medicine &#40;SEMFYC&#41;&#46;<br>Federation of Associations of Community Nursing and Primary Care &#40;FAECAP&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Development of clinical practice guidelines for patients with comorbidity and polypathology&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spanish Society of Internal Medicine &#40;SEMI&#41;<br>Spanish Society of Family and Community Medicine &#40;SEMFYC&#41;&#46;<br>Federation of Associations of Community Nursing and Primary Care &#40;FAECAP&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Healthcare process for polypathological patients with complex chronic diseases<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Castilla y Le&#243;n<br>Ministry of Health<br>Regional Health Management of Castilla y Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Healthcare process for complex chronic polypathological patients<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Recommendations for managing polypathological patients&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Organizaci&#243;n Mundial de la Salud&#46; Enfermedades no transmisibles&#46; Accesible en&#58; www&#46;who&#46;int&#47;mediacentre&#47;factsheets&#47;fs355&#47;es&#47; &#91;accessed 02&#46;12&#46;16&#93;&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dra&#46; Margaret Chan Directora General de la Organizaci&#243;n Mundial de la Salud&#46; Alocuci&#243;n pronunciada en la Reuni&#243;n de alto nivel de la Asamblea General de las Naciones Unidas sobre enfermedades no transmisibles&#46; Nueva York&#44; Estados Unidos de Am&#233;rica&#46; 19 de septiembre de 2011&#46; Accesible en&#58; <a href="http://www.who.int/dg/speeches/2011/un_ncds_09_19/es/">http&#58;&#47;&#47;www&#46;who&#46;int&#47;dg&#47;speeches&#47;2011&#47;un&#95;ncds&#95;09&#95;19&#47;es&#47;</a> &#91;accessed 02&#46;12&#46;16&#93;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ministerio de Sanidad&#44; Servicios Sociales e Igualdad&#46; Indicadores de salud 2013&#46; Evoluci&#243;n de los indicadores de salud en Espa&#241;a y su magnitud en el contexto de la Uni&#243;n Europea&#46; Madrid&#58; Ministerio de Sanidad&#44; Servicios Sociales e Igualdad&#44; 2014&#46; Available from&#58; <a href="http://www.msssi.gob.es/estadEstudios/estadisticas/inforRecopilaciones/docs/Indicadores2013.pdf">http&#58;&#47;&#47;www&#46;msssi&#46;gob&#46;es&#47;estadEstudios&#47;estadisticas&#47;inforRecopilaciones&#47;docs&#47;Indicadores2013&#46;pdf</a> &#91;accessed 04&#46;10&#46;16&#93;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "4"
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                0 => array:1 [
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Symposium. Polypathology
Polypathology, an emerging phenomenon and a challenge for healthcare systems
La pluripatología, un fenómeno emergente y un reto para los sistemas sanitarios
P. Romána,
Corresponding author
roman_pil@gva.es

Corresponding author.
, A. Ruiz-Canterob
a Servicio de Medicina Interna, Hospital General de Requena, Requena, Valencia, Spain
b Servicio de Medicina Interna. Hospital de la Serranía de Ronda, Ronda, Málaga, Spain
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chronic diseases&#44; defined by the World Health Organization &#40;WHO&#41; as long-acting&#44; generally noncommunicable and slow progression diseases&#46; These noncommunicable chronic diseases are currently the leading cause of death worldwide&#46; Many of these diseases share the same risk factors and are related to pronounced lifestyle changes &#40;e&#46;g&#46;&#44; tobacco consumption&#44; physical inactivity&#44; alcohol abuse and unhealthy diets&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The 4 main types of chronic diseases are cardiovascular disease&#44; cancer&#44; chronic respiratory disease and diabetes&#46; These diseases already disproportionately affect low-income and medium-income countries where almost 75&#37; of the 28 million annually recorded deaths are due to these diseases&#46; These diseases occur in all age groups and regions and are usually associated with the oldest age groups&#46; However&#44; the evidence shows that more than 16 million of the deaths attributed to these diseases occur in individuals younger than 70 years and that 82&#37; of these premature deaths occur in low-income and medium-income countries&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">1</span></a> Children&#44; adults and the elderly are all vulnerable to risk factors that promote chronic diseases&#46; According to Margaret Chan&#44; director general of the World Health Organization &#40;WHO&#41;&#44; chronic diseases are a slow-motion catastrophe&#46; Although their development is slow&#44; the lifestyles that feed this epidemic are propagating at an impressive speed&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">2</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aging of the population is a recent fact in Spain&#46; Until the 1950s&#44; individuals older than 65 years represented 7&#37; of the population&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">3&#44;4</span></a> In the past 40 years&#44; this percentage has grown uninterrupted and will represent 25&#37; by 2025&#46; Although Spain has achieved one of longest life expectancies in the world&#44; especially for women&#44; there are other countries in our community that exceed Spain&#39;s life expectancy with good health&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">3&#8211;5</span></a> Good health is one of the pillars of an economically and socially prosperous society&#44; and achieving life-years free of disability must be one of our healthcare goals&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The increase in age directly affects individuals with chronic diseases&#44; due to the addition and accumulation of these diseases over the course of life&#46; In advanced age&#44; there is a propensity to inflammation&#44; mitochondrial dysfunction and epigenetic disorders that lead to a loss of functional reserve in various organs and systems &#40;neurological&#44; cardiovascular&#44; musculoskeletal&#44; respiratory&#44; renal-urological&#44; immune&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">6</span></a> This loss&#44; rooted in the biological determinants of the aging process&#44; leads to greater susceptibility to chronic diseases such as dementia&#44; ischemic heart disease&#44; heart failure&#44; osteoporosis&#44; osteoarthritis&#44; respiratory diseases and chronic renal disease&#46; There is also a progressive development of functional impairment&#44; which causes a loss of quality of life&#44; increased disability&#44; drug interactions&#44; multiple hospitalizations and increased mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">The concepts of multimorbidity and polypathology</span><p id="par0030" class="elsevierStylePara elsevierViewall">The most common chronic condition in adults is the coexistence of numerous chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">7</span></a> Several terms have been designated to define this condition&#44; depending on the language used&#58; &#8220;multimorbidity&#8221; in English and &#8220;pluripatolog&#237;a&#8221; &#40;polypathology&#41; in Spanish&#46; In any case&#44; this type of patient with multiple chronic diseases is not the exception but rather the rule&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">8</span></a> It would therefore be appropriate that the condition of &#8220;multiple chronic conditions&#8221; be included as another diagnosis in the International Classification of Diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The term &#8220;multimorbidity&#8221; was first coined in 1976 by Brandlmeier&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">9</span></a> In a 2008 report&#44; the WHO defined the term as the simultaneous presence of 2 or more chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">10</span></a> In 2015&#44; the term was translated to 10 European languages for use in family medicine&#44; defining the term &#8220;multimorbidity&#8221; in Spanish as &#8220;any combination of a chronic disease with at least one other disease &#40;acute or chronic&#41; or a biopsychosocial factor &#40;associated or not&#41; or a risk factor&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">11</span></a> &#8220;Multimorbidity&#8221; can modify health results and lead to greater disability&#44; poorer quality of life and frailty&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In September 2016&#44; the National Institute for Health and Care Excellence defined the term &#8220;multimorbidity&#8221; as the presence of 2 or more long-standing health conditions&#44; which can include the following&#58; defined physical and mental health disorders&#44; such as diabetes and schizophrenia&#59; complex conditions such as frailty and chronic pain&#59; and sensory deficits such as reduced visual or auditory acuity&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">12</span></a> In short&#44; 2 or more long-term physical health conditions or a mental disease and another physical disease&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The US has lately been using the expression &#8220;patients with high needs and high costs&#8221; to refer to individuals with 3 or more chronic diseases and functional dependence&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">13&#44;14</span></a> The concept of &#8220;polypathology&#8221; &#40;or that of multimorbidity&#41; can be understood&#44; from a strict perspective&#44; as the coexistence of 2 or more chronic diseases with no other requirements&#46; In 2002&#44; this concept was defined differently in Andalusia as follows&#58; the condition in which an individual experiences 2 or more diseases among 8 clinical categories included in a list of common defined chronic diseases with certain severity or complexity &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">15&#44;16</span></a> In other words&#44; to meet this definition&#44; a person needs to have several chronic diseases&#59; however&#44; not all individuals with several chronic diseases meet the criteria for a polypathological patient&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Moreover&#44; the concept of &#8220;complex chronic patient&#8221; has been coined to refer to patients who have 2 or more chronic progressive diseases&#44; with frequent exacerbations or complex societal situations&#44; which cause an impairment in autonomy and functional capacity and result in frequent use of healthcare services&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">17</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The Spanish Ministry of Health&#44; Social Services and Equality&#44; in its strategy for attention on chronicity in the Spanish National Health System&#44; textually defines<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">18</span></a> a&#41; &#8220;polypathology&#8221; if there are 2 or more coexisting chronic diseases&#59; b&#41; &#8220;comorbidity&#8221;&#44; when any disease is associated with a main nosological entity&#44; both acute and chronic&#44; modulating its diagnosis and treatment&#59; and c&#41; &#8220;complex chronic patient&#8221; as an individual who presents greater complexity in their management by having changing needs that require continuous reassessments and requires the orderly use of various healthcare levels and&#44; in some cases&#44; healthcare and social services&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In short&#44; there is no consensus on the terms or concepts when referring to this type of patient&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Magnitude of the problem&#46; consequences</span><p id="par0065" class="elsevierStylePara elsevierViewall">The number of chronic diseases present in a person increases progressively with age&#44; such that individuals 80 years or older have a mean of over 4 diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a> In a study conducted in Scotland&#44; the number of chronic diseases was greater than 8 among individuals older than 85 years&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">20</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The presence of several chronic diseases in an individual is very common&#46; A document by the Organization for Economic Cooperation and Development listed a number of examples&#58; heart failure is the only entity in only 3&#37; of patients&#44; stroke in 6&#37;&#44; atrial fibrillation in 7&#37;&#44; ischemic heart disease in 9&#37;&#44; diabetes in 14&#37;&#44; chronic obstructive pulmonary disease in 18&#37; and dementia in 5&#37;&#46; By contrast&#44; individuals with heart failure&#44; stroke&#44; diabetes and dementia who have 3 or more chronic diseases represent 74&#37;&#44; 62&#37;&#44; 47&#37; and 64&#37;&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a> It can therefore be emphatically stated that the most common chronic situation is the presence of several chronic diseases in a single individual&#46; This report highlighted that the number of chronic diseases increases with age and inversely with the individual&#39;s socioeconomic status&#46; As the number of these diseases increases&#44; the degree of polypharmacy and medical errors increases&#44; especially if the care is provided by various physicians or specialists &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">In a systematic review&#44; the prevalence of multimorbidity in elderly individuals varied between 55&#37; and 98&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">22</span></a> Advanced age&#44; female sex and low socioeconomic level were the factors associated with multimorbidity&#44; whose main consequences were disability&#44; functional impairment&#44; poor quality of life and high healthcare costs&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">In various studies conducted at the state and regional level&#44; the estimated prevalence of polypathological patients was 1&#46;38&#37; of the general population and 5&#37; of those older than 65 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">18&#44;23</span></a> Depending on their characteristics&#44; it is estimated that between 38&#37; and 60&#37; of patients hospitalized In internal medicine departments have multiple diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">24</span></a> In recent years&#44; the prevalence of polypathology has increased dramatically in orthopedic surgery and trauma units &#40;due mainly to hip fractures in the elderly&#41; and in urology units due to prostate disease&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The standard profile of a hospitalized polypathological patient is a 78-year-old individual&#44; with a mean of 2&#46;4 diseases in the clinical categories of the Andalusian classification &#40;69&#37; with 2 categories&#59; 31&#37; with &#8805;3 categories&#41;&#44; predominantly cardiovascular&#44; respiratory&#44; neurological or renal type&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">25</span></a> These are also polymedicated patients&#44; with an average of 8 drugs&#44; with greater functional dependence at hospital discharge and at 1 year &#40;decrease in Barthel index of 11&#8211;20 points&#41;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">25&#44;26</span></a> and greater mortality compared with nonpolypathological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">27</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Impact of polypathology&#47;multimorbidity on healthcare management</span><p id="par0090" class="elsevierStylePara elsevierViewall">For many years&#44; public health organizations worldwide have stated the urgent need to change the way in which we address health promotion and disease care&#46; The evidence that social determinants of health &#40;housing&#44; education&#44; food and hygiene&#41; are the main risk factors for contracting disease&#44; the overwhelming logic of &#8220;prevention is better than cure&#8221; and the &#8220;tsunami&#8221; of chronic diseases have resulted in a multitude of warnings and recommendations on the risk of financial ruin run by healthcare systems and the states themselves&#46; Since 2000&#44; the WHO has developed strategies and action plans to prevent and control chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">28</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In 2011&#44; the United Nations&#44; in a high-level general assembly in which the heads of member states met&#44; put forth the &#8220;Declaration on the Prevention and Control of Non-communicable Diseases&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">29</span></a> All member states agreed that chronic diseases undermine social and economic development worldwide&#44; are a threat for the economies of many states&#44; promote poverty&#44; increase inequalities among countries and populations and represent a threat to achieving the &#8220;Millennium Development Goals&#8221;&#44; placing this topic among the priorities of political agendas&#46; In their political declaration&#44; the UN established the global objective &#8220;25 by 25&#8221;&#59; i&#46;e&#46;&#44; to reduce by 25&#37; the premature mortality associated with chronic diseases by 2025&#46; The declaration also urged the inclusion of prevention for these diseases as a priority in all national and international programs&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In 2006&#44; the European Union prepared a &#8220;European Strategy for the Prevention and Control of Noncommunicable Diseases&#8221;&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">30</span></a> In December 2010&#44; The Council of the European Union adopted a number of conclusions for the development of action plans to decrease the impact of chronic diseases in Europe&#46; Chronic diseases were considered a priority for the present and future of research and the design of intervention programs&#46; The member states and the European Commission were requested to urgently implement specific and coordinated measures to confront this problem&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">31</span></a> More specifically&#44; the Council invited the member states to implement patient-focused policies to promote health&#44; primary and secondary prevention and the treatment and care of chronic diseases&#44; in cooperation with the responsible politicians and&#44; especially&#44; with the patient associations&#46; The Council also invited the states to identify and exchange information on best practices in this setting and assess the incidence&#44; prevalence and impact of this collection of diseases&#46; A project funded by the European Union was created to care for individuals with multiple diseases &#40;Improving care for people with multiple chronic conditions in Europe&#44; ICARE4EU&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">32</span></a> with the objective of assessing and promoting innovation and improvement in the care of patients with several chronic diseases&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">All the recommendations of international organizations advocate the need to facilitate access for all citizens to healthcare and to control risk factors&#44; creating environments that promote health and health prevention and that prevent inequality&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">33</span></a> Universal coverage is the only measure that&#44; by itself&#44; can profoundly improve social equity&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">34</span></a> Additionally&#44; all the recommendations urge changes in the way health care is provided&#46; Due to the fact that communicable diseases have been the predominant type until the 1950s&#44; care has traditionally been based on the disease and generally provided reactively by hospital specialists&#44; with their actions based on the symptoms and focused on treatment&#46; Although the pattern of diseases and the type of patient have changed&#44; the healthcare systems continue acting in the same manner as in the past&#46; Patients with several diseases are treated by several specialists who take care of the acute episode and the organ for which they are exclusively responsible&#46; The specialists do not interrelate and do not cover the individual&#39;s biopsychosocial needs&#46; Thus&#44; examinations and treatments are unnecessarily multiplied&#44; with the subsequent increase in their adverse effects and the prescription cascade to solve them&#46; There is no coordinated and proactive action to prevent decompensations&#44; and patients are admitted and readmitted over and over&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The new focus of the healthcare model should be based on the &#8220;Comprehensive Care Model&#8221;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">35</span></a>&#58; a&#41; focused on the individual and not on the disease&#44; b&#41; based in primary care and not in the hospital&#44; c&#41; focused on the needs of the population and not on those of the individual patient&#44; d&#41; organized for proactive and planned care&#44; not reactive in the face of symptoms and e&#41; focused on promotion and prevention&#44; not treatment&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Care must be integrated across time&#44; places and health problems&#46; The healthcare team members must collaborate with each other and with the patients and their relatives to achieve the treatment objectives&#46; The implemented plans and strategies should be focused on the patient&#39;s needs&#44; values and preferences&#46; Collectively&#44; health professionals must be able to provide a complete range of healthcare services&#44; from prevention and rehabilitation to end-of-life care&#46; Thus&#44; integrated healthcare models that go beyond specific diseases and that place the individual as the main objective provide a viable solution for introducing efficient and effective care&#46; Several specific recommendations have been developed in our setting for this patient group&#44; both by healthcare administrations and scientific societies &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">15&#44;36&#8211;39</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Challenges in healthcare systems</span><p id="par0120" class="elsevierStylePara elsevierViewall">Polypathology&#47;multimorbidity is much more than the sum of the individual diseases&#44; given that it adopts complex disease patterns that require diagnostic and therapeutic approaches that are substantially different from traditional practices focused on a single disease&#46; Strengthening primary care and improving coordination and integration between primary care and hospital care and the health and social care would improve the intervention for individuals with polypathology&#46; Healthcare systems face various challenges in promoting this change&#44; challenges that are discussed below&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Research</span><p id="par0125" class="elsevierStylePara elsevierViewall">We need to generate quality measures for the care of individuals with multiple chronic diseases&#44; focused on the performance of the healthcare system for individuals with more needs&#46; Most of the current registries are directed toward individuals with specific diseases&#46; The development of specific indicators for individuals with multiple diseases could help measure efficiency and compare results between various systems&#44; departments and healthcare models&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Clinical practice guidelines</span><p id="par0130" class="elsevierStylePara elsevierViewall">The current guidelines provide relevant recommendations on specific diseases&#46; Guidelines need to be prepared for patients with several diseases that are usually associated &#40;clusters of diseases&#41;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">40</span></a> typically with a significant burden of therapeutic compliance &#40;lifestyle&#44; complex treatments&#44; visits to various practitioners&#44; etc&#46;&#41;&#46; The guidelines need to also consider the patient&#39;s prognosis and recommendations in the various stages over the course of the patient&#39;s life cycle&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Information systems</span><p id="par0135" class="elsevierStylePara elsevierViewall">Information systems need to be improved to achieve integration of all the patient&#39;s data&#44; which should be accessible to any healthcare or social professional and to the patients themselves&#46; These information systems should also facilitate the exploitation of results so that the organization of the various healthcare systems can be compared&#44; opening new lines of research&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Communication technology</span><p id="par0140" class="elsevierStylePara elsevierViewall">New technology can improve coordination among the various healthcare settings and with the patients themselves&#46; Online health technologies offer a promising solution for providing better care and support for individuals &#40;and their caregivers&#41; who have multiple diseases and complex care needs&#46; These technologies can include electronic medical records&#44; telemonitoring systems&#44; web portals and mobile health technologies &#40;&#8220;mHealth&#8221;&#41;&#44; which help exchange information among healthcare providers&#44; patients and their families&#46; There are various experiences&#44; such as in Ontario &#40;Canada&#41;&#44; Scotland and Kaiser Permanente in Colorado &#40;US&#41; where electronic health tools have been adopted for individuals with multimorbidity and complex care needs&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">41</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Healthy aging</span><p id="par0145" class="elsevierStylePara elsevierViewall">The unprecedented demographic change is revealing the shortcomings of the healthcare and social systems&#46; For 2050&#44; the WHO predicts that the number of people older than 60 years will double&#44; that more than 1 in every 5 individuals will be older than 60 years and that 80&#37; will live in countries with medium to low incomes&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The elderly are not all equal&#59; some need permanent assistance for basic activities of life while others&#44; conversely&#44; will maintain a good functional level&#46; Individual factors influence this condition&#44; such as age-related changes&#44; behavior&#44; genetics and diseases&#44; as do environmental factors&#44; such as housing&#44; healthcare devices&#44; social facilities and transport&#46; A change is therefore needed in how we see aging and the elderly&#44; creating adapted environments&#44; suiting the healthcare systems to their needs and establishing long-term care systems&#46; We will thus achieve healthy aging&#44; which consists of being able to do those things that we value&#44; for as long as possible&#44; ensuring an appropriate retirement through the pension system&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Policies should therefore be established with sufficient potential to mitigate the demographic changes in society and help elderly individuals continue as active and productive citizens&#44; either through flexible work&#44; gradual retirement and ongoing learning&#59; in short&#44; as volunteers or caregivers&#46; Investment in this field will be highly rewarding for society&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">42</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Health promotion and disease prevention</span><p id="par0160" class="elsevierStylePara elsevierViewall">The social determinants of health are the socioeconomic&#44; political&#44; cultural and environmental conditions in which individuals live and grow&#46; These determinants create risk factors that in turn promote the presence of chronic diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">43</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">There are many ways to promote and preserve health&#44; some of which are found at the border of the competencies of the healthcare sector&#46; The circumstances in which individuals grow&#44; work and age influence in considerable measure the form in which individuals live and die&#46; Education&#44; housing&#44; diet and employment all affect health&#46; Reducing inequalities in these aspects will in turn decrease the inequalities resulted from the acquisition of diseases and in the access to healthcare&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Healthcare systems should promote Antonovsky&#39;s &#8220;salutogenic model&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">44</span></a> i&#46;e&#46;&#44; those individual or group factors that promote the creation of health&#59; resilience or the capacity to resist and adapt<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">45</span></a> and health asset maps&#46; A health asset is any factor or resource that strengthens the ability of individuals&#44; groups or populations to maintain or improve their health and wellbeing&#46; These assets can act in the individual&#44; family or community as protective elements to counter stressful conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0485"><span class="elsevierStyleSup">46</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Integration of healthcare and social services</span><p id="par0175" class="elsevierStylePara elsevierViewall">The method for integrating healthcare and social services represents a significant challenge for most countries&#46; Individuals with multiple chronic diseases are more predisposed to disability and therefore need assistance in their daily activities&#46; Traditionally&#44; this type of social care has not been a part of healthcare itself&#44; which multiplies the need for resources and services&#46; Greater mesointegration results in better health results at lower costs&#44; as has been shown by the impact of the US Program for All-Inclusive Care for the Elderly &#40;PACE&#41;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">47</span></a> and the Canadian System of Integrated Services for Aged Persons &#40;SIPA&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">48</span></a> Legislation was recently passed in Scotland on the integration of healthcare and social services&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">49</span></a> The Spanish Ministry of Health has established the basis for social and healthcare coordination&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">50</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding and universal coverage</span><p id="par0180" class="elsevierStylePara elsevierViewall">The WHO&#44; in its report &#8220;Health Systems Financing&#46; The path to universal coverage&#8221;&#44;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">51</span></a> indicated that 20&#8211;40&#37; of healthcare expenditures are lost due to inefficiencies in the system itself&#46; Initiatives were proposed to achieve proper financing&#58; 1&#41; increase the efficiency in revenue collection&#44; preventing evasion and inefficient collection&#44; thereby increasing the funds for providing services&#59; 2&#41; re-establish the priorities of state budgets given that governments often give relatively low importance to health care when creating budgets&#59; 3&#41; provide innovative financing&#58; with increased taxes on foreign exchange transactions&#44; solidarity taxes on a variety of products and services&#44; taxes on products that are harmful for health such as tobacco&#44; alcohol&#44; sugary drinks and food with high salt content or trans-fatty acids&#46; These taxes will thereby decrease the consumption of unhealthy products&#44; promoting health and generating revenue to devote to healthcare&#59; and 4&#41; provide development assistance for healthcare in global solidarity for low-income countries&#46; If countries immediately meet their current international commitments&#44; external financing for health for low-income countries would more than double immediately&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Reducing unnecessary expenditures in drug products and the more appropriate use of these drugs could save the system up to 5&#37; of the total healthcare expenditure&#46; To increase the efficiency of the system&#44; we need to get the most out of healthcare technologies and services&#44; improve hospital efficiency&#44; reduce medical errors&#44; critically assess the necessary healthcare services and eliminate unnecessary expenditures&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Professionals</span><p id="par0190" class="elsevierStylePara elsevierViewall">A focus on public health promotion needs to be one of the fundamental values of healthcare practitioners&#46; Investments should be directed toward developing methodologies for integration that favor a general approach and not a subspecialized and fragmented approach to health problems&#46; Instruments need to be developed in relation to the health results of patient groups &#40;e&#46;g&#46;&#44; those who require home care&#44; who are institutionalized&#44; who have many needs and entail high costs&#41;&#44; which are more useful than those related to individual diseases&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Healthcare practitioners have not followed the changes in their patients&#44; the patients&#8217; needs and their health problems&#46; It is important to include multimorbidity&#47;polypathology in medical education&#44; as well as the necessary skills for improving the care for this type of patient&#46; Healthcare practitioners need to be trained in a&#41; the shared decision-making process&#59; b&#41; in providing value to the patient&#44; avoiding overdiagnosis and overtreatment&#44; including the use of preventive drugs in individuals with limited life expectancy&#59; c&#41; the training of teams&#59; d&#41; helping patients and caregivers to acquire greater responsibility for their health&#59; e&#41; preventing disability&#59; and f&#41; end-of-life care&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Background"
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          "identificador" => "sec0010"
          "titulo" => "The concepts of multimorbidity and polypathology"
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          "titulo" => "Magnitude of the problem&#46; consequences"
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          "titulo" => "Impact of polypathology&#47;multimorbidity on healthcare management"
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          "titulo" => "Challenges in healthcare systems"
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              "titulo" => "Health promotion and disease prevention"
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              "titulo" => "Integration of healthcare and social services"
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              "titulo" => "Funding and universal coverage"
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          "clase" => "keyword"
          "titulo" => "Keywords"
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          "palabras" => array:5 [
            0 => "Polypathology"
            1 => "Multimorbidity"
            2 => "Challenges of healthcare systems"
            3 => "Aging"
            4 => "Chronic diseases"
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        ]
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          "palabras" => array:5 [
            0 => "Pluripatolog&#237;a"
            1 => "Multimorbilidad"
            2 => "Retos de los sistemas sanitarios"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Improvements in living conditions and scientific advances have led to an unprecedented demographic change&#46; The curing of numerous acute diseases and the growing adoption of unhealthy lifestyles have caused a pandemic of cumulative chronic diseases that constitute the leading cause of death worldwide&#46; Currently&#44; the most common situation is the coexistence of multiple chronic diseases &#40;or polypathology&#41;&#46; This situation undermines socio-economic development and increases inequality&#46; This results in an overriding need to change the way in which health and disease are addressed&#46; Healthcare systems are not prepared to meet the needs of complex polypathological patients&#46; In this article&#44; we summarize the challenges facing healthcare systems and states&#44; as well as the main recommendations from the organizations responsible for healthcare&#46;</p></span>"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La mejor&#237;a de las condiciones de vida y los avances cient&#237;ficos han propiciado un cambio demogr&#225;fico sin precedentes&#46; La curaci&#243;n de muchas enfermedades agudas y la adopci&#243;n creciente de estilos de vida no saludables han provocado una pandemia de enfermedades cr&#243;nicas acumulativas que constituyen la primera causa de mortalidad mundial&#46; Lo m&#225;s frecuente&#44; actualmente&#44; es la coexistencia de m&#250;ltiples enfermedades cr&#243;nicas o pluripatolog&#237;a&#46; Esta situaci&#243;n socava el desarrollo socioecon&#243;mico y aumenta las desigualdades&#46; Ello condiciona una necesidad imperiosa de cambiar el modo de abordar la salud y la enfermedad&#46; Los sistemas sanitarios no est&#225;n preparados para satisfacer las necesidades de los pacientes pluripatol&#243;gicos complejos&#46; En el presente art&#237;culo se resumen los desaf&#237;os a los que se enfrentan los sistemas sanitarios y los propios estados&#44; as&#237; como las principales recomendaciones de los organismos responsables de la salud de las personas&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Please cite this article as&#58; Rom&#225;n P&#44; Ruiz-Cantero A&#46; La pluripatolog&#237;a&#44; un fen&#243;meno emergente y un reto para los sistemas sanitarios&#46; Rev Clin Esp&#46; 2017&#59;217&#58;229&#8211;237&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Percentage of patients with several diseases&#46; Abbreviations&#58; AF&#44; atrial fibrillation&#59; AHT&#44; arterial hypertension&#59; COPD&#44; chronic obstructive pulmonary disease&#59; dis&#44; diseases&#59; HF&#44; heart failure&#59; IHD&#44; ischemic heart disease&#46;</p> <p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Own preparation&#46; Modified from Bruce Guthrie&#44; Sally Wyke&#44; Jane Gunn&#44; Marjan van den Akker and Stewart Mercer by OECD&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">19</span></a></p>"
        ]
      ]
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        "figura" => array:1 [
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            "imagen" => "gr2.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Number of medical errors according to the number of specialists who treated a patient&#46; Abbreviations&#58; AUS&#44; Australia&#59; CAN&#44; Canada&#59; FR&#44; France&#59; GER&#44; Germany&#59; NL&#44; The Netherlands&#59; NZ&#44; New Zealand&#59; UK&#44; United Kingdom&#59; US&#44; United States&#46;</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Own preparation&#46; Modified from the 2008 Commonwealth Fund International Health Policy Survey of Sicker Adults&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">21</span></a></p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A&#46;1&#46; Heart failure that in a clinically stable state has been in NYHA class <span class="elsevierStyleSmallCaps">ii</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;symptoms with regular physical activity&#41;<br><span class="elsevierStyleHsp" style=""></span>A&#46;2&#46; Ischemic heart disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>B&#46;1&#46; Vasculitis and systemic autoimmune diseases<br><span class="elsevierStyleHsp" style=""></span>B&#46;2&#46; Chronic kidney disease defined by a glomerular filtration rate<span class="elsevierStyleHsp" style=""></span>&#60;60<span class="elsevierStyleHsp" style=""></span>mL&#47;m or proteinuria<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&#44; maintained for 3 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&#46;1&#46; Chronic respiratory disease that in a clinically stable state has occurred with&#58;<br>dyspnea grade <span class="elsevierStyleSmallCaps">ii</span> of the MRC scale<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a> &#40;dyspnea at normal pace on a level surface&#41; or FEV1<span class="elsevierStyleHsp" style=""></span>&#60;65&#37;&#44; or Sat O<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8804;90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category D</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>D&#46;1&#46; Chronic inflammatory bowel disease<br><span class="elsevierStyleHsp" style=""></span>D&#46;2&#46; Chronic liver disease with hepatocellular insufficiency<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> or portal hypertension<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> data&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category E</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>E&#46;1&#46; Stroke<br><span class="elsevierStyleHsp" style=""></span>E&#46;2&#46; Neurological disease with permanent motor deficit that restricts basic activities of daily life &#40;Barthel index<span class="elsevierStyleHsp" style=""></span>&#60;60&#41;<br><span class="elsevierStyleHsp" style=""></span>E&#46;3&#46; Neurological disease with permanent cognitive impairment&#44; at least moderate &#40;Pfeiffer with 5 or more errors&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category F</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>F&#46;1&#46; Symptomatic peripheral arteriopathy<br><span class="elsevierStyleHsp" style=""></span>F&#46;2&#46; Diabetes mellitus with proliferative retinopathy or symptomatic neuropathy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category G</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>G&#46;1&#46; Chronic anemia due to gastrointestinal losses or acquired blood disorder not responsive to curative treatment&#44; which&#160;presents Hb levels<span class="elsevierStyleHsp" style=""></span>&#60;10<span class="elsevierStyleHsp" style=""></span>mg&#47;dL in 2 measurements separated&#160;by more than 3 months<br><span class="elsevierStyleHsp" style=""></span>G&#46;2&#46; Solid or hematologically neoplasm not responsive to treatment with intent to heal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Category H</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>H&#46;1&#46; Chronic osteoarticular disease that by itself restricts basic activities of daily life &#40;Barthel index<span class="elsevierStyleHsp" style=""></span>&#60;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Number of inclusion categories&#58; 2&#8211;3&#8211;4&#8211;5&#8211;6&#8211;7&#8211;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Slight restriction of physical activity&#46; Normal physical activity causes dyspnea&#44; angina&#44; fatigue or palpitations&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Albumin&#47;creatinine index &#62;300<span class="elsevierStyleHsp" style=""></span>mg&#47;g&#44; microalbuminuria &#62;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL in urine sample or albumin &#62;300<span class="elsevierStyleHsp" style=""></span>mg&#47;day in 24<span class="elsevierStyleHsp" style=""></span>h urine or &#62;200<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;min&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Unable to maintain the pace of another individual of the same age &#40;walking on a level surface&#41; due to respiratory difficulty or having to stop and rest when walking on a level surface at their own pace&#46;</p>"
            ]
            3 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "d"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">INR<span class="elsevierStyleHsp" style=""></span>&#62;1&#46;7&#59; albumin<span class="elsevierStyleHsp" style=""></span>&#60;3&#46;5<span class="elsevierStyleHsp" style=""></span>g&#47;dL&#59; bilirubin<span class="elsevierStyleHsp" style=""></span>&#62;2<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#46;</p>"
            ]
            4 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "e"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Defined as the presence of clinical&#44; laboratory&#44; ultrasound or endoscopic data&#46;</p> <p class="elsevierStyleNotepara" id="npar0030"><span class="elsevierStyleItalic">Source</span>&#58; Care of polypathological patients&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">15</span></a></p>"
            ]
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Definition of polypathological patient&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Organization&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Title&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ministry of Health and Social Policy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Polypathological patient unit&#46; Standards and Recommendations<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">36</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Andalusia<br>Ministry of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Care of polypathological patients<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Andalusia<br>Ministry of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Care of polypathological patients&#46; 2nd Edition<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Navarra&#46;<br>Department of Health&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Navarra strategy for the comprehensive care of chronically ill and polypathological patients<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">37</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spanish Society of Internal Medicine &#40;SEMI&#41;<br>Spanish Society of Family and Community Medicine &#40;SEMFYC&#41;&#46;<br>Federation of Associations of Community Nursing and Primary Care &#40;FAECAP&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Development of clinical practice guidelines for patients with comorbidity and polypathology&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">38</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spanish Society of Internal Medicine &#40;SEMI&#41;<br>Spanish Society of Family and Community Medicine &#40;SEMFYC&#41;&#46;<br>Federation of Associations of Community Nursing and Primary Care &#40;FAECAP&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Healthcare process for polypathological patients with complex chronic diseases<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Government of Castilla y Le&#243;n<br>Ministry of Health<br>Regional Health Management of Castilla y Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Healthcare process for complex chronic polypathological patients<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">39</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Recommendations for managing polypathological patients&#46;</p>"
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    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
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            0 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Organizaci&#243;n Mundial de la Salud&#46; Enfermedades no transmisibles&#46; Accesible en&#58; www&#46;who&#46;int&#47;mediacentre&#47;factsheets&#47;fs355&#47;es&#47; &#91;accessed 02&#46;12&#46;16&#93;&#46;"
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Dra&#46; Margaret Chan Directora General de la Organizaci&#243;n Mundial de la Salud&#46; Alocuci&#243;n pronunciada en la Reuni&#243;n de alto nivel de la Asamblea General de las Naciones Unidas sobre enfermedades no transmisibles&#46; Nueva York&#44; Estados Unidos de Am&#233;rica&#46; 19 de septiembre de 2011&#46; Accesible en&#58; <a href="http://www.who.int/dg/speeches/2011/un_ncds_09_19/es/">http&#58;&#47;&#47;www&#46;who&#46;int&#47;dg&#47;speeches&#47;2011&#47;un&#95;ncds&#95;09&#95;19&#47;es&#47;</a> &#91;accessed 02&#46;12&#46;16&#93;&#46;"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ministerio de Sanidad&#44; Servicios Sociales e Igualdad&#46; Indicadores de salud 2013&#46; Evoluci&#243;n de los indicadores de salud en Espa&#241;a y su magnitud en el contexto de la Uni&#243;n Europea&#46; Madrid&#58; Ministerio de Sanidad&#44; Servicios Sociales e Igualdad&#44; 2014&#46; Available from&#58; <a href="http://www.msssi.gob.es/estadEstudios/estadisticas/inforRecopilaciones/docs/Indicadores2013.pdf">http&#58;&#47;&#47;www&#46;msssi&#46;gob&#46;es&#47;estadEstudios&#47;estadisticas&#47;inforRecopilaciones&#47;docs&#47;Indicadores2013&#46;pdf</a> &#91;accessed 04&#46;10&#46;16&#93;&#46;"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Indicadores claves del SNS&#46; Instituto de informaci&#243;n sanitaria&#46; MSSSI&#46; &#40;BD 20 agosto 2013&#41;&#46; Available from&#58; <a href="http://www.msssi.gob.es/fr/estadEstudios/estadisticas/sisInfSanSNS/docsInclaSNS/Metodologia_INCLASNS_V2.pdf">http&#58;&#47;&#47;www&#46;msssi&#46;gob&#46;es&#47;fr&#47;estadEstudios&#47;estadisticas&#47;sisInfSanSNS&#47;docsInclaSNS&#47;Metodologia&#95;INCLASNS&#95;V2&#46;pdf</a> &#91;accessed 04&#46;12&#46;16&#93;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "5"
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