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study<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">13&#44;14</span></a> &#40;<a class="elsevierStyleCrossRef" href="#sec0060">Appendix</a>&#41; is an intervention study with 2 parallel groups designed to reduce the duration of urinary tract catheterization and intravenous fluid treatment&#46; The intervention was applied to 1 of 2 groups&#46; Twice a week during the meeting of the therapeutic team of physicians and nurses&#44; an assessment was conducted on withdrawing the bladder catheters&#44; finalizing the intravenous fluid treatment&#44; the onset of pressure ulcers and the early detection of delirium&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Procedures</span><p id="par0030" class="elsevierStylePara elsevierViewall">The study included all unselected patients hospitalized in the department of internal medicine during the months of October 2010&#44; January 2011&#44; May 2011 and October 2011&#46; On admission&#44; a nurse interviewed each patient&#44; their relatives or companions to assess the patient&#39;s functional state and risk of pressure ulcers&#46; After the discharge&#44; the medical history data and data from the administrative database on hospital discharges were extracted&#46; The following information was collected from each patient&#58; age&#44; sex&#44; residence &#40;home or assisted living&#41;&#44; ability to perform basic activities of daily life&#44; risk of presenting pressure ulcers&#44; onset of delirium during hospitalization&#44; presence of pressure ulcers&#44; use during hospitalization of urinary catheter&#44; intravenous fluid therapy&#44; placement of nasogastric catheter or percutaneous gastrostomy&#44; major diagnostic category at discharge&#44; duration of the hospitalization and mean weight of the diagnosis-related group &#40;DRG&#41;&#46; The ability to perform the basic activities of daily life was assessed with the Barthel index&#44; which includes 10 tasks&#58; feeding&#44; bathing&#44; dressing&#44; grooming&#44; voiding&#44; defecation&#44; going to the toilet&#44; transferring&#44; walking and climbing up and down stairs&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">15</span></a> The range of scores is 0 to 100&#59; the higher the score&#44; the greater the individual&#39;s capacity&#46; Thus&#44; 0 corresponds to absolute dependence and 100 represents total autonomy for basic activities of daily life&#46; The Barthel index prior to admission in the stable phase was recorded&#46; The risk of presenting pressure ulcers was assessed with the Norton scale&#44; which records 5 parameters&#58; physical state&#44; mental state&#44; activity&#44; movement and incontinence&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">16</span></a> The scale ranges from 5 to 20&#59; the lower the score&#44; the greater the risk of pressure ulcers&#46; The presence of pressure ulcers was assessed at admission and every day during the hospitalization&#46; The severity of the pressure ulcers was graduated from <span class="elsevierStyleSmallCaps">I</span> to IV&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">17</span></a> and the highest degree pressure ulcer was recorded when there were more than one&#46; We also recorded whether the patient presented pressure ulcers at the time of discharge&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A 3-year follow-up was subsequently conducted by reviewing the medical history&#44; by telephone or by consulting the National Death Index&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study was approved by the Clinical Research Ethics Committee of Aragon &#40;PI 12&#47;0009&#41;&#44; and the patients or their relatives provided their consent for inclusion in the study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">The qualitative and quantitative variables are presented as absolute frequencies &#40;percentages&#41;&#44; and means &#40;standard deviation&#41;&#44; respectively&#46; The comparison of qualitative variables was conducted with the chi-squared test&#46; The Kolmogorov&#8211;Smirnov test was employed to verify that the quantitative variables did not follow a normal distribution&#46; The quantitative variables were compared with the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">To assess the association of each variable with the presence of pressure ulcers&#44; we constructed a multivariate logistic regression model that included those variables with a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;1 in the univariate model&#46; To study the association of the variables with mortality&#44; we performed a Cox proportional regression and Kaplan&#8211;Meier survival curves with the log-rank test&#46; In all cases&#44; the level of statistical significance was <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; The statistical analysis was conducted with the SPSS statistical package&#44; version 22&#46;0&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">We included 699 patients with a mean age of 74&#46;6 &#40;15&#46;2&#41; years&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the patient selection diagram&#46; Pressure ulcers occurred in 100 &#40;14&#46;3&#37;&#41; patients&#44; 27 of whom had grade <span class="elsevierStyleSmallCaps">1</span>&#44; 17 had grade <span class="elsevierStyleSmallCaps">2</span>&#44; 21 had grade <span class="elsevierStyleSmallCaps">3</span> and 25 had grade <span class="elsevierStyleSmallCaps">4</span>&#59; this datum was not available for 10 patients&#46; In 69 cases&#44; the pressure ulcers started at home&#44; 25 cases occurred during hospitalization and 3 cases occurred in both circumstances&#46; At discharge&#44; the pressure ulcers were in the process of healing in 86 patients&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Factors associated with the presence of pressure ulcers</span><p id="par0060" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the characteristics of patients with and without pressure ulcers&#46; The patients with pressure ulcers were older&#44; mostly women&#44; resided in assisted living and had greater disability in basic activities of daily life&#46; The patients with pressure ulcers had a greater frequency of infectious diseases and delirium and fewer hepatic&#44; biliary and pancreatic diseases&#46; The placement of a vesical catheter&#44; nasogastric catheter&#44; percutaneous gastrostomy and intravenous fluid treatment were more common in the patients with pressure ulcers&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The multivariate analysis showed that the Barthel index and Norton scale were independently associated with the presence of pressure ulcers &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Mean hospital stay and expenditure</span><p id="par0070" class="elsevierStylePara elsevierViewall">The patients with pressure ulcers had longer mean stays &#40;13&#46;1 &#91;8&#46;4&#93; days vs&#46; 9 &#91;7&#46;4&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; The weight of the DRG&#44; which estimates the hospitalization expenses&#44; was 2&#46;10 &#40;0&#46;96&#41; for the patients with pressure ulcers and 1&#46;58 &#40;0&#46;96&#41; for those without pressure ulcers &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Mortality</span><p id="par0075" class="elsevierStylePara elsevierViewall">Eighty-two patients died during hospitalization&#46; The mortality was greater for the patients with pressure ulcers &#40;23&#37; vs&#46; 9&#46;8&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; At 3 years&#44; 333 &#40;47&#46;6&#37;&#41; patients had died&#44; with a much greater mortality among the patients with pressure ulcers &#40;83&#37; vs&#46; 41&#46;7&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Of these&#44; 23&#37; died during the hospitalization&#44; 56&#37; at 6 months and 68&#37; during the first year&#46; There were no differences in mortality during the hospitalization or at the end of the follow-up among the patients with differing degrees of pressure ulcer severity&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The multivariate analysis showed that age&#44; nervous system diseases&#44; delirium&#44; the Barthel index and pressure ulcers were independently associated with mortality &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The pressure ulcers present at admission &#40;HR&#44; 3&#46;069&#59; 95&#37; CI 2&#46;326&#8211;4&#46;048&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; and those that developed during hospitalization were associated with mortality &#40;HR&#44; 2&#46;340&#59; 95&#37; CI 1&#46;531&#8211;3&#46;576&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">The main findings of this study were that approximately 1 of every 7 patients hospitalized in internal medicine has pressure ulcers at admission or during hospitalization and that patients with pressure ulcers have a high mortality in the short&#44; mean and long-term&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Despite the improvements in treating pressure ulcers and the use of various strategies to prevent their onset in hospitalized patients&#44; the prevalence of pressure ulcers remains constant in the 3 national surveys conducted in Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">7&#8211;9</span></a> The same phenomenon has been observed in studies conducted in acute care tertiary hospitals&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> Age and the admitting department have been associated with pressure ulcers&#44; which are more common in medical departments than in surgical ones&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> The prevalence has varied between 6&#46;3&#37; and 8&#46;6&#37; in the collection of medical departments of acute care hospitals&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">15&#44;16</span></a> We observed a prevalence of 14&#46;3&#37;&#44; which was higher than previously reported and possibly due to the fact that the study was performed exclusively in a department of internal medicine&#44; whose patients are usually older than those of other medical departments&#44; with the exception of geriatric medicine units&#46; In fact&#44; in the study by Tom&#225;s-Life et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">18</span></a> conducted in the medical departments of the Balearic Islands&#44; the prevalence of pressure ulcers in the age group older than 70 years was 11&#46;4&#37;&#44; which is closer to the rate observed in our study&#46; It is known that mild pressure ulcers occasionally go unnoticed and are not recorded in the medical records&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">19</span></a> A meta-analysis found that the exclusive clinical judgment of the nursing staff was insufficient for detecting pressure ulcers and that the judgment needed to be combined with the use of a validated scale&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> Our study falls within a prospective program targeted at the early detection of pressure ulcers using the Norton scale&#46; We therefore expect that the physicians and nurses are more sensitized to detecting and recording pressure ulcers&#44; with a more comprehensive patient assessment&#44; as recommended by the clinical practice guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">21&#44;22</span></a> This could justify the higher prevalence we observed&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">There are various scales for assessing the risk of presenting a pressure ulcer&#46; We employed the Norton scale&#44; which has one of highest predictive capacities&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> One of the items on this scale is the patient&#39;s mobility&#46; Length of stay&#44; presence of coma&#44; carrying a urinary catheter or nasogastric catheter and undergoing intravenous fluid treatment are factors that have been associated with the onset of pressure ulcers&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">1&#44;6&#44;23</span></a> All of these factors are related to immobility&#46; In the univariate analysis&#44; carrying a urinary or nasogastric catheter or percutaneous gastrostomy and the intravenous administration of fluids were associated with the presence of pressure ulcers&#46; It is difficult to establish the causality because this type of catheter is also placed in patients with pressure ulcers to administer drugs&#44; nutrition and to avoid contaminating the pressure ulcers with urine&#46; However&#44; we believe that all strategies directed toward decreasing the duration of catheterization in patients who do not have pressure ulcers can help prevent their onset&#46; Delirium was more common in the patients with pressure ulcers and can sometimes result in restricted movement with the use of hospital beds with guardrails and even restraints&#46; However&#44; only the Norton scale and disability measured by the Barthel index were factors independently associated with pressure ulcers&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Another of this study&#39;s findings was that the hospital stay of patients with pressure ulcers was extended by 4 days&#46; In a study with more than 5 million discharges from departments of internal medicine in Spain&#44; pressure ulcers were 10 times more common in patients with a hospital stay longer than 30 days&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">1</span></a> A study conducted in 2007 estimated that the cost of treating pressure ulcers in Spain was 461 million euros and that 45&#37; of this expenditure was due to prolonged hospital stays&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">24</span></a> In our study&#44; the weight of the DRG was 0&#46;52 higher in the cases with pressure ulcers&#44; which corresponded to an additional expenditure of &#8364; 2435&#46;94 according to data from the Ministry of Health&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">25</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Almost half of the patients had died after the 3 years of follow-up&#46; This is a high mortality rate&#44; which could be explained by the patients&#8217; mean age and their complexity&#46; This complexity was manifested in a high degree of disability and the high weight of the DRG&#46; Pressure ulcers have been associated with increased mortality&#46; In our series&#44; one of every 4 patients with pressure ulcers died during hospitalization&#46; Two of every 3 had died by the end of a year and more than 8 of every 10 had died by the end of 3 years&#46; We can therefore consider pressure ulcers as a factor of poor prognosis in the short&#44; medium and long term&#46; Previous studies have already confirmed this association with mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">10&#44;26</span></a> Recently&#44; pressure ulcers have been included in an index to establish the prognosis at 6 months in patients with chronic diseases in advanced phases&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">27</span></a> Given these findings&#44; we consider that when a patient presents pressure ulcers we must start planning the start of palliative care&#44; especially if the patient is elderly&#44; dependent or has delirium or a nervous system disorder&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">We know of no other study published in Spain on the prevalence of pressure ulcers in a department of internal medicine&#46; This is one of the strengths of our study&#44; along with the extended patient follow-up&#46; However&#44; our study also has a number of limitations&#46; Firstly&#44; the study was conducted in a single hospital&#59; multicenter studies are known to provide evidence with greater rigor&#46; This fact could decrease the extrapolation of the results to other settings&#46; Secondly&#44; the study was conducted within the framework of a specific project for monitoring the onset of pressure ulcers&#44; and its results on prevalence could be different from those outside this research context&#46; However&#44; this is also a strength because the results reflect data from the real world&#44; which in other circumstances could go unnoticed&#46; It is a fact that physicians occasionally ignore the presence of pressure ulcers in their patients&#44; especially when the pressure ulcers are low-grade&#44; delegating their surveillance and care to the nursing staff despite the prognostic importance of pressure ulcers&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In summary&#44; pressure ulcers are very common in patients hospitalized in internal medicine and are associated with a poor prognosis&#46; Their assessment is therefore essential for establishing the short&#44; medium and long-term therapeutic objectives&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interests</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of pressure ulcers in patients hospitalized in internal medicine and the clinical factors and risk of death associated with its presence&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study with patients hospitalized in internal medicine&#46; We recorded the age&#44; sex&#44; presence of pressure ulcers&#44; degree of ulceration&#44; Barthel index&#44; Norton scale&#44; major diagnostic category&#44; length of hospital stay and weight of the diagnosis-related groups&#46; We compared the clinical characteristics of the patients with or without ulcers and analyzed the mortality after 3 years based on the presence of ulcers&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The study included 699 patients&#44; 100 of whom &#40;14&#46;3&#37;&#41; had pressure ulcers &#40;27 with grade I&#44; 17 with grade II&#44; 21 with grade III&#44; 25 with grade IV and 10 with unknown grade&#41;&#46; The Barthel index &#40;OR 0&#46;985&#59; 95&#37; CI 0&#46;972&#8211;0&#46;998&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;022&#41; and Norton scale &#40;OR 0&#46;873&#59; 95&#37; CI 0&#46;780&#8211;0&#46;997&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;018&#41; are independently associated with ulcers&#46; Twenty-three percent of the patients with ulcers died during hospitalization&#44; 68&#37; died within a year&#44; and 83&#37; died within 3 years&#46; The presence of pressure ulcers was independently associated with mortality &#40;HR&#44; 1&#46;531&#59; 95&#37; CI 1&#46;140&#8211;2&#46;056&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pressure ulcers are common in patients hospitalized in internal medicine&#44; and their presence is associated with higher short&#44; medium and long-term mortality&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de las &#250;lceras por presi&#243;n en pacientes hospitalizados en Medicina Interna y los factores cl&#237;nicos y riesgo de muerte asociados a su presencia&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo de cohortes con pacientes ingresados en Medicina Interna&#46; Se recogieron la edad&#44; sexo&#44; presencia de &#250;lceras por presi&#243;n&#44; grado de la &#250;lcera&#44; &#237;ndice de Barthel&#44; escala de Norton&#44; categor&#237;a diagn&#243;stica mayor&#44; duraci&#243;n de la estancia hospitalaria y peso del grupo relacionado de diagn&#243;stico&#46; Se compararon las caracter&#237;sticas cl&#237;nicas de los pacientes con o sin &#250;lceras y se analiz&#243; la mortalidad al cabo de 3 a&#241;os en funci&#243;n de la presencia de &#250;lceras&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 699 pacientes&#44; de los que 100 &#40;14&#44;3&#37;&#41; presentaron &#250;lceras por presi&#243;n &#40;27 de grado <span class="elsevierStyleSmallCaps">I</span>&#44; 17 de grado <span class="elsevierStyleSmallCaps">II</span>&#44; 21 de grado <span class="elsevierStyleSmallCaps">III</span>&#44; 25 de grado <span class="elsevierStyleSmallCaps">IV</span> y 10 de grado no conocido&#41;&#46; El &#237;ndice de Barthel &#40;OR 0&#44;985 IC95&#37; 0&#44;972-0&#44;998&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;022&#41; y la escala de Norton &#40;OR 0&#44;873 IC95&#37; 0&#44;780&#8211;0&#44;997&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#41; se asociaron de forma independiente con las &#250;lceras&#46; Durante el ingreso fallecieron el 23&#37; de los pacientes con &#250;lceras&#44; al cabo de un a&#241;o el 68&#37; y a los 3 a&#241;os el 83&#37;&#46; La presencia de &#250;lceras por presi&#243;n se asoci&#243; de forma independiente con la mortalidad &#40;HR 1&#44;531&#44; IC95&#37; 1&#44;140&#8211;2&#44;056&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las &#250;lceras por presi&#243;n son frecuentes en los pacientes hospitalizados en Medicina Interna y su presencia se asocia con mayor mortalidad a corto&#44; medio y largo plazo&#46;</p></span>"
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            "titulo" => "Pacientes y m&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
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    "NotaPie" => array:3 [
      0 => array:3 [
        "etiqueta" => "&#9674;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">More information about IMPIMI researchers study is available in <a class="elsevierStyleCrossRef" href="#sec0060">Appendix</a>&#46;</p>"
        "identificador" => "fn0010"
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      1 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as&#58; D&#237;ez-Manglano J&#44; Fern&#225;ndez-Jim&#233;nez C&#44; Lamb&#225;n-Aranda MP&#44; Landa-Santesteban MC&#44; Isasi de Isasmendi-P&#233;rez S&#44; Moreno-Garc&#237;a P&#44; et al&#46; &#218;lceras por presi&#243;n en pacientes ingresados en Medicina Interna&#58; factores asociados y mortalidad&#46; Rev Clin Esp&#46; 2016&#59;216&#58;461&#8211;467&#46;</p>"
      ]
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        "etiqueta" => "&#42;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Department of Internal Medicine&#44; Hospital Royo Villanova&#44; Zaragoza&#44; Spain&#46;</p>"
        "identificador" => "fn0005"
      ]
    ]
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      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0125" class="elsevierStylePara elsevierViewall">Jes&#250;s D&#237;ez-Manglano&#44; Patricia Al-Cheikh-Felices&#44; Susana Alcubierre-Iriarte&#44; Mar&#237;a Jes&#250;s Arnal-Longares&#44; Julia Barranco-Us&#243;n&#44; Esperanza Bejarano Tello&#44; Mar&#237;a Pilar Carre&#241;o-Borrego&#44; Esther del Corral-Beamonte&#44; Fabiola D&#237;ez-Mass&#243;&#44; Cristina Fern&#225;ndez-Jim&#233;nez&#44; Juan Carlos Ferrando-Vela&#44; Vanesa Garc&#233;s-Horna&#44; Francisco Javier Gomes-Mart&#237;n&#44; Mar&#237;a Soledad Isasi de Isasmendi-P&#233;rez&#44; Mar&#237;a Pilar Lamb&#225;n-Aranda&#44; Mar&#237;a Cristina Landa-Santesteban&#44; Rosa Mar&#237;a Mart&#237;nez-&#193;lvarez&#44; Pablo Mart&#237;nez-Rod&#233;s&#44; Mar&#237;a Pilar Moreno-Garc&#237;a&#44; Eulalia Munilla L&#243;pez&#44; Claudia Palaz&#243;n-Fraile&#44; Mar&#237;a Jes&#250;s Pardo-D&#237;ez&#44; Pilar Pueyo-Tejedor&#44; Santiago Alfonso Rubio-F&#233;lix&#44; Rogelio Serrano-L&#225;zaro&#44; Mar&#237;a Sevil-Puras&#44; Sof&#237;a Terr&#233;n-Portol&#233;s&#44; Carla Toyas-Miazza&#46;</p>"
            "etiqueta" => "Appendix"
            "titulo" => "List of researchers of the IMPIMI study<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">&#42;</span></a><span class="elsevierStyleFootnote" id="fn0005"><span class="elsevierStyleLabel">&#42;</span><p class="elsevierStyleNotepara" id="npar0030">Department of Internal Medicine&#44; Hospital Royo Villanova&#44; Zaragoza&#44; Spain&#46;</p></span>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Diagram of the patient selection process&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cumulative survival curves &#40;Kaplan&#8211;Meier&#41; according to the presence or absence of pressure ulcers&#46; Abbreviation&#58; PU&#44; pressure ulcers&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviation</span>&#58; MDC&#44; major diagnostic category at discharge&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>699&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">With pressure ulcers &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Without pressure ulcers &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>599&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74&#46;6 &#40;15&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#46;2 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;3 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Sex</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">333 &#40;47&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;35&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">298 &#40;49&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">366 &#40;52&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;65&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">301 &#40;50&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Living in assisted residence</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158 &#40;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55 &#40;55&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">103 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">MDC</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nervous system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;10&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;204&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Respiratory system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;24&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">128 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;555&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Circulatory system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">96 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;16&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80 &#40;13&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;477&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Gastrointestinal system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">126 &#40;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Liver&#44; bile duct and pancreas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Kidneys and urinary tract&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infectious diseases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;4&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">119 &#40;17&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Barthel index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;2 &#40;38&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;8 &#40;30&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;4 &#40;34&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Norton scale</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;0 &#40;4&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;5 &#40;3&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;9 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Delirium</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">91 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Urinary catheter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">247 &#40;35&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;65&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">182 &#40;30&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Intravenous fluids</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">490 &#40;70&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89 &#40;89&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">401 &#40;66&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nasogastric tube</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;2&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;1&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Percutaneous gastrostomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate analysis</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate analysis</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;065 &#40;1&#46;040&#8211;1&#46;091&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;020 &#40;0&#46;990&#8211;1&#46;052&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;192&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Female sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;839 &#40;1&#46;183&#8211;2&#46;858&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;179 &#40;0&#46;668&#8211;2&#46;081&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Living in residence&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;874 &#40;3&#46;755&#8211;9&#46;189&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;235 &#40;0&#46;672&#8211;2&#46;267&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;497&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC gastrointestinal system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;580 &#40;0&#46;307&#8211;1&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;094&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;852 &#40;0&#46;350&#8211;2&#46;075&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC liver&#47;bile duct&#47;pancreas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;113 &#40;0&#46;015&#8211;0&#46;831&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;298 &#40;0&#46;035&#8211;2&#46;507&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;265&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC kidneys&#47;urinary tract&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;885 &#40;0&#46;975&#8211;3&#46;642&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;005 &#40;0&#46;418&#8211;2&#46;416&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;990&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC infectious disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;370 &#40;1&#46;068&#8211;5&#46;260&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;676 &#40;0&#46;614&#8211;4&#46;573&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;313&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;158 &#40;1&#46;263&#8211;3&#46;687&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;822 &#40;0&#46;406&#8211;1&#46;664&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;586&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Barthel index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;963 &#40;0&#46;956&#8211;0&#46;970&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;985 &#40;0&#46;972&#8211;0&#46;998&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Norton scale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;731 &#40;0&#46;687&#8211;0&#46;779&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;873 &#40;0&#46;780&#8211;0&#46;977&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary catheter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;255 &#40;2&#46;723&#8211;6&#46;649&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;686 &#40;0&#46;915&#8211;3&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;094&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Intravenous fluids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;995 &#40;2&#46;087&#8211;7&#46;646&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;603 &#40;0&#46;699&#8211;3&#46;677&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;265&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nasogastric tube&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;715 &#40;1&#46;600&#8211;13&#46;894&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;198 &#40;0&#46;320&#8211;4&#46;482&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Percutaneous gastrostomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;232 &#40;1&#46;523&#8211;55&#46;963&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;774 &#40;0&#46;466&#8211;48&#46;877&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;188&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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Original article
Pressure ulcers in patients hospitalized in internal medicine: Associated factors and mortality
Úlceras por presión en pacientes ingresados en Medicina Interna: factores asociados y mortalidad
J. Díez-Manglanoa,b,c,
Corresponding author
jdiez@aragon.es

Corresponding author.
, C. Fernández-Jiméneza, M.P. Lambán-Arandaa, M.C. Landa-Santestebana, S. Isasi de Isasmendi-Péreza, P. Moreno-Garcíaa, E. Bejarano-Telloa, J. Barranco-Usóna, E. Munilla-Lópeza, E. del Corral-Beamontea,b,c, IMPIMI researchers study
a Servicio de Medicina Interna, Hospital Royo Villanova, Zaragoza, Spain
b Grupo de Investigación en Comorbilidad y Pluripatología de Aragón, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain
c Departamento de Medicina, Dermatología y Psiquiatría, Universidad de Zaragoza, Spain
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immobility and&#44; on occasion&#44; deficient nutrition&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">4&#8211;6</span></a> Over the last 15 years in Spain&#44; several epidemiological surveys have been conducted on pressure ulcers&#44; and the prevalence in hospitalized patients remains approximately 8&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">7&#8211;9</span></a> Sixty percent of pressure ulcers observed in hospitalized patients develop in the hospital&#44; and a third of these are in advanced stages &#40;<span class="elsevierStyleSmallCaps">III</span> or <span class="elsevierStyleSmallCaps">IV</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">9</span></a> In 2013&#44; the prevalence of pressure ulcers was 7&#46;41&#37; in the Spanish medical departments&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">9</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Pressure ulcers can become infected and complicated easily&#44; with bleeding&#44; necrosis and pain appearing and requiring prolonged care&#46; Pressure ulcers are considered a factor of poor prognosis for hospitalized patients and are associated with increased mortality&#44; both if the patient presents them on admission and when they are acquired during hospitalization&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">10&#8211;12</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this study was to determine the prevalence of pressure ulcers in patients hospitalized in internal medicine departments&#44; the factors associated with their presence and their influence on short&#44; medium and long-term mortality&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Design</span><p id="par0025" class="elsevierStylePara elsevierViewall">The Minimal Intervention in Patients Hospitalized in Internal Medicine &#40;IMPIMI&#41; study<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">13&#44;14</span></a> &#40;<a class="elsevierStyleCrossRef" href="#sec0060">Appendix</a>&#41; is an intervention study with 2 parallel groups designed to reduce the duration of urinary tract catheterization and intravenous fluid treatment&#46; The intervention was applied to 1 of 2 groups&#46; Twice a week during the meeting of the therapeutic team of physicians and nurses&#44; an assessment was conducted on withdrawing the bladder catheters&#44; finalizing the intravenous fluid treatment&#44; the onset of pressure ulcers and the early detection of delirium&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Procedures</span><p id="par0030" class="elsevierStylePara elsevierViewall">The study included all unselected patients hospitalized in the department of internal medicine during the months of October 2010&#44; January 2011&#44; May 2011 and October 2011&#46; On admission&#44; a nurse interviewed each patient&#44; their relatives or companions to assess the patient&#39;s functional state and risk of pressure ulcers&#46; After the discharge&#44; the medical history data and data from the administrative database on hospital discharges were extracted&#46; The following information was collected from each patient&#58; age&#44; sex&#44; residence &#40;home or assisted living&#41;&#44; ability to perform basic activities of daily life&#44; risk of presenting pressure ulcers&#44; onset of delirium during hospitalization&#44; presence of pressure ulcers&#44; use during hospitalization of urinary catheter&#44; intravenous fluid therapy&#44; placement of nasogastric catheter or percutaneous gastrostomy&#44; major diagnostic category at discharge&#44; duration of the hospitalization and mean weight of the diagnosis-related group &#40;DRG&#41;&#46; The ability to perform the basic activities of daily life was assessed with the Barthel index&#44; which includes 10 tasks&#58; feeding&#44; bathing&#44; dressing&#44; grooming&#44; voiding&#44; defecation&#44; going to the toilet&#44; transferring&#44; walking and climbing up and down stairs&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">15</span></a> The range of scores is 0 to 100&#59; the higher the score&#44; the greater the individual&#39;s capacity&#46; Thus&#44; 0 corresponds to absolute dependence and 100 represents total autonomy for basic activities of daily life&#46; The Barthel index prior to admission in the stable phase was recorded&#46; The risk of presenting pressure ulcers was assessed with the Norton scale&#44; which records 5 parameters&#58; physical state&#44; mental state&#44; activity&#44; movement and incontinence&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">16</span></a> The scale ranges from 5 to 20&#59; the lower the score&#44; the greater the risk of pressure ulcers&#46; The presence of pressure ulcers was assessed at admission and every day during the hospitalization&#46; The severity of the pressure ulcers was graduated from <span class="elsevierStyleSmallCaps">I</span> to IV&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">17</span></a> and the highest degree pressure ulcer was recorded when there were more than one&#46; We also recorded whether the patient presented pressure ulcers at the time of discharge&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">A 3-year follow-up was subsequently conducted by reviewing the medical history&#44; by telephone or by consulting the National Death Index&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study was approved by the Clinical Research Ethics Committee of Aragon &#40;PI 12&#47;0009&#41;&#44; and the patients or their relatives provided their consent for inclusion in the study&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0045" class="elsevierStylePara elsevierViewall">The qualitative and quantitative variables are presented as absolute frequencies &#40;percentages&#41;&#44; and means &#40;standard deviation&#41;&#44; respectively&#46; The comparison of qualitative variables was conducted with the chi-squared test&#46; The Kolmogorov&#8211;Smirnov test was employed to verify that the quantitative variables did not follow a normal distribution&#46; The quantitative variables were compared with the Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">To assess the association of each variable with the presence of pressure ulcers&#44; we constructed a multivariate logistic regression model that included those variables with a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;1 in the univariate model&#46; To study the association of the variables with mortality&#44; we performed a Cox proportional regression and Kaplan&#8211;Meier survival curves with the log-rank test&#46; In all cases&#44; the level of statistical significance was <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46; The statistical analysis was conducted with the SPSS statistical package&#44; version 22&#46;0&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">We included 699 patients with a mean age of 74&#46;6 &#40;15&#46;2&#41; years&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows the patient selection diagram&#46; Pressure ulcers occurred in 100 &#40;14&#46;3&#37;&#41; patients&#44; 27 of whom had grade <span class="elsevierStyleSmallCaps">1</span>&#44; 17 had grade <span class="elsevierStyleSmallCaps">2</span>&#44; 21 had grade <span class="elsevierStyleSmallCaps">3</span> and 25 had grade <span class="elsevierStyleSmallCaps">4</span>&#59; 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The placement of a vesical catheter&#44; nasogastric catheter&#44; percutaneous gastrostomy and intravenous fluid treatment were more common in the patients with pressure ulcers&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">The multivariate analysis showed that the Barthel index and Norton scale were independently associated with the presence of pressure ulcers &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Mean hospital stay and expenditure</span><p id="par0070" class="elsevierStylePara elsevierViewall">The patients with pressure ulcers had longer mean stays &#40;13&#46;1 &#91;8&#46;4&#93; days vs&#46; 9 &#91;7&#46;4&#93;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; The weight of the DRG&#44; which estimates the hospitalization expenses&#44; was 2&#46;10 &#40;0&#46;96&#41; for the patients with pressure ulcers and 1&#46;58 &#40;0&#46;96&#41; for those without pressure ulcers &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Mortality</span><p id="par0075" class="elsevierStylePara elsevierViewall">Eighty-two patients died during hospitalization&#46; The mortality was greater for the patients with pressure ulcers &#40;23&#37; vs&#46; 9&#46;8&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; At 3 years&#44; 333 &#40;47&#46;6&#37;&#41; patients had died&#44; with a much greater mortality among the patients with pressure ulcers &#40;83&#37; vs&#46; 41&#46;7&#37;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Of these&#44; 23&#37; died during the hospitalization&#44; 56&#37; at 6 months and 68&#37; during the first year&#46; There were no differences in mortality during the hospitalization or at the end of the follow-up among the patients with differing degrees of pressure ulcer severity&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">The multivariate analysis showed that age&#44; nervous system diseases&#44; delirium&#44; the Barthel index and pressure ulcers were independently associated with mortality &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The pressure ulcers present at admission &#40;HR&#44; 3&#46;069&#59; 95&#37; CI 2&#46;326&#8211;4&#46;048&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41; and those that developed during hospitalization were associated with mortality &#40;HR&#44; 2&#46;340&#59; 95&#37; CI 1&#46;531&#8211;3&#46;576&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">The main findings of this study were that approximately 1 of every 7 patients hospitalized in internal medicine has pressure ulcers at admission or during hospitalization and that patients with pressure ulcers have a high mortality in the short&#44; mean and long-term&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Despite the improvements in treating pressure ulcers and the use of various strategies to prevent their onset in hospitalized patients&#44; the prevalence of pressure ulcers remains constant in the 3 national surveys conducted in Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">7&#8211;9</span></a> The same phenomenon has been observed in studies conducted in acute care tertiary hospitals&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> Age and the admitting department have been associated with pressure ulcers&#44; which are more common in medical departments than in surgical ones&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">6</span></a> The prevalence has varied between 6&#46;3&#37; and 8&#46;6&#37; in the collection of medical departments of acute care hospitals&#46;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">15&#44;16</span></a> We observed a prevalence of 14&#46;3&#37;&#44; which was higher than previously reported and possibly due to the fact that the study was performed exclusively in a department of internal medicine&#44; whose patients are usually older than those of other medical departments&#44; with the exception of geriatric medicine units&#46; In fact&#44; in the study by Tom&#225;s-Life et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">18</span></a> conducted in the medical departments of the Balearic Islands&#44; the prevalence of pressure ulcers in the age group older than 70 years was 11&#46;4&#37;&#44; which is closer to the rate observed in our study&#46; It is known that mild pressure ulcers occasionally go unnoticed and are not recorded in the medical records&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">19</span></a> A meta-analysis found that the exclusive clinical judgment of the nursing staff was insufficient for detecting pressure ulcers and that the judgment needed to be combined with the use of a validated scale&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> Our study falls within a prospective program targeted at the early detection of pressure ulcers using the Norton scale&#46; We therefore expect that the physicians and nurses are more sensitized to detecting and recording pressure ulcers&#44; with a more comprehensive patient assessment&#44; as recommended by the clinical practice guidelines&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">21&#44;22</span></a> This could justify the higher prevalence we observed&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">There are various scales for assessing the risk of presenting a pressure ulcer&#46; We employed the Norton scale&#44; which has one of highest predictive capacities&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">20</span></a> One of the items on this scale is the patient&#39;s mobility&#46; Length of stay&#44; presence of coma&#44; carrying a urinary catheter or nasogastric catheter and undergoing intravenous fluid treatment are factors that have been associated with the onset of pressure ulcers&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">1&#44;6&#44;23</span></a> All of these factors are related to immobility&#46; In the univariate analysis&#44; carrying a urinary or nasogastric catheter or percutaneous gastrostomy and the intravenous administration of fluids were associated with the presence of pressure ulcers&#46; It is difficult to establish the causality because this type of catheter is also placed in patients with pressure ulcers to administer drugs&#44; nutrition and to avoid contaminating the pressure ulcers with urine&#46; However&#44; we believe that all strategies directed toward decreasing the duration of catheterization in patients who do not have pressure ulcers can help prevent their onset&#46; Delirium was more common in the patients with pressure ulcers and can sometimes result in restricted movement with the use of hospital beds with guardrails and even restraints&#46; However&#44; only the Norton scale and disability measured by the Barthel index were factors independently associated with pressure ulcers&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Another of this study&#39;s findings was that the hospital stay of patients with pressure ulcers was extended by 4 days&#46; In a study with more than 5 million discharges from departments of internal medicine in Spain&#44; pressure ulcers were 10 times more common in patients with a hospital stay longer than 30 days&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">1</span></a> A study conducted in 2007 estimated that the cost of treating pressure ulcers in Spain was 461 million euros and that 45&#37; of this expenditure was due to prolonged hospital stays&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">24</span></a> In our study&#44; the weight of the DRG was 0&#46;52 higher in the cases with pressure ulcers&#44; which corresponded to an additional expenditure of &#8364; 2435&#46;94 according to data from the Ministry of Health&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">25</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Almost half of the patients had died after the 3 years of follow-up&#46; This is a high mortality rate&#44; which could be explained by the patients&#8217; mean age and their complexity&#46; This complexity was manifested in a high degree of disability and the high weight of the DRG&#46; Pressure ulcers have been associated with increased mortality&#46; In our series&#44; one of every 4 patients with pressure ulcers died during hospitalization&#46; Two of every 3 had died by the end of a year and more than 8 of every 10 had died by the end of 3 years&#46; We can therefore consider pressure ulcers as a factor of poor prognosis in the short&#44; medium and long term&#46; Previous studies have already confirmed this association with mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">10&#44;26</span></a> Recently&#44; pressure ulcers have been included in an index to establish the prognosis at 6 months in patients with chronic diseases in advanced phases&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">27</span></a> Given these findings&#44; we consider that when a patient presents pressure ulcers we must start planning the start of palliative care&#44; especially if the patient is elderly&#44; dependent or has delirium or a nervous system disorder&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">We know of no other study published in Spain on the prevalence of pressure ulcers in a department of internal medicine&#46; This is one of the strengths of our study&#44; along with the extended patient follow-up&#46; However&#44; our study also has a number of limitations&#46; Firstly&#44; the study was conducted in a single hospital&#59; multicenter studies are known to provide evidence with greater rigor&#46; This fact could decrease the extrapolation of the results to other settings&#46; Secondly&#44; the study was conducted within the framework of a specific project for monitoring the onset of pressure ulcers&#44; and its results on prevalence could be different from those outside this research context&#46; However&#44; this is also a strength because the results reflect data from the real world&#44; which in other circumstances could go unnoticed&#46; It is a fact that physicians occasionally ignore the presence of pressure ulcers in their patients&#44; especially when the pressure ulcers are low-grade&#44; delegating their surveillance and care to the nursing staff despite the prognostic importance of pressure ulcers&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In summary&#44; pressure ulcers are very common in patients hospitalized in internal medicine and are associated with a poor prognosis&#46; Their assessment is therefore essential for establishing the short&#44; medium and long-term therapeutic objectives&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interests</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine the prevalence of pressure ulcers in patients hospitalized in internal medicine and the clinical factors and risk of death associated with its presence&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study with patients hospitalized in internal medicine&#46; We recorded the age&#44; sex&#44; presence of pressure ulcers&#44; degree of ulceration&#44; Barthel index&#44; Norton scale&#44; major diagnostic category&#44; length of hospital stay and weight of the diagnosis-related groups&#46; We compared the clinical characteristics of the patients with or without ulcers and analyzed the mortality after 3 years based on the presence of ulcers&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The study included 699 patients&#44; 100 of whom &#40;14&#46;3&#37;&#41; had pressure ulcers &#40;27 with grade I&#44; 17 with grade II&#44; 21 with grade III&#44; 25 with grade IV and 10 with unknown grade&#41;&#46; The Barthel index &#40;OR 0&#46;985&#59; 95&#37; CI 0&#46;972&#8211;0&#46;998&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;022&#41; and Norton scale &#40;OR 0&#46;873&#59; 95&#37; CI 0&#46;780&#8211;0&#46;997&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;018&#41; are independently associated with ulcers&#46; Twenty-three percent of the patients with ulcers died during hospitalization&#44; 68&#37; died within a year&#44; and 83&#37; died within 3 years&#46; The presence of pressure ulcers was independently associated with mortality &#40;HR&#44; 1&#46;531&#59; 95&#37; CI 1&#46;140&#8211;2&#46;056&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;005&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Pressure ulcers are common in patients hospitalized in internal medicine&#44; and their presence is associated with higher short&#44; medium and long-term mortality&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar la prevalencia de las &#250;lceras por presi&#243;n en pacientes hospitalizados en Medicina Interna y los factores cl&#237;nicos y riesgo de muerte asociados a su presencia&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo de cohortes con pacientes ingresados en Medicina Interna&#46; Se recogieron la edad&#44; sexo&#44; presencia de &#250;lceras por presi&#243;n&#44; grado de la &#250;lcera&#44; &#237;ndice de Barthel&#44; escala de Norton&#44; categor&#237;a diagn&#243;stica mayor&#44; duraci&#243;n de la estancia hospitalaria y peso del grupo relacionado de diagn&#243;stico&#46; Se compararon las caracter&#237;sticas cl&#237;nicas de los pacientes con o sin &#250;lceras y se analiz&#243; la mortalidad al cabo de 3 a&#241;os en funci&#243;n de la presencia de &#250;lceras&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 699 pacientes&#44; de los que 100 &#40;14&#44;3&#37;&#41; presentaron &#250;lceras por presi&#243;n &#40;27 de grado <span class="elsevierStyleSmallCaps">I</span>&#44; 17 de grado <span class="elsevierStyleSmallCaps">II</span>&#44; 21 de grado <span class="elsevierStyleSmallCaps">III</span>&#44; 25 de grado <span class="elsevierStyleSmallCaps">IV</span> y 10 de grado no conocido&#41;&#46; El &#237;ndice de Barthel &#40;OR 0&#44;985 IC95&#37; 0&#44;972-0&#44;998&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;022&#41; y la escala de Norton &#40;OR 0&#44;873 IC95&#37; 0&#44;780&#8211;0&#44;997&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#41; se asociaron de forma independiente con las &#250;lceras&#46; Durante el ingreso fallecieron el 23&#37; de los pacientes con &#250;lceras&#44; al cabo de un a&#241;o el 68&#37; y a los 3 a&#241;os el 83&#37;&#46; La presencia de &#250;lceras por presi&#243;n se asoci&#243; de forma independiente con la mortalidad &#40;HR 1&#44;531&#44; IC95&#37; 1&#44;140&#8211;2&#44;056&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;005&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Las &#250;lceras por presi&#243;n son frecuentes en los pacientes hospitalizados en Medicina Interna y su presencia se asocia con mayor mortalidad a corto&#44; medio y largo plazo&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0025">More information about IMPIMI researchers study is available in <a class="elsevierStyleCrossRef" href="#sec0060">Appendix</a>&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as&#58; D&#237;ez-Manglano J&#44; Fern&#225;ndez-Jim&#233;nez C&#44; Lamb&#225;n-Aranda MP&#44; Landa-Santesteban MC&#44; Isasi de Isasmendi-P&#233;rez S&#44; Moreno-Garc&#237;a P&#44; et al&#46; &#218;lceras por presi&#243;n en pacientes ingresados en Medicina Interna&#58; factores asociados y mortalidad&#46; Rev Clin Esp&#46; 2016&#59;216&#58;461&#8211;467&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Department of Internal Medicine&#44; Hospital Royo Villanova&#44; Zaragoza&#44; Spain&#46;</p>"
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            "apendice" => "<p id="par0125" class="elsevierStylePara elsevierViewall">Jes&#250;s D&#237;ez-Manglano&#44; Patricia Al-Cheikh-Felices&#44; Susana Alcubierre-Iriarte&#44; Mar&#237;a Jes&#250;s Arnal-Longares&#44; Julia Barranco-Us&#243;n&#44; Esperanza Bejarano Tello&#44; Mar&#237;a Pilar Carre&#241;o-Borrego&#44; Esther del Corral-Beamonte&#44; Fabiola D&#237;ez-Mass&#243;&#44; Cristina Fern&#225;ndez-Jim&#233;nez&#44; Juan Carlos Ferrando-Vela&#44; Vanesa Garc&#233;s-Horna&#44; Francisco Javier Gomes-Mart&#237;n&#44; Mar&#237;a Soledad Isasi de Isasmendi-P&#233;rez&#44; Mar&#237;a Pilar Lamb&#225;n-Aranda&#44; Mar&#237;a Cristina Landa-Santesteban&#44; Rosa Mar&#237;a Mart&#237;nez-&#193;lvarez&#44; Pablo Mart&#237;nez-Rod&#233;s&#44; Mar&#237;a Pilar Moreno-Garc&#237;a&#44; Eulalia Munilla L&#243;pez&#44; Claudia Palaz&#243;n-Fraile&#44; Mar&#237;a Jes&#250;s Pardo-D&#237;ez&#44; Pilar Pueyo-Tejedor&#44; Santiago Alfonso Rubio-F&#233;lix&#44; Rogelio Serrano-L&#225;zaro&#44; Mar&#237;a Sevil-Puras&#44; Sof&#237;a Terr&#233;n-Portol&#233;s&#44; Carla Toyas-Miazza&#46;</p>"
            "etiqueta" => "Appendix"
            "titulo" => "List of researchers of the IMPIMI study<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">&#42;</span></a><span class="elsevierStyleFootnote" id="fn0005"><span class="elsevierStyleLabel">&#42;</span><p class="elsevierStyleNotepara" id="npar0030">Department of Internal Medicine&#44; Hospital Royo Villanova&#44; Zaragoza&#44; Spain&#46;</p></span>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cumulative survival curves &#40;Kaplan&#8211;Meier&#41; according to the presence or absence of pressure ulcers&#46; Abbreviation&#58; PU&#44; pressure ulcers&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>699&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">With pressure ulcers &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Without pressure ulcers &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>599&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74&#46;6 &#40;15&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#46;2 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;3 &#40;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Sex</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">333 &#40;47&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;35&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">298 &#40;49&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">366 &#40;52&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;65&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">301 &#40;50&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Living in assisted residence</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">158 &#40;22&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55 &#40;55&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">103 &#40;17&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">MDC</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nervous system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;10&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;204&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Respiratory system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;24&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">128 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;555&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Circulatory system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">96 &#40;13&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;16&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">80 &#40;13&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;477&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Gastrointestinal system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">126 &#40;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;12&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">114 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Liver&#44; bile duct and pancreas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;7&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;1&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Kidneys and urinary tract&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;056&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infectious diseases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;9&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;4&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">119 &#40;17&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">100 &#40;16&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Barthel index</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;2 &#40;38&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&#46;8 &#40;30&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&#46;4 &#40;34&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Norton scale</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;0 &#40;4&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;5 &#40;3&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;9 &#40;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Delirium</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">91 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Urinary catheter</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">247 &#40;35&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;65&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">182 &#40;30&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Intravenous fluids</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">490 &#40;70&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">89 &#40;89&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">401 &#40;66&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nasogastric tube</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;2&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;6&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;1&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Percutaneous gastrostomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;0&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate analysis</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate analysis</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;007&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;570&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;235 &#40;0&#46;672&#8211;2&#46;267&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;497&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;580 &#40;0&#46;307&#8211;1&#46;097&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;094&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;852 &#40;0&#46;350&#8211;2&#46;075&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC liver&#47;bile duct&#47;pancreas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;113 &#40;0&#46;015&#8211;0&#46;831&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;298 &#40;0&#46;035&#8211;2&#46;507&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;265&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MDC kidneys&#47;urinary tract&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;885 &#40;0&#46;975&#8211;3&#46;642&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;005 &#40;0&#46;418&#8211;2&#46;416&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;990&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;370 &#40;1&#46;068&#8211;5&#46;260&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;034&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;676 &#40;0&#46;614&#8211;4&#46;573&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;313&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Delirium&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;158 &#40;1&#46;263&#8211;3&#46;687&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;822 &#40;0&#46;406&#8211;1&#46;664&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;586&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Barthel index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;963 &#40;0&#46;956&#8211;0&#46;970&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;985 &#40;0&#46;972&#8211;0&#46;998&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;022&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Norton scale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;731 &#40;0&#46;687&#8211;0&#46;779&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;873 &#40;0&#46;780&#8211;0&#46;977&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Urinary catheter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;255 &#40;2&#46;723&#8211;6&#46;649&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;686 &#40;0&#46;915&#8211;3&#46;106&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;094&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;603 &#40;0&#46;699&#8211;3&#46;677&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;265&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;715 &#40;1&#46;600&#8211;13&#46;894&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;198 &#40;0&#46;320&#8211;4&#46;482&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;789&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Percutaneous gastrostomy&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;774 &#40;0&#46;466&#8211;48&#46;877&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;188&nbsp;\t\t\t\t\t\t\n
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                    0 => array:2 [
                      "titulo" => "Prolonged length of stay in hospitalized internal medicine patients"
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                          "autores" => array:6 [
                            0 => "R&#46; Barba"
                            1 => "J&#46; Marco"
                            2 => "J&#46; Canora"
                            3 => "S&#46; Plaza"
                            4 => "S&#46;N&#46; Juncos"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "La edad de los pacientes atendidos en los servicios de medicina interna en Espa&#241;a&#58; una perspectiva de 20 a&#241;os"
                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => "J&#46; Casademont"
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                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2012"
                        "volumen" => "138"
                        "paginaInicial" => "289"
                        "paginaFinal" => "292"
                      ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
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ISSN: 22548874
Original language: English
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