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Special article
DOI: 10.1016/j.rceng.2024.10.007
Pre-proof, online 29 October 2024
2024 Spanish Society of Internal Medicine (SEMI) recommendations for the management of cancer-associated venous thrombosis
Recomendaciones 2024 de la Sociedad Española de Medicina Interna (SEMI) para el manejo de la trombosis venosa asociada al cáncer
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Aurora Villalobosa, Reina Valleb, Javier Pagán-Escribanoc,d, María Ortize, Pablo Demelo-Rodríguezf,g,h, Carme Fonti,
Corresponding author
Carme.fontpuig@gmail.com
CFONT@clinic.cat

Corresponding author.
a Servicio de Medicina Interna, Hospital Universitario Regional de Málaga
b Servicio de Medicina Interna, Hospital Sierrallana, Torrelavega
c Unidad de Enfermedad Tromboembólica Venosa, Medicina Interna, Hospital General Universitario José María Morales Meseguer
d Centro Regional de Hemodonación, Servicio Murciano de Salud
e Servicio de Medicina Interna, Hospital Clinic de Barcelona
f Unidad de Enfermedad Tromboembólica Venosa, Medicina Interna, Hospital General Universitario Gregorio Marañón
g Instituto de Investigación Sanitaria Gregorio Marañón
h Facultad de Medicina, Universidad Complutense de Madrid
i Servicio de Oncología Médica, Hospital Clinic de Barcelona
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Abstract

Venous thromboembolic disease (VTD) is a common complication associated to greater mortality in patients with cancer. Its etiology is multifactorial and depends on the characteristics and co-morbidities of the patient, the tumor type and extension, and the oncological treatment. The management of VTD is more complex in patients with cancer due to an increased risk of recurrence and major bleeding complications during anticoagulation compared to the general non-oncological population. The above differences have led to the development of specific clinical trials to assess the efficacy and safety of anticoagulant therapy in patients with cancer. The present clinical guidelines are intended to provide general recommendations on the management of cancer-associated VTD according to updated according to the most recent scientific evidence.

Keywords:
cancer-associated thrombosis
paraneoplastic thrombosis
consensus recommendations for clinical practice
Resumen

La enfermedad tromboembólica venosa (ETV) es una complicación frecuente y que se asocia a mayor mortalidad en los pacientes con cáncer. Su etiología es multifactorial y depende de las características y comorbilidades del paciente, del tipo y extensión del tumor y del tratamiento oncológico. El manejo de la ETV en los pacientes con cáncer es más complejo debido a un mayor riesgo de recurrencia a pesar del tratamiento anticoagulante y de complicaciones hemorrágicas comparado con la población general. Estas diferencias han llevado al desarrollo de ensayos clínicos específicos para evaluar la eficacia y seguridad del tratamiento anticoagulante en la población oncológica. Estas guías pretenden dar recomendaciones generales sobre el manejo de la ETV asociada al cáncer según la evidencia científica más reciente.

Palabras clave:
Trombosis asociada al cáncer
Trombosis paraneoplásica
Recomendaciones de consenso para la práctica clínica

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